General hospital psychiatry最新文献

{"title":"Prolactin levels in depressive disorders: A systematic review and meta-analysis","authors":"Mahendra Kumar ,&nbsp;Naksh Raj ,&nbsp;Preeti Kochar ,&nbsp;P. Swabhanu Sriya ,&nbsp;Yanjana ,&nbsp;Mahesh Kumar ,&nbsp;Sunita","doi":"10.1016/j.genhosppsych.2025.06.004","DOIUrl":"10.1016/j.genhosppsych.2025.06.004","url":null,"abstract":"<div><h3>Introduction</h3><div>Depression can impact prolactin (PRL) levels by activating the body's stress response and releasing stress hormones like cortisol, which disrupt normal PRL regulation. PRL plays a role in various physiological systems, including reproduction, metabolism, immune regulation, and neurogenesis. Previous studies on PRL levels in depressive patients have yielded contradictory results. This meta-analysis aims to evaluate PRL concentrations in depressive patients versus healthy controls.</div></div><div><h3>Methods</h3><div>This systematic review and meta-analysis followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A comprehensive search was conducted across multiple databases, including PubMed, Scopus, Web of Science, Embase, PsycINFO, CINAHL, ProQuest, Science Direct, and Google Scholar, up to 2024. Review Manager 5.3, Jamovi, and Open Meta Analyst software were utilized to calculate the standard mean difference (SMD) and assess heterogeneity, publication bias (via funnel plots and Egger's test), subgroup analysis, sensitivity analysis, and meta-regression.</div></div><div><h3>Results</h3><div>Sixteen studies with a combined population (n) of 1492 (776 depressive disorder patients and 716 controls) met the inclusion criteria for serum or plasma PRL. This meta-analysis indicates a statistically significant SMD in serum or plasma PRL between depressed patients and controls, with a pooled SMD of 0.44 (95 % CI: - 0.20 to 0.68, <em>p</em> = 0.0003).</div></div><div><h3>Conclusions</h3><div>This meta-analysis found a statistically significant difference in serum or plasma PRL levels between individuals with depressive disorders. Further research is warranted to explore the potential of PRL as a biomarker for depression diagnosis or severity, as well as its therapeutic implications. Additionally, investigating the underlying mechanisms of PRL dysregulation in depression may lead to the development of novel treatment strategies.</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"96 ","pages":"Pages 62-71"},"PeriodicalIF":4.1,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144298364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is there harm in behavioral weight loss for binge-eating disorder: Controlled comparison to cognitive behavioral therapy","authors":"Carlos M. Grilo ,&nbsp;Sydney Yurkow ,&nbsp;Marney A. White ,&nbsp;Janet A. Lydecker ,&nbsp;Valentina Ivezaj","doi":"10.1016/j.genhosppsych.2025.06.005","DOIUrl":"10.1016/j.genhosppsych.2025.06.005","url":null,"abstract":"","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"96 ","pages":"Pages 72-74"},"PeriodicalIF":4.1,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144321470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between American Heart Association's life's essential 8 metric and depressive symptoms and suicidal behaviors: A population-based study of Korean adults","authors":"Seong-Uk Baek ,&nbsp;Jin-Ha Yoon","doi":"10.1016/j.genhosppsych.2025.06.002","DOIUrl":"10.1016/j.genhosppsych.2025.06.002","url":null,"abstract":"","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"96 ","pages":"Pages 60-61"},"PeriodicalIF":4.1,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144271289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient–therapist relationship in psychedelic-assisted therapy: Implications for future real-world settings","authors":"Daniel Villiger","doi":"10.1016/j.genhosppsych.2025.06.003","DOIUrl":"10.1016/j.genhosppsych.2025.06.003","url":null,"abstract":"<div><div>The view that the use of serotonergic psychedelics in mental health care should always be psychotherapeutically embedded has recently been questioned. One argument against this model concerns the high costs it entails, which could limit the accessibility of psychedelic-assisted therapy (PAT)—a concern likely to gain traction if PAT is officially approved in the future. This paper analyzes the implications of a reductionist approach that primarily frames PAT as a pharmacological intervention, focusing on a key component of the treatment: the patient-therapist relationship. It first reviews evidence highlighting the therapeutic and ethical significance of this relationship in PAT. It then argues that shortening the preparation phase is a probable cost-saving measure that risks undermining the development of a strong patient-therapist relationship. Finally, the paper outlines three strategies to strengthen this relationship even in real-world PAT settings under cost pressure: retaining some relational elements during preparation, maintaining continuity by involving the same therapist throughout all phases, and, where possible, integrating the patient's regular therapist into the process.