General pharmacology最新文献_第10页

Inhibitory effect of the endothelium on thrombin-induced contraction in rabbit aorta. 内皮对血凝素诱导兔主动脉收缩的抑制作用。

General pharmacology Pub Date : 1991-01-01 DOI: 10.1016/0306-3623(91)90569-r

N Sakiyama, I Wakabayashi, K Hatake, E Kakishita

引用次数: 10

Effects of the calcium channel agonist, Bay K 8644, on the mechanical output of skeletal muscle fibers. 钙通道激动剂Bay k8644对骨骼肌纤维机械输出的影响。

General pharmacology Pub Date : 1991-01-01 DOI: 10.1016/0306-3623(91)90088-n

J H Williams, C W Ward

{"title":"Effects of the calcium channel agonist, Bay K 8644, on the mechanical output of skeletal muscle fibers.","authors":"J H Williams, C W Ward","doi":"10.1016/0306-3623(91)90088-n","DOIUrl":"https://doi.org/10.1016/0306-3623(91)90088-n","url":null,"abstract":"1. The effects of the calcium agonist, Bay K 8644, on the mechanical output of skeletal muscle were studied in frog semitendinosus fiber bundles and in whole sartorius muscles. 2. Low concentrations of Bay K 8644 (less than or equal to 1 microM) had no significant influence on isometric twitches. Concentrations between 5-20 microM increased peak tension by 28.6 +/- 2.9% while higher concentrations (greater than or equal to 50 microM) initially increased then depressed twitches by 70 +/- 3.5%. 3. 10 microM Bay K 8644 also increased peak tension developed during low frequency stimulation (i.e. less than or equal to 40 Hz), slightly depressed high frequency contractions (i.e. greater than or equal to 80 Hz) but did not reduce maximal tetanic tension which occurred at about 60 Hz. 4. Potentiation of twitches and low frequency tetani and depression of high frequency tetani by Bay K 8644 were partially antagonized by nifedipine (10 microM), low extracellular calcium and D-600 (5 microM). These conditions did not, however, block the depressant actions of greater than or equal to 50 microM Bay K 8644. 5. In skinned fibers, 10 microM Bay K 8644 had no effect on resting or maximal Ca2+ activated tension. Also, 10 microM Bay K 8644 had no effect on caffeine contractures when added to the previous Ca2+ loading solution. 6. These results suggest that Bay K 8644 has both positive and negative inotropic actions on isolated skeletal muscle, which are dependent on drug concentration and muscle activation pattern.","PeriodicalId":12487,"journal":{"name":"General pharmacology","volume":"22 4","pages":"735-40"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0306-3623(91)90088-n","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12882743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Peptides do not induce contractions in gastrointestinal smooth muscle in calcium-free solution. 在无钙溶液中，多肽不能诱导胃肠道平滑肌收缩。

General pharmacology Pub Date : 1991-01-01 DOI: 10.1016/0306-3623(91)90590-3

A W Mangel, J G Fitz, I L Taylor

引用次数: 3

Capric acid as a potent dilator of canine vessels in vitro and in vivo. 己酸在体外和体内作为一种有效的犬血管扩张剂。

General pharmacology Pub Date : 1991-01-01 DOI: 10.1016/0306-3623(91)90089-o

R P White, A M el-Bauomy, W B Wood

引用次数: 3

A comparative study on the thermoregulatory effects of prazosin, dihydrobenzperidol and nifedipin on 2,4-dinitrophenol induced hyperthermia in rabbits. 吡唑嗪、二氢苯并哌啶醇和硝苯地平对2,4-二硝基苯酚致兔热疗的热调节作用比较研究。

General pharmacology Pub Date : 1991-01-01 DOI: 10.1016/0306-3623(91)90591-s

Z Szreder, I Gagało

引用次数: 6

Characterization of muscarinic receptors of bovine adrenal chromaffin cells: binding, secretion and anti-microtubule drug effects. 牛肾上腺嗜铬细胞毒蕈碱受体的表征:结合、分泌和抗微管药物作用。

General pharmacology Pub Date : 1991-01-01 DOI: 10.1016/0306-3623(91)90599-2

D B McKay, I Lopez, P A Sanchez, J L English, L J Wallace

引用次数: 7

Effects of forced shaking stress at low temperature on pentobarbital-induced sleeping in mice. 低温强制摇应力对戊巴比妥诱导小鼠睡眠的影响。

General pharmacology Pub Date : 1991-01-01 DOI: 10.1016/0306-3623(91)90087-m

K Matsumoto, T Satoh, L H Bing, H Ohta, H Watanabe

{"title":"Effects of forced shaking stress at low temperature on pentobarbital-induced sleeping in mice.","authors":"K Matsumoto, T Satoh, L H Bing, H Ohta, H Watanabe","doi":"10.1016/0306-3623(91)90087-m","DOIUrl":"https://doi.org/10.1016/0306-3623(91)90087-m","url":null,"abstract":"1. Effects of a new stressful manipulation, forced shaking stress at low temperature (4 degrees C) (FSLT stress), on sleeping induced by pentobarbital were investigated 70 min following its application. 2. Repeated application (7 times) decreased the duration of sleep induced by pentobarbital-Na (45 mg/kg, i.p.) in mice without affecting that induced by ketamine-HCl and chloral hydrate. This effect of FSLT stress disappeared 3 days after termination of application. 3. The latency of nociceptive response in hot-plate test increased in a naloxone-sensitive manner by single and repeated FSLT stress when tested immediately (2 min) after but not 70 min after the last stress application. 4. Diazepam (0.3 mg/kg, i.p.) significantly prolonged the duration of sleep induced by pentobarbital (45 mg/kg, i.p.) in stressed animals without changing that in unstressed animals. The effect of diazepam was blocked by Ro 15-1788 (10 mg/kg, i.p.), a specific benzodiazepine receptor antagonist. 5. Repeated FSLT stress thus appears to decrease pentobarbital sleep by inducing functional changes in the central nervous system and the GABAergic system may partially participate in FSLT stress-induced decrease in pentobarbital sleep.","PeriodicalId":12487,"journal":{"name":"General pharmacology","volume":"22 4","pages":"729-33"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0306-3623(91)90087-m","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13095114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Effect of homotaurine in experimental analgesia tests. 同型牛磺酸在实验性镇痛试验中的作用。

General pharmacology Pub Date : 1991-01-01 DOI: 10.1016/0306-3623(91)90085-k

R M Ruiz de Valderas, M I Serrano, J S Serrano, A Fernandez

引用次数: 10

Alterations in the potassium-evoked release of substance P from the spinal cord of streptozotocin-induced diabetic rats in vitro. 链脲佐菌素诱导的糖尿病大鼠脊髓钾诱导P物质释放的变化。

General pharmacology Pub Date : 1991-01-01 DOI: 10.1016/0306-3623(91)90583-r

J Kamei, Y Ogawa, Y Ohhashi, Y Kasuya

引用次数: 15

Effects of aminophylline and terbutaline sulfate on the contractility of feline diaphragm. 氨茶碱和硫酸特布他林对猫隔膜收缩性的影响。

General pharmacology Pub Date : 1991-01-01 DOI: 10.1016/0306-3623(91)90600-b

C F Nassar, F M Saadeh, R E Ayyash, N M Kanj

引用次数: 5