General pharmacology最新文献_第6页

Protection against alcohol-induced gastric mucosal injury by nitecapone. 尼替卡酮对酒精性胃黏膜损伤的保护作用。

General pharmacology Pub Date : 1991-01-01 DOI: 10.1016/0306-3623(91)90577-s

B L Slomiany, J Piotrowski, A Ismail, G Rajiyah, S Tamura, W Bielanski, A Slomiany

{"title":"Protection against alcohol-induced gastric mucosal injury by nitecapone.","authors":"B L Slomiany, J Piotrowski, A Ismail, G Rajiyah, S Tamura, W Bielanski, A Slomiany","doi":"10.1016/0306-3623(91)90577-s","DOIUrl":"https://doi.org/10.1016/0306-3623(91)90577-s","url":null,"abstract":"1. The mechanism of gastric mucosal protection by an anticular agent, nitecapone, against injury was investigated in rats with and without indomethacin pretreatment. 2. Animals received intragastrically either a dose of nitecapone or vehicle alone, followed by ethanol given at various intervals up to 5 hr, and their gastric mucosa subjected to histologic and physicochemical assessment. 3. Ethanol caused extensive gastric hemorrhagic lesions which were essentially prevented by nitecapone at doses of 30 mg and higher per kg body weight. The maximal protection was achieved by 1.5 hr which persisted up to 4 hr and was not thwarted by indomethacin. 4. Physicochemical measurements revealed that nitecapone evoked 78% increase in mucus gel dimension, and showed 21% increase in phospholipids, and the content of sulfo-(22%) and sialomucins (72%). This was accompanied by 1.6-fold increase in mucus viscosity, 31% increase in H+ retardation capacity and 2.2-fold increase in hydrophobicity. 5. The results suggest that the gastroprotective action of nitecapone occurs through the enhancement of the physicochemical characteristics of mucus layer.","PeriodicalId":12487,"journal":{"name":"General pharmacology","volume":"22 6","pages":"1055-62"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0306-3623(91)90577-s","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12972670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Effects of vanadate, ouabain and amiloride on the contraction of the rat testicular capsule to oxytocin. 钒酸盐、瓦巴因和阿米洛利对大鼠睾丸囊对催产素收缩的影响。

General pharmacology Pub Date : 1991-01-01 DOI: 10.1016/0306-3623(91)90082-h

M Sanchez, F Andrés-Trelles, A Hidalgo

引用次数: 3

Interaction of bradykinin and angiotensin in the regulation of blood pressure in conscious rats. 缓激素和血管紧张素在清醒大鼠血压调节中的相互作用。

General pharmacology Pub Date : 1991-01-01 DOI: 10.1016/0306-3623(91)90092-k

M van den Buuse, J Kerkhoff

{"title":"Interaction of bradykinin and angiotensin in the regulation of blood pressure in conscious rats.","authors":"M van den Buuse, J Kerkhoff","doi":"10.1016/0306-3623(91)90092-k","DOIUrl":"https://doi.org/10.1016/0306-3623(91)90092-k","url":null,"abstract":"1. The interaction between bradykinin (BK) and the renin-angiotensin system was studied in conscious, catheterized rats. 2. Intravenous injection of BK induced dose-dependent decreases in blood pressure in normotensive Wistar and Wistar-Kyoto rats and spontaneously hypertensive rats. Pretreatment with the angiotensin-converting enzyme (ACE) inhibitor captopril markedly enhanced the effect of BK, such that the dose-response curve shifted significantly to the left in all three strains. 3. In a second series of experiments, captopril did not change basal blood pressure, but blocked the pressor response to angiotensin I (AI), but not angiotensin II (AII). 4. The partial agonist Sar1-Ala8-angiotensin II (SAR) increased blood pressure and blocked the pressor response to subsequent AII treatment. 5. After pretreatment with BK (50 micrograms/kg), captopril evoked a decrease in blood pressure, while still blocking the effect of AI. 6. After pretreatment with BK, SAR decreased blood pressure, while still antagonizing the action of AII. 7. These results suggest that ACE plays a role in the inactivation of circulating BK in normotensive and hypertensive rats. Conversely, BK can influence the activity of the renin-angiotensin system, probably by interacting with ACE.","PeriodicalId":12487,"journal":{"name":"General pharmacology","volume":"22 4","pages":"759-62"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0306-3623(91)90092-k","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13095117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Expression of arylhydrocarbon hydroxylase, epoxide hydrolases, glutathione S-transferase and UDP-glucuronosyltransferases in H5-6 hepatoma cells. 芳烃羟化酶、环氧化物水解酶、谷胱甘肽s -转移酶和udp -葡萄糖醛基转移酶在H5-6肝癌细胞中的表达。

