Frontiers in Medicine最新文献

{"title":"A randomized controlled trial of meditation and health education on carotid intima-media thickness and major adverse cardiovascular events in Black men and women.","authors":"Keith C Norris, John Salerno, C Noel Bairey Merz, Vidya Kaushik, Simon Gelleta, Amparo Castillo, Sanford Nidich, Carolyn Gaylord-King, Robert H Schneider","doi":"10.3389/fmed.2025.1513699","DOIUrl":"10.3389/fmed.2025.1513699","url":null,"abstract":"<p><strong>Introduction: </strong>Black Americans suffer from disproportionately high rates of cardiovascular disease (CVD). Psychosocial stress contributes to this disparity. Previous studies reported that the Transcendental Meditation (TM) technique reduced CVD risk factors, surrogate endpoints, and clinical events in high-risk populations. However, no study has evaluated the effects of stress reduction with meditation on surrogate CVD markers such as carotid intima-media thickness (cIMT) along with CVD clinical events. Therefore, this randomized clinical trial evaluated the long-term effects of meditation and health education (HE) on cIMT and CVD events in high-risk Black adults.</p><p><strong>Materials and methods: </strong>Participants were Black women and men with CVD or at high risk who were randomized to either TM or HE. The primary outcome was a change in cIMT measured using B-mode ultrasound at baseline and 12 months. The main secondary outcome was major adverse cardiovascular events (MACE) at 5 years (maximum) of follow-up. Other secondary outcomes were MACE at 1 and 10 years of follow-up, blood pressure, and serum lipids after 1 year. Exploratory variables were a comparison of cIMT changes to historical controls and MACE after 14 years.</p><p><strong>Results: </strong>There were 197 randomized participants, of whom 136 completed posttest for cIMT. After 1 year, the TM and HE groups showed average cIMT changes of -0.0004 and -0.0003 mm, respectively, with no significant difference between the groups. Additionally, there were no significant differences between the groups in lipid levels or BP. However, both TM and HE groups showed prevention of progression of cIMT compared to historical controls at 12 months. In the survival analysis of MACE, there was a 65% relative risk reduction in the TM group after 5 (maximum) years of follow-up (HR = 0.346; 95% CI = 0.134-0.893; <i>p</i> = 0.017). At 1 and 10 years of follow-up, there were significant risk reductions in the TM vs. HE group, which was not significant at 14 years (all yearly maximums).</p><p><strong>Discussion: </strong>Both treatment groups demonstrated prevention of progression of cIMT over 12 months compared to historical controls. However, the TM group showed a relative risk reduction for MACE of 65% at 5 years. Therefore, as a lifestyle modification method, TM may be useful in the secondary prevention of CVD in this and possibly other high-risk groups.</p><p><strong>Clinical trial registration: </strong>ClinicalTrials.gov, NCT05642936.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1513699"},"PeriodicalIF":3.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11962031/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics and risk factors of hospital mortality in elderly patients with community-acquired pneumonia.","authors":"Shasha Li, Lu Li, Shengyu Wang, Hao Wu","doi":"10.3389/fmed.2025.1512288","DOIUrl":"10.3389/fmed.2025.1512288","url":null,"abstract":"<p><strong>Background: </strong>Community-acquired pneumonia (CAP) leads to high morbidity and mortality among the elderly, with 3 million deaths annually worldwide. Multiple comorbidities significantly increase the risk. This study aims to identify independent risk factors for mortality in elderly patients with CAP to optimize individualized treatment strategies.</p><p><strong>Methods: </strong>This single-center retrospective study was conducted at First Affiliated Hospital of Xi'an Medical University. Clinical data from elderly patients diagnosed with CAP between December 2018 and December 2023 were retrospectively collected. Logistic regression analysis was used to determine risk factors for in-hospital mortality. A nomogram was constructed based on the final model for risk assessment.