</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"96 ","pages":"Pages 54-59"},"PeriodicalIF":4.1,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144240446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of ondansetron in schizophrenia: A systematic review and meta-analysis of randomized controlled trials","authors":"Omar Kassar ,&nbsp;Omar Shaheen ,&nbsp;Abdullah Selim ,&nbsp;Mahmoud Soliman ,&nbsp;Lamees Taman ,&nbsp;Ahmed Elshahat ,&nbsp;Moaz Elsayed Abouelmagd","doi":"10.1016/j.genhosppsych.2025.06.001","DOIUrl":"10.1016/j.genhosppsych.2025.06.001","url":null,"abstract":"<div><h3>Purpose</h3><div>It has been shown that 5-hydroxytryptamine3 (5-HT3) receptors are involved in the pathogenesis of schizophrenia. This systematic review and meta-analysis of randomized clinical trials (RCTs) evaluates the efficacy and safety of ondansetron, a potent 5-HT3 receptor antagonist, as adjunctive treatment for the management of schizophrenia, especially the negative symptoms.</div></div><div><h3>Methods</h3><div>A comprehensive search of electronic databases, including PubMed, Scopus, Cochrane, and Web of Science, was performed in October 2024. We included only randomized controlled trials (RCTs), and their data were extracted and analyzed using RevMan 5.4 software. The primary outcome was the PANSS (Positive and Negative Syndrome Scale) negative subscale.</div></div><div><h3>Results</h3><div>Eight RCTs involving 533 patients were included in the study. Ondansetron showed a statistically significant improvement in PANSS negative subscale at 12 weeks [pooled as mean difference, MD = −2.96, 95 % CI [−4.69, −1.24], <em>P</em>-value = 0.00007] and in general psychopathology scale [MD = −2.71, 95 % CI [−3.52, −1.90] compared to placebo. However, ondansetron and placebo did not differ in reduction of PANSS positive subscale [MD = 0.1, 95 % CI [−1.19, 1.38], P-value = 0.88], and depression scale. Ondansetron showed no significant difference regarding tardive dyskinesia between the two groups. However, constipation was significant in the ondansetron group over placebo.</div></div><div><h3>Conclusion</h3><div>The study findings provide valuable insights into the efficacy of ondansetron, a serotonin receptor antagonist, in managing schizophrenia, particularly negative symptoms. However, the limitations of the study highlight the need for caution in interpreting these results. Further high-quality trials are required to confirm our findings and explore the long-term impact of ondansetron in the treatment of schizophrenia.</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"96 ","pages":"Pages 37-46"},"PeriodicalIF":4.1,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144230699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global trends in major depressive disorder among women of childbearing age, 1990–2021","authors":"Hanpu Zhang ,&nbsp;Shuangfei Xu ,&nbsp;Yanyan Zhu ,&nbsp;Yan-Ci Zhao","doi":"10.1016/j.genhosppsych.2025.05.011","DOIUrl":"10.1016/j.genhosppsych.2025.05.011","url":null,"abstract":"","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"96 ","pages":"Pages 34-36"},"PeriodicalIF":4.1,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144230599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary prevention in Psychiatry in India – An overview of the current state of affairs","authors":"Sagarika Ray ,&nbsp;Amit Kumar Pal ,&nbsp;Partha Sarathi Kundu","doi":"10.1016/j.genhosppsych.2025.05.014","DOIUrl":"10.1016/j.genhosppsych.2025.05.014","url":null,"abstract":"","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"96 ","pages":"Pages 28-33"},"PeriodicalIF":4.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144212515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Referral to chronic pain management and physiotherapy services in adults with severe mental illness: A matched cohort study","authors":"Ruimin Ma ,&nbsp;Eugenia Romano ,&nbsp;Gayan Perera ,&nbsp;Trevor Thompson ,&nbsp;Davy Vancampfort ,&nbsp;Robert Stewart ,&nbsp;Kerem Böge ,&nbsp;Nilufar Mossaheb ,&nbsp;Mark Ashworth ,&nbsp;Brendon Stubbs","doi":"10.1016/j.genhosppsych.2025.05.013","DOIUrl":"10.1016/j.genhosppsych.2025.05.013","url":null,"abstract":"<div><h3>Introduction</h3><div>Chronic pain (CP) is common among people with severe mental illness (SMI). It remains unclear whether patients with comorbid CP and SMI receive equivalent pain management referrals compared to those with CP alone. This retrospective cohort study used linked primary and mental healthcare data to address this knowledge gap.