Geburtshilfe Und Frauenheilkunde最新文献

{"title":"INTERLACE Study: Real-world Data for Germany Based on a Case Series of Patients with Locally Advanced Cervical Cancer.","authors":"Alina Lohner, Volkmar Müller, Andrea Baehr, David Krug, Cordula Petersen, Anna Jaeger, Barbara Schmalfeldt, Charlotte Sachs, Linn Woelber","doi":"10.1055/a-2781-3692","DOIUrl":"10.1055/a-2781-3692","url":null,"abstract":"<p><strong>Introduction: </strong>Primary chemoradiotherapy is the established and standard treatment for locally advanced cervical cancer. The INTERLACE study investigated the impact of adding induction chemotherapy with six cycles of carboplatin AUC2 and paclitaxel 80 mg/m ² weekly prior to chemoradiotherapy on recurrence-free and overall survival. However, adaptation with adoption into routine clinical practice in Germany has been rather cautious.</p><p><strong>Methods: </strong>Patients treated according to the INTERLACE scheme at the University Medical Center Hamburg-Eppendorf between October 2023 and December 2024 were evaluated and described.</p><p><strong>Results: </strong>Seven patients with advanced cervical cancer (ECOG 0-1, median age 37 years, 43% FIGO stage IB1/2) treated with the INTERLACE regimen were identified during the study period. All patients received six cycles of the planned induction chemotherapy. The median time between completion of chemotherapy and the start of radiotherapy was 10 days, with the total duration of treatment varying between 43 and 63 days. All patients were able to complete radiotherapy using tele- and brachytherapy. 43% received all 5-6 cycles of cisplatin, 86% received at least four cycles of cisplatin simultaneously with radiotherapy. There were various reasons for discontinuing concomitant chemotherapy (1 hematological, 3 non-hematological).</p>","PeriodicalId":12481,"journal":{"name":"Geburtshilfe Und Frauenheilkunde","volume":"86 4","pages":"376-381"},"PeriodicalIF":2.6,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13082883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147767813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stereotactic Vacuum-Assisted Biopsy in Photon-Counting Dedicated Spiral Breast CT: A Proof of Concept.","authors":"Rüdiger Schulz-Wendtland, Till Wacker, David Heinemann, Christian Steiding, Daniel Kolditz, Felix Althoff, Evelyn Wenkel, Sabine Ohlmeyer, Matthias Wetzl, George Mpourazanis, Panagiotis Tsirkas, Matthias W Beckmann, Michael Uder","doi":"10.1055/a-2804-3849","DOIUrl":"10.1055/a-2804-3849","url":null,"abstract":"<p><p>In recent years, a new dedicated spiral breast CT (SBCT) with photon-counting technology has been developed that offers clear advantages over established methods such as mammography and tomosynthesis, as well as the existing cone-beam breast CT (CBBCT) without a direct-conversion detector, particularly due to its unique feature of three-dimensional visualization of microcalcifications. Microcalcifications cannot be visualized using non-X-ray-based methods such as ultrasound and MRI. However, microcalcifications are particularly noticeable in 70% to 90% of DCIS cases 1 2 . Our experimental phantom study shows for the first time that the newly developed SBCT-compatible biopsy unit closes the previous diagnostic gap and enables both vacuum-assisted biopsy (VAB) and the marking of detected findings (especially microcalcifications and round foci) after precise three-dimensional target planning with the help of SBCT.</p>","PeriodicalId":12481,"journal":{"name":"Geburtshilfe Und Frauenheilkunde","volume":"86 5","pages":"463-469"},"PeriodicalIF":2.6,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13287934/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148316485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Barriers and Facilitators Affecting the Care of Patients with Endometriosis: A Scoping Review.","authors":"Selina Bayrak, Alena Allak, Till Neugebauer, Siegrun Pardon, Yüce Yilmaz-Aslan, Sven Schiermeier, Claudia Kiessling, Sven Schmiedl, Christoph Dockweiler, Patrick Brzoska","doi":"10.1055/a-2765-4322","DOIUrl":"10.1055/a-2765-4322","url":null,"abstract":"<p><strong>Background: </strong>Endometriosis affects around 10-15% of women of reproductive age worldwide. Despite its prevalence and the considerable pain and psychological stress associated with the disease, the care of those affected is associated with numerous challenges. A central problem is the often delayed diagnosis, which takes 6-10 years on average. However, early diagnosis is essential for appropriately targeted therapeutic approaches. The specific barriers that contribute to delayed diagnosis and inadequate care have not yet been comprehensively identified. The aim of this scoping review was therefore to systematically identify existing barriers and facilitators to derive approaches for improving diagnosis and doctor-patient communication in Germany.