General hospital psychiatry最新文献

{"title":"Association between systemic inflammatory markers and depression: A meta-analysis","authors":"Xiaowei Jiang ,&nbsp;Jiahui Pei ,&nbsp;Houze Diao,&nbsp;Qingzhen He,&nbsp;Tong Zhu,&nbsp;Qiming Liu,&nbsp;Yaxu Cui,&nbsp;Fang Fang,&nbsp;Weiwei Cui","doi":"10.1016/j.genhosppsych.2025.07.005","DOIUrl":"10.1016/j.genhosppsych.2025.07.005","url":null,"abstract":"<div><h3>Background</h3><div>Many studies have evaluated possible associations between the SII, NLR, SIRI, AISI, NLPR with depression, but the results remain controversial.</div></div><div><h3>Objective</h3><div>To determine the association between levels of the systemic inflammatory markers and the prevalence of depression.</div></div><div><h3>Methods</h3><div>Databases like Web of Science, PubMed, Cochrane Library, and EMBASE were searched for relevant studies. Differences in SII, NLR, SIRI, AISI, and NLPR levels between depressed patients and controls were assessed using OR, SMD, and 95 % CI. Subgroup and sensitivity analyses explored heterogeneity based on diagnostic criteria, region, study design, gender, and underlying disease. A meta-analysis was also performed to evaluate the diagnostic effectiveness of inflammatory markers for depression.</div></div><div><h3>Results</h3><div>A total of 41 studies with 205,438 participants were analyzed. Depressed subjects showed significantly higher NLR (SMD = 0.35, 95 % CI [0.17, 0.53], <em>P</em> &lt; 0.001) and SII (OR = 1.38, 95 % CI [1.15, 1.65], <em>P</em> &lt; 0.001) than controls. Subgroup analyses suggested that diagnostic criteria, study design, and country influence the association. Meta-analysis showed that NLR was effective in diagnosing depression (AUC = 0.70, 95 % CI [0.66, 0.74]), whereas SII was less effective (AUC = 0.37, 95 % CI [0.33, 0.41]).</div></div><div><h3>Conclusions</h3><div>This study supports the hypothesis that inflammation is associated with depression and that NLR and SII can be a potential predictor, but there are fewer studies related to SIRI, AISI, and NLPR, and further research is needed.</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"96 ","pages":"Pages 121-131"},"PeriodicalIF":4.1,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144605144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between loneliness, social isolation and incident depression: a prospective study based on UK Biobank","authors":"Li-Peng Wan ,&nbsp;Zhen-Yu Zhao ,&nbsp;Bao-Peng Liu ,&nbsp;Jia-Hui Zhu ,&nbsp;Cun-Xian Jia ,&nbsp;Xin-Ting Wang","doi":"10.1016/j.genhosppsych.2025.07.007","DOIUrl":"10.1016/j.genhosppsych.2025.07.007","url":null,"abstract":"<div><h3>Purpose</h3><div>In existing research on social isolation and loneliness, although both are widely recognized as independent risk factors for health, their interrelationship has not been fully explored. Therefore, clarifying whether there is an interaction between them is crucial to understanding their impact on an individual's health.</div></div><div><h3>Methods</h3><div>Loneliness and social isolation were assessed by means of touch-screen questionnaire. The occurrence of clinically diagnosed depression was determined based on the section of mental and behavioral disorders of the UKB's first occurrence fields. Cox proportional hazard models and additive and multiplicative models were used to assess the associations between loneliness, social isolation, and incident depression.</div></div><div><h3>Results</h3><div>Among the 339,051 participants, 48.47 % were men and 13,096 depression cases were recorded during a median follow-up period of 12.45 years. Loneliness (yes vs no: adjusted HR: 1.77; 95 % CI: 1.67–1.89) and social isolation (yes vs no: adjusted HR: 1.14; 95 % CI: 1.08–1.21) were associated with an increased risk of incident depression. The association between increased risk of depression and social isolation was modified by gender (<em>P</em>_interaction = 0.018). The interactive effect of loneliness and social isolation was not statistically associated with incident depression (<em>P</em> = 0.124).</div></div><div><h3>Conclusions</h3><div>Loneliness and social isolation were independently associated with a higher risk of incident depression, with no interaction between the two.