Geburtshilfe Und Frauenheilkunde最新文献

{"title":"Individual Prediction of Insulin Therapy in Gestational Diabetes: Development of a Risk Calculator Based on Real-World Data from the GestDiab Registry.","authors":"Friederike Weschenfelder, Barbara Dusek, Heinke Adamczewski, Dietmar Weber, Matthias Kaltheuner, Yvonne Heimann, Tanja Groten","doi":"10.1055/a-2689-4637","DOIUrl":"10.1055/a-2689-4637","url":null,"abstract":"<p><strong>Introduction: </strong>The prevalence of gestational diabetes mellitus in Germany is approximately 10%. One third of affected women require insulin therapy when conservative measures such as dietary changes and physical activity are insufficient to achieve target glucose levels. Timely initiation of insulin therapy is crucial for optimising obstetric outcomes. Early identification of high-risk patients at the time of diagnosis would facilitate prompt and individualised treatment adjustments.</p><p><strong>Materials and methods: </strong>A risk calculator was developed based on clinical parameters and medical history information to estimate the individual risk for insulin therapy. The models were derived from real-world data of the GestDiab registry, comprising 14157 pregnancies between 2018 and 2020, of which 4319 (30.5%) required insulin therapy.</p><p><strong>Results: </strong>Various models incorporating maternal age, gestational age at diagnosis, parity, gravidity, body mass index, 75 g oral glucose tolerance test values, HbA1c levels, history of gestational diabetes mellitus, and family history of diabetes were developed. Validation using the GestDiab cohort from 2021 demonstrated that the model including all variables exhibited the highest predictive power (AUC 0.740).</p><p><strong>Conclusions: </strong>The risk calculator is provided online to support both patients and physicians in making informed decisions. Individualised counselling based on personal risk assessments may enhance therapy adherence and potentially reduce the necessity for insulin therapy.</p>","PeriodicalId":12481,"journal":{"name":"Geburtshilfe Und Frauenheilkunde","volume":"85 12","pages":"1334-1341"},"PeriodicalIF":1.9,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12674896/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145677073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endometriosis and Fertility: A Practical Guide: Results of the Working Group of the Weissensee 2025 Workshop of the Scientific Endometriosis Foundation.","authors":"Susanne Beyer, Predrag Drazic, Franz Bitto, Alexander Boosz, Iris Brandes, Olaf Buchweitz, Radek Chvatal, Davut Dayan, Daniela Hornung, Elisabeth Janschek, Joerg Keckstein, Sylvia Mechsner, Lilo Mettler, Anja Mutz, Stefan Rimbach, Behrus Salehin, Sebastian Schäfer, Rasmus Schmädecker, Annemarie Schweizer-Arau, Karl-Werner Schweppe, Beata Seeber, Réné Wenzl, Monika Wölfler, Sonja Wüllner, Martin Sillem","doi":"10.1055/a-2663-4218","DOIUrl":"10.1055/a-2663-4218","url":null,"abstract":"<p><strong>Target group: </strong>Physicians interested in endometriosis and infertility as well as medical teams in reproductive medicine and endometriosis centers.</p><p><strong>Objective: </strong>A practical guide for clinical decision-making. This guide was compiled by the working group at the 2025 Weissensee Workshop of the Scientific Endometriosis Foundation. The contents are based on the available evidence regarding fertility and endometriosis and, where this was lacking, on the authors' clinical experience. It is intended as a guide for persons responsible for caring and treating patients with this condition in everyday clinical practice. This work is explicitly not intended to be a guideline as the authors were not commissioned to draft a guideline. Rather, its aim is to provide quality care in clinical practice, avoid unnecessary or potentially harmful measures, and establish the optimal therapy for individual patients.