ramelteon使用与跌倒和骨折相关：一项系统回顾和荟萃分析。

IF 3.7 2区医学 Q1 PSYCHIATRY

General hospital psychiatry Pub Date : 2025-09-27 DOI:10.1016/j.genhosppsych.2025.09.009

Rintaro Sogawa , Yuki Nakano , Kazumasa Kotake , Hiroshi Tateishi , Yoshito Mizoguchi , Akira Monji , Chisato Shimanoe

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引用次数: 0

摘要

催眠药与跌倒和骨折的风险增加有关。然而，大多数评估ramelteon与这些结果之间关系的研究都是单中心的，缺乏全面的分析。我们的目的是评估ramelteon使用与跌倒和骨折风险之间的关系。方法：我们通过PubMed、Cochrane中央对照试验注册库、国际临床试验注册平台和ClinicalTrials.gov，系统地在医学文献分析和在线检索系统中检索“ramelteon”一词。2025年1月7日。采用基于Sidik-Jonkman方法的随机效应模型，对检索到的研究进行偏倚风险评估，分析ramelteon使用与跌倒或骨折之间的关系，并使用I2统计量分析研究间异质性。对7项观察性研究和3项随机对照试验进行meta分析。结果：Ramelteon的使用与跌倒风险的增加没有显著相关（优势比：1.26；95%可信区间：0.83-1.92;I2 = 0%）。骨折分析显示ramelteon使用的潜在风险增加（风险比：3.29；95%可信区间：0.53-20.45;I2 = 0%），尽管这没有统计学意义。结论：无论研究设计如何，Ramelteon与跌倒或骨折风险的统计学显著增加无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Falls and fractures associated with ramelteon use: A systematic review and meta-analysis

Introduction

Hypnotics are associated with increased risk of falls and fractures. However, most studies evaluating the association between ramelteon, and these outcomes, are single-center and lack comprehensive analysis. We aimed to evaluate the association between ramelteon use and the risk of falls and fractures.

Methods

We systematically searched for the term “ramelteon” in the Medical Literature Analysis and Retrieval System Online via PubMed, Cochrane Central Register of Controlled Trials, International Clinical Trials Registry Platform, and ClinicalTrials.gov. in January 7, 2025. Retrieved studies were assessed for risk of bias and analyzed for the association between ramelteon use and falls or fractures using a random-effects model based on the Sidik–Jonkman method, as well as inter-study heterogeneity using the I² statistic. Meta-analyses were conducted on seven observational studies and three randomized controlled trials.

Results

Ramelteon use was not significantly associated with an increased fall risk (odds ratio: 1.26; 95 % confidence interval: 0.83–1.92; I² = 0 %). Analysis of fractures showed a potential increased risk with ramelteon use (risk ratio: 3.29; 95 % confidence interval: 0.53–20.45; I² = 0 %), although this was not statistically significant.

Conclusion

Ramelteon was not associated with a statistically significant increase in the risk of falls or fractures, regardless of the study design.

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来源期刊

General hospital psychiatry 医学-精神病学

CiteScore

9.60

自引率

2.90%

发文量

125

审稿时长

20 days

期刊介绍： General Hospital Psychiatry explores the many linkages among psychiatry, medicine, and primary care. In emphasizing a biopsychosocial approach to illness and health, the journal provides a forum for professionals with clinical, academic, and research interests in psychiatry''s role in the mainstream of medicine.