</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"96 ","pages":"Pages 171-177"},"PeriodicalIF":4.1,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144655416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Joint associations of restless sleep and loneliness with cardiovascular diseases in middle-aged and older Chinese adults: A national prospective cohort study","authors":"Yu-Hua Liu ,&nbsp;Lu Zhai ,&nbsp;Rong-Rui Huo ,&nbsp;Cui Ma","doi":"10.1016/j.genhosppsych.2025.07.002","DOIUrl":"10.1016/j.genhosppsych.2025.07.002","url":null,"abstract":"<div><h3>Background</h3><div>Restless sleep and loneliness are common in older adults and may contribute to cardiovascular disease (CVD) risk. However, the joint associations of these factors with incident CVD have not been fully elucidated.</div></div><div><h3>Methods</h3><div>The China Health and Retirement Longitudinal Study (CHARLS) is an ongoing nationally representative prospective cohort study initiated in 2011. The primary outcome was incident CVD, defined by self-reported physician diagnoses of heart disease or stroke during follow-up (2011–2018). Cox proportional hazard models were used to calculate hazard ratios (HRs) for CVD, adjusting for demographic, lifestyle, and health-related factors.</div></div><div><h3>Results</h3><div>Among 12,212 participants (mean [SD] age, 58.39 [9.34] years; 48.4 % men), 2353 (19.3 %) participants have both restless sleep and loneliness at baseline. During the 7 years of follow-up, 2323 experienced CVD. Restless sleep (hazard ratio [HR], 1.28; 95 % confidence interval [CI], 1.18–1.40) and loneliness (HR, 1.31; 95 % CI, 1.19–1.43) were independently associated with increased CVD risk. Participants with both restless sleep and loneliness had a 53.0 % higher risk of CVD (HR, 1.53; 95 % CI, 1.37–1.71) compared with those with neither. Synergistic interactions between restless sleep and loneliness on CVD were observed on both the multiplicative (HR, 1.36; 95 % CI, 1.20–1.54) and additive scales (synergy index [SI], 1.20; 95 % CI, 1.07–2.81). Similar results were observed for stroke and heart disease.</div></div><div><h3>Conclusions</h3><div>The joint presence of restless sleep and loneliness increases CVD risk, suggesting that addressing both factors may help mitigate CVD risk in middle-aged and older adults.</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"96 ","pages":"Pages 107-115"},"PeriodicalIF":4.1,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144570143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Should we skip the trip? Clinical implications of psychedelic-associated subjective effects and the potential role of non-hallucinogenic alternatives","authors":"Kush V. Bhatt,&nbsp;James D. Asuncion,&nbsp;Al Alam,&nbsp;Sidney Zisook,&nbsp;Stephen M. Stahl","doi":"10.1016/j.genhosppsych.2025.07.001","DOIUrl":"10.1016/j.genhosppsych.2025.07.001","url":null,"abstract":"<div><div>The resurgence of interest in classical psychedelics brings both promise and challenges to psychiatric care. Increasing evidence supports the therapeutic potential of psychedelics for a range of mental health conditions, and approval for clinical use appears inevitable. The psychedelic-associated acute subjective experience may mediate or enhance therapeutic outcomes, but also presents significant clinical challenges. This review explores the role of psychedelic-associated subjective effects in psychiatric treatment, including their phenomenology, therapeutic benefit, potential risks, and challenges for implementation. We also explore emerging research on nonhallucinogenic psychedelic analogues that may retain neuroplastic effects while minimizing or eliminating the acute subjective effects. We argue that a debate over the necessity of acute subjective effects of psychedelics may be avoidable and that clinical psychiatry warrants space for both perspectives. Future research should continue to explore the clinical implications of psychedelic-associated subjective experience, while also exploring alternative compounds that broaden the breadth of treatment options for patients.</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"96 ","pages":"Pages 116-120"},"PeriodicalIF":4.1,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144596124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between depressive symptom trajectories and risk of all-cause mortality and premature death: A 10-year follow-up study in United States and England","authors":"Mengyang Jia ,&nbsp;Xiyu Chen ,&nbsp;Chen Liang ,&nbsp;Shuojia Wang ,&nbsp;Cheng Jiang ,&nbsp;Yupeng Zeng ,&nbsp;Xin Jiang ,&nbsp;Lixin Cheng ,&nbsp;Qingshan Geng","doi":"10.1016/j.genhosppsych.2025.06.011","DOIUrl":"10.1016/j.genhosppsych.2025.06.011","url":null,"abstract":"<div><h3>Background</h3><div>Depression has emerged as a leading cause of disease burden and disability worldwide. This study aimed to investigate the association between depressive symptom trajectories, all-cause mortality, and premature death.