General hospital psychiatry最新文献

{"title":"Sex-specific risks for cardiovascular disease across the specific depressive symptoms spectrum: A national prospective cohort study","authors":"Yu-Hua Liu ,&nbsp;Lu Zhai ,&nbsp;Rong-Rui Huo ,&nbsp;Cui Ma","doi":"10.1016/j.genhosppsych.2025.02.006","DOIUrl":"10.1016/j.genhosppsych.2025.02.006","url":null,"abstract":"<div><h3>Background</h3><div>To examine sex-specific risks for cardiovascular disease across the specific depressive symptoms spectrum: a national prospective cohort in China.</div></div><div><h3>Methods</h3><div>Using data from the China Health and Retirement Longitudinal Study (CHARLS), involving 11,735 individuals aged 45 and older in China. Ten specific depressive symptoms, assessed at baseline using the CES-D short form. Cox proportional hazard models estimated hazard ratios (HRs) for each symptom's association with CVD.</div></div><div><h3>Results</h3><div>During the 7 years of follow-up, 1246 (20.8 %) incident CVD cases were identified among women, compared to 985 (17.1 %) among men. All ten specific depressive symptoms exhibited a higher incidence in women than in men. Nine of these symptoms were associated with an increased risk of CVD in both sexes. Restless sleep was more strongly associated with CVD in women (HR, 1.44; 95 % CI, 1.28–1.62) than in men (HR, 1.18; 95 % CI, 1.04–1.34) at baseline (<em>P</em> = 0.013 for interaction), whereas the HRs for other specific depressive symptoms were similar among women and men. Loneliness was the most important symptom for CVD risk in men, while restless sleep was the most significant for women.</div></div><div><h3>Conclusions</h3><div>Nine of 10 specific depressive symptoms may increase the risk of CVD in Chinese adults, regardless of gender. Notably, the association between restless sleep and CVD was strong in women, while loneliness showed a stronger association with CVD in men. These findings highlight the importance of considering specific depressive symptoms in assessing CVD risk among middle-aged and older adults, particularly across sexes.</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"94 ","pages":"Pages 37-45"},"PeriodicalIF":4.1,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143464698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of falls associated with non-GABAergic hypnotics and benzodiazepines in hospitalized patients","authors":"Kazuhiro Shishida ,&nbsp;Waka Nishimura ,&nbsp;Yutaro Shimomura ,&nbsp;Masayuki Murayama ,&nbsp;Kimio Yoshimura ,&nbsp;Hiroyuki Uchida ,&nbsp;Masaru Mimura ,&nbsp;Hiroyoshi Takeuchi","doi":"10.1016/j.genhosppsych.2025.02.004","DOIUrl":"10.1016/j.genhosppsych.2025.02.004","url":null,"abstract":"<div><h3>Objective</h3><div>Non-GABAergic hypnotics introduced into clinical practice within the last two decades are pharmacologically presumed to have a lower risk of falls, but clinical investigations are scarce. We aimed to evaluate the risk of falls associated with different classes of hypnotics, namely benzodiazepines, ramelteon, suvorexant, and trazodone, in hospitalized individuals at a general hospital.</div></div><div><h3>Method</h3><div>In this retrospective cohort study, data on the incidence of falls, hypnotic use, age, sex, body mass index (BMI), activities of daily living (ADL) score, presence of surgery, emergency admission, and ambulance use were collected for hospitalized patients aged 20 years or older who had been discharged from a tertiary general hospital in Japan between April 1, 2014, and March 31, 2019. The Cox proportional hazards model was used to examine factors associated with falls, adjusting for other demographics as covariates.</div></div><div><h3>Results</h3><div>Among 28,029 patients, 383 falls occurred in 322 patients. Ramelteon or suvorexant was not associated with an elevated incidence of falls (adjusted hazard ratio [aHR], 0.78; 95 % CI, 0.34 to 1.81 and 0.44; 95 % CI, 0.13–1.46, respectively), in contrast to benzodiazepines (aHR, 2.17; 95 % CI 1.67–2.83) or trazodone (aHR, 1.96; 95 % CI 1.25–3.07). Advanced age, lower BMI, wheelchair dependency, non-surgical status, absence of emergency admissions, and ambulance use were also associated with the elevated incidence of falls.</div></div><div><h3>Conclusions</h3><div>In hospitalized patients at general hospitals, ramelteon and suvorexant may not increase the risk of falls, while the use of benzodiazepines and trazodone requires careful attention to minimize this risk.