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Laparoscopic Transabdominal Needle-free Emergency Cerclage in the Early Second Trimester of Pregnancy after Failed Transvaginal Cerclage: Two Case Reports and a Review of the Literature. 腹腔镜经腹无针紧急宫腔粘连术在经阴道宫腔粘连术失败后的妊娠早期第二孕期应用:两例病例报告及文献综述。
IF 2.4 4区 医学
Geburtshilfe Und Frauenheilkunde Pub Date : 2024-10-01 DOI: 10.1055/a-2373-0639
Davut Dayan, Marinus Schmid, Florian K Ebner, Wolfgang Janni, Frank Reister, Beate Hüner, Krisztian Lato, Ulrike Friebe-Hoffmann, Stefan Lukac
{"title":"Laparoscopic Transabdominal Needle-free Emergency Cerclage in the Early Second Trimester of Pregnancy after Failed Transvaginal Cerclage: Two Case Reports and a Review of the Literature.","authors":"Davut Dayan, Marinus Schmid, Florian K Ebner, Wolfgang Janni, Frank Reister, Beate Hüner, Krisztian Lato, Ulrike Friebe-Hoffmann, Stefan Lukac","doi":"10.1055/a-2373-0639","DOIUrl":"10.1055/a-2373-0639","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of the study was to describe the preventive option and safety of laparoscopic transabdominal emergency cerclage in pregnant women with advanced cervical shortening after failed vaginal cerclage or in whom vaginal cerclage is no longer possible.</p><p><strong>Method: </strong>Laparoscopic isthmo-cervical emergency cerclage was carried out in two patients at 13+0 and 15+5 weeks of gestation (GW) respectively. Both patients had cervical shortening and it was no longer possible to expose the cervix after conization or re-conization. The attempts to carry out transvaginal cerclage were unsuccessful. The technical aspects, feasibility, safety, and pregnancy outcomes after laparoscopic transabdominal cerclage are presented here, based on two case reports.</p><p><strong>Results: </strong>The cerclages were placed after blunt dissection of the uterine vessels and careful introduction of a KELLY forceps through the avascular space between the ascending and descending branches of the uterine vessels without using a needle. The operating times were 93 and 134 minutes (min), respectively. The estimated blood loss during the procedure was less than 50 ml and neither perioperative nor postoperative complications occurred. The subsequent course of both pregnancies was uneventful and fetal development in both cases was normal. In the first case, the baby was delivered by secondary cesarean section following premature rupture of membranes in week 35+4 of gestation. The baby had a birthweight of 2786 g, APGAR scores of 8/9/10 and an umbilical cord arterial pH of 7.36. In the second case, delivery was by primary cesarean section in week 39+5 of gestation. The infant had a birth weight of 4160 g, APGAR scores of 5/9/10 and an umbilical cord arterial pH of 7.20.</p><p><strong>Conclusion: </strong>Laparoscopic transabdominal cerclage is a safe and effective treatment option, even early in the second trimester of pregnancy, for patients in whom transvaginal cerclage is no longer possible due to anatomical factors. The method is technically very feasible and is associated with positive obstetric outcomes. The overall risk of perioperative complications is within acceptable limits.</p>","PeriodicalId":12481,"journal":{"name":"Geburtshilfe Und Frauenheilkunde","volume":"84 10","pages":"989-998"},"PeriodicalIF":2.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11444752/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142364995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pregnancy Metabolic Adaptation and Changes in Placental Metabolism in Preeclampsia. 子痫前期的妊娠代谢适应和胎盘代谢变化。
IF 2.4 4区 医学
Geburtshilfe Und Frauenheilkunde Pub Date : 2024-09-19 eCollection Date: 2024-11-01 DOI: 10.1055/a-2403-4855
Yaxi Li, Ling Ma, Ruifen He, Fei Teng, Xue Qin, Xiaolei Liang, Jing Wang
