General pharmacology最新文献_第7页

Different effects of direct and indirect dopamine receptor agonists on immobility time in reserpine-treated mice. 直接和间接多巴胺受体激动剂对利血平处理小鼠静止时间的不同影响。

General pharmacology Pub Date : 1991-01-01 DOI: 10.1016/0306-3623(91)90571-m

M R Zarrindast, A Minaian

引用次数: 12

Action of pregnane compounds from Mandevilla illustris against contractions induced by kinins and other oxytocics in the rat isolated uterus. 山柑孕酮类化合物对大鼠离体子宫收缩素及其他催产素诱导的收缩作用。

General pharmacology Pub Date : 1991-01-01 DOI: 10.1016/0306-3623(91)90579-u

J B Calixto, R L Brum, R A Yunes

{"title":"Action of pregnane compounds from Mandevilla illustris against contractions induced by kinins and other oxytocics in the rat isolated uterus.","authors":"J B Calixto, R L Brum, R A Yunes","doi":"10.1016/0306-3623(91)90579-u","DOIUrl":"https://doi.org/10.1016/0306-3623(91)90579-u","url":null,"abstract":"1. The effects of 5 pregnane compounds isolated from the rhizomes of Mandevilla illustris were examined against bradykinin (BK), Lysyl-bradykinin (L-BK), acetylcholine (ACh) and oxytocin (Ot)-induced contractions in the isolated uteri of the rat. 2. Compounds MI 15 and MI 18 (5-40 micrograms/ml) caused a parallel and concentration-dependent rightward displacement of BK and L-BK concentration-response curves. Compound MI 21 (2.5-10 micrograms/ml) also produced a concentration-dependent displacement to the right of the BK concentration-response curve, but reduced its maximal response. Schild analysis of these data were linear (r close to 1) and furnished the following PA2 values (as G/ml): 6.0, 5.1 and 5.9, respectively. However, the slopes were significantly higher than unity. Compounds MI 25 and MI 27 (10-40 micrograms/ml) caused little or even no effect against BK and ACh responses. 3. In addition, compounds MI 18 and MI 21 (10-40 micrograms/ml) also antagonized in a concentration-dependent manner L-BK concentration-response curves. Schild plot were linear (r close to 1) and yielded the nominal pA2 values (as G/ml) of 5.0 and 5.8, respectively, but the slopes were significantly different from one. 4. Like the results obtained previously with the crude extract from M. illustris, the purified compounds from the rhizome of this plant were not selective towards kinin action since at the same range concentrations they markedly interfered with both the sensitivities and the maximal responses caused by ACh and Ot in this preparation.","PeriodicalId":12487,"journal":{"name":"General pharmacology","volume":"22 6","pages":"1071-5"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0306-3623(91)90579-u","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12972671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Pharmacological properties of novel bicyclic isoquinoline analogs in isolated guinea pig atria, trachea and in human platelets: relationship to trimetoquinol. 新型双环异喹啉类似物在离体豚鼠心房、气管和人血小板中的药理特性:与三甲喹啉的关系。

General pharmacology Pub Date : 1991-01-01 DOI: 10.1016/0306-3623(91)90595-w

G Shams, J Fedyna, K J Romstedt, A Adejare, D D Miller, V F Roche, D R Feller

{"title":"Pharmacological properties of novel bicyclic isoquinoline analogs in isolated guinea pig atria, trachea and in human platelets: relationship to trimetoquinol.","authors":"G Shams, J Fedyna, K J Romstedt, A Adejare, D D Miller, V F Roche, D R Feller","doi":"10.1016/0306-3623(91)90595-w","DOIUrl":"https://doi.org/10.1016/0306-3623(91)90595-w","url":null,"abstract":"1. Antiplatelet and beta-adrenoceptor activities of a set of secondary and tertiary N-methyl substituted amine analogs of trimetoquinol (TMQ, I and II, respectively) and 5,8-ethano-l-(p-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquin oline (bicyclic isoquinoline compounds III and IV, respectively) were examined. 2. Compounds III and IV induced relaxations of guinea pig trachea which were blocked by propranolol whereas neither compound acted as an agonist nor antagonist of beta-adrenoceptors (chronotropy) in guinea pig atria. TMQ analogs (I and II) were agonists in both beta-adrenoceptor systems. 3. When tested in human platelets, compounds III and IV, like the TMQ analogs, blocked several inducers of the prostaglandin-dependent and -independent pathways, and the alpha 2-adrenoceptor-mediated pathway of platelet activation. 4. The bicyclic isoquinoline analogs (III and IV) possessed more selective beta 2-adrenoceptor stimulatory activity and equal or greater inhibitory activity against inducers of the prostaglandin-independent pathways of platelet function than the corresponding TMQ analogs (I and II). 5. These chemically novel lipophilic bicyclic compounds provide a new lead to the development of agents useful for the treatment of asthma and thrombotic disorders.","PeriodicalId":12487,"journal":{"name":"General pharmacology","volume":"22 6","pages":"1155-63"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0306-3623(91)90595-w","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12851832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Differential effects of dopamine agonists on locomotion in intact and reserpine-treated mice. 多巴胺激动剂对完整小鼠和利血平小鼠运动的不同影响。

