General hospital psychiatry最新文献

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Trauma and PTSD symptoms in a drug abuse service center in Hong Kong 香港一间药物滥用服务中心的创伤及PTSD症状
IF 4.1 2区 医学
General hospital psychiatry Pub Date : 2025-04-26 DOI: 10.1016/j.genhosppsych.2025.04.012
Hong Wang Fung
{"title":"Trauma and PTSD symptoms in a drug abuse service center in Hong Kong","authors":"Hong Wang Fung","doi":"10.1016/j.genhosppsych.2025.04.012","DOIUrl":"10.1016/j.genhosppsych.2025.04.012","url":null,"abstract":"","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"95 ","pages":"Pages 65-66"},"PeriodicalIF":4.1,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143882954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acupuncture for alcohol use disorder: Research status and potential strategies to improve therapeutic efficacy 针刺治疗酒精使用障碍:研究现状及提高疗效的潜在策略
IF 4.1 2区 医学
General hospital psychiatry Pub Date : 2025-04-26 DOI: 10.1016/j.genhosppsych.2025.04.010
Han Gao , Yixuan Jin , Guan-Hua Lv , Rongwei Huang
{"title":"Acupuncture for alcohol use disorder: Research status and potential strategies to improve therapeutic efficacy","authors":"Han Gao ,&nbsp;Yixuan Jin ,&nbsp;Guan-Hua Lv ,&nbsp;Rongwei Huang","doi":"10.1016/j.genhosppsych.2025.04.010","DOIUrl":"10.1016/j.genhosppsych.2025.04.010","url":null,"abstract":"<div><div>Alcohol use disorder (AUD) is a prevalent, chronic relapsing substance use disorder, with its prevalence increasing worldwide, along with socioeconomic development. Given the limitations of conventional AUD treatments, including the variable efficacy of pharmacotherapy and implementation challenges of some psychotherapy methods, researchers have increasingly investigated acupuncture as a potential adjunctive therapy. Acupuncture is a traditional complementary therapy that has shown potential in managing mental and behavioral disorders. While its cost-effectiveness and accessibility vary across healthcare systems, preliminary evidence suggests adjunctive benefits for AUD. Through modulation of the dopaminergic and opioid systems and the hypothalamic–pituitary–adrenal axis, acupuncture may reduce alcohol consumption and cravings, thereby facilitating AUD management and alleviating associated mental health issues such as anxiety, depression, and insomnia. This review investigated and stratified commonly used acupoints in preclinical and clinical studies, offering recommendations for enhanced application and investigation of acupuncture treatment for AUD. The paucity of research in this domain warrants further exploration through well-structured research initiatives.</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"95 ","pages":"Pages 67-77"},"PeriodicalIF":4.1,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143898769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnostic yield of laboratory testing in hospitalized older adults with altered mental status 精神状态改变的住院老年人实验室检查的诊断率
IF 4.1 2区 医学
General hospital psychiatry Pub Date : 2025-04-22 DOI: 10.1016/j.genhosppsych.2025.04.007
Izumi Sato , Hideki Onishi , Yoshitaka Ooya , Nozomu Uchida , Akira Yoshioka , Mayumi Ishida
{"title":"Diagnostic yield of laboratory testing in hospitalized older adults with altered mental status","authors":"Izumi Sato ,&nbsp;Hideki Onishi ,&nbsp;Yoshitaka Ooya ,&nbsp;Nozomu Uchida ,&nbsp;Akira Yoshioka ,&nbsp;Mayumi Ishida","doi":"10.1016/j.genhosppsych.2025.04.007","DOIUrl":"10.1016/j.genhosppsych.2025.04.007","url":null,"abstract":"","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"95 ","pages":"Page 62"},"PeriodicalIF":4.1,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143870264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The prevalence of suicide ideation, suicide attempt and suicide in borderline personality disorder patients: A systematic review and meta-analysis 边缘型人格障碍患者自杀意念、自杀企图和自杀的患病率:一项系统综述和荟萃分析