{"title":"Pregnancy Metabolic Adaptation and Changes in Placental Metabolism in Preeclampsia.","authors":"Yaxi Li, Ling Ma, Ruifen He, Fei Teng, Xue Qin, Xiaolei Liang, Jing Wang","doi":"10.1055/a-2403-4855","DOIUrl":"https://doi.org/10.1055/a-2403-4855","url":null,"abstract":"<p><p>Pregnancy is a unique physiological state in which the maternal body undergoes a series of changes in the metabolism of glucose, lipids, amino acids, and other nutrients in order to adapt to the altered state of pregnancy and provide adequate nutrients for the fetus' growth and development. The metabolism of various nutrients is regulated by one another in order to maintain homeostasis in the body. Failure to adapt to the altered physiological conditions of pregnancy can lead to a range of pregnancy issues, including fetal growth limitation and preeclampsia. A failure of metabolic adaptation during pregnancy is linked to the emergence of preeclampsia. The treatment of preeclampsia by focusing on metabolic changes may provide new therapeutic alternatives.</p>","PeriodicalId":12481,"journal":{"name":"Geburtshilfe Und Frauenheilkunde","volume":"84 11","pages":"1033-1042"},"PeriodicalIF":2.4,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11543110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142618259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Induction of Labor Using Castor Oil Cocktail - an Analysis of Real-world Data. 使用蓖麻油鸡尾酒引产--真实世界数据分析。
IF 2.4 4区 医学
Geburtshilfe Und Frauenheilkunde Pub Date : 2024-09-12 eCollection Date: 2024-11-01 DOI: 10.1055/a-2397-1490
Stefanie Mona Ziegler, Yvonne Heimann, Ekkehard Schleussner, Friederike Weschenfelder, Tanja Groten
{"title":"Induction of Labor Using Castor Oil Cocktail - an Analysis of Real-world Data.","authors":"Stefanie Mona Ziegler, Yvonne Heimann, Ekkehard Schleussner, Friederike Weschenfelder, Tanja Groten","doi":"10.1055/a-2397-1490","DOIUrl":"https://doi.org/10.1055/a-2397-1490","url":null,"abstract":"<p><strong>Introduction: </strong>Induction of labor is indicated when benefits of delivery outweigh benefits of prolonged pregnancy, which is not always welcomed by women. Castor oil is accepted as an \"old household remedy\" for labor induction but is not yet part of the official guidelines. Nevertheless, it is often used, mostly even before the women are admitted to the hospital. Data on its actual benefits and safety are missing. Upon accepting the real-world practice of applying castor oil cocktail for labor induction we added castor oil as one option of labor induction in our clinical routine for multiparous women at term, with a history of at least one vaginal delivery. Here we aimed to generate data on the effectivity and safety of castor oil in labor induction by analyzing the real-world data generated in our cohort.</p><p><strong>Methods: </strong>In our retrospective analysis we included data of a cohort of 148 multiparous women induced by castor oil cocktail and of 286 matched controls receiving established methods according to the current guidelines for labor induction. The castor oil cocktail was prepared following a standardized recipe with quality-tested castor oil. Statistical analysis was performed with SPSS 27.0.</p><p><strong>Results: </strong>Perinatal outcome data including the rate of vaginal deliveries did not differ between groups, except significantly more neonates were admitted to the neonatal intensive care unit in the group receiving established methods for induction of labor (p = 0.01). In 39 women (26%), administration of castor oil cocktail alone failed to induce labor. The time from initiation of labor induction until delivery was significantly shorter in the castor oil cocktail group (p = 0.04).</p><p><strong>Conclusion: </strong>Our study demonstrates the safety and effectivity of a castor oil cocktail induction in multiparous women at term in a hospital-based setting using quality-controlled castor oil in a standardized recipe.</p>","PeriodicalId":12481,"journal":{"name":"Geburtshilfe Und Frauenheilkunde","volume":"84 11","pages":"1050-1056"},"PeriodicalIF":2.4,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11543103/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142618257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Self-reported Costs of Endometriosis Patients in Germany.