</p><p><strong>Results: </strong>A total of 613 eligible patients were included, with 68.2% being male, and a median age of 78 (IQR 70-86) years. The prevalence of hypertension, coronary heart disease (CHD), stroke, diabetes, malignancy, and chronic obstructive pulmonary disease (COPD) was 55.5, 39.8, 29.5, 27, 16.6, and 7%, respectively. The in-hospital mortality rate was 48%. Compared to survivors, non-survivors were older, had a higher proportion of males, faster heart rates, and higher rates of comorbidities. Multivariate logistic regression analysis identified age (OR 1.05, 95% CI [1.02-1.07], <i>P</i> < 0.01), BMI (OR 0.92, 95% CI [0.86-0.98], <i>P</i> < 0.01), stroke (OR 2.21, 95% [1.43-3.42], <i>P</i> < 0.01), ARDS (OR 4.0, 95% CI [2.17-7.37], <i>P</i> < 0.01), AKI (OR 2.98, 95% CI [1.77-5.01], <i>P</i> < 0.01), malignancy (OR 2.11, 95% CI [1.22-3.65], <i>P</i> < 0.01), elevated WBC (OR 1.20, 95% [1.14-1.27], <i>P</i> < 0.01), PLT (OR 0.995, 95% CI [0.993-0.998], <i>P</i> < 0.01), and albumin (OR 0.93, 95% CI [0.90-0.97], <i>P</i> < 0.01) as independent risk factors for in-hospital mortality. The area under the curve (AUC) of the multivariable model was 0.85 (95% CI [0.81-0.87], <i>P</i> < 0.01).</p><p><strong>Conclusion: </strong>Elderly CAP patients have a high prevalence of comorbidities and a high in-hospital mortality rate. Advanced age, low BMI, stroke, ARDS, AKI, malignancy, elevated WBC, decreased PLT, and low albumin were independent risk factors for in-hospital mortality.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1512288"},"PeriodicalIF":3.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11961441/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical manifestations of Long-COVID: an observational perspective.","authors":"Muhammad Omair Sultan Meo, Noara AlHusseini, Dania Imad Ibrahim, Muhammad Zain Sultan Meo, Faridul Ahsan, Hani Tamim, Muhammad Raihan Sajid","doi":"10.3389/fmed.2025.1523817","DOIUrl":"10.3389/fmed.2025.1523817","url":null,"abstract":"<p><strong>Objectives: </strong>Coronavirus Disease-19, also known as COVID-19, resulted in a pandemic that caused massive health concerns and economic losses globally. Worldwide, people are still facing persistent clinical symptoms following COVID-19 infection, characterized as Long-COVID. This study aimed to assess the experience and awareness of Long-COVID clinical symptoms in Saudi Arabia.</p><p><strong>Methods: </strong>This cross-sectional study was conducted at the College of Medicine, Alfaisal University, Riyadh, Saudi Arabia during the period April 5, 2023 to August 30, 2023. An online questionnaire was created using Google Forms and distributed with a URL to students via email and WhatsApp. The questionnaire consisted of 17 questions classifying the respondent's responses. The survey consisted of three sections, addressing demographics, their experience with COVID-19 and whether they had Long-COVID symptoms. A total of 490 participants participated in the study survey. The Statistical Package for Social Sciences (SPSS) version 28 was used for data administration and analysis. <i>P</i>-values <0.05 were considered statistically significant.</p><p><strong>Results: </strong>Out of the participants, 53.9% had prior exposure to COVID-19. During acute infection, tiredness was the most common symptom in participants, observed in 84.5% of people. The other common symptoms which were reported among the participants included fever (75%), soreness of throat (65.5%), headache (65.2). Some symptoms were more dominant in males (such as acne) and some in females (hair loss). Regarding prolonged symptoms, 43.6% of females and 33.3% of males had experienced symptoms of Long-COVID. Tiredness was once again the most dominant symptom (16.7%). The other common prolonged symptoms of Long-COVID observed were loss of taste or smell (9.1%), body pain (7.6%), headache (7.2%), foggy memory (7.2%) and shortness of breath (6.4%). Lastly, awareness of Long COVID was lower than expected, with 51.5% of females and 55.1% of males unaware of the syndrome.</p><p><strong>Conclusion: </strong>This study's findings show the effects Long COVID-19 has on the general population, which includes various symptoms affecting physical, mental and emotional needs. The findings also suggest potential gender differences in Long-COVID clinical symptoms, thus highlighting the need for further research with larger and more diverse samples.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1523817"},"PeriodicalIF":3.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11961443/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global research trend of Herpes simplex keratitis: a bibliometric analysis and visualization from 1941 to 2024.","authors":"Ke Song, Shujiao Li, Jian Liu, Zefeng Kang","doi":"10.3389/fmed.2025.1526116","DOIUrl":"10.3389/fmed.2025.1526116","url":null,"abstract":"<p><strong>Objective: </strong>Herpes simplex keratitis (HSK), caused by the herpes simplex virus (HSV), is a leading cause of infectious blindness worldwide. This study aims to explore the research trends, key contributors, and emerging areas of focus in HSK research through bibliometric analysis.</p><p><strong>Methods: </strong>Publications related to HSK from 1941 to 2024 were retrieved from the Web of Science Core Collection (WoSCC). Bibliometric and visual analyses were conducted using VOSviewer, CiteSpace, and R 4.3.3.