Geburtshilfe Und Frauenheilkunde最新文献

{"title":"Fertility Preservation for Patients with Malignant Disease. Guideline of the DGGG, OEGGG and SGGG (S2k-Level, AWMF Registry No. 015/082, May 2025).","authors":"Laura Lotz, Sabine Kliesch, Dunja Baston-Buest, Andreas Schüring, Magdalena Balcerek, Brigitta Bartsch, René Baumann, Matthias Beckmann, Karolin Behringer, Anja Borgmann-Staudt, Bettina Böttcher, Stefanie Corradini, Wolfgang Cremer, Andreas Dinkel, Tamara Diesch-Furlanetto, Stefanie Frenz, Ariane Germeyer, Maren Goeckenjan, Vera Hepp, Franc Hetzer, Andrea Jarisch, Heribert Kentenich, Ulrich A Knuth, Matthias Korell, Frank-Michael Köhn, Jana Bender-Liebenthron, Katja Lindel, Gloria Sarah Leszinski, Michael Lux, Julia Meißner, Oliver Micke, Alexander Müller, Frank Nawroth, Verena Nordhoff, Patricia Oppelt, Nicole Reisch, Elisabeth Reiser, Felix Reschke, Andreas Rink, Alexander Sahi, Nicole Sänger, Armin Soave, Schwab Roxana, Christian Sigg, Meike Sikora, Sascha Tauchert, Petra Thorn, Tobias Weberschock, Pauline Wimberger, Tewes Wischmann, Rachel Würstlein, Michael von Wolff, Ralf Dittrich","doi":"10.1055/a-2811-6101","DOIUrl":"https://doi.org/10.1055/a-2811-6101","url":null,"abstract":"<p><p><b>Goal</b> The aim of this official guideline, which was coordinated by the German Society of Gynaecology and Obstetrics (DGGG) together with the German Society of Urology (DGU) and the German Society of Reproductive Medicine (DGRM), is to provide consensus-based recommendations for counselling and the use of fertility preservation measures in prepuscent girls and boys and for patients of reproductive age by evaluating the relevant literature. <b>Methods</b> This S2k guideline was developed by a structured consensus of representative members of various professional associations on behalf of the guideline commission of the DGGG, DGU and DGRM. <b>Recommendations</b> Recommendations for counselling and the use of fertility-preserving measures in patients are presented, taking into account their life circumstances, the planned oncological therapy and the individual risk profile, as well as the procedure for selected tumour entities.</p>","PeriodicalId":12481,"journal":{"name":"Geburtshilfe Und Frauenheilkunde","volume":"86 4","pages":"333-375"},"PeriodicalIF":1.9,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13082884/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147767767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Registry Study of the Working Group on Cervical Pathology and Colposcopy (AGCPC) on the Diagnostic Algorithm for the New Cervical Cancer Screening - Persistent HPV Infections and Squamous Cell Lesions: Evaluation of over 10000 Patients.","authors":"Melanie Henes, Ellen Mann, Christine Hirchenhain, Alexander Kentner, Christina Selgrad, Monika Hampl, Mignon-Denise Keyver-Paik, Jens Quaas, Julia Gallwas, Christopher Koßagk, Martina Helbig, Paul Gaß, Farnaz Jakubek, Maximilian Klar, Leon Henes, Volkmar Küppers","doi":"10.1055/a-2800-5139","DOIUrl":"https://doi.org/10.1055/a-2800-5139","url":null,"abstract":"<p><strong>Introduction: </strong>Cervical cancer screening in Germany was newly regulated as of January 1, 2020. Since then, an organized cancer screening guideline (oKFE-RL) for cervical cancer screening has been effective. From the age of 20, a cytological smear is taken once a year and from the age of 35 a co-test is carried out every three years. In the event of abnormalities, an algorithm regulates the procedure. This algorithm states that even so-called low-risk groups should have a diagnostic colposcopy at an early stage. This approach has been widely discussed and continues to serve as the basis of this registry study.</p><p><strong>Methods: </strong>All patients who presented for a diagnostic colposcopy to the respective participating centers were included after consent. The focus was on the detection rate of CIN 3+ in diagnoses related to squamous cell changes and persistent HPV infection. The current data were compared with previous results to obtain information about the development of the new screening program.