{"title":"Risk of agranulocytosis and neutropenia in patients with Parkinson's disease psychosis receiving clozapine treatment: A systematic review and meta-analysis.","authors":"Nahathai Limveeraprajak, Worawut Makkapavee, Surinporn Likhitsathian, Manit Srisurapanont","doi":"10.1016/j.genhosppsych.2024.12.003","DOIUrl":"https://doi.org/10.1016/j.genhosppsych.2024.12.003","url":null,"abstract":"<p><strong>Objective: </strong>To assess the cumulative incidence of severe neutropenia and agranulocytosis (SNA) and mild and moderate neutropenia (MMN) in patients with Parkinson's disease psychosis (PDP) who receive clozapine treatment.</p><p><strong>Methods: </strong>We searched multiple databases to identify clozapine studies in PDP patients. Incidence rates were assessed during short-term (within 1 month), medium-term (within 6 months), and long-term (> 6 months) monitoring periods. A proportional meta-analysis was performed using random-effects and generalized linear mixed models (GLMMs).</p><p><strong>Results: </strong>We included 691 PDP patients from 19 studies. During the short-term monitoring period, none of the 573 participants in 16 studies developed SNA. The pooled incidence of SNA was 0.001 (95 % confidence interval [CI]: 0.000-0.253, 525 participants, 15 studies) during the medium-term period and 0.002 (95 % CI: 0.000-0.015, 475 participants, 12 studies) during the long-term period. The pooled incidence of MMN was 0.004 (95 % CI: 0.000-0.281, 164 participants, 7 studies) for short- and medium-term periods and 0.013 (95 % CI: 0.002-0.094, 193 participants, 7 studies) in the long-term period. Funnel plot asymmetry indicated potential bias in the medium-term dataset of SNA (p = 0.035).</p><p><strong>Conclusion: </strong>Clozapine treatment in PDP patients may carry a very low risk of SNA and a low risk of MMN.</p>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"92 ","pages":"4-11"},"PeriodicalIF":4.1,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Runtang Meng, Nongnong Yang, Yi Luo, Ciarán O'Driscoll, Haiyan Ma, Alice M Gregory, Joseph M Dzierzewski
{"title":"Detecting psychometric and diagnostic performance of the RU_SATED v2.0 multidimensional sleep health scale in community-dwelling adults combining exploratory graph analysis and ROC analysis.","authors":"Runtang Meng, Nongnong Yang, Yi Luo, Ciarán O'Driscoll, Haiyan Ma, Alice M Gregory, Joseph M Dzierzewski","doi":"10.1016/j.genhosppsych.2024.12.001","DOIUrl":"https://doi.org/10.1016/j.genhosppsych.2024.12.001","url":null,"abstract":"<p><strong>Objective: </strong>The RU_SATED scale is increasingly used across the globe to measure sleep health. However, there is a lack of consensus around its psychometric and diagnostic performance. We conducted an empirical investigation into the psychometrics of the Chinese version of the RU_SATED (RU_SATED-C) scale, with a focus on structural validity and diagnostic performance.</p><p><strong>Methods: </strong>1171 adults were enrolled from three communities in Hangzhou, China in July 2022. The dataset was spilt in half, and we ran a bootstrapped exploratory graph analysis (bootEGA) in one half and a confirmatory factor analysis (CFA) in the other half to assess structural validity. Correlations with insomnia, wellness, anxiety, and depression symptoms were examined in order to assess concurrent validity; and Cronbach's α and McDonald's ω were calculated to assess internal consistency. Additionally, a Receiver Operating Characteristic (ROC) analysis established and externally validated the optimal score for identifying insomnia symptoms.</p><p><strong>Results: </strong>A one-dimensional structure, as identified by bootEGA, was corroborated in the CFA [comparative fit index = 0.934, root mean square error of approximation = 0.088, standardized root mean square residual = 0.051]. A moderate correlation was shown with insomnia symptoms, while weak correlations were observed with wellness, anxiety, and depression symptoms. The RU_SATED-C scale displayed sub-optimal internal consistency where coefficients dropped if any item was removed. A recommended cutoff score of ≤13 was derived for probable insomnia with a satisfactory diagnostic performance.</p><p><strong>Conclusion: </strong>The RU_SATED-C scale displayed a one-dimensional model, along with adequate concurrent validity, internal consistency, and diagnostic performance. Further work necessitates multi-scenario testing and additional validation using objective sleep assessments.</p>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"92 ","pages":"75-83"},"PeriodicalIF":4.1,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Response to the comments on “Global prevalence of poor sleep quality in cancer patients: A systematic review and meta-analysis”","authors":"Meng-Yi Chen , Gabor S. Ungvari , Yu-Tao Xiang","doi":"10.1016/j.genhosppsych.2024.11.012","DOIUrl":"10.1016/j.genhosppsych.2024.11.012","url":null,"abstract":"","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"92 ","pages":"Page 1"},"PeriodicalIF":4.1,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142758743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prevalence of reversible visual impairments and their association with the psychiatric illness severity among inpatients with psychotic disorders.","authors":"Mathieu Fradet, Fannie Nadeau, Alexandre Suey, Mazen Choulakian, Sylvain Grignon","doi":"10.1016/j.genhosppsych.2024.11.005","DOIUrl":"https://doi.org/10.1016/j.genhosppsych.2024.11.005","url":null,"abstract":"","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142618304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Irving Gabriel Calisaya-Madariaga, Lia Valentina Ubillús Peña
{"title":"Mental health effects of neurosurgery for drug-resistant epilepsy.","authors":"Irving Gabriel Calisaya-Madariaga, Lia Valentina Ubillús Peña","doi":"10.1016/j.genhosppsych.2024.11.002","DOIUrl":"https://doi.org/10.1016/j.genhosppsych.2024.11.002","url":null,"abstract":"","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142618298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Braden O'Neill, John Wang, Jessica Gronsbell, Debra Butt, Anthony Train, Angela Ortigoza, Bianca Seaton, Andrea Gershon, Karen Tu
{"title":"Cancer screening among people with schizophrenia before and after the COVID-19 pandemic in Ontario, Canada: Retrospective cohort study.","authors":"Braden O'Neill, John Wang, Jessica Gronsbell, Debra Butt, Anthony Train, Angela Ortigoza, Bianca Seaton, Andrea Gershon, Karen Tu","doi":"10.1016/j.genhosppsych.2024.10.017","DOIUrl":"https://doi.org/10.1016/j.genhosppsych.2024.10.017","url":null,"abstract":"","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142618293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
General hospital psychiatryPub Date : 2024-11-01Epub Date: 2024-08-21DOI: 10.1016/j.genhosppsych.2024.08.004
Kevin G Saulnier, Julia Browne, Stephanie Merrill, Anna L Philibert, Peter P Grau, Benjamin R Szymanski, Nicholas W Bowersox
{"title":"Rapid transition to virtual care during the COVID-19 pandemic for VHA patients with serious mental illness.","authors":"Kevin G Saulnier, Julia Browne, Stephanie Merrill, Anna L Philibert, Peter P Grau, Benjamin R Szymanski, Nicholas W Bowersox","doi":"10.1016/j.genhosppsych.2024.08.004","DOIUrl":"10.1016/j.genhosppsych.2024.08.004","url":null,"abstract":"","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":" ","pages":"240-242"},"PeriodicalIF":4.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142035638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}