General pharmacology Pub Date : 1991-01-01 DOI: 10.1016/0306-3623(91)90077-j

M Roques, D Bagrel, J Magdalou, G Siest

{"title":"Expression of arylhydrocarbon hydroxylase, epoxide hydrolases, glutathione S-transferase and UDP-glucuronosyltransferases in H5-6 hepatoma cells.","authors":"M Roques, D Bagrel, J Magdalou, G Siest","doi":"10.1016/0306-3623(91)90077-j","DOIUrl":"https://doi.org/10.1016/0306-3623(91)90077-j","url":null,"abstract":"1. The presence of arylhydrocarbon hydroxylase (cytochrome P-450 IA1 dependent), glutathione S-transferase, two distinct forms of epoxide hydrolases and UDP-glucuronosyltransferases was detected in H5-6 hepatoma cell homogenates using model substrates, selective inhibitors and specific antibodies. 2. The activity of arylhydrocarbon hydroxylase decreased strongly at the first days after plating and remained at a minimal value (1.5 pmol/min per mg) after 5 days of culture. 3. The hydratation of trans-stilbene oxide catalyzed by the soluble form of epoxide hydrolase was very low (11.0 pmol/min per mg), whereas the hepatoma cells contained appreciable amounts of the membrane-bound epoxide hydrolase and glutathione S-transferase measured with cis-stilbene oxide as substrate (maximal specific activity: 1.46 and 2.73 nmol/min per mg, respectively). 4. These cells also glucuronidated 1-naphthol efficiently (6 nmol/min per mg) and, at a lower extent, bilirubin (12 pmol/min per mg). 5. Addition of fenofibrate (70 microM) into the culture medium for 1-3 days failed to significantly stimulate the activity of cytosolic epoxide hydrolase. Only bilirubin glucuronidation increased 2-fold after 2 days of presence of the drug.","PeriodicalId":12487,"journal":{"name":"General pharmacology","volume":"22 4","pages":"677-84"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0306-3623(91)90077-j","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13095282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Chronic administration of nicotine fails to alter the MPTP-induced neurotoxicity in mice. 长期给药尼古丁不能改变mptp诱导的小鼠神经毒性。

General pharmacology Pub Date : 1991-01-01 DOI: 10.1016/0306-3623(91)90075-h

Y K Fung, L A Fiske, Y S Lau

引用次数: 22

Changes in benzodiazepine receptors of rat brain after long-term treatment with the Ca(2+)-antagonists nifedipine, verapamil, flunarizine and with the calmodulin antagonist trifluoperazine. Ca(2+)拮抗剂硝苯地平、维拉帕米、氟桂嗪和钙调素拮抗剂三氟拉嗪长期治疗后大鼠脑苯二氮卓受体的变化