</p><p><strong>Results: </strong>A total of 12311 patients were included. The referral diagnosis was normal cytology and persistent HPV infection in 30.7%, normal cytology but positive case history and persistent HPV infection in 2.6%, and ASC-US in 11.0%. 7.7% had a cytological diagnosis of ASC-H and 17.6% had LSIL. 16.3% had HSIL (moderate dysplasia), 9.2% had HSIL (severe dysplasia) and 0.3% had HSIL with features suspicious for invasion. Cytology-diagnosed squamous cell carcinoma was found 0.2%. CIN 3+ was found in 63.3% of cases with HSIL (severe dysplasia). 27.4% of the HSIL group (moderate dysplasia) were diagnosed as CIN 3+ and 27.6% of the ASC-H group as CIN 3+ but with a relatively high percentage of cervical carcinomas (n = 7). CIN 3+ was identified in 10.7% of the LSIL group and in 10.8% of the ASC-US group. In the groups with persistent HPV infection/normal cytology (with or without a positive case history), 7.1/6.3% were diagnosed as CIN 3+ and 12.8% of HPV-negative patients as CIN 3+. When groups were differentiated according to age into \"below the age of 35\" and \"35 years and above\", only the younger group of HPV-negative patients had a statistically significantly higher rate of CIN 3+.</p><p><strong>Discussion: </strong>Using these data, we were able to show that, with the exception of the group with persistent HPV infection/normal cytology (without or with a positive case history), the target lesion CIN 3+ was identified in over 10% of cases. We suggest that a reevaluation to take high-risk HPV types into consideration should be carried out as some HPV types are associated with a significantly higher risk of developing cervical cancer and its precursors than other types. It is too early to say whether the new screening program will reduce the incidence and mortality of cervical cancer; this will need to be checked in further evaluations.</p>","PeriodicalId":12481,"journal":{"name":"Geburtshilfe Und Frauenheilkunde","volume":"86 4","pages":"382-394"},"PeriodicalIF":1.9,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13082886/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147767765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cervical Dysplasia Diagnosed in Pregnancy - A Pre- and Postpartum Analysis.","authors":"Carsten Hagenbeck, Martina Helbig, Luisa Brandi, Jan-Philipp Cieslik, Nadine Scholten, Tanja Fehm, Monika Hampl","doi":"10.1055/a-2823-0518","DOIUrl":"https://doi.org/10.1055/a-2823-0518","url":null,"abstract":"<p><strong>Background/purpose: </strong>Cervical lesion regression and persistence rates are notably high. This study aims to analyse postpartum changes in cervical dysplasia diagnosed during pregnancy. Furthermore, the impact of age, tobacco use, and mode of delivery on cervical findings was assessed as the existing data is inconclusive.</p><p><strong>Methods: </strong>This retrospective analysis included pregnant women diagnosed with cervical dysplasia, with complete pre- and postpartum colposcopy, cytology, and histological findings, along with HPV status. Postpartum rates of regression, persistence, and progression were determined and the influence of age, tobacco use, and mode of delivery on cervical preneoplastic lesions was analysed using ordered logistic regression.</p><p><strong>Results: </strong>The study included 102 patients treated between 2010 and 2015 with complete pre- and postpartum cytology and/or biopsy data. Postpartum evaluation showed a regression rate of 45.1%, persistence in 52%, and progression in 2.9%. No significant influence on these rates was observed for age (p = 0.255), tobacco use (p = 0.310), or mode of delivery (p = 0.217).</p><p><strong>Conclusion: </strong>Our findings support the recommended conservative approach of managing cervical lesions during pregnancy which advocates for continuation of the pregnancy with regular monitoring and postpartum surgery if necessary. If invasive cancer can be excluded, the mode of delivery should be based on obstetric criteria, irrespective of cervical findings.