IF 4.1 2区 医学
General hospital psychiatry Pub Date : 2025-04-21 DOI: 10.1016/j.genhosppsych.2025.04.005
Mohammadmahdi Lak , Shima Shakiba , Behrooz Dolatshahi , Mohammad Saatchi , Mohammadamin Shahrbaf , Atefeh Jafarpour
{"title":"The prevalence of suicide ideation, suicide attempt and suicide in borderline personality disorder patients: A systematic review and meta-analysis","authors":"Mohammadmahdi Lak ,&nbsp;Shima Shakiba ,&nbsp;Behrooz Dolatshahi ,&nbsp;Mohammad Saatchi ,&nbsp;Mohammadamin Shahrbaf ,&nbsp;Atefeh Jafarpour","doi":"10.1016/j.genhosppsych.2025.04.005","DOIUrl":"10.1016/j.genhosppsych.2025.04.005","url":null,"abstract":"<div><h3>Background</h3><div>Borderline personality disorder (BPD) is associated with a high risk of suicidality, including suicide ideation, suicide attempts, and suicide. This meta-analysis aims to determine the lifetime prevalence of these dimensions in patients with BPD and to identify associated factors to inform clinical practice and intervention strategies.</div></div><div><h3>Methods</h3><div>We searched PubMed, Scopus, Web of Science, and Embase for observational articles (cross-sectional, cohort, longitudinal and case-control) reporting suicide ideation, suicide attempts, and suicide in patients with BPD. Data including age, sex, diagnostic criteria, inpatient/outpatient care, comorbidity, and rates of suicide ideation, suicide attempts, and suicide were extracted. A pooled analysis with a random effects model was performed using STATA.</div></div><div><h3>Results</h3><div>35 studies including 34,832 patients with BPD were included in the final analysis. The pooled rate of suicidal ideation, suicide attempts, and suicides in patients with BPD was 80 % (95 % CI: 61 %–94 %), 52 % (95 % CI: 47 %–58 %), and 6 % (95 % CI: 4 %–8 %), respectively. The younger age group of BPD patients had a significantly higher lifetime prevalence of suicide ideation, and suicide attempt (<em>p</em> &lt; 0.001). The inpatient group of BPD patients had a significantly higher lifetime prevalence of suicidal attempt (<em>p</em> &lt; 0.001), while the outpatient group had a significantly higher lifetime prevalence of suicide (<em>p</em> = 0.003).</div></div><div><h3>Conclusion</h3><div>BPD carries a high suicide risk, influenced by factors like age and clinical setting, while the impact of comorbid depression remains unclear. Future research should standardize diagnostics and use longitudinal studies to better understand and mitigate suicide risk in BPD.</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"95 ","pages":"Pages 52-61"},"PeriodicalIF":4.1,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143870263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Red flag: A notable proportion of anti-NMDAR encephalitis cases may be admitted to psychiatric units in general hospitals 危险信号:相当大比例的抗nmdar脑炎病例可能被送入综合医院的精神科
IF 4.1 2区 医学
General hospital psychiatry Pub Date : 2025-04-20 DOI: 10.1016/j.genhosppsych.2025.04.006
Michitaka Funayama , Hisashi Wada , Risa Hirata , Takaki Akahane , Yusuke Hasegawa , Naoko Satake , Shigeki Sato , Hiraki Koishikawa , Shigeru Nohara , Naohisa Tsujino , Ken Wada , On Kato , Shin Yokoyama , Hirokazu Kumazaki , Katsuji Nishimura
{"title":"Red flag: A notable proportion of anti-NMDAR encephalitis cases may be admitted to psychiatric units in general hospitals","authors":"Michitaka Funayama ,&nbsp;Hisashi Wada ,&nbsp;Risa Hirata ,&nbsp;Takaki Akahane ,&nbsp;Yusuke Hasegawa ,&nbsp;Naoko Satake ,&nbsp;Shigeki Sato ,&nbsp;Hiraki Koishikawa ,&nbsp;Shigeru Nohara ,&nbsp;Naohisa Tsujino ,&nbsp;Ken Wada ,&nbsp;On Kato ,&nbsp;Shin Yokoyama ,&nbsp;Hirokazu Kumazaki ,&nbsp;Katsuji Nishimura","doi":"10.1016/j.genhosppsych.2025.04.006","DOIUrl":"10.1016/j.genhosppsych.2025.04.006","url":null,"abstract":"","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"95 ","pages":"Pages 41-43"},"PeriodicalIF":4.1,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143855772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Five-year survival following a non-small-cell lung cancer diagnosis among Veterans Health Administration patients with schizophrenia and bipolar disorder 退伍军人健康管理局诊断患有精神分裂症和双相情感障碍的非小细胞肺癌患者的五年生存率