IF 2.4 4区 医学
Geburtshilfe Und Frauenheilkunde Pub Date : 2024-09-05 eCollection Date: 2024-12-01 DOI: 10.1055/a-2378-3468
Nicole Rebecca Heinze, Teresa Götz, Nadine Rohloff, Lisa Schaller, Roman Spelsberg, Sebastian Daniel Schäfer
{"title":"Self-reported Costs of Endometriosis Patients in Germany.","authors":"Nicole Rebecca Heinze, Teresa Götz, Nadine Rohloff, Lisa Schaller, Roman Spelsberg, Sebastian Daniel Schäfer","doi":"10.1055/a-2378-3468","DOIUrl":"10.1055/a-2378-3468","url":null,"abstract":"<p><p>Endometriosis patients face a significant economic burden. In addition to the directly attributable costs of the diagnosis and therapy of endometriosis, such as drug treatment and multimodal pain therapy, various indirect follow-up costs can be expected, e.g., due to incapacity for work and reduced work performance. As already reported in previous publications, endometriosis is associated with considerable costs for the health care system and society as well as for the affected women and their families. In order to measure the extent of the costs associated with endometriosis patients, 250 patients with an average age of 32.80 years were recruited via social media and interviewed about their self-financed costs as part of an online survey. The assessed direct costs comprise inpatient treatments, outpatient or pain therapy, fertility treatments, hormone therapies, prescribed and privately paid medications and aids, other therapeutic procedures, and directly attributable travel costs for endometriosis treatments. This resulted in an average cost of € 2059.55 per year. Indirect costs were calculated based on loss of income, day-to-day support, care costs, costs due to follow-up illnesses and other costs. On average, the indirect costs were € 2174.25. The average costs resulting from the survey totalled € 4233.81 per year with a standard deviation of € 8240.31. An increase of out-of-pocket costs can be assumed. This may result from an improved range of services for alternative treatment methods and an increased awareness of the need for personal investment in health. However, further health economic studies are needed to validate the results.</p>","PeriodicalId":12481,"journal":{"name":"Geburtshilfe Und Frauenheilkunde","volume":"84 12","pages":"1143-1149"},"PeriodicalIF":2.4,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11624002/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142793918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From Gaps to Solutions: Semi-Structured Interviews to Identify Care Gaps in Breast Cancer Care and How to Solve Them with Digital Solutions. 从差距到解决方案:通过半结构式访谈找出乳腺癌护理方面的差距,以及如何利用数字解决方案解决这些差距。
IF 2.4 4区 医学
Geburtshilfe Und Frauenheilkunde Pub Date : 2024-09-02 eCollection Date: 2024-09-01 DOI: 10.1055/a-2369-1489
Therese Pross, Maria Margarete Karsten, Jens-Uwe Blohmer
{"title":"From Gaps to Solutions: Semi-Structured Interviews to Identify Care Gaps in Breast Cancer Care and How to Solve Them with Digital Solutions.","authors":"Therese Pross, Maria Margarete Karsten, Jens-Uwe Blohmer","doi":"10.1055/a-2369-1489","DOIUrl":"10.1055/a-2369-1489","url":null,"abstract":"<p><strong>Background: </strong>Standardized treatment pathways should make it easier for medical staff and patients to achieve the best possible individual treatment outcome by making sure all relevant information are taken into consideration. The aim of this paper is to identify gaps in care along the treatment pathway through semi-structured patient interviews. Subsequently, it will be discussed if mobile health applications can close these identified gaps in care.</p><p><strong>Material and methods: </strong>Nine semi-structured interviews of patients with invasive lobular breast cancer were conducted in March 2023 in German at the breast cancer center at Charité Universitätsmedizin Berlin, which were subsequently transcribed word for word and processed using a thematic analysis approach.</p><p><strong>Results: </strong>Eight recurring themes are identified in the patient interviews: 1. Limited capacity to absorb information, 2. Discrepancy between information needs and information provision, 3. Need for individual initiative, 4. Uncertainty, 5. not being seen and heard, 6. Patient's desires and suggestions for improvement, 7. Use of mobile health apps, 8. Support through an app for patients.</p><p><strong>Conclusions: </strong>The identified gaps in care of breast cancer patients can be largely addressed through the use of digital health solutions after the establishment of regulatory frameworks, thus improving care for patients with early breast cancer.