</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"94 ","pages":"Pages 10-15"},"PeriodicalIF":4.1,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143422465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The longitudinal association of optimism with quality of life after percutaneous coronary intervention for coronary heart disease; The THORESCI study","authors":"Nina Kupper ,&nbsp;Nienke Post ,&nbsp;Willem J. Kop ,&nbsp;Jos Widdershoven","doi":"10.1016/j.genhosppsych.2025.02.008","DOIUrl":"10.1016/j.genhosppsych.2025.02.008","url":null,"abstract":"<div><h3>Background</h3><div>Positive psychological factors such as optimism are predictive of favorable clinical outcomes in patients with cardiac disease. Evidence suggests that trait optimism can vary over time, especially after a coronary event. We therefore examined whether the level and change in optimism across the one-year time period after percutaneous coronary intervention (PCI) were associated with changes in quality of life (QoL) over time. The analyses were adjusted for negative psychological functioning and health behavior adherence as potential explanatory factors.</div></div><div><h3>Methods</h3><div>Patients who underwent PCI (<em>n</em> = 1759, 21 % female, mean age = 64 ± 10 years) filled out a psychological survey including positive (optimism; LOT-R) and negative psychological factors (depression (PHQ9) and anxiety (GAD7)), QoL (WHOQOL-BREF), and health behavior adherence (MOS-GAS) at inclusion and one year later (<em>n</em> = 1474). Data were analyzed using hierarchical linear mixed modeling with time-varying predictors and covariates.</div></div><div><h3>Results</h3><div>Optimism levels increased from baseline (Mean_BL = 7.6 (SD = 2.1) to 1-year follow-up in 43 % of the patients, whereas optimism decreased in 36 %; <em>r</em>_intraclass = 0.53). Optimism was associated with a higher level of overall QoL (B = 1.96, se = 0.09, <em>p</em> &lt; .001) and more positive 1-year change in QoL (B = 0.55, se = 0.09, p &lt; .001), adjusting for demographic and clinical covariates, with similar findings for all subdomains. Adding depression and anxiety (both significant negatively correlated with of QoL) explained part of the associations of optimism with physical, psychological and environmental QoL, but not with social QoL. Health behavior adherence was significantly correlated with most QoL components, but adherence did not affect the association between optimism and QoL.</div></div><div><h3>Conclusion</h3><div>These data indicate marked individual differences in the magnitude of changes in optimism following PCI. Both higher levels and increases in optimism were associated with higher and improving QoL. Depression and anxiety, but not health behavior adherence, explained part of this relationship. Optimism might be an important psychological factor to address in cardiac rehabilitation.</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"94 ","pages":"Pages 1-9"},"PeriodicalIF":4.1,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143422464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transforming primary care with transdiagnostic approaches: The future of mental health treatment through technology","authors":"Dwi Sri Rahayu ,&nbsp;Erfan Ramadhani ,&nbsp;Nila Zaimatus Septiana ,&nbsp;Palasara Brahmani Laras ,&nbsp;Rosalia Dewi Nawantara ,&nbsp;Laelatul Arofah","doi":"10.1016/j.genhosppsych.2025.02.007","DOIUrl":"10.1016/j.genhosppsych.2025.02.007","url":null,"abstract":"","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"93 ","pages":"Pages 129-130"},"PeriodicalIF":4.1,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143395331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing mental health outcomes in COPD patients: The global potential of telehealth interventions for anxiety and depression management","authors":"Nila Zaimatus Septiana ,&nbsp;Binti Isrofin ,&nbsp;Rosalia Dewi Nawantara","doi":"10.1016/j.genhosppsych.2025.02.003","DOIUrl":"10.1016/j.genhosppsych.2025.02.003","url":null,"abstract":"","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"94 ","pages":"Pages 24-25"},"PeriodicalIF":4.1,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143445213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of antidepressant and antipsychotic use in the occurence of torsades de pointes arrhythmia: a case-control study","authors":"Samuel Cyr ,&nbsp;Lydia Abdelaziz ,&nbsp;Anthony Minichiello ,&nbsp;Maxime Bouvier ,&nbsp;Orielle Djona ,&nbsp;Céline Fiset ,&nbsp;Rafik Tadros ,&nbsp;Sylvie Levesque ,&nbsp;Charline Daval ,&nbsp;Viviane Lavigne ,&nbsp;Paul Khairy ,&nbsp;Stanley Nattel ,&nbsp;Judith Brouillette","doi":"10.1016/j.genhosppsych.2025.02.002","DOIUrl":"10.1016/j.genhosppsych.2025.02.002","url":null,"abstract":"<div><h3>Objectives and methods</h3><div>Psychotropic drugs may prolong the corrected QT interval (QTc), which has been associated with torsades de pointes (TdP). Our aim is to measure the relative impact of psychotropic drug use on TdP. A case-control study was conducted on 110 cases of confirmed TdP, and 330 matched controls. Hierarchical regression was performed by first including pre-identified risk factors (including demographic, medical conditions, and drugs such as antiarrhythmics) and then psychotropic drugs (antidepressants and antipsychotics). Population attributable risks (PAR) were calculated.