</p><p><strong>Results: </strong>A total of 1,076 publications on HSK were identified. The top three contributing countries were the United States (267 papers), China (99), and Japan (64). Harvard University was the leading institution with 75 publications, while the <i>American Journal of Ophthalmology</i> emerged as the most influential journal, boasting an h-index of 29. Kaufman, HE, was the most cited author, with 1,988 citations. The top three keywords were \"infection\" (82), \"stromal keratitis\" (73), and \"penetrating keratoplasty\" (62). Burst keyword analysis indicated a growing interest in terms such as \"outcome\" and \"ultraviolet A\" since 2018.</p><p><strong>Conclusion: </strong>This bibliometric analysis underscores two primary research areas in HSK: the clinical management of stromal keratitis and infection, as well as the mechanisms of HSK recurrence, which include strategies for preventing reactivation and managing immune rejection. Future research is anticipated to focus on innovative treatments, particularly ultraviolet A therapy.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1526116"},"PeriodicalIF":3.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11961934/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A trauma-informed care model for HIV prevention and care for refugee women in the United States: perspectives and implementation framework.","authors":"Emmanuel Nazaire Essam Nkodo, Nada Fadul","doi":"10.3389/fmed.2025.1537930","DOIUrl":"10.3389/fmed.2025.1537930","url":null,"abstract":"<p><p>HIV disproportionately impacts women, particularly in sub-Saharan Africa and other low-and middle-income countries, where conflict and displacement heighten their vulnerability to HIV. Refugee women face compounded challenges, including trauma before and during migration and healthcare inequities in host countries. This perspective paper aims to assess existing evidence on HIV treatment and prevention for refugee women resettling in the U.S., using intersectional stigma and the status-neutral service delivery model as theoretical frameworks, to propose an implementation strategy. Trauma-informed care (TIC) offers a promising approach to address these challenges, emphasizing culturally responsive, safe, and empowering healthcare. Integrating TIC with the status-neutral model, which centers on HIV testing and pathways for prevention or treatment, can improve care access and outcomes. Moreover, including refugee women and stakeholders in designing tailored interventions that address individual and systemic-level barriers is critical to fostering health equity.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1537930"},"PeriodicalIF":3.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11961426/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report on Rapunzel syndrome: a large gastric trichobezoar extending to the proximal jejunum in a young adult female.","authors":"Ksenija Mijović, Dragan Vasin, Sanela Hasanagić, Jelica Vukmirović, Tijana Tomić, Vasko Tošić, Aleksandar Pavlović, Dragan Mašulović, Aleksandra Đurić Stefanović","doi":"10.3389/fmed.2025.1504822","DOIUrl":"10.3389/fmed.2025.1504822","url":null,"abstract":"<p><p>A trichobezoar is an intraluminal mass of hair growing continuously with additional ingestion, while Rapunzel syndrome refers to a giant gastric trichobezoar that extends from the stomach into the small intestine. We present a case of Rapunzel syndrome as an uncommon cause of upper gastrointestinal (GI) symptoms in a young adult woman who denied trichotillomania and trichophagia. Preoperative radiological assessment was pivotal in planning a preferable therapeutic approach. The patient underwent laparotomy and prepyloric gastrotomy, resulting in satisfactory postoperative outcomes. Trichobezoars are extremely rare and predominantly affect young women with underlying psychiatric conditions. Although uncommon, they cause severe upper gastrointestinal symptoms and may even lead to various complications. This case report helps in understanding the presentation of gastric trichobezoar and Rapunzel syndrome, including their range of symptoms, radiological appearance, and associated findings, to make an accurate diagnosis and guide an appropriate treatment approach.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1504822"},"PeriodicalIF":3.