</p>","PeriodicalId":12481,"journal":{"name":"Geburtshilfe Und Frauenheilkunde","volume":"86 2","pages":"123-132"},"PeriodicalIF":1.9,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12893803/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146178853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current Endometriosis Classifications (rASRM, #Enzian, AAGL2021) and their Correlation with Operative Time.","authors":"Teresa Eichinger, Peter Oppelt, Julia Lastinger, Natalia Anna Palasz, Hanna Elisabeth Fickert, Simon-Hermann Enzelsberger","doi":"10.1055/a-2697-6364","DOIUrl":"10.1055/a-2697-6364","url":null,"abstract":"<p><strong>Introduction: </strong>In the ongoing effort to identify or develop the optimal classification system for endometriosis, there is a paucity of data regarding the association between currently used classification systems and operative times. This study aims to evaluate the correlation between the rASRM, #Enzian, and AAGL2021 classifications and the duration of endometriosis surgery to determine the most accurate system for planning operating room resources.</p><p><strong>Materials and methods: </strong>This retrospective study included patients who underwent laparoscopic endometriosis surgery at Kepler University Hospital in 2021 and 2022. Surgeries were performed by experienced gynecologic surgeons, with endometriosis extent assessed using rASRM, #Enzian, and AAGL2021 classifications. Corrected operative time (total time minus fixed durations for common concomitant procedures) was used for analysis. Statistical analyses included descriptive statistics, Kendall's tau correlation, Spearman's correlation, Mann-Whitney U test, and generalized linear models.</p><p><strong>Results: </strong>Out of 248 patients with laparoscopic surgery for endometriosis, 139 met the in-/exclusion criteria. The median corrected operative time was 68.50 minutes. Significant positive correlations were found between surgery duration and stages in both rASRM and AAGL2021 classifications. The #Enzian classification also showed positive correlations with more complex analyses attributable to the classification structure. Operative times were longest in surgeries affecting compartments C3, A3, FI, and FU. Regression analysis identified several significant variables impacting surgery duration.</p><p><strong>Conclusions: </strong>All three classification systems significantly impact operative time, with higher stages or specific coding correlating with longer durations. The AAGL2021 and #Enzian classifications can be used as preoperative diagnostic tools, with #Enzian offering more detailed coding. Future research should focus on prospective, multi-center studies to develop algorithms incorporating #Enzian codings for enhanced preoperative planning.</p>","PeriodicalId":12481,"journal":{"name":"Geburtshilfe Und Frauenheilkunde","volume":"86 2","pages":"201-207"},"PeriodicalIF":1.9,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12893800/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146178907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Induction of Labor at Term with Oral Misoprostol or as a Vaginal Insert and Dinoprostone Vaginal Insert - A Multicenter Prospective Cohort Study.","authors":"Jana Beyer, Yvonne Jäger, Derya Balci, Gelia Kolb, Friederike Weschenfelder, Sven Seeger, Dietmar Schlembach, Michael Abou-Dakn, Ekkehard Schleußner","doi":"10.1055/a-2704-9622","DOIUrl":"https://doi.org/10.1055/a-2704-9622","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1055/a-1860-0419.].</p>","PeriodicalId":12481,"journal":{"name":"Geburtshilfe Und Frauenheilkunde","volume":"85 9","pages":"e3"},"PeriodicalIF":1.9,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12453902/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145129866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High Adherence to Adjuvant Endocrine Therapy Improves Outcome in Early Breast Cancer - Results from a Large Real-World Claims Data Analysis in Germany.","authors":"Dominik Dannehl, Tjeerd Dijkstra, Lea Volmer, Markus Hahn, Alexandra von Au, Sabine Hawighorst-Knapstein, Ariane Chaudhuri, Markus Wallwiener, Armin Bauer, Diethelm Wallwiener, Sara Brucker, Stephanie Wallwiener, Tobias Engler, Andreas Hartkopf","doi":"10.1055/a-2687-9258","DOIUrl":"10.1055/a-2687-9258","url":null,"abstract":"<p><p>In hormone-receptor positive (HR+) early breast cancer (EBC), adjuvant endocrine therapy (ET) significantly reduces recurrence and mortality. A common means of estimating therapy adherence is to use patient-reported outcome measures. Yet, this method is inaccurate due to social-desirability bias. We therefore aimed to analyze adherence to ET over the first five years of treatment by using claims