General hospital psychiatry最新文献

{"title":"The association between depressive symptom trajectories and risk of all-cause mortality and premature death: A 10-year follow-up study in United States and England","authors":"Mengyang Jia ,&nbsp;Xiyu Chen ,&nbsp;Chen Liang ,&nbsp;Shuojia Wang ,&nbsp;Cheng Jiang ,&nbsp;Yupeng Zeng ,&nbsp;Xin Jiang ,&nbsp;Lixin Cheng ,&nbsp;Qingshan Geng","doi":"10.1016/j.genhosppsych.2025.06.011","DOIUrl":"10.1016/j.genhosppsych.2025.06.011","url":null,"abstract":"<div><h3>Background</h3><div>Depression has emerged as a leading cause of disease burden and disability worldwide. This study aimed to investigate the association between depressive symptom trajectories, all-cause mortality, and premature death.</div></div><div><h3>Method</h3><div>We utilized the data from Health Retirement Study (HRS) and English Longitudinal Study of Aging (ELSA). Depressive symptoms were assessed using the 8-item CESD scale and categorized into somatic and cognitive-affective subtypes. Cox proportional risk mode was employed to estimate the relationship between depressive symptom trajectories and all-cause mortality and premature death.</div></div><div><h3>Result</h3><div>Among 17,930 enrolled participants, 4543 died, including 1063 premature deaths. Increasing total depressive symptoms had the highest risk for all-cause mortality with HR 2.01 (95 %CI: 1.72–2.35) followed by consistently high with HR 1.53 (95 %CI: 1.36–1.72) adjusted for covariates compared to consistently low. Increasing and consistently high total trajectories had elevated risks for premature death with HR 1.83 (95 %CI: 1.29–2.59) and HR 2.01 (95 %CI: 1.61–2.51). Increasing, consistently high somatic or cognitive-affective depressive symptom trajectories also increased the risks of all-cause mortality and premature death. Decreasing somatic, cognitive-affective, and total trajectories showed no higher risk for premature death (HR 1.56, 95 %CI: 0.90–2.72; HR 1.00, 95 %CI: 0.56–1.78; HR 1.17, 95 %CI: 0.76–1.81).</div></div><div><h3>Conclusion</h3><div>Increasing or consistently high trajectories of somatic, cognitive-affective, and total depressive symptoms were associated with elevated risks of all-cause mortality and premature death, whereas decreasing trajectories were not associated with increased risks. Early interventions aimed at reducing the duration of depressive symptoms may help to extend lifespan.</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"96 ","pages":"Pages 97-106"},"PeriodicalIF":4.1,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144502151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of self-harm and overdose after starting buprenorphine for opioid use disorder","authors":"Gregory E. Simon ,&nbsp;Susan M. Shortreed ,&nbsp;Eric Johnson ,&nbsp;Brian K. Ahmedani ,&nbsp;Stacy A. Sterling ,&nbsp;Cynthia I. Campbell ,&nbsp;Rulin C. Hechter ,&nbsp;Rebecca A. Ziebell ,&nbsp;Sujaya Parthasarathy","doi":"10.1016/j.genhosppsych.2025.06.010","DOIUrl":"10.1016/j.genhosppsych.2025.06.010","url":null,"abstract":"<div><h3>Objective</h3><div>Compare risk of intentional self-harm and overdose after visits for opioid use disorder (OUD) followed by starting vs. not starting buprenorphine.</div></div><div><h3>Methods</h3><div>Records from four health systems identified visits during 1/1/2012–12/31/2019 by health system members aged 13 or older with OUD diagnosis and no recent OUD medication. Following a target-trial emulation approach, visits followed by buprenorphine dispensing within 7 days were matched to unexposed visits. Analyses compared risk of diagnosed self-harm injury or poisoning (primary outcome) as well as opioid-involved poisoning and any injury or poisoning (secondary outcomes) within 90 days.</div></div><div><h3>Results</h3><div>Among 183,809 visits by 30,955 patients, 15,508 (8.4 %) had buprenorphine dispensing within 7 days, and 2260 (1.2 %) had self-harm diagnosis within 90 days. Average duration of buprenorphine treatment before interruption was 44.3 days (SD 32.1). In primary intention-to-treat analyses using logistic regression and adjusting for baseline risk of self-harm, starting buprenorphine was not associated with significant difference in self-harm (odds ratio [OR] 1.01, 95 % CI 0.81–1.24) or opioid-involved poisoning (OR 1.09, 95 % CI 0.86–1.38). In secondary as-treated analyses censoring outcomes after treatment change, buprenorphine initiation was associated with no significant difference in hazard of self-harm (Hazard Ratio [HR] 0.74, 95 % CI 0.53–1.02) and with significantly lower hazard of opioid-involved poisoning (HR 0.63, 95 % CI 0.43–0.94).