IF 4.1 2区 医学
General hospital psychiatry Pub Date : 2025-04-18 DOI: 10.1016/j.genhosppsych.2025.04.004
Anna L. Philibert , Benjamin R. Szymanski , Phoebe A. Tsao , Daniel W. Bradford , Nicholas W. Bowersox
{"title":"Five-year survival following a non-small-cell lung cancer diagnosis among Veterans Health Administration patients with schizophrenia and bipolar disorder","authors":"Anna L. Philibert ,&nbsp;Benjamin R. Szymanski ,&nbsp;Phoebe A. Tsao ,&nbsp;Daniel W. Bradford ,&nbsp;Nicholas W. Bowersox","doi":"10.1016/j.genhosppsych.2025.04.004","DOIUrl":"10.1016/j.genhosppsych.2025.04.004","url":null,"abstract":"<div><h3>Objective</h3><div>Veterans with schizophrenia or bipolar disorder (SZ/BP) experience excess mortality due to several reasons, including cancer. We evaluated whether disparities exist in stage of non-small-cell lung cancer (NSCLC) diagnosis and survival between Veterans Health Administration (VHA) patients with and without SZ/BP.</div></div><div><h3>Method</h3><div>This retrospective evaluation used VHA data to identify patients newly diagnosed with NSCLC from 2005 to 2014. Bivariate analyses compared NSCLC stage at diagnosis by SZ/BP status. Kaplan-Meier and adjusted Cox proportional hazards regression analyses examined differences in survival by SZ/BP status. Meaningful differences were assessed using statistical significance, <em>p</em> &lt; .01, and effect sizes of least 0.2 less/greater than 1.</div></div><div><h3>Results</h3><div>The cohort included 64,269 VHA patients with newly diagnosed NSCLC. These included 1605 (2.5 %) patients with schizophrenia and 1099 (1.7 %) with bipolar disorder. Stage at diagnosis did not meaningfully differ between patients with and without SZ/BP. After adjusting for stage of diagnosis and other factors, schizophrenia, but not bipolar disorder, was associated with an increased risk of five-year all-cause mortality compared to no SZ/BP (schizophrenia: HR 1.22, 95 % CI 1.14–1.30; bipolar: HR 1.01, 95 % CI 0.94–1.10).</div></div><div><h3>Conclusions</h3><div>VHA patients diagnosed with NSCLC who had schizophrenia experienced greater mortality compared to those without SZ/BP, despite no meaningful differences between the two groups in stage of NSCLC at diagnosis. Further work to understand drivers of this difference (e.g., access to NSCLC treatment) and subsequent interventions are needed.</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"95 ","pages":"Pages 44-51"},"PeriodicalIF":4.1,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143859259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnostic yield of laboratory testing in hospitalized older adults with altered mental status 精神状态改变的住院老年人实验室检查的诊断率
IF 4.1 2区 医学
General hospital psychiatry Pub Date : 2025-04-12 DOI: 10.1016/j.genhosppsych.2025.04.001
Kamber L. Hart , Kathleen M. McFadden , Sara B. Golas , Chana A. Sacks , Thomas H. McCoy