data from a large health insurance provider in Germany (AOK Baden-Wuerttemberg). Female patients diagnosed with HR+ EBC who received inpatient treatment and breast cancer surgery between 1 July 2010 and 31 December 2019 were included in the analysis. Adherence to ET was defined as the ratio between the sum of the number of pills from filled prescriptions and the duration of ET in days (from the start of the first prescription after completing surgery and chemotherapy). ET use was observed over five years. Low adherence was defined as a ratio smaller than 0.8 and high adherence as a ratio larger than or equal to 0.8. Distant recurrence-free survival (DRFS) was calculated from the day of the first diagnosis of EBC until onset of distant recurrence. Overall survival (OS) was defined as the period between first diagnosis of EBC until death of any cause. In total, 16642 patients with EBC were included. Of these patients, 4303 (86%) showed high adherence to ET in the first year after initiating treatment. After five years, high adherence persisted in 68% of patients. Continuous high adherence to ET had a significant impact on DRFS (HR: 0.66; 95% CI: 0.58-0.76, p > 0.0001) and OS (HR 0.52, 95% CI: 0.47-0.57, p < 0.0001). In conclusion, adherence to ET is an independent risk factor that significantly influences DRFS and OS. Further real-world studies should explore the factors contributing to treatment discontinuation and evaluate prospective strategies to enhance adherence.</p>","PeriodicalId":12481,"journal":{"name":"Geburtshilfe Und Frauenheilkunde","volume":"86 1","pages":"75-83"},"PeriodicalIF":1.9,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12803760/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145988967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shock in Pregnancy - Recommendations of the German Interdisciplinary Association for Intensive and Emergency Medicine (DIVI - Section Shock) and the Working Group on Obstetrics and Prenatal Medicine (AGG - Section on Maternal Disorders).","authors":"Thomas Standl, Thorsten Annecke, Stefan Geiger, Jan Kähler, Franz Kainer, Silvia Schönenberger, Sven Kehl","doi":"10.1055/a-2672-3968","DOIUrl":"10.1055/a-2672-3968","url":null,"abstract":"<p><p><b>Objective</b> The recommendations of the Shock Section of the German Interdisciplinary Association for Intensive and Emergency Medicine (DIVI) and the Maternal Disorders Section of the Working Group on Obstetrics and Prenatal Medicine (AGG) aim to improve the diagnosis and management of pregnant patients in shock. In 2018, the DIVI Shock Section published a revised classification of shock types. Given that pregnancy involves extensive physiological changes affecting all organ systems - with direct implications for the development and progression of shock - specific characteristics of shock in pregnancy were analyzed. <b>Methods</b> A selective literature review and iterative consensus process were conducted within the DIVI Shock Section and the Maternal Disorders Section of the AGG. <b>Results</b> Shock, defined as a state of circulatory failure characterized by a critical mismatch between oxygen delivery (DO ₂ ) and consumption (VO ₂ ), is common to all shock types, including in pregnant women. Unique features of pregnancy include altered sensitivity to triggering factors, modified classical shock symptoms, and specific diagnostic and therapeutic approaches to optimize outcomes for both mother and child. <b>Conclusions</b> The statements and recommendations facilitate the identification of underlying causes across the different forms of shock (hypovolemic, distributive, cardiogenic, and obstructive) and support the initiation of appropriate management strategies.</p>","PeriodicalId":12481,"journal":{"name":"Geburtshilfe Und Frauenheilkunde","volume":"85 12","pages":"1268-1275"},"PeriodicalIF":1.9,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12674898/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145677125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Prenatally Diagnosed Malformations of the Central Nervous System: Factors Influencing Decision-making and the Time of Termination of Pregnancy.","authors":"Christine Ibold, Massimiliano Lia, Holger Stepan, Renaldo Faber, Sabine Riße, Andreas Merkenschlager, Susanne Schrey-Petersen","doi":"10.1055/a-2641-7664","DOIUrl":"10.1055/a-2641-7664","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;CNS malformations are among the most common malformations diagnosed prenatally and one of the main reasons for late terminations of pregnancy. Making the correct diagnosis and prognostic counseling a33re complex. The aim of this study was to analyze pregnancy outcomes with regard to specific malformations, the factors which affect decision-making, and the time between diagnosis and termination as well as the causes of late diagnosis and late termination.