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11962009/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strategies to support the mental health and well-being of health and care workforce: a rapid review of reviews.","authors":"Cindy E Frias, Nimesh Samarasinghe, Cecilia Cuzco, Jaseem Koorankot, Andrés de Juan, Husameldin Mohamed Ali Rudwan, Hanan F Abdul Rahim, Adela Zabalegui, Iain Tulley, Sanaa T Al-Harahsheh, Mona Shaheen S T Al-Homaiddi, Meredith Fendt-Newlin, Jim Campbell","doi":"10.3389/fmed.2025.1530287","DOIUrl":"10.3389/fmed.2025.1530287","url":null,"abstract":"<p><strong>Background: </strong>Countries globally face challenges in educating, employing and retaining their health and care workforce, largely due to underinvestment in health systems. Health and care workforce report significantly greater levels of job-related burnout and mental health problems, which in turn are associated with poorer patient outcomes, increased medical errors, diminished quality and safety, decreased patient satisfaction, and reduced healthcare efficiency.</p><p><strong>Objective: </strong>We conducted a rapid review of systematic reviews to evaluate the mental health and well-being of health and care workers since the onset of the COVID-19 pandemic and to identify interventions available at organizational and individual levels.</p><p><strong>Methods: </strong>PubMed and Epistemonikos were searched for systematic reviews published between May 2022 and February 2024. The inclusion criteria were systematic reviews written in English with quantitative design, with or without meta-analysis.</p><p><strong>Results: </strong>Fifty articles met the criteria for inclusion in the analysis. Overall, there has not been a significant change in the prevalence of depression and anxiety among health and care workforce since 2022, suggesting the impact of the COVID-19 pandemic on workers' mental health and well-being was not specific to their experience working during the pandemic. Sixteen studies reported two types of mental health and well-being interventions: individual-level interventions and organizational-level interventions with specific impact on mental health and work environment variables. No specific policy interventions were found. However, some studies suggested policy interventions to improve the mental health and well-being of the health and care workforce.</p><p><strong>Discussion: </strong>Our analysis highlighted the need for systemic changes to protect the mental health and well-being of the health and care workforce in the post-COVID-19 era. Despite the wealth of evidence on mental health problems and on effective interventions, there remains a notable gap in systemic implementation and organizational accountability. The call to action for a paradigm shift must be embraced and we must strive to build resilient healthcare systems and invest in active support and sustain them, incorporating structural, non-structural and functional aspects of organizational resilience.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1530287"},"PeriodicalIF":3.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11961965/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in the clinical diagnosis of lung cancer using contrast-enhanced ultrasound.","authors":"Jian-Wei Huang, Hai Zeng, Quan Zhang, Xiao-Yu Liu, Chong Feng","doi":"10.3389/fmed.2025.1543033","DOIUrl":"10.3389/fmed.2025.1543033","url":null,"abstract":"<p><p>Lung cancer (LC) remains one of the leading causes of cancer-related mortality worldwide, emphasizing the urgent need for innovative diagnostic tools to improve early detection and patient outcomes. Contrast-enhanced ultrasound (CEUS) has emerged as a promising complement to conventional imaging modalities, offering distinct advantages such as real-time dynamic imaging, cost-effectiveness, and the absence of ionizing radiation. By enhancing the visualization of tumor vascularization, CEUS enables differentiation between benign and malignant pulmonary nodules while providing valuable insights into tumor angiogenesis, a hallmark of malignancy, and therapeutic response. Additionally, CEUS demonstrates utility in assessing regional lymph nodes, detecting distant metastases, and analyzing blood flow dynamics through quantitative methods such as time-intensity curve analysis. Despite these benefits, certain limitations persist, including reduced efficacy in imaging deep-seated lesions, variability due to patient-specific physiological factors, and dependency on operator expertise. However, advancements in targeted contrast agents, integration with multimodal imaging techniques, and the application of artificial intelligence hold significant potential to address these challenges. This review systematically evaluates the clinical applications, advantages, and limitations of CEUS in LC diagnosis, providing a comprehensive understanding of its role in modern precision oncology. Furthermore, it highlights future research directions aimed at enhancing diagnostic accuracy, improving clinical workflows, and expanding the adoption of CEUS in routine practice.