</div></div><div><h3>Results</h3><div>At the time of admission, TdP was the primary, secondary, or complication diagnosis in 32.7 %, 30.9 %, and 36.4 % of cases, respectively. There were more patients with TdP who died during hospitalization compared to controls (7.3 % vs. 2.7 %, <em>p</em> &lt; 0.05), but TdP was the cause of death in only two (1.8 %) of them. In our final regression model, age, hepatic and/or renal failure and antidepressant/antipsychotic drug monotherapy were not associated with TdP. On the other hand, the use of other QTc-prolonging drugs, female sex, left ventricular dysfunction, acute myocardial infarction, hypokalemia, and use of ≥ 2 antidepressants were all significantly associated with TdP, with PAR of 55.3 %, 41.8 %, 26.2 %, 13.0 %, 11.7 %, and 6.3 % respectively.</div></div><div><h3>Conclusions</h3><div>In analyses adjusting for concomitant conditions/drugs, antidepressant or antipsychotic monotherapy was not associated with TdP while the use of ≥ 2 antidepressants was. However in terms of PAR, the use of other QTc-prolonging drug, including antiarrhythmics, sex, and left ventricular dysfunction carried a higher burden than the use of ≥2 antidepressants. These findings may inform and assist in balancing the risks and benefits of psychotropic drugs.</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"94 ","pages":"Pages 16-23"},"PeriodicalIF":4.1,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143445396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transforming mental health: The impact of sensory substitution technologies on suicide ideation in hearing-impaired individuals","authors":"Nila Zaimatus Septiana ,&nbsp;Luthfi Atmasari ,&nbsp;Dwi Sri Rahayu ,&nbsp;Laelatul Arofah ,&nbsp;Rosalia Dewi Nawantara","doi":"10.1016/j.genhosppsych.2025.02.005","DOIUrl":"10.1016/j.genhosppsych.2025.02.005","url":null,"abstract":"","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"93 ","pages":"Pages 127-128"},"PeriodicalIF":4.1,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143395436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review of randomized controlled trials in a general practice setting aiming to reduce excess all-cause and enhance cardiovascular health in patients with severe mental illness","authors":"Kristina Langkilde ,&nbsp;Maria Haahr Nielsen ,&nbsp;Sofie Damgaard,&nbsp;Anne Møller,&nbsp;Maarten Pieter Rozing","doi":"10.1016/j.genhosppsych.2025.01.013","DOIUrl":"10.1016/j.genhosppsych.2025.01.013","url":null,"abstract":"<div><h3>Objective</h3><div>People with severe mental illness (SMI) have a reduced life expectancy, primarily due to chronic somatic diseases like cardiovascular disorders. Integrated care in general practice addressing mental and physical health may reduce excess mortality in this population. This review assessed the effectiveness of collaborative care, general integrated care, and physical health interventions in reducing overall mortality in patients with SMI. Secondary outcomes included disease-specific mortality, cardiovascular health indicators, and health-related quality of life.</div></div><div><h3>Methods</h3><div>We searched PubMed, PsycINFO, Cochrane Library, and Embase for randomized controlled trials published before April 24, 2024. Eligible studies focused on integrated care interventions targeting somatic health in patients with SMI. Two reviewers independently conducted data extraction and risk of bias assessment. The study was registered with PROSPERO (CRD42022328464).</div></div><div><h3>Results</h3><div>Of 2904 identified publications, 17 were included (covering 13 studies). Seven studies reported mortality data, with one showing reduced mortality in patients with major depressive disorder receiving collaborative care. No studies examined disease-specific mortality. Nine studies assessed cardiovascular outcomes, with three reporting reduced cardiovascular risk in collaborative care interventions simultaneously targeting depression and cardiovascular factors. Seven studies reported on quality of life, with three finding improvements. Study quality was rated moderate to high.</div></div><div><h3>Conclusion</h3><div>We found low-certainty evidence that collaborative care reduces mortality in depression. There was moderate evidence that collaborative care models, simultaneously addressing mental and cardiovascular health could potentially improve cardiovascular health in depression. The limited number of studies and their focus on depression limit the generalizability of these findings to other SMIs.