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Patients and method: &lt;/strong&gt;A retrospective examination was carried out of all pregnancies with fetal CNS malformations treated at a perinatal center between 2003 and 2014. Termination rates, type of malformation, and gestational age at initial diagnosis and at termination were recorded. The factors influencing decision-making and the time between diagnosis and termination were analyzed statistically. A case-by-case analysis was carried out of any terminations performed after week 26+0 of gestation.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;In 139 of 251 cases (55.44%), the pregnancy was terminated between week 13+1 and week 38+2 of gestation (median: 22+4 GW). The median time from the initial diagnosis to the start of termination (Δtermination) was 10 days (range: 1 to 94 days). Relevant factors influencing the decision to terminate the pregnancy were the type of malformation compared to isolated ventriculomegaly (non-isolated ACC [aOR 17.5; p &lt; 0.001], holoprosencephaly [aOR 24.4; p &lt; 0.001], spina bifida [aOR 7.24; p &lt; 0.001], other neural tube defects [aOR 62.5; p &lt; 0.001]) and the presence of additional genetic anomalies (aOR 6.38; p = 0.014). The decision to terminate the pregnancy occurred less often when the diagnosis was made at or after week 22+0 of gestation (aOR 0.24; p &lt; 0.001). Significant factors which affected the time between diagnosis and the start of termination (Δtermination) were: having a fetal MRI (HR 0.41; p = 0.003) and maternal age (HR 0.95 per additional year; p = 0.034). The interval between diagnosis and termination was significantly shorter if a destructive abnormality (HR 10.5; p = 0.004) or a (non-spina bifida) neural tube defect (HR 3.86; p = 0.002) was present. A known chromosomal aberration (p = 0.87), non-CNS anomalies (p = 0.58), or a diagnosis ≥ 22+0 GW (p = 0.74) affected the time between diagnosis and termination. The analysis of particularly late terminations from week 26+0 of gestation onwards found that avoidable delays in making the diagnosis or terminating the pregnancy only occurred in a few individual cases.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;The diagnostic and prognostic complexity of cerebral malformations means that delayed diagnosis and prolonged decision-making are common, even under optimal conditions of care. Early introduction of standardized prenatal diagnostic examinations is needed for to ensure that the pregnant woman receives open-ended, informed counseling as soon as possible. But late termination","PeriodicalId":12481,"journal":{"name":"Geburtshilfe Und Frauenheilkunde","volume":"85 11","pages":"1203-1214"},"PeriodicalIF":1.9,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12591831/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145481484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interpregnancy Interval as a Determinant of Outcome in Women with Prophylactic Cerclage Following Preterm Birth or Late Miscarriage.","authors":"Filiz Markfeld-Erol, Aaron Riedling, Ingolf Juhasz-Böss, Mirjam Kunze, Julia Meschede","doi":"10.1055/a-2651-4971","DOIUrl":"10.1055/a-2651-4971","url":null,"abstract":"<p><strong>Background: </strong>Patients with a history of late miscarriage or preterm birth in a previous pregnancy may have a cerclage with total cervical closure (TCC) in a subsequent pregnancy to increase the likelihood of term delivery. This analysis investigates whether the interpregnancy interval influences the outcome of the subsequent pregnancy.