</p><p><strong>Trial registration: </strong>The interviews were done within a registry for which ethical approval was obtained by the Ethics Committee of Charité Universitätsmedizin Berlin EA4/180/17.</p>","PeriodicalId":12481,"journal":{"name":"Geburtshilfe Und Frauenheilkunde","volume":"84 9","pages":"845-854"},"PeriodicalIF":2.4,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11368466/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142125349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel Antibody-Drug-Conjugates in Routine Clinical Practice for the Treatment of Metastatic Breast Cancer: Adherence, Efficacy and Tolerability - Real-World Data from German Breast Centers. 常规临床实践中用于治疗转移性乳腺癌的新型抗体药物轭合物:依从性、疗效和耐受性--来自德国乳腺中心的真实世界数据。
IF 2.4 4区 医学
Geburtshilfe Und Frauenheilkunde Pub Date : 2024-09-02 eCollection Date: 2024-09-01 DOI: 10.1055/a-2375-5194
Henning Schäffler, Dorothee Jakob, Sophia Huesmann, Kerstin Pfister, Kristina Veselinovic, Fabienne Schochter, Elena Leinert, Visnja Fink, Brigitte Rack, Alexander Englisch, Lea-Louise Volmer, Tobias Engler, Marie Louise Frevert, Ingolf Juhasz-Böss, Sara Brucker, Sabine Heublein, Wolfgang Janni, Florin-Andrei Taran, Andreas Hartkopf, Dominik Dannehl
{"title":"Novel Antibody-Drug-Conjugates in Routine Clinical Practice for the Treatment of Metastatic Breast Cancer: Adherence, Efficacy and Tolerability - Real-World Data from German Breast Centers.","authors":"Henning Schäffler, Dorothee Jakob, Sophia Huesmann, Kerstin Pfister, Kristina Veselinovic, Fabienne Schochter, Elena Leinert, Visnja Fink, Brigitte Rack, Alexander Englisch, Lea-Louise Volmer, Tobias Engler, Marie Louise Frevert, Ingolf Juhasz-Böss, Sara Brucker, Sabine Heublein, Wolfgang Janni, Florin-Andrei Taran, Andreas Hartkopf, Dominik Dannehl","doi":"10.1055/a-2375-5194","DOIUrl":"10.1055/a-2375-5194","url":null,"abstract":"<p><strong>Introduction: </strong>The third-generation antibody-drug conjugates (ADC), trastuzumab deruxtecan (T-DXd) and sacituzumab govitecan (SG), recently obtained approval for metastatic breast cancer treatment across various subtypes and therapeutic contexts.</p><p><strong>Materials and methods: </strong>This retrospective, multicentric study evaluated real-world tolerability, feasibility and efficacy in a pre-treated, real-world cohort at three major German breast cancer centers.</p><p><strong>Results: </strong>125 patients treated with T-DXd or SG from November 2020 to June 2023 were included (T-DXd: 77 patients; SG: 48 patients). The median treatment duration was 6.0 months for T-DXd and 3.5 months for SG therapy, with a median follow-up duration of 10.4 months for T-DXd (95% CI: 8.4-11.6) and 11.8 months for SG (95% CI: 8.0-14.4). Severe neutropenia (CTC ≥ III°) occurred in 33.3% during SG therapy, with a numerical reduction observed following primary, prophylactic use of G-CSF. T-DXd-associated pneumonitis occurred in 8 out of 77 patients (10.4 %). Median progression-free survival (mPFS) was 8.6 months (95% CI: 5.8-12.4) with T-DXd (HER2+: 10.8; HER2-low: 4.7) and 4.9 months (95% CI: 2.8-6.3) with SG (TNBC 4.9; HR+/HER2-: not reached). Median overall survival (OS) was 23.8 months (95% CI: 16.1-not estimable) with T-DXd (HER2+: 27.1; HER2-low: not reached), and 12.4 months (95% CI: 8.7-not estimable) with SG therapy (TNBC: 12.4, HR+/HER2-: not reached). 95.7% of the protocol-specified, therapeutic dose was administered for T-DXd and 89.6% for SG.</p><p><strong>Conclusion: </strong>Overall, this indicates good feasibility, tolerability, and effectiveness of ADC therapies in the real-world setting.</p>","PeriodicalId":12481,"journal":{"name":"Geburtshilfe Und Frauenheilkunde","volume":"84 9","pages":"855-865"},"PeriodicalIF":2.4,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11368468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142125351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic Impact of Surgical Margin Status on Overall Survival of Patients with Early Breast Cancer: A Retrospective Analysis from the Department for Women's Medicine at Charité - University Hospital Berlin. 手术边缘状态对早期乳腺癌患者总生存期的预后影响:柏林夏里特大学医院妇女医学部的回顾性分析。
IF 2.4 4区 医学
Geburtshilfe Und Frauenheilkunde Pub Date : 2024-09-02 eCollection Date: 2024-09-01 DOI: 10.1055/a-2374-2270
Maximilian Heinz Beck, Karoline Barbara Stephanie Weiler, Anna Trelinska-Finger, Jens-Uwe Blohmer