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1543033"},"PeriodicalIF":3.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11961447/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social behavioral analysis of the influence of residential area and grade on pupils' myopia rate: a cross-sectional survey in Nanjing, China.","authors":"Yi-Jing Xie, Wen Bai, Yun-Fan Zhou, Xin Shui, An-Yi Ren, Ying Tang, Xuan Zhou, Qin Jiang, Wei-Hong Shang","doi":"10.3389/fmed.2025.1565313","DOIUrl":"10.3389/fmed.2025.1565313","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to examine the prevalence of myopia among pupils in different residential areas (city center, nearby suburbs, and far suburbs) and grade levels (lower, middle, and upper), analyzing social behaviors and risk factors to guide early intervention.</p><p><strong>Methods: </strong>A cross-sectional survey was conducted with elementary students across various regions in Nanjing. A total of 2,342 valid questionnaires were collected. Univariate and multivariate logistic regression analyses were used to identify and assess risk factors for myopia and their variations across regions and grade levels.</p><p><strong>Results: </strong>The survey revealed an overall myopia prevalence of 35.65% (95% CI = 33.71-37.59) among pupils in Nanjing, with the highest rate observed in nearby suburbs (41.34, 95% CI = 38.37-44.31). Myopia prevalence increased with grade level. Multivariate logistic regression analysis identified 8 significant risk factors for myopia, including visual fatigue, frequent eye rubbing, late bedtimes, heavy study burdens, insufficient time spent outdoors, insufficient device breaks, mobile phone use, and infrequent vision checks. Risk factors for myopia varied by region and grade level. Common risk factors across all groups included visual fatigue and infrequent vision checks. City center exhibited unique risk factors, such as late bedtimes and insufficient time spent outdoors. Nearby suburbs displayed unique risk factors, including heavy study burdens and entertainment-oriented electronic device use. Far suburbs displayed a unique risk factor in the prevalent use of mobile phones. Besides, lower grade students showed notably higher entertainment-oriented electronic device use, while upper grade students were more likely to have late bedtimes and insufficient device breaks.</p><p><strong>Conclusion: </strong>Different social behavioral factors play a key role in the occurrence of myopia among pupils in different regions and grades, and targeted intervention measures need to be developed based on regional characteristics and grade level features.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1565313"},"PeriodicalIF":3.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11961650/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Tattoo sarcoidosis with epithelioid cell granuloma positive for <i>Propionibacterium acne</i>s.","authors":"Yuiko Masuda, Hiroko Okabayashi, Kimitaka Akaike, Shohei Hamada, Aiko Masunaga, Hidenori Ichiyasu, Kenichi Ohashi, Takuro Sakagami","doi":"10.3389/fmed.2025.1552114","DOIUrl":"10.3389/fmed.2025.1552114","url":null,"abstract":"<p><strong>Introduction: </strong>Tattoo sarcoidosis is characterized by a granulomatous reaction localized to the tattoo site and typical systemic symptoms of sarcoidosis. Herein, we report the case of a patient diagnosed with tattoo sarcoidosis.</p><p><strong>Case report: </strong>A 28-year-old man presented with subcutaneous nodules at two tattoo sites, bilateral hilar and mediastinal lymphadenopathy, multiple micronodules predominantly in the upper lobes of both lungs, elevated serum angiotensin-converting enzyme and soluble interleukin-2 receptor levels, hypercalcemia, and renal dysfunction. Skin biopsy of a subcutaneous nodule revealed epithelioid cell granulomas. Although periodic acid-Schiff, Grocott methenamine silver, and acid-fast staining showed negative results, antibody staining for <i>Propionibacterium acnes</i> within the epithelioid cell granuloma was positive. Remarkably, all lesions spontaneously resolved, and the systemic manifestations also improved without medical treatment.</p><p><strong>Conclusion: </strong>The pathogenesis of tattoo sarcoidosis remains unknown, although an immune response to tattoo pigments has been suspected. However, there is a theory that <i>P. acnes</i> is the causative agent of sarcoidosis. In the present case, the detection of <i>P. acnes</i> within the epithelioid cell granuloma suggests that the bacterium may play a role in the etiology of tattoo sarcoidosis.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1552114"},"PeriodicalIF":3.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11962038/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}