</div></div><div><h3>Conclusions</h3><div>Among people with OUD, starting buprenorphine was not followed by lower risk of self-harm, likely reflecting frequent discontinuation and high risk of self-harm or overdose shortly after discontinuation. These findings reinforce the need to improve treatment continuity among those starting buprenorphine.</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"96 ","pages":"Pages 90-96"},"PeriodicalIF":4.1,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144491265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between organizational factors and mental health outcomes: Insights from Vietnamese frontline healthcare workers in COVID-19 field hospitals","authors":"Tra Thu Doan ,&nbsp;Vuong Minh Nong ,&nbsp;Cuong Duy Do ,&nbsp;Giap Van Vu","doi":"10.1016/j.genhosppsych.2025.06.009","DOIUrl":"10.1016/j.genhosppsych.2025.06.009","url":null,"abstract":"","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"96 ","pages":"Pages 87-89"},"PeriodicalIF":4.1,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144480665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond diagnosis: Examining body dissatisfaction across obesity and eating disorders","authors":"Elvira Anna Carbone ,&nbsp;Marianna Rania ,&nbsp;Ettore D'Onofrio ,&nbsp;Andrea Scaramuzzino ,&nbsp;Daria Quirino ,&nbsp;Lavinia Rotella ,&nbsp;Matteo Aloi ,&nbsp;Renato de Filippis ,&nbsp;Cristina Segura-Garcia","doi":"10.1016/j.genhosppsych.2025.06.007","DOIUrl":"10.1016/j.genhosppsych.2025.06.007","url":null,"abstract":"","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"96 ","pages":"Pages 85-86"},"PeriodicalIF":4.1,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144469964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prefrontal cortex modulation using transcranial direct current stimulation in opioid craving: A sham-control double-blind study","authors":"Ikhlaq Ahmed ,&nbsp;Mohammed Qutishat ,&nbsp;Rima Ikhlaq ,&nbsp;Nishant Goyal ,&nbsp;Salim AL-Huseini","doi":"10.1016/j.genhosppsych.2025.06.008","DOIUrl":"10.1016/j.genhosppsych.2025.06.008","url":null,"abstract":"<div><h3>Background</h3><div>Opioid addiction, a major global health crisis, has necessitated innovative therapeutic approaches. This study aims to investigate the efficacy of Transcranial Direct Current Stimulation (tDCS) targeting the right dorsolateral prefrontal cortex (DLPFC) in reducing cravings among individuals with opioid dependence.</div></div><div><h3>Method</h3><div>In this single-centre, double-blind, randomized, sham-controlled trial, 40 male inpatients with opioid dependence at the Central Institute of Psychiatry (Ranchi, India) were allocated to either active right-DLPFC tDCS (2 mA, 20 min) or sham stimulation for five consecutive days. Craving and psychosocial functioning were assessed via the Obsessive–Compulsive Drug Use Scale (OCDUS) and Addiction Severity Index (ASI) at baseline, immediately post-treatment, and at 2- and 4-week follow-ups. Repeated-measures ANOVA tested group × time differences.</div></div><div><h3>Results</h3><div>At baseline, OCDUS scores did not differ between groups (Active: 32.00 ± 2.47 vs. Sham: 31.60 ± 2.85; F (1,38) = 0.582, <em>p</em> = 0.582, η²p = 0.015). Following treatment, the Active group showed markedly greater reductions in craving than Sham at Day 5 (10.35 ± 2.21 vs. 24.25 ± 5.29; F(1,38) = 956.5, <em>p</em> &lt; 0.001, η²ₚ = 0.672) and Day 14 (6.30 ± 1.98 vs. 20.75 ± 5.22; F(1,38) = 99.56, p &lt; 0.001, η²ₚ = 0.503), with effects maintained at Day 28 (5.75 ± 1.65 vs. 23.35 ± 6.07).</div></div><div><h3>Conclusion</h3><div>Five sessions of right-DLPFC tDCS produced rapid, significant, and sustained reductions in opioid craving compared with sham, supporting its promise as an adjunctive treatment in opioid use disorder.</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"96 ","pages":"Pages 78-84"},"PeriodicalIF":4.1,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are diabetes self-management interventions delivered in the psychiatric inpatient setting effective?: A systematic review","authors":"Zoe Goff ,&nbsp;Charlotte Palmer ,&nbsp;Eleanor Morris","doi":"10.1016/j.genhosppsych.2025.06.006","DOIUrl":"10.1016/j.genhosppsych.2025.06.006","url":null,"abstract":"","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"96 ","pages":"Pages 75-77"},"PeriodicalIF":4.1,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144330064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prolactin levels in depressive disorders: A systematic review and meta-analysis","authors":"Mahendra Kumar ,&nbsp;Naksh Raj ,&nbsp;Preeti Kochar ,&nbsp;P. Swabhanu Sriya ,&nbsp;Yanjana ,&nbsp;Mahesh Kumar ,&nbsp;Sunita","doi":"10.1016/j.genhosppsych.2025.06.004","DOIUrl":"10.1016/j.genhosppsych.2025.06.004","url":null,"abstract":"<div><h3>Introduction</h3><div>Depression can impact prolactin (PRL) levels by activating the body's stress response and releasing stress hormones like cortisol, which disrupt normal PRL regulation. PRL plays a role in various physiological systems, including reproduction, metabolism, immune regulation, and neurogenesis. Previous studies on PRL levels in depressive patients have yielded contradictory results. This meta-analysis aims to evaluate PRL concentrations in depressive patients versus healthy controls.