General pharmacology Pub Date : 1991-01-01 DOI: 10.1016/0306-3623(91)90573-o

M R Zarrindast, A Eliassi

引用次数: 17

The effects of free radical scavengers on arachidonic acid metabolism by ovine placental microsomes. 自由基清除剂对绵羊胎盘微粒体花生四烯酸代谢的影响。

General pharmacology Pub Date : 1991-01-01 DOI: 10.1016/0306-3623(91)90586-u

G E Rice, M S Baker

引用次数: 2

Impact of neonatal benzpyrene imprinting on thymocytic dexamethasone binding in ascitic tumor bearing rats. 新生儿苯并芘印迹对腹水荷瘤大鼠胸腺细胞地塞米松结合的影响。

General pharmacology Pub Date : 1991-01-01 DOI: 10.1016/0306-3623(91)90080-p

G Csaba, O Mag, M Holub

引用次数: 0

Influences of sodium on the contraction induced by oxytocin in rat testicular capsule. 钠对催产素诱导大鼠睾丸囊收缩的影响。

General pharmacology Pub Date : 1991-01-01 DOI: 10.1016/0306-3623(91)90083-i

M Sanchez, F Andrés-Trelles, A Hidalgo

引用次数: 5

Modulatory action of acetylcholine on cerebrovascular sympathetic neurotransmission. 乙酰胆碱对脑血管交感神经传递的调节作用。

General pharmacology Pub Date : 1991-01-01 DOI: 10.1016/0306-3623(91)90587-v

F J Miranda, G Torregrosa, J B Salom, J A Alabadí, C Alvarez, E Alborch

引用次数: 2

Vasorelaxing action of melatonin in rat isolated aorta; possible endothelium dependent relaxation. 褪黑素对大鼠离体主动脉血管的舒张作用可能是内皮依赖性松弛。

General pharmacology Pub Date : 1991-01-01 DOI: 10.1016/0306-3623(91)90589-x

N Satake, H Oe, S Shibata

{"title":"Vasorelaxing action of melatonin in rat isolated aorta; possible endothelium dependent relaxation.","authors":"N Satake, H Oe, S Shibata","doi":"10.1016/0306-3623(91)90589-x","DOIUrl":"https://doi.org/10.1016/0306-3623(91)90589-x","url":null,"abstract":"1. Melatonin (10(-4)-10(-3) M) inhibited contractile response to 5-hydroxytryptamine (5-HT) and KCl in rat isolated aorta. 2. In the presence of verapamil but not nifedipine, melatonin failed to inhibit residual response to KCl. 3. In the aorta precontracted with 5-HT, PGF2 alpha, or KCl, melatonin (10(-6)-10(3) M) caused relaxation. Removal of endothelium only inhibited the melatonin relaxation on the 5-HT response. Methylene blue also inhibited the melatonin relaxation. 4. Nifedipine and verapamil partly inhibited the melatonin relaxation on the 5-HT response. In the absence of endothelium, verapamil but not nifedipine further inhibited the melatonin relaxation. 5. M & B 22,948 inhibited the melatonin relaxation. Melatonin potentiated the nitroglycerin relaxation. In the absence of endothelium, nitroglycerin and melatonin potentiated the relaxation by melatonin and nitroglycerin, respectively. 6. These results suggest that the mode of inhibitory action of melatonin is somewhat similar to that of verapamil. In addition, the vasorelaxing effect of melatonin on the 5-HT response is endothelium dependent and also may be related to the inhibition of cGMP metabolism.","PeriodicalId":12487,"journal":{"name":"General pharmacology","volume":"22 6","pages":"1127-33"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0306-3623(91)90589-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12832654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 50

Is the inhibitory effect of somatostatin on the heart due to K+ channel activation? 生长抑素对心脏的抑制作用是由于K+通道的激活吗?

General pharmacology Pub Date : 1991-01-01 DOI: 10.1016/0306-3623(91)90575-q

S E Freeman, W M Lau, M Szilagyi

引用次数: 0