General pharmacology最新文献_第8页

Esculine, ranitidine and carbenoxolone: different modes of action on gastric mucosa. 埃斯库林、雷尼替丁和卡贝诺洛酮对胃粘膜的不同作用方式。

General pharmacology Pub Date : 1991-01-01 DOI: 10.1016/0306-3623(91)90568-q

M J Martin, E Marhuenda, C Alarcon de la Lastra

{"title":"Esculine, ranitidine and carbenoxolone: different modes of action on gastric mucosa.","authors":"M J Martin, E Marhuenda, C Alarcon de la Lastra","doi":"10.1016/0306-3623(91)90568-q","DOIUrl":"https://doi.org/10.1016/0306-3623(91)90568-q","url":null,"abstract":"1. This study was designed to determine the antiulcerogenicity of esculine in various types of experimentally induced gastric ulcers in which the appearance of lesions is due to an ischemic process: cold-restraint stress and pylorus-ligated induced ulcers. 2. In the first experimental model, esculine (50 mg/kg) produced a significant diminution not only in the number of haemorrhagic stomachs (21.5% by 37.5% of the controls) but also in the ulcer index, U.I. (1.00 +/- 0.63, P less than 0.05). 3. When the mucosal damage was induced as a consequence of the pylorus-ligated gastric secretion, pretreatment of esculine (25 and 50 mg/kg) prevented the formation of gastric lesions (12.4 +/- 2.8, P less than 0.05 and 12.2 +/- 1.20, P less than 0.005), although it was less effective than ranitidine (2.8 +/- 1.8, P less than 0.025). However a significant reduction on the acidity with a dose of 25 mg/kg was observed (31.69 +/- 6.42, P less than 0.025). For the rest of the studied parameters: pepsin, histamine and Na and K electrolytes no differences with regard to the control groups were produced. 4. The effects of esculine on mucosal lesions produced by intragastric instillation of 1 ml of absolute ethanol, were also studied. In this model esculine did not show any protective effect and high U.I. values were obtained.","PeriodicalId":12487,"journal":{"name":"General pharmacology","volume":"22 6","pages":"1001-4"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0306-3623(91)90568-q","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12889007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Effects of steroidal and non-steroidal antiandrogens on the left atrium of the rat in vitro. 甾体和非甾体抗雄激素对体外大鼠左心房的影响。

General pharmacology Pub Date : 1991-01-01 DOI: 10.1016/0306-3623(91)90581-p

V Garcia Valencia, M Sanchez, M Gutierrez, B Cantabrana, A Hidalgo

{"title":"Effects of steroidal and non-steroidal antiandrogens on the left atrium of the rat in vitro.","authors":"V Garcia Valencia, M Sanchez, M Gutierrez, B Cantabrana, A Hidalgo","doi":"10.1016/0306-3623(91)90581-p","DOIUrl":"https://doi.org/10.1016/0306-3623(91)90581-p","url":null,"abstract":"1. The effect of steroidal-cyproterone acetate (CPA, 10(-7)-10(-5) M), clormadinone acetate (CMA, 10(-7)-10(-5) M), medroxyprogesterone acetate (MPA, 10(-7)-10(-5) M) and spironolactone (SPI, 10(-7)10(-5)M) and non-steroidal-flutamide (F, 10(-7)-6 x 10(-5) M) and cimetidine (C, 10(-7)-10(-4)M) antiandrogens on contractile force of electrically stimulated left atria of the rat have been assayed. 2. CPA, CMA, MPA and F inhibit, in a dose-dependent way, the contractile force of left atria. SPI enhanced (P less than 0.01 at 10(-6) M), and cimetidine did not modify the contractile force. 3. F, but not CPA, CMA, MPA or SPI, inhibit the contractile force induced by CaCl2 (0.9-7.2 mM) on electrically stimulated left atria. 4. The inhibitory effect of CPA (10(-7)-10(-5) M) was significantly increased by atropine (10(-6) M) and diltiazen (10(-5) M), and significantly reduced by yohimbine (10(-7) M) and in reserpinized (2.5 mg/kg, 48 and 24 hr before experiments) rats. 5. Our results suggest that the negative inotropism of steroidal antiandrogens could be related to inhibition of noradrenaline release, presumably through an alpha 2 adrenergic effect. The negative inotropism produced by F is related to inhibition of calcium dependent process on left atria contraction.","PeriodicalId":12487,"journal":{"name":"General pharmacology","volume":"22 6","pages":"1081-6"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0306-3623(91)90581-p","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12890045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Beneficial effect of dexamethasone in decreasing the lethality of acute T-2 toxicosis. 地塞米松对降低急性T-2中毒致死性的有益作用。