General pharmacology Pub Date : 1991-01-01 DOI: 10.1016/0306-3623(91)90594-v

D Staneva-Stoytcheva, N Danchev, P Popov

{"title":"Changes in benzodiazepine receptors of rat brain after long-term treatment with the Ca(2+)-antagonists nifedipine, verapamil, flunarizine and with the calmodulin antagonist trifluoperazine.","authors":"D Staneva-Stoytcheva, N Danchev, P Popov","doi":"10.1016/0306-3623(91)90594-v","DOIUrl":"https://doi.org/10.1016/0306-3623(91)90594-v","url":null,"abstract":"1. The binding of [3H]flunitrazepam to benzodiazepine receptors in the cerebral cortex and hippocampus (membrane fraction P2) was studied after 13-day oral treatment of male Wistar rats with the Ca(2+)-antagonists nifedipine (20 mg/kg), verapamil (50 mg/kg), flunarizine (10 mg/kg) and with the calmodulin (CaM)-antagonist trifluoperazine (TFP) (3 mg/kg). 2. The changes in the binding characteristics of the benzodiazepine receptors in the frontal cortex were studied in vitro after the addition of nifedipine (10(-6) and 10(-5) M) and verapamil (10(-6) and 10(-5) M). 3. A significant decrease of the binding capacity (Bmax) of [3H]flunitrazepam was established after in vivo treatment with the three Ca(2+)-antagonists as well as after TFP, the decrease being much more pronounced in the hippocampus. 4. Changes in the affinity values (Kd) of [3H]flunitrazepam binding were found in neither of the groups. 5. No data for a direct interaction of nifedipine and verapamil with the brain benzodiazepine receptors were obtained in in vitro experiments.","PeriodicalId":12487,"journal":{"name":"General pharmacology","volume":"22 6","pages":"1151-4"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0306-3623(91)90594-v","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12832655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Colchicine inhibition of duodenal absorption of calcium. 秋水仙碱对十二指肠钙吸收的抑制。

General pharmacology Pub Date : 1991-01-01 DOI: 10.1016/0306-3623(91)90091-j

C F Nassar, L E Abdallah, N Nuwayri-Salti, E G Karkaji

引用次数: 4

Some substances with proposed digitalis-like effects evaluated on platelet functions sensitive for cardiac glycosides. 一些具有洋地黄样作用的物质对心脏糖苷敏感的血小板功能进行了评估。

General pharmacology Pub Date : 1991-01-01 DOI: 10.1016/0306-3623(91)90090-s

T L Andersson, P Zygmunt, E Vinge

引用次数: 4

Biological actions of beta-hydroxy-l-glutamic acid, a synthesized structural analogue of glutamic acid. 合成的谷氨酸结构类似物- β -羟基-l-谷氨酸的生物作用。

General pharmacology Pub Date : 1991-01-01 DOI: 10.1016/0306-3623(91)90596-x

K Watanabe, M Onozuka, M Niwa, A Pongchaidecha

引用次数: 0

Evaluation of dopamine receptor involvement in rat feeding behaviour. 多巴胺受体参与大鼠摄食行为的评估。

General pharmacology Pub Date : 1991-01-01 DOI: 10.1016/0306-3623(91)90570-v

M R Zarrindast, A A Owji, T Hosseini-Nia

{"title":"Evaluation of dopamine receptor involvement in rat feeding behaviour.","authors":"M R Zarrindast, A A Owji, T Hosseini-Nia","doi":"10.1016/0306-3623(91)90570-v","DOIUrl":"https://doi.org/10.1016/0306-3623(91)90570-v","url":null,"abstract":"1. The anorectic effect of dopamine agonists and antagonists were studied in rats. 2. Dopamine agonists bromocriptine, quinpirole or SKF 38393 treatment induced, a dose-dependent anorexia in rats. 3. Anorectic effect of bromocriptine was decreased in animals pretreated with pimozide (D-2 antagonist), but not by sulpiride (D-2 antagonist) or SCH 23390 (D-1 antagonist) pretreatment. 4. Anorexia induced by quinpirole was decreased by sulpiride or pimozide, but not by SCH 23390 administration. 5. While sulpiride and SCH 23390 failed to antagonize the anorectic response of SKF 38393, methergoline (5-HT antagonist) decreased anorexia induced by the drug. 6. A combination of quinpirole with SKF 38393 did not elicit potentiated anorectic response. 7. Decrease in food intake induced by bromocriptine, quinpirole or SKF 38393 was potentiated in reserpinized animals, although single administration of reserpine also induced a marked decrease in feeding. 8. Single administration of sulpiride, pimozide or methergoline did not change the feeding behaviour of rats, but SCH 23390 induced anorexia. 9. It is concluded that D-2 activation may induce inhibition of feeding and anorexia induced by SKF 38393 may be mediated through serotonergic mechanism(s).","PeriodicalId":12487,"journal":{"name":"General pharmacology","volume":"22 6","pages":"1011-6"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0306-3623(91)90570-v","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12852636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 38