General pharmacology最新文献_第10页

Capric acid as a potent dilator of canine vessels in vitro and in vivo. 己酸在体外和体内作为一种有效的犬血管扩张剂。

General pharmacology Pub Date : 1991-01-01 DOI: 10.1016/0306-3623(91)90089-o

R P White, A M el-Bauomy, W B Wood

引用次数: 3

Inhibitory effect of the endothelium on thrombin-induced contraction in rabbit aorta. 内皮对血凝素诱导兔主动脉收缩的抑制作用。

General pharmacology Pub Date : 1991-01-01 DOI: 10.1016/0306-3623(91)90569-r

N Sakiyama, I Wakabayashi, K Hatake, E Kakishita

引用次数: 10

Growth hormone and somatostatin treatment change 5-HT1 receptor activity. 生长激素和生长抑素治疗可改变5-HT1受体活性。

General pharmacology Pub Date : 1991-01-01 DOI: 10.1016/0306-3623(91)90592-t

J Popova, E Ivanova, T Tosheva, N Iavorska

引用次数: 0

Effects of (+/-)- (+)- and (-)-metoprolol, (+/-)- (+)- and (-)-pindolol, (+/-)-mepindolol and (+/-)-bopindolol on the rat left atria and portal vein. (+/-)-(+)-和(-)-美托洛尔，(+/-)-(+)-和(-)-品多洛尔，(+/-)-美品多洛尔和(+/-)-bopindolol对大鼠左心房和门静脉的影响。

General pharmacology Pub Date : 1991-01-01 DOI: 10.1016/0306-3623(91)90597-y

S A Doggrell

{"title":"Effects of (+/-)- (+)- and (-)-metoprolol, (+/-)- (+)- and (-)-pindolol, (+/-)-mepindolol and (+/-)-bopindolol on the rat left atria and portal vein.","authors":"S A Doggrell","doi":"10.1016/0306-3623(91)90597-y","DOIUrl":"https://doi.org/10.1016/0306-3623(91)90597-y","url":null,"abstract":"1. The effects of (+/-)- (+)- and (-)-metoprolol, (+/-)- (+)- and (-)-pindolol, (+/-)-mepindolol and (+/-)-bopindolol on the beta 1-adrenoceptor mediated responses of the rat left atria and the beta 2-adrenoceptor mediated responses of the rat portal vein to isoprenaline have been determined. 2. Racemic and (-)-metoprolol were selective beta 1-adrenoceptor antagonists. (+)-Metoprolol was devoid of beta-adrenoceptor antagonistic activity. 3. Racemic and (-)-pindolol were potent and (+)-pindolol was a modest beta-adrenoceptor antagonist. 4. (+/-)-Mepindolol and (+/-)-bopindolol were apparently competitive antagonists of the isoprenaline beta 1-adrenoceptor mediated responses of the rat left atria but non-competitive antagonists of the isoprenaline beta 2-adrenoceptor mediated responses of the rat portal vein. 5. It is suggested that (+/-)-mepindolol and (+/-)-bopindolol are slowly dissociating beta-adrenoceptor antagonists and the non-competitive antagonism can only be detected on tissues with modest receptor reserves for maximum responses to isoprenaline.","PeriodicalId":12487,"journal":{"name":"General pharmacology","volume":"22 6","pages":"1169-77"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0306-3623(91)90597-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12851833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Effects of the calcium channel agonist, Bay K 8644, on the mechanical output of skeletal muscle fibers. 钙通道激动剂Bay k8644对骨骼肌纤维机械输出的影响。

General pharmacology Pub Date : 1991-01-01 DOI: 10.1016/0306-3623(91)90088-n

J H Williams, C W Ward

{"title":"Effects of the calcium channel agonist, Bay K 8644, on the mechanical output of skeletal muscle fibers.","authors":"J H Williams, C W Ward","doi":"10.1016/0306-3623(91)90088-n","DOIUrl":"https://doi.org/10.1016/0306-3623(91)90088-n","url":null,"abstract":"1. The effects of the calcium agonist, Bay K 8644, on the mechanical output of skeletal muscle were studied in frog semitendinosus fiber bundles and in whole sartorius muscles. 2. Low concentrations of Bay K 8644 (less than or equal to 1 microM) had no significant influence on isometric twitches. Concentrations between 5-20 microM increased peak tension by 28.6 +/- 2.9% while higher concentrations (greater than or equal to 50 microM) initially increased then depressed twitches by 70 +/- 3.5%. 3. 10 microM Bay K 8644 also increased peak tension developed during low frequency stimulation (i.e. less than or equal to 40 Hz), slightly depressed high frequency contractions (i.e. greater than or equal to 80 Hz) but did not reduce maximal tetanic tension which occurred at about 60 Hz. 4. Potentiation of twitches and low frequency tetani and depression of high frequency tetani by Bay K 8644 were partially antagonized by nifedipine (10 microM), low extracellular calcium and D-600 (5 microM). These conditions did not, however, block the depressant actions of greater than or equal to 50 microM Bay K 8644. 5. In skinned fibers, 10 microM Bay K 8644 had no effect on resting or maximal Ca2+ activated tension. Also, 10 microM Bay K 8644 had no effect on caffeine contractures when added to the previous Ca2+ loading solution. 6. These results suggest that Bay K 8644 has both positive and negative inotropic actions on isolated skeletal muscle, which are dependent on drug concentration and muscle activation pattern.","PeriodicalId":12487,"journal":{"name":"General pharmacology","volume":"22 4","pages":"735-40"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0306-3623(91)90088-n","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12882743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Peptides do not induce contractions in gastrointestinal smooth muscle in calcium-free solution. 在无钙溶液中，多肽不能诱导胃肠道平滑肌收缩。

General pharmacology Pub Date : 1991-01-01 DOI: 10.1016/0306-3623(91)90590-3

A W Mangel, J G Fitz, I L Taylor

引用次数: 3

A comparative study on the thermoregulatory effects of prazosin, dihydrobenzperidol and nifedipin on 2,4-dinitrophenol induced hyperthermia in rabbits. 吡唑嗪、二氢苯并哌啶醇和硝苯地平对2,4-二硝基苯酚致兔热疗的热调节作用比较研究。

General pharmacology Pub Date : 1991-01-01 DOI: 10.1016/0306-3623(91)90591-s

Z Szreder, I Gagało

引用次数: 6

Effect of homotaurine in experimental analgesia tests. 同型牛磺酸在实验性镇痛试验中的作用。

General pharmacology Pub Date : 1991-01-01 DOI: 10.1016/0306-3623(91)90085-k

R M Ruiz de Valderas, M I Serrano, J S Serrano, A Fernandez