Forensic Science, Medicine and Pathology最新文献_第7页

A novel COL3A1 gene variant associated with sudden death due to spontaneous pneumothorax. 一种新的COL3A1基因变异与自发性气胸猝死相关

IF 1.4 4区医学

Forensic Science, Medicine and Pathology Pub Date : 2025-09-01 Epub Date: 2025-01-14 DOI: 10.1007/s12024-025-00942-8

Syeda Hania Qamar, Maliha Khara, Jayantha C Herath

引用次数: 0

Remarkable spine erosion in cardiovascular syphilis - Computed tomography reconstruction of a century-old forensic case. 心血管梅毒中显著的脊柱侵蚀——一个世纪前法医病例的计算机断层扫描重建。

IF 1.4 4区医学

Forensic Science, Medicine and Pathology Pub Date : 2025-09-01 Epub Date: 2025-02-17 DOI: 10.1007/s12024-025-00961-5

Aleksa Leković, Petar Milenković, Jasmina Stevanović, Slobodan Nikolić

{"title":"Remarkable spine erosion in cardiovascular syphilis - Computed tomography reconstruction of a century-old forensic case.","authors":"Aleksa Leković, Petar Milenković, Jasmina Stevanović, Slobodan Nikolić","doi":"10.1007/s12024-025-00961-5","DOIUrl":"10.1007/s12024-025-00961-5","url":null,"abstract":"This is the most intriguing museum specimen of cardiovascular syphilis, collected in the Forensic Museum founded by professor Milovan Milovanović (1884-1948) in 1923, the first professor of Forensic Pathology in the newly established University School of Medicine in Belgrade. We aimed to analyze the specimen of an autopsy case from the year 1929 in which severe thoracic spine erosion occurred due to syphilitic aneurism and to demonstrate findings by multi-detector computed tomography (MDCT). The specimen comprises an en-block-eviscerated heart, thoracic aorta, thoracic spine, and posterior segments of the ribs, with a partial section of the heart and a longitudinal section of the aorta. We performed histology and MDCT analyses almost a century after the autopsy and revised the original case documentation. The conducted analyses confirmed the characteristic pathology. Most importantly, MDCT imaging revealed intriguing destruction of the vertebral bodies by the pulsatile saccular aneurysm of the descending aorta. The calcified aneurysm led to the extensive irregular mechanically caused osteolysis of the anterior segments of the several vertebral corpora. After the analysis and revision of the original case documentation, we discussed these findings, as well as additional characteristic autopsy findings in syphilis-related deaths, some of which might be forgotten. The direct close contact of the syphilitic aortic aneurysm with the thoracic spine was preserved. By utilizing postmortem MDCT and 3D reconstruction, we better visualize the thoracic spine bone resorption and alteration: in the time of Milovanović, only roentgenography was available, providing less detail.","PeriodicalId":12449,"journal":{"name":"Forensic Science, Medicine and Pathology","volume":" ","pages":"1581-1588"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnosing coronary artery dissection using virtual autopsy in a resource-poor setting- a case report. 在资源贫乏的情况下使用虚拟尸检诊断冠状动脉夹层- 1例报告。

IF 1.4 4区医学

Forensic Science, Medicine and Pathology Pub Date : 2025-09-01 Epub Date: 2025-03-07 DOI: 10.1007/s12024-025-00967-z

Chathula Ushari Wickramasinghe, Murugupillai Sivasubramanium, Sameera Gunasekara, Gayan Kumarasinghe, Saman Chandradasa

{"title":"Diagnosing coronary artery dissection using virtual autopsy in a resource-poor setting- a case report.","authors":"Chathula Ushari Wickramasinghe, Murugupillai Sivasubramanium, Sameera Gunasekara, Gayan Kumarasinghe, Saman Chandradasa","doi":"10.1007/s12024-025-00967-z","DOIUrl":"10.1007/s12024-025-00967-z","url":null,"abstract":"Introduction: The development of technology has significantly impacted the evolution of autopsy techniques worldwide. Initially described by Richard Dirnhofer, the concept of \"Virtual Autopsy (VA)\" or \"Virtopsy\" involves combining innovative technology with Conventional Autopsy (CA). This has permitted a non-/minimally invasive approach to postmortem examinations.Case report: A 65-year-old male, a known patient with ischaemic heart disease, hypertension, and dyslipidaemia, who had defaulted treatment, was found dead at home. The body was brought to the National Hospital Kandy for post-mortem examination. The internal dissection revealed a haemopericardium of 50 ml. Bleeding into the epicardial tissue throughout the course of the circumflex artery was noted. With the suspicion of coronary artery aneurysm rupture/dissection, ex-situ contrast-enhanced radiography was done on the heart to identify the point of bleeding. This was done by cannulating the left coronary ostia, through which a contrast dye was injected and X-ray images taken. With the assistance of the radiographs combined with careful dissection and histology, circumflex artery dissection and the rupture site were identified more accurately.Conclusion: VA has many uses, as an adjunct to CA to accentuate the findings of CA and enable targeted system-specific CA. Based on various factors such as the availability of technology, expertise, and post-mortem rate, the use of VA should be customized to each country to obtain the maximum benefits.","PeriodicalId":12449,"journal":{"name":"Forensic Science, Medicine and Pathology","volume":" ","pages":"1570-1573"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A rare case of lethal lactic acid poisoning: an autopsy case report. 一例罕见的致死性乳酸中毒：尸检病例报告。