</p><p><strong>Methods: </strong>A systematic search of international studies was conducted in accordance with the PRISMA-ScR guidelines to identify relevant German- and English-language publications in the period from 2014 to 2024. The search was conducted in various scientific databases. Empirical studies on barriers and facilitators in endometriosis care were included. After screening and selection, 39 relevant publications remained, based on which eight main categories were inductively derived.</p><p><strong>Results: </strong>Primary barriers include delays in diagnosis, stigmatization of menstrual pain, emotional distress such as shame and fear, inadequate pain management, and structural barriers. The findings suggest that effective interdisciplinary collaboration and patient-centered communication between doctors and patients are essential to reduce diagnostic delays and optimize care. Furthermore, individual studies suggest that digital technologies have the potential to encourage patients to document and communicate their symptoms.</p><p><strong>Discussion: </strong>The results of the study suggest that the stigmatization of endometriosis significantly complicates its care in the health care system. Consequently, interdisciplinary care models, targeted training of medical professionals, and measures to strengthen doctor-patient communication are key approaches for patient-centered and early care.</p>","PeriodicalId":12481,"journal":{"name":"Geburtshilfe Und Frauenheilkunde","volume":"86 2","pages":"189-200"},"PeriodicalIF":1.9,"publicationDate":"2026-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12893801/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146178861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis and Therapy of Endometriosis. Guideline of the DGGG, OEGGG and SGGG (S2k-Level, AWMF Registry No. 015/045, April 2025).","authors":"Stefanie Burghaus, Sebastian D Schäfer, Karl-Jürgen Bär, Julia Bartley, Matthias W Beckmann, Angelika Behrens, Katharina Beyer, Nicole Bianchi, Iris Brandes, Christian Brünahl, Eike-Christian Burandt, Radek Chvátal, Frederic Dietzel, Beate Ditzen, Jan Drahoňovský, Axel Eickhoff, Joachim Erlenwein, Tanja Fehm, Peter Martin Fehr, Ricardo E Felberbaum, Reinhild Georgieff, Dieter Grab, Donata Grimm-Glang, Andreas Hackethal, Katharina Hancke, Winfried Häuser, Markus Hoopmann, Christian Houbois, Christian Krautz, Harald Krentel, Klaudija Künzel, Simone Linsenbühler, Gwendolin Manegold-Brauer, Ines Mayer-Hrusa, Sylvia Mechsner, Harald Meden, Michael Müller, Monika Nothacker, Patricia G Oppelt, Peter Oppelt, Barbara Pasiecznyk, Esther Pogatzki-Zahn, Stefan P Renner, Michelle Röhrig, Daniela Rosenberger, Frank Ruhland, Nicole Sänger, Jana Schmid, Karl-Werner Schweppe, Friederike Siedentopf, Horia Sirbu, Runa Speer, Petra Thorn, Denis I Trufa, Frauke von Versen-Höynck, Friederike Vogeler, Kerstin Weidner, Tewes Wischmann, Katharina Wittek, Monika Wölfler, Isabella Zraik, Uwe A Ulrich","doi":"10.1055/a-2760-4867","DOIUrl":"https://doi.org/10.1055/a-2760-4867","url":null,"abstract":"<p><p><b>Objective</b> The objective of this revised official guideline, published by the German Society for Gynecology and Obstetrics (DGGG) and coordinated in the joint guidelines program of the DGGG, the Austrian Society for Gynecology and Obstetrics (OEGGG), and the Swiss Society for Gynecology and Obstetrics (SGGG), is to provide evidence-based and consensus-based recommendations for the diagnosis, treatment, care, and support of girls and women with confirmed or suspected endometriosis. <b>Methods</b> This S2k guideline was developed through a structured consensus process involving representative members of various professions (37 professional associations, organizations, and self-help groups) and includes 25 statements and 73 recommendations which are based on a systematic literature review (2019 - 2023) and expert consensus. <b>Recommendations</b> For the first time, the revised guideline has placed a greater focus on individualized, symptom-oriented diagnosis and treatment that combines hormonal, surgical, and multimodal approaches. A significant innovation is the use of transvaginal ultrasound as the central diagnostic procedure for detecting endometriosis. Therapeutically, primary hormone treatment is now recommended as the first choice approach, with surgical interventions and multimodal approaches supplemented on an individual and symptom-oriented basis.