Miika Vanhanen , Jussi Jaakkola , Juhani K.E. Airaksinen , Olli Halminen , Jukka Putaala , Pirjo Mustonen , Jari Haukka , Juha Hartikainen , Alex Luojus , Mikko Niemi , Miika Linna , Mika Lehto , Konsta Teppo
{"title":"Alcohol use disorder and initiation of oral anticoagulant therapy in patients with atrial fibrillation: A nationwide cohort study","authors":"Miika Vanhanen , Jussi Jaakkola , Juhani K.E. Airaksinen , Olli Halminen , Jukka Putaala , Pirjo Mustonen , Jari Haukka , Juha Hartikainen , Alex Luojus , Mikko Niemi , Miika Linna , Mika Lehto , Konsta Teppo","doi":"10.1016/j.genhosppsych.2025.01.017","DOIUrl":"10.1016/j.genhosppsych.2025.01.017","url":null,"abstract":"<div><h3>Objective</h3><div>Patients with alcohol use disorders (AUD) often receive inferior care for somatic comorbidities. Our objective was to explore whether AUDs influence oral anticoagulant (OAC) initiation for stroke prevention among atrial fibrillation (AF) patients, using a nationwide dataset to assess treatment disparities.</div></div><div><h3>Methods</h3><div>The Finnish AntiCoagulation in Atrial Fibrillation registry includes data on all 229,565 patients diagnosed with incident AF in Finland during 2007–2018, identified from national registries covering all levels of care. The main outcome was OAC initiation compared between patients with and without AUD.</div></div><div><h3>Results</h3><div>The patients' mean age was 72.7 years, 50 % were female, 85.0 % were eligible for OAC therapy (CHA<sub>2</sub>DS<sub>2</sub>-VA score ≥ 1), and 4.7 % had AUD. OAC therapy was initiated in a smaller proportion of patients with AUD compared to those without (52.5 % vs. 71.4 %, <em>p</em> < 0.001). This disparity remained significant even after adjusting for comorbidities, socioeconomic status, and laboratory values influencing OAC initiation (adjusted hazard ratio [HR] 0.68; 95 % confidence interval [0.66–0.71]). The absolute difference in OAC initiation between groups stayed consistent at approximately 20 % throughout the study period. Interaction analyses indicated that the association between AUD and lower OAC initiation was stronger in patients with lower income, lower educational attainment, and lower thrombocyte levels, but there was no significant interaction with sex, bleeding history, or hemoglobin levels.</div></div><div><h3>Conclusions</h3><div>AUDs are associated with a significantly lower rate of OAC initiation even after accounting for comorbidities that influence OAC initiation.</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"93 ","pages":"Pages 116-121"},"PeriodicalIF":4.1,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143387288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Psychological inflexibility and its impact on mental health and quality of life: Expanding insights and interventions","authors":"Paul Arjanto, Vando Kristi Makaruku","doi":"10.1016/j.genhosppsych.2025.01.015","DOIUrl":"10.1016/j.genhosppsych.2025.01.015","url":null,"abstract":"","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"93 ","pages":"Pages 84-85"},"PeriodicalIF":4.1,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Letter to the editor concerning: Risk of agranulocytosis and neutropenia in patients with Parkinson's disease psychosis receiving clozapine treatment: A systematic review and meta-analysis. Limveeraprajak N, Makkapavee W, Likhitsathian S, Srisurapanont M. Possibly a greater risk?","authors":"Joseph H. Friedman","doi":"10.1016/j.genhosppsych.2025.01.010","DOIUrl":"10.1016/j.genhosppsych.2025.01.010","url":null,"abstract":"","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"93 ","pages":"Pages 80-81"},"PeriodicalIF":4.1,"publicationDate":"2025-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143003628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anna Rihs , Anna Schoeni , Tamara Scharf , Julian Jakob , Kali Tal , Isabelle Jacot-Sadowski , Jean-Paul Humair , Anja Frei , Martin Brutsche , Nicolas Rodondi , Reto Auer , Stéphanie Baggio
{"title":"Effect of e-cigarettes for smoking cessation on depressive and anxiety symptoms: Secondary analysis of a randomized controlled trial","authors":"Anna Rihs , Anna Schoeni , Tamara Scharf , Julian Jakob , Kali Tal , Isabelle Jacot-Sadowski , Jean-Paul Humair , Anja Frei , Martin Brutsche , Nicolas Rodondi , Reto Auer , Stéphanie Baggio","doi":"10.1016/j.genhosppsych.2025.01.011","DOIUrl":"10.1016/j.genhosppsych.2025.01.011","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to assess differences in depressive and anxiety symptoms at 6-month follow-up in a smoking cessation trial using e-cigarettes as quitting aids.</div></div><div><h3>Methods</h3><div>We conducted a secondary analysis of the Swiss multicentre ESTxENDS smoking cessation randomized controlled trial (RCT) assessing differences in depressive (Patient Health Questionnaire-9, PHQ-9, range: 0–27) and anxiety symptoms (General Anxiety Disorder-7, GAD-7, range: 0–21) at 6-month follow-up comparing participants who received e-cigarettes to those who received smoking cessation counseling alone.</div></div><div><h3>Results</h3><div>Of 1244 participants 913 completed the PHQ-9 and 884 the GAD-7 at 6-month follow-up. Mean PHQ-9 scores (SD) at 6 months for the intervention group were 3.7 (3.9), control group: 4.0 (4.2); mean GAD-7 scores (SD) at 6 months for the intervention group were 4.6 (4.3), control group: 4.6 (4.4). Multivariable analyses showed no evidence of a clinically relevant intervention effect on the PHQ-9 [coefficient − 0.101, 95 % CI -0.182 to −0.019, <em>p</em> = .016, corresponding to a 0.9 decrease of the original PHQ-9 score] and the GAD-7 scores [coefficient − 0.056, 95 % CI -0.135 to 0.022, <em>p</em> = .160] in the main adjusted models.</div></div><div><h3>Conclusions</h3><div>Among smokers who participated in the ESTxENDS smoking cessation trial, we found distribution of e-cigarettes for smoking cessation in addition to standard counseling compared to counseling alone had no clinically relevant effect on depressive or anxiety symptoms at 6-month follow-up.</div><div>Trial Registration: ClinicalTrials <span><span>NCT03603340</span><svg><path></path></svg></span></div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"93 ","pages":"Pages 67-72"},"PeriodicalIF":4.1,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143003617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}