IF 1.4 4区医学

Forensic Science, Medicine and Pathology Pub Date : 2025-09-01 Epub Date: 2025-04-16 DOI: 10.1007/s12024-025-01005-8

Deepu Mathew, Keerthi Kumaran, Alagarasan Naveen, Ambika Prasad Patra, Pampa Ch Toi

{"title":"A rare case of lethal lactic acid poisoning: an autopsy case report.","authors":"Deepu Mathew, Keerthi Kumaran, Alagarasan Naveen, Ambika Prasad Patra, Pampa Ch Toi","doi":"10.1007/s12024-025-01005-8","DOIUrl":"10.1007/s12024-025-01005-8","url":null,"abstract":"More than 700,000 people die due to suicide every year, and ingestion of pesticides, hanging, and firearms are among the most commonly used suicide methods globally. Although corrosives are among the least preferred agents for suicide due to the extreme pain caused and the possibility of prolonged suffering instead of immediate death, cases of ingestion continue to be observed. Commonly ingested corrosive substances include acids such as hydrochloric and sulfuric acid, alkalis such as sodium and potassium hydroxide, heavy metal salts, formalin, and iodine tincture. However, previous literature has not reported cases of poisoning with lactic acid preparations in adults. In this report, we discuss the death of a 67-year-old male following the consumption of Lactisan, a commercial preparation of lactic acid used in the dairy industry. The diagnosis and management of lactic acid poisoning pose challenges due to the lack of any previous data and the short half-life of lactic acid in the bloodstream. The laboratory investigation showed severe lactic acidosis. We discuss in detail the gross and microscopic features of lactic acid poisoning. This case report emphasizes the need for awareness among healthcare professionals about such uncommon but potentially fatal poisonings.","PeriodicalId":12449,"journal":{"name":"Forensic Science, Medicine and Pathology","volume":" ","pages":"1267-1272"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144000082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Utility of 3D facial reconstruction for forensic identification: a focus on facial soft tissue thickness and customized techniques. 用于法医鉴定的3D面部重建的实用性：侧重于面部软组织厚度和定制技术。

IF 1.4 4区医学

Forensic Science, Medicine and Pathology Pub Date : 2025-09-01 Epub Date: 2025-01-17 DOI: 10.1007/s12024-025-00945-5

Thawanthorn Chaimongkhol, Pagorn Navic, Apichat Sinthubua, Patison Palee, Nuttaya Pattamapaspong, Sukon Prasitwattanaseree, Arnon Charuakkra, Pasuk Mahakkanukrauh

{"title":"Utility of 3D facial reconstruction for forensic identification: a focus on facial soft tissue thickness and customized techniques.","authors":"Thawanthorn Chaimongkhol, Pagorn Navic, Apichat Sinthubua, Patison Palee, Nuttaya Pattamapaspong, Sukon Prasitwattanaseree, Arnon Charuakkra, Pasuk Mahakkanukrauh","doi":"10.1007/s12024-025-00945-5","DOIUrl":"10.1007/s12024-025-00945-5","url":null,"abstract":"Facial reconstruction, a crucial method in forensic identification, finds particular significance in cases where conventional means of identification are unavailable. This study addresses a significant gap in the field of forensic facial reconstruction focusing on facial soft tissue thickness (FSTT) and facial reconstruction techniques specifically tailored to the Thai population. By developing and implementing the 3D (three-dimensional) facial reconstruction program and compiling an extensive dataset of FSTT, this research makes substantial progress in advancing forensic facial reconstruction methodologies employing the combination Manchester Method, 3D skull images obtained through cone beam computed tomography (CBCT) scans were reconstructed using Autodesk Maya software. A dataset comprising 100 Thai cadavers underwent FSTT measurements via ultrasound (US) for 53 landmarks, with subsequent facial comparisons of 10 samples between reconstructed faces and real photographs conducted using the facial pool comparison and the structural similarity index (SSIM). The accuracy of facial pool comparison ranged from 30 to 80%, reflecting a wide range due to human errors. Thus, incorporating computerized assessment is necessary to minimize human bias. SSIM values ranged from 0.76 to 0.89, indicating strong similarity between reconstructed and real faces and validating the reconstruction process's accuracy. These findings suggest that the facial soft tissue thickness database of the Thai population used in this study can effectively support 3D computerized facial reconstruction. Moreover, this study sets the stage for future advancements in facial reconstruction methodologies tailored to diverse populations, emphasizing the ongoing need for comprehensive data gathering and technique refinement to enhance accuracy and applicability in forensic investigations.","PeriodicalId":12449,"journal":{"name":"Forensic Science, Medicine and Pathology","volume":" ","pages":"1112-1126"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143003163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review of micro-computed tomography and artificial intelligence in talus-based forensic anthropology for sex and age estimation. 基于距骨的法医人类学中用于性别和年龄估计的微型计算机断层扫描和人工智能综述。