</div></div><div><h3>Methods</h3><div>We identified patients aged ≥18 years with comorbid SMI and CP from secondary mental healthcare records, with the later of either diagnosis serving as the index date. Cases were matched 1:4 by age bands and gender to controls with CP but no SMI diagnosis. Co-primary outcomes were referrals to specialized pain treatment services and musculoskeletal physiotherapy. Cox regression models analyzed associations between SMI status and referral patterns, with sensitivity analyses stratifying follow-up into early (0–3.99 years), medium (4–7.99 years), and late (≥8 years) periods.</div></div><div><h3>Results</h3><div>The final sample included 1120 patients with CP and SMI and 2681 matched non-SMI controls. SMI diagnosis strongly predicted increased healthcare utilization in adjusted analyses, with significantly higher referral rates to pain treatments (HR = 13.2, 95 % CI 7.8–22.4, <em>p</em> &lt; 0.001) and physiotherapy (HR = 11.5, 95 % CI 9.3–14.4, p &lt; 0.001). The association between SMI and pain treatment referrals was strongest during the early post-diagnosis period (HR = 13.2, 95 % CI 6.6–26.4, p &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>Contrary to expectations, people with SMI and CP received more pain management referrals compared to matched controls, particularly in the early post-diagnosis period. These findings were restricted to those with a CP diagnosis already, and further research should investigate whether increased referrals translate to improved clinical outcomes.</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"96 ","pages":"Pages 47-53"},"PeriodicalIF":4.1,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144230598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A national movement or just a ripple? Few outpatient perinatal visits engage in essential perinatal behavioral health screening practices","authors":"M.E. Deichen Hansen,&nbsp;J. Day,&nbsp;A.M. Spitz,&nbsp;S. Goldfarb,&nbsp;J.S. Harman","doi":"10.1016/j.genhosppsych.2025.05.012","DOIUrl":"10.1016/j.genhosppsych.2025.05.012","url":null,"abstract":"<div><h3>Objectives</h3><div>Perinatal behavioral health conditions are currently the leading cause of US maternal mortality. To prevent morbidity and mortality, obstetrics clinicians must screen for behavioral health conditions using a validated screener. However, many women's behavioral health conditions go undetected and untreated. This brief highlights the extent of the US health system's failure to adequately screen for critical perinatal health conditions.</div></div><div><h3>Methods</h3><div>Pooled data from the 2015–16, and 2018–19 National Ambulatory Medical Care Survey were generated to assess rates of screening for depression, alcohol use, substance use, and domestic violence during routine prenatal care visits.</div></div><div><h3>Results</h3><div>In the pooled 2015–2016 and 2018–2019 NAMCS sample (<em>n</em> = 1135) there were 82,986,275 weighted office visits for routine prenatal care. Clinicians most frequently identified as physicians. Screening data was nearly absent from the data, with domestic violence screenings being conducted most frequently at a reported 2.7 %.</div></div><div><h3>Conclusions</h3><div>This study found behavioral health screening tools are used infrequently during office visits for routine prenatal care. While many clinicians endorse at least some behavioral health screening practices, the adoption of these screenings in all healthcare settings has not occurred.</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"96 ","pages":"Pages 16-17"},"PeriodicalIF":4.1,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144166895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between perceived stress and burnout among Chinese nurses: A moderated-mediation model","authors":"Xingbo Suo ,&nbsp;Yang Zhang ,&nbsp;Yi Zhang ,&nbsp;Shenshuai Zhang ,&nbsp;Jinguo Zhai ,&nbsp;Maorong Hu","doi":"10.1016/j.genhosppsych.2025.05.010","DOIUrl":"10.1016/j.genhosppsych.2025.05.010","url":null,"abstract":"","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"96 ","pages":"Pages 11-12"},"PeriodicalIF":4.1,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144148045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}