</p>","PeriodicalId":12481,"journal":{"name":"Geburtshilfe Und Frauenheilkunde","volume":"86 2","pages":"133-188"},"PeriodicalIF":1.9,"publicationDate":"2026-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12893799/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146178884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Induction of Labour with Prostaglandins: Does Their Pro-Inflammatory Effect Mimic Chorioamnionitis After PROM?","authors":"Anne Karge, Lukas Knabe, Chiara Lecce, Bernhard Haller, Gabriel Eisenkolb, Maximilian Riedel, Silvia M Lobmaier, Javier U Ortiz, Bettina Kuschel, Oliver Graupner, Kathrin Abel","doi":"10.1055/a-2774-7487","DOIUrl":"10.1055/a-2774-7487","url":null,"abstract":"<p><strong>Purpose: </strong>Induction of labour (IOL) is commonly performed by administration of prostaglandin E (PGE). As pro-inflammatory agents, a known side-effect of PGE is maternal fever. This is problematic as it potentially mimics chorioamnionitis and may lead to unnecessary interventions such as administration of antibiotics or cesarean section. The aim of the study was therefore to investigate the effect of PGE on pregnancy outcomes.</p><p><strong>Methods: </strong>Retrospective single-centre cohort study with inclusion of women ≥ 37 weeks of gestation who underwent IOL with PGE and subsequently developed PROM (Group 1) or women who presented with spontaneous PROM without contractions (Group 2). At the time of PROM, CRP and white blood count (WBC) were assessed. We compared rates of maternal fever, Triple I, mode of delivery, and administration of antibiotics between Group 1 and Group 2.</p><p><strong>Results: </strong>A total of n = 850 women were included (Group 1: 200, Group 2: 650). CRP levels were higher in patients with more prolonged PGE administration (< 12 hours: 0.3 mg/dL vs. > 48 hours: 1.4 mg/dL, p = 0.002; r = 0.309; p < 0.001). WBCs were also higher after PGE administration (11.1 × 10 ⁹ /L vs. 9.5 × 10 ⁹ /L, p < 0.001). The logistic regression model revealed an association between IOL with PGE and antibiotics during labour. However, the rates of maternal fever and suspected Triple I did not differ significantly between the two groups, nor did the mode of delivery.</p><p><strong>Conclusion: </strong>IOL with PGE increases maternal serum levels of CRP (time-dependently), as well as WBC. This might lead to overtreatment with antibiotics during labour. However, the diagnosis of maternal fever or rates of suspected Triple I were not affected in our cohort.</p>","PeriodicalId":12481,"journal":{"name":"Geburtshilfe Und Frauenheilkunde","volume":"86 3","pages":"273-280"},"PeriodicalIF":2.6,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12978870/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147443040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infant-driven versus Practitioner-driven Feeding of Preterm Infants: A Systematic Review of Randomized Controlled Trials.","authors":"Kevin Bernhard Arnolds, Frank Peinemann","doi":"10.1055/a-2783-2468","DOIUrl":"10.1055/a-2783-2468","url":null,"abstract":"<p><strong>Background: </strong>Oral feeding should be mindful of individual ability. It is important that caregivers and parents are made aware of the infant's behavioral signs to prevent distress. This type of feeding is based on responding to infant cues, and we call it \"infant driven.\" The traditional type of feeding is characterized by prescribing a predefined amount of liquid to be given at scheduled times and we call it \"practitioner driven.\"</p><p><strong>Objective: </strong>To assess whether infant-driven feeding results in earlier full oral feeding compared to practitioner-driven feeding.</p><p><strong>Methods: </strong>We included randomized controlled trials (RCTs) and searched MEDLINE and the Cochrane Library on 26 June 2024. The primary outcome was days to full oral feeding, and the effect measure was the mean difference. A meta-analysis was conducted using the inverse variance method and random effects model, and we used the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach.</p><p><strong>Results: </strong>Twelve RCTs matched the inclusion criteria. Of those, five studies were included in a meta-analysis. The estimated mean difference favored infant-driven groups when compared to practitioner-driven groups: -4.93 (95% confidence interval -6.60 to -3.26, p < 0.00001, I ²  = 66%). The certainty of the evidence was graded as moderate.