Effectiveness and safety of repeated transcranial magnetic stimulation for smoking cessation: A systematic review and meta-analysis

IF 3.7 2区医学 Q1 PSYCHIATRY

General hospital psychiatry Pub Date : 2025-05-16 DOI:10.1016/j.genhosppsych.2025.05.005

Xue Shang , Lin Guo , Yan Wang , Kangle Guo , Kehu Yang

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引用次数: 0

Abstract

Objective

To evaluate the effectiveness and safety of Repeated Transcranial magnetic stimulation (rTMS) for smoking cessation.

Methods

Randomized Controlled Trials (RCT) with rTMS on smokers were included. The meta-analysis was performed using R 4.3.2 software. GRADE method was used to evaluate the quality of the evidence.

Results

15 RCTs involving 967 smokers were included. The meta-analysis showed that, comparing with the control group, active rTMS significantly decreased the average daily number of cigarettes smoked (MD = −6.72, 95 % CI [−9.47, −3.97], very low quality) and FTND score (MD = −2.57, 95 % CI [−3.84, −1.29], very low quality). Meanwhile it significantly improved the smoking cessation rates (OR = 2.77, 95 % CI [1.56, 4.92], moderate quality). 10 Hz had a better effect on the three outcomes than 0 Hz. When the treatment was ≥20 sessions, it was more helpful to quit smoking, reduce smoking and nicotine dependence. People with schizophrenia were more likely to reduce smoking and nicotine dependence. Adverse reactions were mild, with only the incidence of headache being significantly increased (P < 0.05).

Conclusion

rTMS might provide effective support for people trying to stop smoking. Meanwhile, population characteristics, stimulation frequency, sessions, and duration will affect the treatment effect of rTMS.

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反复经颅磁刺激戒烟的有效性和安全性：系统回顾和荟萃分析

目的评价反复经颅磁刺激（rTMS）戒烟的有效性和安全性。方法采用随机对照试验（RCT）对吸烟者进行rTMS。meta分析采用r4.3.2软件进行。采用GRADE法评价证据质量。结果纳入15项随机对照试验，涉及967名吸烟者。荟萃分析显示，与对照组相比，有效的rTMS显著降低了平均每日吸烟次数（MD = - 6.72, 95% CI[- 9.47, - 3.97]，极低质量）和FTND评分（MD = - 2.57, 95% CI[- 3.84, - 1.29]，极低质量）。同时显著提高了戒烟率（OR = 2.77, 95% CI[1.56, 4.92]，质量中等）。10hz比0hz对三个结果的影响更好。当治疗≥20次时，对戒烟、减少吸烟和尼古丁依赖更有帮助。精神分裂症患者更有可能减少吸烟和对尼古丁的依赖。不良反应轻微，仅头痛发生率显著增加(P <；0.05)。结论经颅磁刺激可为戒烟者提供有效的支持。同时，人群特征、刺激频率、次数和持续时间都会影响rTMS的治疗效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

General hospital psychiatry 医学-精神病学

CiteScore

9.60

自引率

2.90%

发文量

125

审稿时长

20 days

期刊介绍： General Hospital Psychiatry explores the many linkages among psychiatry, medicine, and primary care. In emphasizing a biopsychosocial approach to illness and health, the journal provides a forum for professionals with clinical, academic, and research interests in psychiatry''s role in the mainstream of medicine.