{"title":"Diagnostic yield of laboratory testing in hospitalized older adults with altered mental status","authors":"Kamber L. Hart ,&nbsp;Kathleen M. McFadden ,&nbsp;Sara B. Golas ,&nbsp;Chana A. Sacks ,&nbsp;Thomas H. McCoy","doi":"10.1016/j.genhosppsych.2025.04.001","DOIUrl":"10.1016/j.genhosppsych.2025.04.001","url":null,"abstract":"<div><h3>Background</h3><div>Altered mental status (AMS) is a common cause of hospitalization among older adults, with a wide range of potential etiologies. However, the diagnostic and therapeutic yield of routine laboratory testing in such patients is unknown.</div></div><div><h3>Methods</h3><div>In a retrospective cohort of inpatient hospital admissions to a large academic medical center from 2017 to 2022 of patients 65 years and older for whom the admitting diagnosis was AMS, we assessed laboratory testing for thyroid stimulating hormone (TSH), syphilis, vitamin B12, folate, vitamin C, vitamin D, zinc, niacin, and thiamine. We calculated the frequency of testing, rate of abnormal results, and rate of follow-up treatment.</div></div><div><h3>Results</h3><div>Of the 3169 patients, 2312 (73 %) received at least one designated lab, and overall, 12 % of labs were abnormal. Labs varied in frequency of use (0.2 % for niacin–66 % for TSH) and rate of abnormality (0 % for niacin–71 % for zinc). 16 % of abnormal index labs led to a new prescription at discharge. The most common tests – TSH, folate, and B12– were of relatively low diagnostic and therapeutic utility. Tests that were less common–zinc, vitamin D, and vitamin C–were more commonly abnormal. 3.8 % of patients tested for syphilis had abnormal results, and 72 % of patients with an abnormal result received treatment with penicillin during the index hospitalization.</div></div><div><h3>Conclusions</h3><div>These analyses suggest that commonly obtained labs in the workup of AMS have varied diagnostic and therapeutic utility. The contribution of observed laboratory abnormalities to a patients' AMS warrants further study to improve the delivery of high-value care.</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"95 ","pages":"Pages 19-24"},"PeriodicalIF":4.1,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143829360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sex differences in the comorbidity between attention deficit-hyperactivity disorder and posttraumatic stress disorder: A systematic literature review and meta-analysis 注意缺陷多动障碍与创伤后应激障碍共病的性别差异:系统文献回顾与荟萃分析
IF 4.1 2区 医学
General hospital psychiatry Pub Date : 2025-04-12 DOI: 10.1016/j.genhosppsych.2025.04.003
Julia Wilson , Doruntina Fida , Rie Maurer , Aleta Wiley , Therese Rajasekera , Primavera Spagnolo
{"title":"Sex differences in the comorbidity between attention deficit-hyperactivity disorder and posttraumatic stress disorder: A systematic literature review and meta-analysis","authors":"Julia Wilson ,&nbsp;Doruntina Fida ,&nbsp;Rie Maurer ,&nbsp;Aleta Wiley ,&nbsp;Therese Rajasekera ,&nbsp;Primavera Spagnolo","doi":"10.1016/j.genhosppsych.2025.04.003","DOIUrl":"10.1016/j.genhosppsych.2025.04.003","url":null,"abstract":"<div><h3>Objective</h3><div>Attention Deficit-Hyperactivity Disorder (ADHD) and Posttraumatic Stress Disorder (PTSD) are often comorbid and share a common core of symptoms. However, sex and gender-related factors significantly influence their prevalence, clinical presentation, and diagnosis. Here, we conducted a systematic literature review and meta-analysis to examine sex differences in ADHD/PTSD comorbidity during childhood and adulthood.</div></div><div><h3>Methods</h3><div>A scoping review of PsycINFO and PubMed yielded 13 eligible studies with complete outcome data. We conducted fixed-effects meta-analyses of the sex-stratified prevalence of ADHD/PTSD using pooled odds ratios (OR) with a 95 % confidence interval (CI). Fixed-effects subgroup analyses were performed using age as a subgroup. Effect size heterogeneity was assessed using the I<sup>2</sup> index and Cochran's Q test.</div></div><div><h3>Results</h3><div>In the whole sample (<em>N</em> = 13,585; F = 7005, M = 6580), the diagnosis of ADHD/PTSD was significantly higher in females than in males (OR = 1.32, <em>p</em> = 0.02). Between-study heterogeneity was low-to-moderate and not significant (I<sup>2</sup> = 41 %; <em>p</em> = 0.06), validating the fixed-effects model. Age-stratified subgroup analyses revealed higher ADHD/PTSD odds in females compared to males only in adult populations (OR = 1.41; <em>p =</em> 0.01). Additionally, females were more likely to be diagnosed with both disorders in studies where ADHD was the primary diagnosis (OR = 1.60; <em>p =</em> 0.002), and in studies employing structured clinical interviews as diagnostic tools (OR = 1.46; <em>p =</em> 0.009).