</p>","PeriodicalId":12481,"journal":{"name":"Geburtshilfe Und Frauenheilkunde","volume":"86 4","pages":"395-402"},"PeriodicalIF":1.9,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13082885/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147767801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Treatment of Patients with Early Breast Cancer: 19th St. Gallen International Breast Cancer Consensus Discussed against the Background of German Treatment Recommendations.","authors":"Michael Untch, Maggie Banys-Paluchowski, Sara Y Brucker, Carsten Denkert, Peter A Fasching, Renate Haidinger, Nadia Harbeck, Wolfgang Janni, David Krug, Sibylle Loibl, Diana Lüftner, Laura Michel, Eva Schumacher-Wulf, Christine Solbach, Rachel Würstlein, Jens Huober, Nina Ditsch","doi":"10.1055/a-2832-0168","DOIUrl":"https://doi.org/10.1055/a-2832-0168","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1055/a-2612-3790.].</p>","PeriodicalId":12481,"journal":{"name":"Geburtshilfe Und Frauenheilkunde","volume":"86 3","pages":"e1"},"PeriodicalIF":1.9,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12981963/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147467525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"INTERLACE Study: Real-world Data for Germany Based on a Case Series of Patients with Locally Advanced Cervical Cancer.","authors":"Alina Lohner, Volkmar Müller, Andrea Baehr, David Krug, Cordula Petersen, Anna Jaeger, Barbara Schmalfeldt, Charlotte Sachs, Linn Woelber","doi":"10.1055/a-2781-3692","DOIUrl":"https://doi.org/10.1055/a-2781-3692","url":null,"abstract":"<p><strong>Introduction: </strong>Primary chemoradiotherapy is the established and standard treatment for locally advanced cervical cancer. The INTERLACE study investigated the impact of adding induction chemotherapy with six cycles of carboplatin AUC2 and paclitaxel 80 mg/m ² weekly prior to chemoradiotherapy on recurrence-free and overall survival. However, adaptation with adoption into routine clinical practice in Germany has been rather cautious.</p><p><strong>Methods: </strong>Patients treated according to the INTERLACE scheme at the University Medical Center Hamburg-Eppendorf between October 2023 and December 2024 were evaluated and described.</p><p><strong>Results: </strong>Seven patients with advanced cervical cancer (ECOG 0-1, median age 37 years, 43% FIGO stage IB1/2) treated with the INTERLACE regimen were identified during the study period. All patients received six cycles of the planned induction chemotherapy. The median time between completion of chemotherapy and the start of radiotherapy was 10 days, with the total duration of treatment varying between 43 and 63 days. All patients were able to complete radiotherapy using tele- and brachytherapy. 43% received all 5-6 cycles of cisplatin, 86% received at least four cycles of cisplatin simultaneously with radiotherapy. There were various reasons for discontinuing concomitant chemotherapy (1 hematological, 3 non-hematological).</p>","PeriodicalId":12481,"journal":{"name":"Geburtshilfe Und Frauenheilkunde","volume":"86 4","pages":"376-381"},"PeriodicalIF":1.9,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13082883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147767813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Barriers and Facilitators Affecting the Care of Patients with Endometriosis: A Scoping Review.","authors":"Selina Bayrak, Alena Allak, Till Neugebauer, Siegrun Pardon, Yüce Yilmaz-Aslan, Sven Schiermeier, Claudia Kiessling, Sven Schmiedl, Christoph Dockweiler, Patrick Brzoska","doi":"10.1055/a-2765-4322","DOIUrl":"10.1055/a-2765-4322","url":null,"abstract":"<p><strong>Background: </strong>Endometriosis affects around 10-15% of women of reproductive age worldwide. Despite its prevalence and the considerable pain and psychological stress associated with the disease, the care of those affected is associated with numerous challenges. A central problem is the often delayed diagnosis, which takes 6-10 years on average. However, early diagnosis is essential for appropriately targeted therapeutic approaches. The specific barriers that contribute to delayed diagnosis and inadequate care have not yet been comprehensively identified. The aim of this scoping review was therefore to systematically identify existing barriers and facilitators to derive approaches for improving diagnosis and doctor-patient communication in Germany.