</p><p><strong>Methods: </strong>In a retrospective cohort of 131 women who received a prophylactic cerclage with TCC following late miscarriage or preterm birth, the impact of the interpregnancy interval on pregnancy outcome was evaluated. Women were divided into three interpregnancy interval groups (0-6, 6-12, and > 12 months). Outcomes assessed included late miscarriage, preterm birth (stratified by gestational age), term birth (≥ 37+0 weeks of gestation), and neonatal parameters (Apgar scores, umbilical cord pH, birth weight, and admission to the neonatal intensive care unit [NICU]).</p><p><strong>Results: </strong>An interpregnancy interval of more than 12 months was associated with the highest rate of term deliveries (85.4%) and the best neonatal outcomes overall. This group had the lowest NICU admission rates, the highest birth weights, and the best Apgar scores. Very early preterm births (< 28+0 weeks) were observed more frequently in the shorter interval groups. Umbilical artery pH showed no correlation with the interpregnancy interval.</p><p><strong>Conclusion: </strong>A longer interpregnancy interval of more than 12 months was associated with a higher rate of deliveries ≥ 37+0 weeks and improved fetal outcomes in women with prophylactic cerclage and TCC after prior preterm birth or late miscarriage. In contrast, very early preterm births (< 28+0 weeks) occurred more often with shorter intervals.</p>","PeriodicalId":12481,"journal":{"name":"Geburtshilfe Und Frauenheilkunde","volume":"85 11","pages":"1195-1202"},"PeriodicalIF":1.9,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12591834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145481458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recommendations of the AGG (Obstetrics Working Group, Section for Maternal Diseases) for the Management of Anemia in Pregnancy - Part 1 (Iron Deficiency Anemia).","authors":"Amr Sherif Hamza, Sven Kehl, Jörg Bittenbring, Peter Kranke, Ulrich Pecks, Klaus Doubek, Monika Rehn","doi":"10.1055/a-2628-7308","DOIUrl":"10.1055/a-2628-7308","url":null,"abstract":"<p><strong>Objective: </strong>These recommendations by the AGG (Committee for Obstetrics, Department of Maternal Diseases) on how to treat iron-deficiency anemia during pregnancy aim to improve the diagnosis and management of iron-deficiency anemia in pregnancy.</p><p><strong>Methods: </strong>The task force members developed the following recommendations and statements based on the current literature. Recommendations were adopted after the members of the working group achieved consensus.</p><p><strong>Recommendations: </strong>This article gives an insight into the diagnosis and management of iron-deficiency anemia in pregnancy and provides recommendations on its treatment.</p>","PeriodicalId":12481,"journal":{"name":"Geburtshilfe Und Frauenheilkunde","volume":"85 12","pages":"1276-1287"},"PeriodicalIF":1.9,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12674900/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145677076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polycystic Ovary Syndrome - Support and Prevention in Adolescence.","authors":"Katja Wechsung, Uta Neumann, Nicole Balint, Susanna Wiegand","doi":"10.1055/a-2622-6321","DOIUrl":"10.1055/a-2622-6321","url":null,"abstract":"<p><p>For up to eight years after menarche, adolescents are in a developmental stage where PCOS (polycystic ovary syndrome) symptoms are physiological. The diagnostic criteria for PCOS in adult women therefore only partially apply. A new German S2k guideline and the international PCOS guideline of 2023 provide standardized diagnostic criteria for hyperandrogenemia and menstrual disorders in adolescence. The provisional diagnosis of PCOS at risk has been introduced for adolescents who only partially meet the criteria and this diagnosis must be revisited three and eight years after menarche. Recommendations for therapy focus on providing information and lifestyle advice to adolescents and on the prevention and treatment of possible comorbidities such as obesity, insulin resistance and hypertension. This paper presents an overview of a structured diagnostic workup and therapeutic approaches to support adolescents with PCOS.</p>","PeriodicalId":12481,"journal":{"name":"Geburtshilfe Und Frauenheilkunde","volume":"85 9","pages":"927-933"},"PeriodicalIF":1.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12404792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144992176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}