</div></div><div><h3>Method</h3><div>We utilized the data from Health Retirement Study (HRS) and English Longitudinal Study of Aging (ELSA). Depressive symptoms were assessed using the 8-item CESD scale and categorized into somatic and cognitive-affective subtypes. Cox proportional risk mode was employed to estimate the relationship between depressive symptom trajectories and all-cause mortality and premature death.</div></div><div><h3>Result</h3><div>Among 17,930 enrolled participants, 4543 died, including 1063 premature deaths. Increasing total depressive symptoms had the highest risk for all-cause mortality with HR 2.01 (95 %CI: 1.72–2.35) followed by consistently high with HR 1.53 (95 %CI: 1.36–1.72) adjusted for covariates compared to consistently low. Increasing and consistently high total trajectories had elevated risks for premature death with HR 1.83 (95 %CI: 1.29–2.59) and HR 2.01 (95 %CI: 1.61–2.51). Increasing, consistently high somatic or cognitive-affective depressive symptom trajectories also increased the risks of all-cause mortality and premature death. Decreasing somatic, cognitive-affective, and total trajectories showed no higher risk for premature death (HR 1.56, 95 %CI: 0.90–2.72; HR 1.00, 95 %CI: 0.56–1.78; HR 1.17, 95 %CI: 0.76–1.81).</div></div><div><h3>Conclusion</h3><div>Increasing or consistently high trajectories of somatic, cognitive-affective, and total depressive symptoms were associated with elevated risks of all-cause mortality and premature death, whereas decreasing trajectories were not associated with increased risks. Early interventions aimed at reducing the duration of depressive symptoms may help to extend lifespan.</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"96 ","pages":"Pages 97-106"},"PeriodicalIF":4.1,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144502151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of self-harm and overdose after starting buprenorphine for opioid use disorder","authors":"Gregory E. Simon ,&nbsp;Susan M. Shortreed ,&nbsp;Eric Johnson ,&nbsp;Brian K. Ahmedani ,&nbsp;Stacy A. Sterling ,&nbsp;Cynthia I. Campbell ,&nbsp;Rulin C. Hechter ,&nbsp;Rebecca A. Ziebell ,&nbsp;Sujaya Parthasarathy","doi":"10.1016/j.genhosppsych.2025.06.010","DOIUrl":"10.1016/j.genhosppsych.2025.06.010","url":null,"abstract":"<div><h3>Objective</h3><div>Compare risk of intentional self-harm and overdose after visits for opioid use disorder (OUD) followed by starting vs. not starting buprenorphine.</div></div><div><h3>Methods</h3><div>Records from four health systems identified visits during 1/1/2012–12/31/2019 by health system members aged 13 or older with OUD diagnosis and no recent OUD medication. Following a target-trial emulation approach, visits followed by buprenorphine dispensing within 7 days were matched to unexposed visits. Analyses compared risk of diagnosed self-harm injury or poisoning (primary outcome) as well as opioid-involved poisoning and any injury or poisoning (secondary outcomes) within 90 days.</div></div><div><h3>Results</h3><div>Among 183,809 visits by 30,955 patients, 15,508 (8.4 %) had buprenorphine dispensing within 7 days, and 2260 (1.2 %) had self-harm diagnosis within 90 days. Average duration of buprenorphine treatment before interruption was 44.3 days (SD 32.1). In primary intention-to-treat analyses using logistic regression and adjusting for baseline risk of self-harm, starting buprenorphine was not associated with significant difference in self-harm (odds ratio [OR] 1.01, 95 % CI 0.81–1.24) or opioid-involved poisoning (OR 1.09, 95 % CI 0.86–1.38). In secondary as-treated analyses censoring outcomes after treatment change, buprenorphine initiation was associated with no significant difference in hazard of self-harm (Hazard Ratio [HR] 0.74, 95 % CI 0.53–1.02) and with significantly lower hazard of opioid-involved poisoning (HR 0.63, 95 % CI 0.43–0.94).