</div></div><div><h3>Conclusions</h3><div>Our study is the first to show that the association between ADHD and PTSD is stronger in females, suggesting that ADHD may increase risk for PTSD in a sex-specific manner.</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"95 ","pages":"Pages 32-39"},"PeriodicalIF":4.1,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preoperative psychological distress is associated with mortality within 1 year of non-cardiac surgery 术前心理困扰与非心脏手术1年内的死亡率相关
IF 4.1 2区 医学
General hospital psychiatry Pub Date : 2025-04-11 DOI: 10.1016/j.genhosppsych.2025.04.002
Renée El-Gabalawy , Jordana L Sommer , Jitender Sareen , Corey S Mackenzie , P.J. Devereaux , Kailey Penner , Sadeesh Srinathan
{"title":"Preoperative psychological distress is associated with mortality within 1 year of non-cardiac surgery","authors":"Renée El-Gabalawy ,&nbsp;Jordana L Sommer ,&nbsp;Jitender Sareen ,&nbsp;Corey S Mackenzie ,&nbsp;P.J. Devereaux ,&nbsp;Kailey Penner ,&nbsp;Sadeesh Srinathan","doi":"10.1016/j.genhosppsych.2025.04.002","DOIUrl":"10.1016/j.genhosppsych.2025.04.002","url":null,"abstract":"<div><h3>Objective</h3><div>To characterize the association between preoperative psychological distress and postoperative complications at 30 days and mortality at 1 year in a non-cardiac surgery sample.</div></div><div><h3>Method</h3><div>Data were taken from a subsample of the VISION cohort study (<em>n</em> = 997; 2011–2012). Participants were scheduled to undergo major non-cardiac surgery under general or regional anesthesia. Participants self-reported past 30-day psychological distress on the day of surgery using the Kessler-6 (K6) Scale. Complications were assessed via interviews and/or chart reviews. Multivariable logistic regressions characterized the relationship between preoperative psychological distress and postoperative complications. Models were fitted for sociodemographics, surgery type, preoperative medical morbidity, and smoking.</div></div><div><h3>Results</h3><div>Among participants with a completed K6 (<em>n</em> = 938), 7.9 % experienced mortality within 1 year. After controlling for age, ethnicity, sex, surgery type, preoperative medical morbidity, and smoking, higher levels of preoperative psychological distress were associated with 30 day complications such as myocardial infarction, non-fatal cardiac arrest, leg/arm deep vein thrombosis/ pulmonary embolism, new acute renal failure, pneumonia, and congestive heart failure (AOR3 (3rd model), 1.12, [95 % CI, 1.02–1.22, <em>p</em> &lt; 0.05]) and 1-year mortality (AOR3, 1.09, [95 % CI, 1.02–1.18, p &lt; 0.05]). Sensitivity analyses demonstrate that the latter association was being driven by symptoms of depression (AOR3, 1.17 [95 % CI 1.04–1.33, p &lt; 0.05]) but not anxiety (AOR2, 0.94 [95 % CI, 0.61–1.62, <em>p</em> &gt; 0.05]).</div></div><div><h3>Conclusion</h3><div>Elevated preoperative distress increased the risk of 30-day complications and mortality at 1 year. These results underscore the need for future research to examine if supporting patients' mental health during the perioperative period can mitigate risk.</div><div><strong>Clinical Trial Registration</strong>: <span><span>clinicaltrials.gov</span><svg><path></path></svg></span>, no. <span><span>NCT00512109</span><svg><path></path></svg></span> (main VISION study).</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"95 ","pages":"Pages 25-31"},"PeriodicalIF":4.1,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143843212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of gut microbiota and depression and anxiety: Mendelian randomization from three datasets 肠道菌群与抑郁和焦虑的分析:来自三个数据集的孟德尔随机化
