A comparative study on the thermoregulatory effects of prazosin, dihydrobenzperidol and nifedipin on 2,4-dinitrophenol induced hyperthermia in rabbits.

Abstract

1. Thermal responses to prazosin (PRA) and dihydrobenzperidol (DHBP) (0.75 mg/kg) or nifedipin (ADA: 0.05 mg/kg) administered intravenously were investigated in hyperthermic rabbits. 2. Hyperthermia produced by dinitrophenol (DNP; 20 mg/kg; i.v.), resulted from stimulation of the metabolic rate. 3. All the investigated drugs; i.e. PRA, DHBP, ADA reduced the hyperthermic activity of DNP. Contrary to DHBP and ADA, PRA did not change DNP--stimulated metabolism. 4. Possible mechanisms responsible for prazosin antihyperthermizing action are discussed.