Evaluation of dopamine receptor involvement in rat feeding behaviour.

General pharmacology Pub Date : 1991-01-01 DOI:10.1016/0306-3623(91)90570-v

M R Zarrindast, A A Owji, T Hosseini-Nia

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引用次数: 38

Abstract

1. The anorectic effect of dopamine agonists and antagonists were studied in rats. 2. Dopamine agonists bromocriptine, quinpirole or SKF 38393 treatment induced, a dose-dependent anorexia in rats. 3. Anorectic effect of bromocriptine was decreased in animals pretreated with pimozide (D-2 antagonist), but not by sulpiride (D-2 antagonist) or SCH 23390 (D-1 antagonist) pretreatment. 4. Anorexia induced by quinpirole was decreased by sulpiride or pimozide, but not by SCH 23390 administration. 5. While sulpiride and SCH 23390 failed to antagonize the anorectic response of SKF 38393, methergoline (5-HT antagonist) decreased anorexia induced by the drug. 6. A combination of quinpirole with SKF 38393 did not elicit potentiated anorectic response. 7. Decrease in food intake induced by bromocriptine, quinpirole or SKF 38393 was potentiated in reserpinized animals, although single administration of reserpine also induced a marked decrease in feeding. 8. Single administration of sulpiride, pimozide or methergoline did not change the feeding behaviour of rats, but SCH 23390 induced anorexia. 9. It is concluded that D-2 activation may induce inhibition of feeding and anorexia induced by SKF 38393 may be mediated through serotonergic mechanism(s).

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多巴胺受体参与大鼠摄食行为的评估。

1. 研究了多巴胺激动剂和拮抗剂对大鼠的厌食作用。2. 多巴胺激动剂溴隐亭、喹匹罗或SKF 38393治疗诱导大鼠出现剂量依赖性厌食症。3.经吡莫齐(D-2拮抗剂)预处理的动物，溴隐亭的厌食作用降低，但经舒必利(D-2拮抗剂)或SCH 23390 (D-1拮抗剂)预处理的动物无此作用。4. 舒必利或匹莫齐能减轻喹匹罗引起的厌食症，而SCH 23390不能。5. 舒必利和SCH 23390不能拮抗SKF 38393的厌食反应，而美高林(5-羟色胺拮抗剂)能降低SKF 38393引起的厌食反应。6. 喹匹罗与SKF 38393联用没有引起增强的厌食反应。7. 溴隐亭、喹匹罗或SKF 38393在利血平化的动物中引起的食物摄取量减少被增强，尽管单次给药利血平也引起摄食量明显减少。8. 单次给药舒必利、吡莫齐或美高林对大鼠的摄食行为没有影响，但SCH 23390引起了大鼠厌食。9. 综上所述，SKF 38393可能通过血清素能机制介导D-2活化对摄食和厌食的抑制作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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General pharmacology

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