</p><p><strong>Conclusions: </strong>The evidence base is compatible with a slight favorable effect of infant-driven feeding of preterm infants compared to practitioner-driven feeding of preterm infants. Future studies could provide more data on adverse events during feeding and add information obtained from follow-up at home.</p>","PeriodicalId":12481,"journal":{"name":"Geburtshilfe Und Frauenheilkunde","volume":"86 6","pages":"538-553"},"PeriodicalIF":2.6,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13287937/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148316500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RSV Prophylaxis in Neonates: Implementation and Parental Acceptance during the First RSV Season in Germany.","authors":"Esther S Schouten, Annika S Kraft, Maria V Delius, Nicole Ellenbach, Andreas W Flemmer, Linda Hertlein, Sven Kehl, Sven Mahner, Teresa Starrach","doi":"10.1055/a-2776-6900","DOIUrl":"10.1055/a-2776-6900","url":null,"abstract":"<p><strong>Background: </strong>RSV is the leading cause of lower respiratory tract infections (LRTI) in infants. Since 2024, STIKO recommends immunising all neonates with nirsevimab prior to or during their first RSV season. This study aims to assess parental acceptance and uptake of RSV immunisation during the first implementation season in Germany.</p><p><strong>Methods: </strong>All neonates born at our hospital between 11 November 2024 and 31 January 2025 were included in this study. Parents received an antenatal information leaflet; counselling was part of the U2 medical checkup. The immunisation rate was assessed using data from electronic medical records. In addition, an online questionnaire surveyed parental satisfaction with the information provided.</p><p><strong>Results: </strong>Of 1030 neonates, 76% received nirsevimab, 6% were protected by maternal RSVpreF vaccination (overall immunisation rate: 82%). Children of multiparous mothers were immunised less often than children of primiparous mothers (OR = 0.52; p < 0.001). Mothers aged ≥ 30 years were more likely to consent to vaccination (30-34: OR = 1.75; ≥ 35: OR = 1.72). 68% of parents had already made their decision prior to delivery. Of 153 respondents, 17% requested more detailed information on safety, duration of vaccination protection, and availability of the vaccine.</p><p><strong>Conclusion: </strong>Maternal age and parity appear to be associated with nirsevimab uptake. Early prepartum counselling and transparent communications regarding product safety could further increase acceptance.</p>","PeriodicalId":12481,"journal":{"name":"Geburtshilfe Und Frauenheilkunde","volume":"86 6","pages":"554-562"},"PeriodicalIF":2.6,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13287936/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148316484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Setting of Induction of Labour with Double-Balloon Catheter in Low-risk Pregnancies: Outpatient Versus Inpatient.","authors":"Sven Kehl, Anne Gernhardt, Christel Weiss, Michael O Schneider, Matthias W Beckmann, Jutta Pretscher","doi":"10.1055/a-2780-1607","DOIUrl":"10.1055/a-2780-1607","url":null,"abstract":"<p><strong>Objectives: </strong>Induction of labour is one of the most frequently performed obstetric procedures. This analysis aimed to assess maternal and neonatal outcomes after labour induction with a double-balloon catheter in an outpatient versus inpatient setting in low-risk term pregnancies.</p><p><strong>Methods: </strong>In this retrospective cohort study, 1010 women with singleton, low-risk term pregnancies undergoing labour induction with a double-balloon catheter were analysed. Of these, 394 received outpatient and 616 inpatient cervical ripening. The primary outcome was the caesarean section rate; secondary outcomes included the induction-to-delivery interval, vaginal delivery within 24 hours and neonatal parameters.</p><p><strong>Results: </strong>Delivery modes were comparable between groups (p = 0.5524), but vaginal delivery within 24 hours occurred less frequently in the outpatient group (25.2% vs. 32.9%, p = 0.0201). Neonatal outcomes were significantly better in the outpatient cohort, with lower rates of arterial umbilical cord pH < 7.10 (2.0% vs. 5.5%, p = 0.0067) and NICU admissions (6.9% vs. 15.1%, p < 0.0001). Multiple logistic regression analysis identified nulliparity (OR = 10.545), maternal age (OR = 1.076), and birth weight (OR = 1.733) as significant predictors for caesarean section. Failure to achieve vaginal delivery within 24 hours was associated with higher BMI (OR = 1.080), nulliparity (OR = 4.191), and fetal macrosomia (OR = 3.675), while labour onset by balloon catheter alone reduced this risk (OR = 0.149). Outpatient induction was associated with a lower risk of arterial pH < 7.10 (OR = 0.352, p = 0.0088).