General pharmacology最新文献_第9页

Factors in the lethality of i.v. phencyclidine in conscious dogs. 清醒犬静脉注射苯环利定致死性因素分析。

General pharmacology Pub Date : 1991-01-01 DOI: 10.1016/0306-3623(91)90086-l

W M Davis, R B Hackett, K W Obrosky, I W Waters

引用次数: 3

Propylbenzilylcholine mustard-sensitive and -resistant muscarinic receptors in cardiac muscle. 心肌中丙基苄基胆碱对芥菜敏感和耐药的毒蕈碱受体。

General pharmacology Pub Date : 1991-01-01 DOI: 10.1016/0306-3623(91)90079-l

I Takayanagi, K Koike, K Saito

引用次数: 5

Effects of N-methyl- and N-isobutyl-1,2-diphenyl ethanol amines on the spontaneous and evoked contractions in the rat isolated uterus. n -甲基和n -异丁基-1,2-二苯基乙醇胺对大鼠离体子宫自发和诱发性收缩的影响。

General pharmacology Pub Date : 1991-01-01 DOI: 10.1016/0306-3623(91)90078-k

K E el Tahir, M A el Nasser, A M Ageel, H A el-Obeid, K A al-Rashood

引用次数: 2

Influence of psychogenetics in opiate tolerance and abstinence in mice. 心理遗传学对小鼠阿片耐受性和戒断的影响。

General pharmacology Pub Date : 1991-01-01 DOI: 10.1016/0306-3623(91)90084-j

M Navarro, J C Leza, I Lizasoain, P Lorenzo

引用次数: 9

The effect of modifying potassium concentration on the inhibition of myocardial Na(+)-K(+)-ATPase by two class IB antiarrhythmic drugs: lidocaine and tocainide. 改变钾浓度对两类IB抗心律失常药物利多卡因和托卡因对心肌Na(+)-K(+)- atp酶抑制的影响。

General pharmacology Pub Date : 1991-01-01 DOI: 10.1016/0306-3623(91)90584-s

A A Almotrefi, N Dzimiri

{"title":"The effect of modifying potassium concentration on the inhibition of myocardial Na(+)-K(+)-ATPase by two class IB antiarrhythmic drugs: lidocaine and tocainide.","authors":"A A Almotrefi, N Dzimiri","doi":"10.1016/0306-3623(91)90584-s","DOIUrl":"https://doi.org/10.1016/0306-3623(91)90584-s","url":null,"abstract":"1. The inhibitory actions of two class IB antiarrhythmics, lidocaine and tocainide, on Mg(2+)-dependent ATP hydrolysis by myocardial Na(+)-K(+)-ATPase (EC 3.6.1.3), were tested in guinea-pig heart preparations incubated in media containing 2.5, 5.0 and 10 mM K+. 2. The IC50 values for lidocaine were 2.4 +/- 0.4 mM at 2.5, 4.1 +/- 0.8 mM at 5.0 and 5.3 +/- 0.5 mM at 10 mM K+. The corresponding IC20 values were 0.82 +/- 0.12 mM at 2.5, 1.3 +/- 0.2 mM at 5.0 and 1.7 +/- 0.4 mM at 10.0 mM K+ respectively. Tocainide exerted similar action with IC50 values of 3.1 +/- 0.9 mM at 2.5, 7.6 +/- 1.4 mM at 5.0 and 15.5 +/- 1.6 mM at 10.0 mM K+ and IC20 values of 0.71 +/- 0.19 at 2.5, 2.7 +/- 0.5 mM at 5.0 and 12.3 +/- 1.2 mM at 10.0 mM K+ respectively. 3. Thus, the inhibitory potencies of the drugs on myocardial Na(+)-K(+)-ATPase activity increased significantly with reduction in the K+ concentration. These results demonstrate therefore that the inhibitory actions of both lidocaine and tocainide depend on the K+ concentration of the incubation medium. 4. These findings may be indicative of the importance of K+ in some of the cardiac effects of the antiarrhythmic agents, particularly their tendency to induce or enhance already existing cardiac arrhythmias.","PeriodicalId":12487,"journal":{"name":"General pharmacology","volume":"22 6","pages":"1097-101"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0306-3623(91)90584-s","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12832652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The effect of griseofulvin on the heme pathway--II. An exhaustive analysis during short and long-term challenge. 灰黄霉素对血红素通路的影响——ⅱ。短期和长期挑战的详尽分析。

General pharmacology Pub Date : 1991-01-01 DOI: 10.1016/0306-3623(91)90598-z

N M Navone, A M Buzaleh, C F Polo, S G Afonso, E S Vázquez, A M Batlle

引用次数: 5

The potentiation of cardiodepressant and hypotensive effects of bradykinin by enalapril and captopril both in vitro and in vivo. 依那普利和卡托普利在体内外增强缓激肽的心脏抑制和降压作用。

General pharmacology Pub Date : 1991-01-01 DOI: 10.1016/0306-3623(91)90567-p

M Prostran, R Samardzić, Z Todorović, D Jovanović-Mićić, N Japundzić, B D Beleslin