</p><p><strong>Methods: </strong>A systematic search of international studies was conducted in accordance with the PRISMA-ScR guidelines to identify relevant German- and English-language publications in the period from 2014 to 2024. The search was conducted in various scientific databases. Empirical studies on barriers and facilitators in endometriosis care were included. After screening and selection, 39 relevant publications remained, based on which eight main categories were inductively derived.</p><p><strong>Results: </strong>Primary barriers include delays in diagnosis, stigmatization of menstrual pain, emotional distress such as shame and fear, inadequate pain management, and structural barriers. The findings suggest that effective interdisciplinary collaboration and patient-centered communication between doctors and patients are essential to reduce diagnostic delays and optimize care. Furthermore, individual studies suggest that digital technologies have the potential to encourage patients to document and communicate their symptoms.</p><p><strong>Discussion: </strong>The results of the study suggest that the stigmatization of endometriosis significantly complicates its care in the health care system. Consequently, interdisciplinary care models, targeted training of medical professionals, and measures to strengthen doctor-patient communication are key approaches for patient-centered and early care.</p>","PeriodicalId":12481,"journal":{"name":"Geburtshilfe Und Frauenheilkunde","volume":"86 2","pages":"189-200"},"PeriodicalIF":1.9,"publicationDate":"2026-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12893801/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146178861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis and Therapy of Endometriosis. Guideline of the DGGG, OEGGG and SGGG (S2k-Level, AWMF Registry No. 015/045, April 2025).","authors":"Stefanie Burghaus, Sebastian D Schäfer, Karl-Jürgen Bär, Julia Bartley, Matthias W Beckmann, Angelika Behrens, Katharina Beyer, Nicole Bianchi, Iris Brandes, Christian Brünahl, Eike-Christian Burandt, Radek Chvátal, Frederic Dietzel, Beate Ditzen, Jan Drahoňovský, Axel Eickhoff, Joachim Erlenwein, Tanja Fehm, Peter Martin Fehr, Ricardo E Felberbaum, Reinhild Georgieff, Dieter Grab, Donata Grimm-Glang, Andreas Hackethal, Katharina Hancke, Winfried Häuser, Markus Hoopmann, Christian Houbois, Christian Krautz, Harald Krentel, Klaudija Künzel, Simone Linsenbühler, Gwendolin Manegold-Brauer, Ines Mayer-Hrusa, Sylvia Mechsner, Harald Meden, Michael Müller, Monika Nothacker, Patricia G Oppelt, Peter Oppelt, Barbara Pasiecznyk, Esther Pogatzki-Zahn, Stefan P Renner, Michelle Röhrig, Daniela Rosenberger, Frank Ruhland, Nicole Sänger, Jana Schmid, Karl-Werner Schweppe, Friederike Siedentopf, Horia Sirbu, Runa Speer, Petra Thorn, Denis I Trufa, Frauke von Versen-Höynck, Friederike Vogeler, Kerstin Weidner, Tewes Wischmann, Katharina Wittek, Monika Wölfler, Isabella Zraik, Uwe A Ulrich","doi":"10.1055/a-2760-4867","DOIUrl":"https://doi.org/10.1055/a-2760-4867","url":null,"abstract":"<p><p><b>Objective</b> The objective of this revised official guideline, published by the German Society for Gynecology and Obstetrics (DGGG) and coordinated in the joint guidelines program of the DGGG, the Austrian Society for Gynecology and Obstetrics (OEGGG), and the Swiss Society for Gynecology and Obstetrics (SGGG), is to provide evidence-based and consensus-based recommendations for the diagnosis, treatment, care, and support of girls and women with confirmed or suspected endometriosis. <b>Methods</b> This