</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"93 ","pages":"Pages 131-143"},"PeriodicalIF":4.1,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143402834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mental health in the first year after ICU-treated sepsis: Analysis of administrative diagnoses in German health claims data","authors":"S. Sell ,&nbsp;C. Fleischmann-Struzek ,&nbsp;M. Spoden ,&nbsp;J. Rosendahl","doi":"10.1016/j.genhosppsych.2025.02.001","DOIUrl":"10.1016/j.genhosppsych.2025.02.001","url":null,"abstract":"<div><h3>Objective</h3><div>We aimed to quantify the (co-)occurrence of and risk factors for mental health impairments (MHI) in a cohort of sepsis survivors within 12 months after ICU stay in Germany.</div></div><div><h3>Method</h3><div>Population-based cohort study using nationwide de-identified health claims data of the German AOK health insurance. Patients with sepsis hospitalization and ICU treatment were identified by ICD-10 and procedural codes. Among 12-months survivors, we assessed new and prevalent MHI by ICD-10 diagnoses in the outpatient and inpatient health sector. Risk factors for MHI were assessed by multiple logistic regression analyses.</div></div><div><h3>Results</h3><div>Of 21,980 sepsis survivors, 54.8 % were diagnosed with any MHI in the 12 months post-discharge. 25.4 % of patients without pre-existing MHI had a new MHI diagnosis. Co-occurrence of MHI was common. Pre-existing depression, anxiety disorder, PTSD, substance use disorder and sleep disorder significantly increased the odds for a diagnosis of any MHI post-sepsis between six- and nine-fold, while treatment-related factors had no influence.</div></div><div><h3>Conclusions</h3><div>MHI is common among sepsis survivors, particularly in those affected by any pre-existing psychological diagnoses. Early assessment of pre-existing psychopathology might help to identify patients at risk for prevention or treatment interventions.</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"93 ","pages":"Pages 109-115"},"PeriodicalIF":4.1,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143372861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The reliability and validity of the Chinese version of premenstrual dysphoric disorder questionnaire for DSM-5","authors":"Shanyi Huang ,&nbsp;Qiao Zhang ,&nbsp;Leire Aperribai ,&nbsp;Itziar Alonso-Arbiol ,&nbsp;Nekane Balluerka ,&nbsp;Ying Chen ,&nbsp;Yuecheng Wang ,&nbsp;Yuqun Zhang","doi":"10.1016/j.genhosppsych.2025.01.021","DOIUrl":"10.1016/j.genhosppsych.2025.01.021","url":null,"abstract":"<div><h3>Objective</h3><div>Premenstrual dysphoric disorder (PMDD) seriously affects women's work and life, and early screening and diagnosis of PMDD can improve the quality of life of potential PMDD patients. The Premenstrual Dysphoric Disorder Questionnaire for DSM-5 (CTDP-DSM-5) is a validated screening tool for PMDD based on the DSM-5. This study intends to conduct reliability testing and validity evaluation of the scale after translation and revision in Chinese women.</div></div><div><h3>Methods</h3><div>669 Chinese female college students were evaluated by a set of questionnaires including the Chinese version of CTDP-DSM-5 (CTDP-C), Patient Health Questionnaire-9 (PHQ-9), General Anxiety Disorder-7 (GAD-7) and Premenstrual Symptoms Screening Tool (PSST).</div></div><div><h3>Results</h3><div>CTDP-C is a bi-dimensional screening instrument with 25 items. The factor structure of the CTDP-C fits well to the factor model of the original Spanish version (CFI = 0.957; TLI = 0.953; RMSEA = 0.036; <em>χ</em>^<em>2</em> = 5983.585, <em>df</em> = 300, <em>p</em> &lt; 0.0001). The McDonald's omega reliability index obtained in this study was good (0.8) for both dimensions. In terms of convergent validity, the CTDP-C is significantly positively correlated with PSST (<em>r</em> = 0.533, <em>p</em> &lt; 0.01). Furthermore, the instrument correlates positively with depression and anxiety. Finally, the CTDP-C scores can sensitively differentiate depressed from non-depressed patients (<em>Cohen's d</em> = 0.72). Similarly, sensitively differentiated anxious from non-anxious patients (<em>Cohen's d</em> = 0.80).</div></div><div><h3>Conclusions</h3><div>CTDP-C has good validity and reliability and it is an effective screening tool to identify Chinese patients with PMDD among college students, providing a basis for early detection, early diagnosis and early treatment of PMDD.</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"93 ","pages":"Pages 122-126"},"PeriodicalIF":4.1,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143395435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}