General hospital psychiatry最新文献

{"title":"Efficacy and safety of ondansetron in schizophrenia: A systematic review and meta-analysis of randomized controlled trials","authors":"Omar Kassar ,&nbsp;Omar Shaheen ,&nbsp;Abdullah Selim ,&nbsp;Mahmoud Soliman ,&nbsp;Lamees Taman ,&nbsp;Ahmed Elshahat ,&nbsp;Moaz Elsayed Abouelmagd","doi":"10.1016/j.genhosppsych.2025.06.001","DOIUrl":"10.1016/j.genhosppsych.2025.06.001","url":null,"abstract":"<div><h3>Purpose</h3><div>It has been shown that 5-hydroxytryptamine3 (5-HT3) receptors are involved in the pathogenesis of schizophrenia. This systematic review and meta-analysis of randomized clinical trials (RCTs) evaluates the efficacy and safety of ondansetron, a potent 5-HT3 receptor antagonist, as adjunctive treatment for the management of schizophrenia, especially the negative symptoms.</div></div><div><h3>Methods</h3><div>A comprehensive search of electronic databases, including PubMed, Scopus, Cochrane, and Web of Science, was performed in October 2024. We included only randomized controlled trials (RCTs), and their data were extracted and analyzed using RevMan 5.4 software. The primary outcome was the PANSS (Positive and Negative Syndrome Scale) negative subscale.</div></div><div><h3>Results</h3><div>Eight RCTs involving 533 patients were included in the study. Ondansetron showed a statistically significant improvement in PANSS negative subscale at 12 weeks [pooled as mean difference, MD = −2.96, 95 % CI [−4.69, −1.24], <em>P</em>-value = 0.00007] and in general psychopathology scale [MD = −2.71, 95 % CI [−3.52, −1.90] compared to placebo. However, ondansetron and placebo did not differ in reduction of PANSS positive subscale [MD = 0.1, 95 % CI [−1.19, 1.38], P-value = 0.88], and depression scale. Ondansetron showed no significant difference regarding tardive dyskinesia between the two groups. However, constipation was significant in the ondansetron group over placebo.</div></div><div><h3>Conclusion</h3><div>The study findings provide valuable insights into the efficacy of ondansetron, a serotonin receptor antagonist, in managing schizophrenia, particularly negative symptoms. However, the limitations of the study highlight the need for caution in interpreting these results. Further high-quality trials are required to confirm our findings and explore the long-term impact of ondansetron in the treatment of schizophrenia.</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"96 ","pages":"Pages 37-46"},"PeriodicalIF":4.1,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144230699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global trends in major depressive disorder among women of childbearing age, 1990–2021","authors":"Hanpu Zhang ,&nbsp;Shuangfei Xu ,&nbsp;Yanyan Zhu ,&nbsp;Yan-Ci Zhao","doi":"10.1016/j.genhosppsych.2025.05.011","DOIUrl":"10.1016/j.genhosppsych.2025.05.011","url":null,"abstract":"","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"96 ","pages":"Pages 34-36"},"PeriodicalIF":4.1,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144230599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary prevention in Psychiatry in India – An overview of the current state of affairs","authors":"Sagarika Ray ,&nbsp;Amit Kumar Pal ,&nbsp;Partha Sarathi Kundu","doi":"10.1016/j.genhosppsych.2025.05.014","DOIUrl":"10.1016/j.genhosppsych.2025.05.014","url":null,"abstract":"","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"96 ","pages":"Pages 28-33"},"PeriodicalIF":4.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144212515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Referral to chronic pain management and physiotherapy services in adults with severe mental illness: A matched cohort study","authors":"Ruimin Ma ,&nbsp;Eugenia Romano ,&nbsp;Gayan Perera ,&nbsp;Trevor Thompson ,&nbsp;Davy Vancampfort ,&nbsp;Robert Stewart ,&nbsp;Kerem Böge ,&nbsp;Nilufar Mossaheb ,&nbsp;Mark Ashworth ,&nbsp;Brendon Stubbs","doi":"10.1016/j.genhosppsych.2025.05.013","DOIUrl":"10.1016/j.genhosppsych.2025.05.013","url":null,"abstract":"<div><h3>Introduction</h3><div>Chronic pain (CP) is common among people with severe mental illness (SMI). It remains unclear whether patients with comorbid CP and SMI receive equivalent pain management referrals compared to those with CP alone. This retrospective cohort study used linked primary and mental healthcare data to address this knowledge gap.