IF 4.1 2区 医学
General hospital psychiatry Pub Date : 2025-03-22 DOI: 10.1016/j.genhosppsych.2025.03.012
Yaoyong Lai, Peng Xiong
{"title":"Analysis of gut microbiota and depression and anxiety: Mendelian randomization from three datasets","authors":"Yaoyong Lai,&nbsp;Peng Xiong","doi":"10.1016/j.genhosppsych.2025.03.012","DOIUrl":"10.1016/j.genhosppsych.2025.03.012","url":null,"abstract":"<div><h3>Background</h3><div>Emerging evidence supports gut microbiota's association with mental distress, particularly depression and anxiety, the microbiota-gut-brain axis was the believed to be the underlying mechanism. This study investigated the causal relationships between specific gut microbiota and depression and anxiety disorders using large-scale genome-wide association study (GWAS) data.</div></div><div><h3>Methods</h3><div>A two-sample bidirectional Mendelian randomization (MR) analysis was conducted to explore the causal effects of 211 microbial taxa on depression and anxiety across three large GWAS databases: FinnGen, Pan-UKBB, and PGC. Sensitive analyses were followed to validate the robustness of results. Random-effect meta-analysis was further performed to enhance the statistical power.</div></div><div><h3>Results</h3><div>The MR analysis revealed that the <em>Bifidobacteriales</em> (IVW: OR 0.90, 95 %CI 0.83 to 0.98) and <em>Bifidobacteriaceae</em> (IVW: OR 0.90, 95 %CI 0.83 to 0.98) had a protective effect against depression. <em>Clostridiales</em> (cML-MA: OR 0.88, 95 %CI 0.81 to 0.95) and <em>Parasutterella</em> (cML-MA: OR 0.75, 95 %CI 0.64 to 0.88) showed negative associations with depression. Increased abundance of <em>Oxalobacteraceae</em> (cML-MA: OR 1.78, 95 %CI 1.24 to 2.56), <em>Deltaproteobacteria</em> (cML-MA: OR 2.17, 95 %CI 1.38 to 3.40), and <em>Desulfovibrionales</em> (cML-MA: OR 2.22, 95 %CI 1.41 to 3.49) was associated with a higher risk of depression. For anxiety, protective effects were found for <em>Actinobacteria</em> (phylum: IVW: OR 0.83, 95 %CI 0.76 to 0.87; class: IVW: OR 0.84, 95 %CI 0.75 to 0.93), <em>Bifidobacteriales</em> (IVW: OR 0.80, 95 %CI 0.75 to 0.85), <em>Bifidobacteriaceae</em> (IVW: OR 0.80, 95 %CI 0.75 to 0.85) and <em>Bifidobacterium</em> [g] (IVW: OR 0.79, 95 %CI 0.74 to 0.84). <em>Lactobacillaceae [f]</em> (cML-MA: OR 1.18, 95 %CI 1.08 to 1.28), <em>Clostridia</em> [c] (cML-MA: OR 1.15, 95 %CI 0.1.06 to 1.26) and <em>Clostridiales</em> [o] (IVW: OR 1.15, 95 %CI 1.05 to 1.27) were associated with increased anxiety risk. Meta-analysis results indicated significant associations, particularly the protective effects of <em>Actinobacteria</em> (OR 0.90, 95 % CI, 0.83 to 0.98) and <em>Clostridiaceae1</em> (OR 0.91, 95 % CI, 0.83 to 0.99) on depression and several taxa on anxiety. No significant instrumental variables for depression or anxiety on gut microbiota were identified.</div></div><div><h3>Conclusions</h3><div>Our findings highlight specific gut microbiota that are associated with depression and anxiety, underscoring the causal relationships between these intestinal microbes and psychiatric disorders. These results suggest potential strategies for mitigating disease symptoms and improving quality of life through microbiome-targeted therapies. Further studies, including randomized controlled trials and investigations into sex-specific effects, are essential to validate and expand upon t","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"94 ","pages":"Pages 206-218"},"PeriodicalIF":4.1,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143705528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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