</div></div><div><h3>Methods</h3><div>This systematic review and meta-analysis followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A comprehensive search was conducted across multiple databases, including PubMed, Scopus, Web of Science, Embase, PsycINFO, CINAHL, ProQuest, Science Direct, and Google Scholar, up to 2024. Review Manager 5.3, Jamovi, and Open Meta Analyst software were utilized to calculate the standard mean difference (SMD) and assess heterogeneity, publication bias (via funnel plots and Egger's test), subgroup analysis, sensitivity analysis, and meta-regression.</div></div><div><h3>Results</h3><div>Sixteen studies with a combined population (n) of 1492 (776 depressive disorder patients and 716 controls) met the inclusion criteria for serum or plasma PRL. This meta-analysis indicates a statistically significant SMD in serum or plasma PRL between depressed patients and controls, with a pooled SMD of 0.44 (95 % CI: - 0.20 to 0.68, <em>p</em> = 0.0003).</div></div><div><h3>Conclusions</h3><div>This meta-analysis found a statistically significant difference in serum or plasma PRL levels between individuals with depressive disorders. Further research is warranted to explore the potential of PRL as a biomarker for depression diagnosis or severity, as well as its therapeutic implications. Additionally, investigating the underlying mechanisms of PRL dysregulation in depression may lead to the development of novel treatment strategies.</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"96 ","pages":"Pages 62-71"},"PeriodicalIF":4.1,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144298364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is there harm in behavioral weight loss for binge-eating disorder: Controlled comparison to cognitive behavioral therapy","authors":"Carlos M. Grilo ,&nbsp;Sydney Yurkow ,&nbsp;Marney A. White ,&nbsp;Janet A. Lydecker ,&nbsp;Valentina Ivezaj","doi":"10.1016/j.genhosppsych.2025.06.005","DOIUrl":"10.1016/j.genhosppsych.2025.06.005","url":null,"abstract":"","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"96 ","pages":"Pages 72-74"},"PeriodicalIF":4.1,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144321470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between American Heart Association's life's essential 8 metric and depressive symptoms and suicidal behaviors: A population-based study of Korean adults","authors":"Seong-Uk Baek ,&nbsp;Jin-Ha Yoon","doi":"10.1016/j.genhosppsych.2025.06.002","DOIUrl":"10.1016/j.genhosppsych.2025.06.002","url":null,"abstract":"","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"96 ","pages":"Pages 60-61"},"PeriodicalIF":4.1,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144271289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient–therapist relationship in psychedelic-assisted therapy: Implications for future real-world settings","authors":"Daniel Villiger","doi":"10.1016/j.genhosppsych.2025.06.003","DOIUrl":"10.1016/j.genhosppsych.2025.06.003","url":null,"abstract":"<div><div>The view that the use of serotonergic psychedelics in mental health care should always be psychotherapeutically embedded has recently been questioned. One argument against this model concerns the high costs it entails, which could limit the accessibility of psychedelic-assisted therapy (PAT)—a concern likely to gain traction if PAT is officially approved in the future. This paper analyzes the implications of a reductionist approach that primarily frames PAT as a pharmacological intervention, focusing on a key component of the treatment: the patient-therapist relationship. It first reviews evidence highlighting the therapeutic and ethical significance of this relationship in PAT. It then argues that shortening the preparation phase is a probable cost-saving measure that risks undermining the development of a strong patient-therapist relationship. Finally, the paper outlines three strategies to strengthen this relationship even in real-world PAT settings under cost pressure: retaining some relational elements during preparation, maintaining continuity by involving the same therapist throughout all phases, and, where possible, integrating the patient's regular therapist into the process.</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"96 ","pages":"Pages 54-59"},"PeriodicalIF":4.1,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144240446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}