S2k guideline was developed through a structured consensus process involving representative members of various professions (37 professional associations, organizations, and self-help groups) and includes 25 statements and 73 recommendations which are based on a systematic literature review (2019 - 2023) and expert consensus. <b>Recommendations</b> For the first time, the revised guideline has placed a greater focus on individualized, symptom-oriented diagnosis and treatment that combines hormonal, surgical, and multimodal approaches. A significant innovation is the use of transvaginal ultrasound as the central diagnostic procedure for detecting endometriosis. Therapeutically, primary hormone treatment is now recommended as the first choice approach, with surgical interventions and multimodal approaches supplemented on an individual and symptom-oriented basis.</p>","PeriodicalId":12481,"journal":{"name":"Geburtshilfe Und Frauenheilkunde","volume":"86 2","pages":"133-188"},"PeriodicalIF":1.9,"publicationDate":"2026-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12893799/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146178884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Induction of Labour with Prostaglandins: Does Their Pro-Inflammatory Effect Mimic Chorioamnionitis After PROM?","authors":"Anne Karge, Lukas Knabe, Chiara Lecce, Bernhard Haller, Gabriel Eisenkolb, Maximilian Riedel, Silvia M Lobmaier, Javier U Ortiz, Bettina Kuschel, Oliver Graupner, Kathrin Abel","doi":"10.1055/a-2774-7487","DOIUrl":"https://doi.org/10.1055/a-2774-7487","url":null,"abstract":"<p><strong>Purpose: </strong>Induction of labour (IOL) is commonly performed by administration of prostaglandin E (PGE). As pro-inflammatory agents, a known side-effect of PGE is maternal fever. This is problematic as it potentially mimics chorioamnionitis and may lead to unnecessary interventions such as administration of antibiotics or cesarean section. The aim of the study was therefore to investigate the effect of PGE on pregnancy outcomes.</p><p><strong>Methods: </strong>Retrospective single-centre cohort study with inclusion of women ≥ 37 weeks of gestation who underwent IOL with PGE and subsequently developed PROM (Group 1) or women who presented with spontaneous PROM without contractions (Group 2). At the time of PROM, CRP and white blood count (WBC) were assessed. We compared rates of maternal fever, Triple I, mode of delivery, and administration of antibiotics between Group 1 and Group 2.</p><p><strong>Results: </strong>A total of n = 850 women were included (Group 1: 200, Group 2: 650). CRP levels were higher in patients with more prolonged PGE administration (< 12 hours: 0.3 mg/dL vs. > 48 hours: 1.4 mg/dL, p = 0.002; r = 0.309; p < 0.001). WBCs were also higher after PGE administration (11.1 × 10 ⁹ /L vs. 9.5 × 10 ⁹ /L, p < 0.001). The logistic regression model revealed an association between IOL with PGE and antibiotics during labour. However, the rates of maternal fever and suspected Triple I did not differ significantly between the two groups, nor did the mode of delivery.</p><p><strong>Conclusion: </strong>IOL with PGE increases maternal serum levels of CRP (time-dependently), as well as WBC. This might lead to overtreatment with antibiotics during labour. However, the diagnosis of maternal fever or rates of suspected Triple I were not affected in our cohort.</p>","PeriodicalId":12481,"journal":{"name":"Geburtshilfe Und Frauenheilkunde","volume":"86 3","pages":"273-280"},"PeriodicalIF":1.9,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12978870/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147443040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Setting of Induction of Labour with Double-Balloon Catheter in Low-risk Pregnancies: Outpatient Versus Inpatient.","authors":"Sven Kehl, Anne Gernhardt, Christel Weiss, Michael O Schneider, Matthias W Beckmann, Jutta Pretscher","doi":"10.1055/a-2780-1607","DOIUrl":"https://doi.org/10.1055/a-2780-1607","url":null,"abstract":"<p><strong>Objectives: </strong>Induction of labour is one of the most frequently performed obstetric procedures. This analysis aimed to assess maternal and neonatal outcomes after labour induction with a double-balloon catheter in an outpatient versus inpatient setting in low-risk term pregnancies.