</p><p><strong>Conclusions: </strong>Outpatient cervical ripening with a double-balloon catheter is a safe and effective alternative to inpatient induction in low-risk term pregnancies, with comparable delivery outcomes and potential neonatal benefits.</p>","PeriodicalId":12481,"journal":{"name":"Geburtshilfe Und Frauenheilkunde","volume":"86 3","pages":"281-288"},"PeriodicalIF":2.6,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12978867/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147443088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of <i>PIK3CA</i> Mutation Detection via Microfluidic Isolation of Disseminated Tumor Cells from Bone Marrow in Breast Cancer Patients.","authors":"Hanne Grollmann, Barbara Volz, Werner Schroth, Veronika Bahlinger, Andreas Hartkopf, Sara Y Brucker, Léa L Volmer, André Koch","doi":"10.1055/a-2764-9625","DOIUrl":"10.1055/a-2764-9625","url":null,"abstract":"<p><p>Disseminated tumor cells originating from the bone marrow serve as precursors of distant metastasis and are associated with increased mortality in breast cancer. With the emergence of targeted therapies for breast cancer, accurate procedures for enrichment of disseminated tumor cells are crucial to investigate the molecular heterogeneity between disseminated tumor cells and primary tumors. This study evaluated the feasibility of <i>PIK3CA</i> mutation analysis in disseminated tumor cells enriched using a microfluidic-based separation system. Bone marrow and primary tumor samples from 84 breast cancer patients were collected. Disseminated tumor cells were enriched from bone marrow aspirates using the Parsortix system, followed by <i>PIK3CA</i> mutation analysis via MassARRAY PIK3CA Breast Panel and digital droplet PCR. <i>PIK3CA</i> mutations were detected in 42.9% of primary tumors. <i>PIK3CA</i> mutations were neither detected via digital droplet PCR in disseminated tumor cells-positive bone marrow samples, nor in disseminated tumor cells-negative samples with a high allele frequency of <i>PIK3CA</i> mutations in the primary tumor. These findings suggest that current microfluidic enrichment methods, such as Parsortix, may be insufficient for reliable <i>PIK3CA</i> mutation detection in disseminated tumor cells. Additional research is required to investigate alternative enrichment techniques for the analysis of mutations in disseminated tumor cells.</p>","PeriodicalId":12481,"journal":{"name":"Geburtshilfe Und Frauenheilkunde","volume":"86 5","pages":"453-462"},"PeriodicalIF":2.6,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13287949/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148316465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iodine Supplementation Before, During and After Pregnancy.","authors":"Rolf Grossklaus, Klaus-Peter Liesenkötter, Burkhard Lawrenz, Frank Thieme","doi":"10.1055/a-2739-3580","DOIUrl":"10.1055/a-2739-3580","url":null,"abstract":"<p><p>This narrative review reports on the currently insufficient intake of iodine and the iodine status of pregnant and breastfeeding women in Germany, Europe, and worldwide, as well as presenting the associated risks, particularly for children's neurocognitive and psychomotor development. The responsibility of public health bodies to introduce appropriate measures which will ensure adequate iodine intake for all population groups and to monitor their implementation, especially during pregnancy and lactation which are particularly critical periods for the unborn child and the breastfed infant, is emphasized. Based on recent studies, the current national recommendations for iodine supplementation are reviewed, and the benefits and drawbacks of necessary measures to improve iodine intake for pregnant and breastfeeding women and their children are discussed. The most important iodine prophylaxis method - even during pregnancy and lactation - remains universal salt iodization. If this approach to improve widespread iodine intake is not feasible, the AKJ recommends that especially women of reproductive age should take continuous iodine supplements, starting at least three months prior to conception and continuing throughout pregnancy and breastfeeding.</p>","PeriodicalId":12481,"journal":{"name":"Geburtshilfe Und Frauenheilkunde","volume":"86 3","pages":"257-272"},"PeriodicalIF":2.6,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12978872/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147442988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}