An in vitro study on the hippocampal epileptogenic properties of enkephalins and enkephalinase inhibitors in rats.

A Scotti De Carolis, S Sagratella, C Frank, M Trampus, M L Proietti
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引用次数: 6

Abstract

1. The effects of enkephalins and enkephalinase inhibitors were studied in CA1 area in rat hippocampal slices. 2. The data demonstrate a prevalent involvement of mu opiate receptors in the epileptogenic properties of enkephalins. 3. A potentiation of the mu opiate receptor-mediated epileptogenic response by enkephalinase inhibitors has been shown. 4. The results also show an inability to affect basal CA1 field potentials by inhibition of endogenous endopeptidase.

脑啡肽及脑啡肽酶抑制剂对大鼠海马致痫性的体外研究。
1. 研究脑啡肽和脑啡酶抑制剂对大鼠海马CA1区的影响。2. 这些数据表明,阿片受体普遍参与脑啡肽的致痫特性。3.脑啡肽酶抑制剂可增强阿片剂受体介导的致痫反应。4. 结果还显示无法通过抑制内源性内肽酶来影响基础CA1场电位。
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