{"title":"Prognostic Impact of Surgical Margin Status on Overall Survival of Patients with Early Breast Cancer: A Retrospective Analysis from the Department for Women's Medicine at Charité - University Hospital Berlin.","authors":"Maximilian Heinz Beck, Karoline Barbara Stephanie Weiler, Anna Trelinska-Finger, Jens-Uwe Blohmer","doi":"10.1055/a-2374-2270","DOIUrl":"10.1055/a-2374-2270","url":null,"abstract":"<p><strong>Introduction: </strong>The impact of surgical margins on the prognosis of early breast cancer remains uncertain, particularly in the context of modern treatment approaches. This study aimed to investigate whether involved margins after surgery for early breast cancer affect overall survival.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of 3767 patients who underwent surgery for primary breast cancer or carcinoma in situ between 2006 and 2022 at Charité - University Hospital Berlin. Survival analysis based on margin status and a subsequent multivariate Cox regression analysis were conducted.</p><p><strong>Results: </strong>With a median follow-up of 72.2 months, clear margins were achieved in 81.4% of patients (n = 3068) after primary surgery, while 16.2% (n = 610) required re-excision. Only 2.4% of patients (n = 89) had definitively involved margins. Margin involvement was more common in hormone receptor-positive disease, lobular subtype, carcinoma in situ, or locally advanced tumors, but less frequent in patients with previous neoadjuvant chemotherapy or triple-negative breast cancer. The Kaplan-Meier survival curves showed a significant separation with worse outcomes for patients with definitive R1 resections. However, the multivariate Cox regression analysis detected no statistically significant difference in overall survival based on margin status. Breast conserving surgery (HR 0.66; 95% CI 0.54-0.81) and HER2 overexpression (HR 0.65; 95% CI 0.48-0.89) were associated with improved survival.</p><p><strong>Conclusion: </strong>Patients who underwent breast-conserving surgery in our study demonstrated favorable outcomes compared to patients after mastectomy. Although margin status did not significantly affect overall survival, larger multicenter studies are needed to evaluate the prognostic implications of margin involvement in breast cancer treatment in different tumor stages, tumor subtypes and local and systemic treatments.</p>","PeriodicalId":12481,"journal":{"name":"Geburtshilfe Und Frauenheilkunde","volume":"84 9","pages":"837-844"},"PeriodicalIF":2.4,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11368467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142125362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply to: Letter to the Editor: Administration of Antenatal Corticosteroids: Optimal Timing. 答复致编辑的信:产前皮质类固醇的使用:最佳时间。
IF 2.4 4区 医学
Geburtshilfe Und Frauenheilkunde Pub Date : 2024-09-02 eCollection Date: 2024-09-01 DOI: 10.1055/a-2342-5218
Richard Berger, Patrick Stelzl, Holger Maul
{"title":"Reply to: Letter to the Editor: Administration of Antenatal Corticosteroids: Optimal Timing.","authors":"Richard Berger, Patrick Stelzl, Holger Maul","doi":"10.1055/a-2342-5218","DOIUrl":"10.1055/a-2342-5218","url":null,"abstract":"","PeriodicalId":12481,"journal":{"name":"Geburtshilfe Und Frauenheilkunde","volume":"84 9","pages":"877"},"PeriodicalIF":2.4,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11368460/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142125363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter to the Editor: Administration of Antenatal Corticosteroids: Optimal Timing. 致编辑的信:产前皮质类固醇的使用:最佳时间。
IF 2.4 4区 医学
Geburtshilfe Und Frauenheilkunde Pub Date : 2024-09-02 eCollection Date: 2024-09-01 DOI: 10.1055/a-2328-9427
Themistoklis Dagklis, Cihat Sen
{"title":"Letter to the Editor: Administration of Antenatal Corticosteroids: Optimal Timing.","authors":"Themistoklis Dagklis, Cihat Sen","doi":"10.1055/a-2328-9427","DOIUrl":"10.1055/a-2328-9427","url":null,"abstract":"","PeriodicalId":12481,"journal":{"name":"Geburtshilfe Und Frauenheilkunde","volume":"84 9","pages":"876"},"PeriodicalIF":2.4,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11368461/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142125350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Palbociclib: Randomized Studies and Real-world Evidence as the Basis for Therapeutic Planning in Metastatic Breast Cancer. 帕博西尼(Palbociclib):作为转移性乳腺癌治疗计划基础的随机研究和现实世界的证据。
IF 2.4 4区 医学
Geburtshilfe Und Frauenheilkunde Pub Date : 2024-09-02 eCollection Date: 2024-09-01 DOI: 10.1055/a-2344-5269
Eugen Ruckhäberle, Marcus Schmidt, Anja Welt, Nadia Harbeck, Achim Wöckel, Oleg Gluz, Tjoung-Won Park-Simon, Michael Untch, Michael P Lux
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