</div></div><div><h3>Methods</h3><div>We identified patients aged ≥18 years with comorbid SMI and CP from secondary mental healthcare records, with the later of either diagnosis serving as the index date. Cases were matched 1:4 by age bands and gender to controls with CP but no SMI diagnosis. Co-primary outcomes were referrals to specialized pain treatment services and musculoskeletal physiotherapy. Cox regression models analyzed associations between SMI status and referral patterns, with sensitivity analyses stratifying follow-up into early (0–3.99 years), medium (4–7.99 years), and late (≥8 years) periods.</div></div><div><h3>Results</h3><div>The final sample included 1120 patients with CP and SMI and 2681 matched non-SMI controls. SMI diagnosis strongly predicted increased healthcare utilization in adjusted analyses, with significantly higher referral rates to pain treatments (HR = 13.2, 95 % CI 7.8–22.4, <em>p</em> &lt; 0.001) and physiotherapy (HR = 11.5, 95 % CI 9.3–14.4, p &lt; 0.001). The association between SMI and pain treatment referrals was strongest during the early post-diagnosis period (HR = 13.2, 95 % CI 6.6–26.4, p &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>Contrary to expectations, people with SMI and CP received more pain management referrals compared to matched controls, particularly in the early post-diagnosis period. These findings were restricted to those with a CP diagnosis already, and further research should investigate whether increased referrals translate to improved clinical outcomes.</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"96 ","pages":"Pages 47-53"},"PeriodicalIF":4.1,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144230598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A national movement or just a ripple? Few outpatient perinatal visits engage in essential perinatal behavioral health screening practices","authors":"M.E. Deichen Hansen,&nbsp;J. Day,&nbsp;A.M. Spitz,&nbsp;S. Goldfarb,&nbsp;J.S. Harman","doi":"10.1016/j.genhosppsych.2025.05.012","DOIUrl":"10.1016/j.genhosppsych.2025.05.012","url":null,"abstract":"<div><h3>Objectives</h3><div>Perinatal behavioral health conditions are currently the leading cause of US maternal mortality. To prevent morbidity and mortality, obstetrics clinicians must screen for behavioral health conditions using a validated screener. However, many women's behavioral health conditions go undetected and untreated. This brief highlights the extent of the US health system's failure to adequately screen for critical perinatal health conditions.</div></div><div><h3>Methods</h3><div>Pooled data from the 2015–16, and 2018–19 National Ambulatory Medical Care Survey were generated to assess rates of screening for depression, alcohol use, substance use, and domestic violence during routine prenatal care visits.</div></div><div><h3>Results</h3><div>In the pooled 2015–2016 and 2018–2019 NAMCS sample (<em>n</em> = 1135) there were 82,986,275 weighted office visits for routine prenatal care. Clinicians most frequently identified as physicians. Screening data was nearly absent from the data, with domestic violence screenings being conducted most frequently at a reported 2.7 %.</div></div><div><h3>Conclusions</h3><div>This study found behavioral health screening tools are used infrequently during office visits for routine prenatal care. While many clinicians endorse at least some behavioral health screening practices, the adoption of these screenings in all healthcare settings has not occurred.</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"96 ","pages":"Pages 16-17"},"PeriodicalIF":4.1,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144166895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between perceived stress and burnout among Chinese nurses: A moderated-mediation model","authors":"Xingbo Suo ,&nbsp;Yang Zhang ,&nbsp;Yi Zhang ,&nbsp;Shenshuai Zhang ,&nbsp;Jinguo Zhai ,&nbsp;Maorong Hu","doi":"10.1016/j.genhosppsych.2025.05.010","DOIUrl":"10.1016/j.genhosppsych.2025.05.010","url":null,"abstract":"","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"96 ","pages":"Pages 11-12"},"PeriodicalIF":4.1,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144148045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The rise of AI-generated content in academic writing: A cautionary note for commentaries and letters to the editor.","authors":"Stéphanie Baggio ,&nbsp;Kali Tal","doi":"10.1016/j.genhosppsych.2025.05.008","DOIUrl":"10.1016/j.genhosppsych.2025.05.008","url":null,"abstract":"","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"95 ","pages":"Pages 158-159"},"PeriodicalIF":4.1,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144146867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SARS-CoV-2 vaccination for individuals with schizophrenia in Ontario, Canada: A retrospective cohort study","authors":"Catherine Ji ,&nbsp;Karen Tu ,&nbsp;John Wang ,&nbsp;Debra A. Butt ,&nbsp;Andrea S. Gershon ,&nbsp;Jessica Gronsbell ,&nbsp;Anthony D. Train ,&nbsp;Braden O'Neill","doi":"10.1016/j.genhosppsych.2025.05.009","DOIUrl":"10.1016/j.genhosppsych.2025.05.009","url":null,"abstract":"","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"96 ","pages":"Pages 13-15"},"PeriodicalIF":4.1,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144148046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between prenatal anxiety and gestational age: A systematic review","authors":"Semra Worrall ,&nbsp;Naomi Carlisle ,&nbsp;Olivia Pike ,&nbsp;John Moffitt ,&nbsp;Jenny Carter ,&nbsp;Paul Christiansen ,&nbsp;Asma Khalil ,&nbsp;Sergio A. Silverio ,&nbsp;Victoria Fallon","doi":"10.1016/j.genhosppsych.2025.05.007","DOIUrl":"10.1016/j.genhosppsych.2025.05.007","url":null,"abstract":"<div><div>Preterm birth poses a significant risk to short- and long-term infant health, and can have significant negative effects on maternal mental health. Increased levels of anxiety during pregnancy might be related to gestational age. Identifying potential risk factors for preterm birth may offer the opportunity for early intervention and reduce adverse outcomes. Ten databases, including empirical and grey literature, were searched. Articles were screened at title, abstract, and full-text review by two independent reviewers, and were quality assessed using the JBI critical appraisal tools. Forty-one studies were identified for inclusion in the review, published between 1990 and 2022. Data were narratively synthesised due to heterogeneity in study designs. Results of the data synthesis indicate there is an inverse relationship between anxiety and gestational age or preterm birth. This relationship may be dependent upon timing of assessment, and measure of anxiety used. Assessing anxiety at a single timepoint may not be as accurate as assessments across all three trimesters. Concerted efforts should be made to distinguish between spontaneous preterm birth and medically indicated preterm birth, as anxieties during pregnancy may present differently between the two groups. Future studies should consider the assessment of anxiety across trimesters to assess change in mood, as well as the use of pregnancy-specific measures alongside general measures to support intervention during pregnancy.</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"96 ","pages":"Pages 1-10"},"PeriodicalIF":4.1,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144138077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness and safety of repeated transcranial magnetic stimulation for smoking cessation: A systematic review and meta-analysis","authors":"Xue Shang ,&nbsp;Lin Guo ,&nbsp;Yan Wang ,&nbsp;Kangle Guo ,&nbsp;Kehu Yang","doi":"10.1016/j.genhosppsych.2025.05.005","DOIUrl":"10.1016/j.genhosppsych.2025.05.005","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the effectiveness and safety of Repeated Transcranial magnetic stimulation (rTMS) for smoking cessation.</div></div><div><h3>Methods</h3><div>Randomized Controlled Trials (RCT) with rTMS on smokers were included. The meta-analysis was performed using R 4.3.2 software. GRADE method was used to evaluate the quality of the evidence.</div></div><div><h3>Results</h3><div>15 RCTs involving 967 smokers were included. The meta-analysis showed that, comparing with the control group, active rTMS significantly decreased the average daily number of cigarettes smoked (MD = −6.72, 95 % CI [−9.47, −3.97], very low quality) and FTND score (MD = −2.57, 95 % CI [−3.84, −1.29], very low quality). Meanwhile it significantly improved the smoking cessation rates (OR = 2.77, 95 % CI [1.56, 4.92], moderate quality). 10 Hz had a better effect on the three outcomes than 0 Hz. When the treatment was ≥20 sessions, it was more helpful to quit smoking, reduce smoking and nicotine dependence. People with schizophrenia were more likely to reduce smoking and nicotine dependence. Adverse reactions were mild, with only the incidence of headache being significantly increased (<em>P</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>rTMS might provide effective support for people trying to stop smoking. Meanwhile, population characteristics, stimulation frequency, sessions, and duration will affect the treatment effect of rTMS.</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"96 ","pages":"Pages 18-27"},"PeriodicalIF":4.1,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144203423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}