General pharmacology Pub Date : 1991-01-01 DOI: 10.1016/0306-3623(91)90582-q

R F Fricke, J Jorge

引用次数: 0

Inhibition of gastric mucosal laminin receptor by Helicobacter pylori lipopolysaccharide: effect of nitecapone. 幽门螺杆菌脂多糖对胃粘膜层粘连蛋白受体的抑制作用:尼替卡酮的作用。

General pharmacology Pub Date : 1991-01-01 DOI: 10.1016/0306-3623(91)90578-t

B L Slomiany, J Piotrowski, G Rajiah, A Slomiany

引用次数: 22

Angiogenesis: modulation with opioids. 血管生成:阿片类药物的调节。

General pharmacology Pub Date : 1991-01-01 DOI: 10.1016/0306-3623(91)90580-y

A Pasi, B X Qu, R Steiner, H J Senn, W Bär, F S Messiha

引用次数: 43

Involvement of calcium ions in the modulation of electrically-induced rat vas deferens contractions by histaminergic drugs. 钙离子参与组胺能药物对电诱导大鼠输精管收缩的调节。

General pharmacology Pub Date : 1991-01-01 DOI: 10.1016/0306-3623(91)90081-g

P Vassilev, V Mutafova-Yambolieva, D Staneva-Stoytcheva, S Todorov

{"title":"Involvement of calcium ions in the modulation of electrically-induced rat vas deferens contractions by histaminergic drugs.","authors":"P Vassilev, V Mutafova-Yambolieva, D Staneva-Stoytcheva, S Todorov","doi":"10.1016/0306-3623(91)90081-g","DOIUrl":"https://doi.org/10.1016/0306-3623(91)90081-g","url":null,"abstract":"1. The modulatory action of histaminergic drugs: histamine; 2-(2-aminoethyl)thiazole (H1-agonist); dimaprit (H2-agonist); diphenhydramine (H1-receptor antagonist); and cimetidine (H2-receptor antagonist) on rat vas deferens contractions induced by electrical field stimulation (0.1 Hz, 1 pulse, 1 msec duration, supramaximal voltage) was studied either at different calcium concentrations in the nutrient fluid or after verapamil. 2. Histamine and 2-(2-aminoethyl)thiazole inhibited the electrically-evoked contractions (EEC). This effect was unchanged after verapamil. 3. Diphenhydramine potentiated the EEC. Verapamil added before the H1-receptor antagonist inhibited this action. 4. The effects of agonists and antagonists of H-receptors decreased with the increasing of calcium concentration. 5. The results obtained suggested the existence of heterogeneity of prejunctional H-receptors. The function of histaminergic drugs on adrenergic neurotransmission in field stimulated rat vas deferens is Ca(2+)-dependent.","PeriodicalId":12487,"journal":{"name":"General pharmacology","volume":"22 4","pages":"699-702"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0306-3623(91)90081-g","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12995372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rat heart anaphylaxis: influence of mediator antagonists. 大鼠心脏过敏反应:介质拮抗剂的影响。

General pharmacology Pub Date : 1991-01-01 DOI: 10.1016/0306-3623(91)90076-i

H A Bakathir, J Giessler, R Hirschelmann

引用次数: 5

Regional histaminergic potencies in rabbit systemic circulation. 兔体循环的局部组胺能效价。

General pharmacology Pub Date : 1991-01-01 DOI: 10.1016/0306-3623(91)90073-f

H Gürbüz, H O Onaran, T A Bökesoy

引用次数: 1

The haemodynamic effect of Bitis nasicornis (rhinoceros horned viper) venom. 鼻角蝰(Bitis nasicornis)毒液的血流动力学效应。

General pharmacology Pub Date : 1991-01-01 DOI: 10.1016/0306-3623(91)90335-4

G Alloatti, D Gattullo, R Dalla Valle, N A Marsh, P Pagliaro, P Vono