{"title":"The potentiation of cardiodepressant and hypotensive effects of bradykinin by enalapril and captopril both in vitro and in vivo.","authors":"M Prostran, R Samardzić, Z Todorović, D Jovanović-Mićić, N Japundzić, B D Beleslin","doi":"10.1016/0306-3623(91)90567-p","DOIUrl":"https://doi.org/10.1016/0306-3623(91)90567-p","url":null,"abstract":"1. Bradykinin (cumulative concentrations of 0.007-0.09 micrograms ml-1) produced a dose-related, but statistically insignificant depression of the isometric contraction of the isolated, spontaneously beating atria of the guinea-pig. The same concentrations of bradykinin did not change the atrial rate, but a tendency to a slight decrease was observed. 2. Enalapril (4.06 or 13.54 mumol l-1), produced a dose-related potentiation of the effect of the highest concentration of bradykinin on the isometric contraction. 3. Captopril (equimolar concentrations) also potentiated the effect of the highest concentration of bradykinin on the isometric contraction. This effect of captopril was not dose-related. 4. Both enalapril and captopril did not change the effect of bradykinin on the heart rate. 5. Bradykinin induced dose-related hypotensive responses in anaesthetized cats (0.03-1.0 microgram/kg b.w., i.v.) with a tendency towards bradycardia. 6. Enalapril (0.3 and 1.0 mg/kg b.w., i.v.) significantly potentiated bradykinin-induced hypotension and bradycardia. However, the potentiating effect of enalapril was not dose-dependent. 7. Captopril (0.1, 0.3 and 1.0 mg/kg b.w., i.v.) significantly potentiated bradykinin-induced hypotension and bradycardia. Also, the potentiating effect of captopril was not dose-dependent. 8. The failure of ACE inhibitors to potentiate the cardiodepressant and hypotensive effects of bradykinin in a dose-dependent manner is explained with some other mechanism(s) independent of ACE inhibition.","PeriodicalId":12487,"journal":{"name":"General pharmacology","volume":"22 6","pages":"995-1000"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0306-3623(91)90567-p","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12973917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

An in vitro study on the hippocampal epileptogenic properties of enkephalins and enkephalinase inhibitors in rats. 脑啡肽及脑啡肽酶抑制剂对大鼠海马致痫性的体外研究。

General pharmacology Pub Date : 1991-01-01 DOI: 10.1016/0306-3623(91)90072-e

A Scotti De Carolis, S Sagratella, C Frank, M Trampus, M L Proietti

引用次数: 6

Characterization of muscarinic receptors of bovine adrenal chromaffin cells: binding, secretion and anti-microtubule drug effects. 牛肾上腺嗜铬细胞毒蕈碱受体的表征:结合、分泌和抗微管药物作用。

General pharmacology Pub Date : 1991-01-01 DOI: 10.1016/0306-3623(91)90599-2

D B McKay, I Lopez, P A Sanchez, J L English, L J Wallace

引用次数: 7

Effects of forced shaking stress at low temperature on pentobarbital-induced sleeping in mice. 低温强制摇应力对戊巴比妥诱导小鼠睡眠的影响。

General pharmacology Pub Date : 1991-01-01 DOI: 10.1016/0306-3623(91)90087-m

K Matsumoto, T Satoh, L H Bing, H Ohta, H Watanabe

{"title":"Effects of forced shaking stress at low temperature on pentobarbital-induced sleeping in mice.","authors":"K Matsumoto, T Satoh, L H Bing, H Ohta, H Watanabe","doi":"10.1016/0306-3623(91)90087-m","DOIUrl":"https://doi.org/10.1016/0306-3623(91)90087-m","url":null,"abstract":"1. Effects of a new stressful manipulation, forced shaking stress at low temperature (4 degrees C) (FSLT stress), on sleeping induced by pentobarbital were investigated 70 min following its application. 2. Repeated application (7 times) decreased the duration of sleep induced by pentobarbital-Na (45 mg/kg, i.p.) in mice without affecting that induced by ketamine-HCl and chloral hydrate. This effect of FSLT stress disappeared 3 days after termination of application. 3. The latency of nociceptive response in hot-plate test increased in a naloxone-sensitive manner by single and repeated FSLT stress when tested immediately (2 min) after but not 70 min after the last stress application. 4. Diazepam (0.3 mg/kg, i.p.) significantly prolonged the duration of sleep induced by pentobarbital (45 mg/kg, i.p.) in stressed animals without changing that in unstressed animals. The effect of diazepam was blocked by Ro 15-1788 (10 mg/kg, i.p.), a specific benzodiazepine receptor antagonist. 5. Repeated FSLT stress thus appears to decrease pentobarbital sleep by inducing functional changes in the central nervous system and the GABAergic system may partially participate in FSLT stress-induced decrease in pentobarbital sleep.","PeriodicalId":12487,"journal":{"name":"General pharmacology","volume":"22 4","pages":"729-33"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0306-3623(91)90087-m","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13095114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21