</p><p><strong>Methods: </strong>In this retrospective cohort study, 1010 women with singleton, low-risk term pregnancies undergoing labour induction with a double-balloon catheter were analysed. Of these, 394 received outpatient and 616 inpatient cervical ripening. The primary outcome was the caesarean section rate; secondary outcomes included the induction-to-delivery interval, vaginal delivery within 24 hours and neonatal parameters.</p><p><strong>Results: </strong>Delivery modes were comparable between groups (p = 0.5524), but vaginal delivery within 24 hours occurred less frequently in the outpatient group (25.2% vs. 32.9%, p = 0.0201). Neonatal outcomes were significantly better in the outpatient cohort, with lower rates of arterial umbilical cord pH < 7.10 (2.0% vs. 5.5%, p = 0.0067) and NICU admissions (6.9% vs. 15.1%, p < 0.0001). Multiple logistic regression analysis identified nulliparity (OR = 10.545), maternal age (OR = 1.076), and birth weight (OR = 1.733) as significant predictors for caesarean section. Failure to achieve vaginal delivery within 24 hours was associated with higher BMI (OR = 1.080), nulliparity (OR = 4.191), and fetal macrosomia (OR = 3.675), while labour onset by balloon catheter alone reduced this risk (OR = 0.149). Outpatient induction was associated with a lower risk of arterial pH < 7.10 (OR = 0.352, p = 0.0088).</p><p><strong>Conclusions: </strong>Outpatient cervical ripening with a double-balloon catheter is a safe and effective alternative to inpatient induction in low-risk term pregnancies, with comparable delivery outcomes and potential neonatal benefits.</p>","PeriodicalId":12481,"journal":{"name":"Geburtshilfe Und Frauenheilkunde","volume":"86 3","pages":"281-288"},"PeriodicalIF":1.9,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12978867/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147443088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iodine Supplementation Before, During and After Pregnancy.","authors":"Rolf Grossklaus, Klaus-Peter Liesenkötter, Burkhard Lawrenz, Frank Thieme","doi":"10.1055/a-2739-3580","DOIUrl":"https://doi.org/10.1055/a-2739-3580","url":null,"abstract":"<p><p>This narrative review reports on the currently insufficient intake of iodine and the iodine status of pregnant and breastfeeding women in Germany, Europe, and worldwide, as well as presenting the associated risks, particularly for children's neurocognitive and psychomotor development. The responsibility of public health bodies to introduce appropriate measures which will ensure adequate iodine intake for all population groups and to monitor their implementation, especially during pregnancy and lactation which are particularly critical periods for the unborn child and the breastfed infant, is emphasized. Based on recent studies, the current national recommendations for iodine supplementation are reviewed, and the benefits and drawbacks of necessary measures to improve iodine intake for pregnant and breastfeeding women and their children are discussed. The most important iodine prophylaxis method - even during pregnancy and lactation - remains universal salt iodization. If this approach to improve widespread iodine intake is not feasible, the AKJ recommends that especially women of reproductive age should take continuous iodine supplements, starting at least three months prior to conception and continuing throughout pregnancy and breastfeeding.</p>","PeriodicalId":12481,"journal":{"name":"Geburtshilfe Und Frauenheilkunde","volume":"86 3","pages":"257-272"},"PeriodicalIF":1.9,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12978872/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147442988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}