</div></div><div><h3>Conclusions</h3><div>Among people with OUD, starting buprenorphine was not followed by lower risk of self-harm, likely reflecting frequent discontinuation and high risk of self-harm or overdose shortly after discontinuation. These findings reinforce the need to improve treatment continuity among those starting buprenorphine.</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"96 ","pages":"Pages 90-96"},"PeriodicalIF":4.1,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144491265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between organizational factors and mental health outcomes: Insights from Vietnamese frontline healthcare workers in COVID-19 field hospitals","authors":"Tra Thu Doan ,&nbsp;Vuong Minh Nong ,&nbsp;Cuong Duy Do ,&nbsp;Giap Van Vu","doi":"10.1016/j.genhosppsych.2025.06.009","DOIUrl":"10.1016/j.genhosppsych.2025.06.009","url":null,"abstract":"","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"96 ","pages":"Pages 87-89"},"PeriodicalIF":4.1,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144480665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond diagnosis: Examining body dissatisfaction across obesity and eating disorders","authors":"Elvira Anna Carbone ,&nbsp;Marianna Rania ,&nbsp;Ettore D'Onofrio ,&nbsp;Andrea Scaramuzzino ,&nbsp;Daria Quirino ,&nbsp;Lavinia Rotella ,&nbsp;Matteo Aloi ,&nbsp;Renato de Filippis ,&nbsp;Cristina Segura-Garcia","doi":"10.1016/j.genhosppsych.2025.06.007","DOIUrl":"10.1016/j.genhosppsych.2025.06.007","url":null,"abstract":"","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"96 ","pages":"Pages 85-86"},"PeriodicalIF":4.1,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144469964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prefrontal cortex modulation using transcranial direct current stimulation in opioid craving: A sham-control double-blind study","authors":"Ikhlaq Ahmed ,&nbsp;Mohammed Qutishat ,&nbsp;Rima Ikhlaq ,&nbsp;Nishant Goyal ,&nbsp;Salim AL-Huseini","doi":"10.1016/j.genhosppsych.2025.06.008","DOIUrl":"10.1016/j.genhosppsych.2025.06.008","url":null,"abstract":"<div><h3>Background</h3><div>Opioid addiction, a major global health crisis, has necessitated innovative therapeutic approaches. This study aims to investigate the efficacy of Transcranial Direct Current Stimulation (tDCS) targeting the right dorsolateral prefrontal cortex (DLPFC) in reducing cravings among individuals with opioid dependence.</div></div><div><h3>Method</h3><div>In this single-centre, double-blind, randomized, sham-controlled trial, 40 male inpatients with opioid dependence at the Central Institute of Psychiatry (Ranchi, India) were allocated to either active right-DLPFC tDCS (2 mA, 20 min) or sham stimulation for five consecutive days. Craving and psychosocial functioning were assessed via the Obsessive–Compulsive Drug Use Scale (OCDUS) and Addiction Severity Index (ASI) at baseline, immediately post-treatment, and at 2- and 4-week follow-ups. Repeated-measures ANOVA tested group × time differences.</div></div><div><h3>Results</h3><div>At baseline, OCDUS scores did not differ between groups (Active: 32.00 ± 2.47 vs. Sham: 31.60 ± 2.85; F (1,38) = 0.582, <em>p</em> = 0.582, η²p = 0.015). Following treatment, the Active group showed markedly greater reductions in craving than Sham at Day 5 (10.35 ± 2.21 vs. 24.25 ± 5.29; F(1,38) = 956.5, <em>p</em> &lt; 0.001, η²ₚ = 0.672) and Day 14 (6.30 ± 1.98 vs. 20.75 ± 5.22; F(1,38) = 99.56, p &lt; 0.001, η²ₚ = 0.503), with effects maintained at Day 28 (5.75 ± 1.65 vs. 23.35 ± 6.07).</div></div><div><h3>Conclusion</h3><div>Five sessions of right-DLPFC tDCS produced rapid, significant, and sustained reductions in opioid craving compared with sham, supporting its promise as an adjunctive treatment in opioid use disorder.</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"96 ","pages":"Pages 78-84"},"PeriodicalIF":4.1,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are diabetes self-management interventions delivered in the psychiatric inpatient setting effective?: A systematic review","authors":"Zoe Goff ,&nbsp;Charlotte Palmer ,&nbsp;Eleanor Morris","doi":"10.1016/j.genhosppsych.2025.06.006","DOIUrl":"10.1016/j.genhosppsych.2025.06.006","url":null,"abstract":"","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"96 ","pages":"Pages 75-77"},"PeriodicalIF":4.1,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144330064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}