IF 1.4 4区医学

Forensic Science, Medicine and Pathology Pub Date : 2025-09-01 Epub Date: 2025-03-29 DOI: 10.1007/s12024-025-00987-9

Intasin Kitpatanasombat, Pittayarat Intasuwan, Pasuk Mahakkanukrauh

{"title":"A review of micro-computed tomography and artificial intelligence in talus-based forensic anthropology for sex and age estimation.","authors":"Intasin Kitpatanasombat, Pittayarat Intasuwan, Pasuk Mahakkanukrauh","doi":"10.1007/s12024-025-00987-9","DOIUrl":"10.1007/s12024-025-00987-9","url":null,"abstract":"Biological profiling is a crucial tool in forensic science, allowing for evaluating biological information from bones found at crime scenes. This method includes assessments of sex, age, stature, and ancestry. Sex assessment is the first step in biological profiling, as it influences other assessments. Age estimation is a particularly challenging aspect. Combining sex and age assessment may improve accuracy in age estimation. Researchers often use the pelvis and skull bones for these assessments due to their prevalence at crime scenes and their higher accuracy in evaluation. However, the talus, a foot bone with robust density, resilience, and resistance to damage, is another bone frequently encountered at crime scenes and may be a valuable subject for study. Medical imaging technology, particularly micro-CT imaging, supports sex and age assessment. Micro-CT images can significantly enhance the accuracy of assessments. The high resolution of these images presents an exciting opportunity for exploration in conjunction with artificial intelligence (AI), which has revolutionized forensic science workflows. AI can potentially improve the efficiency and accuracy of sex and age assessment from bones. This article compiles research on past sex and age assessments and evaluations of the talus, including the application of micro-CT images to support these assessments. The aim is to provide a comprehensive knowledge base for studying sex and age assessment from the talus using micro-CT images in conjunction with AI.","PeriodicalId":12449,"journal":{"name":"Forensic Science, Medicine and Pathology","volume":" ","pages":"1345-1357"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the capabilities of Micro-XRF to study the dispersion of GSR in firearms cases. 探索Micro-XRF在火器案件中研究GSR扩散的能力。

IF 1.4 4区医学

Forensic Science, Medicine and Pathology Pub Date : 2025-09-01 Epub Date: 2025-03-22 DOI: 10.1007/s12024-025-00989-7

Niha Ansari, Hemang Parmar

{"title":"Exploring the capabilities of Micro-XRF to study the dispersion of GSR in firearms cases.","authors":"Niha Ansari, Hemang Parmar","doi":"10.1007/s12024-025-00989-7","DOIUrl":"10.1007/s12024-025-00989-7","url":null,"abstract":"The forensic scientific establishment requires an evaluation of GSR obtained at the scene of the incident because it provides answers to challenges like differentiating between different types of ammunition, estimating the firing range, and linking an individual to the discharge of a firearm. There is inadequate information on the classification of ammunition types utilizing GSR analysis. This paper delves into the capabilities of Micro-XRF in characterizing GSR particles, assessing their distribution, and elucidating their significance in forensic investigations. A cloth substrate as a target sample for assemblage of firearm discharge that is GSR particles was selected as an analog of sample obtained from the crime scene from victim or suspect. Micro-XRF proved to very advantageous non-destructive technique for the aimed study herein. The results of Micro-XRF are were able to characterize the heterogeneity of GSR particles originating from different distance & firearm-ammunition respectively. The technique provided non-destructive, highly sensitive, qualitative, quantity analysis with Fast deconvolution of the samples signals proving to be beneficial in GSR discrimination with respect ammunition and shooting distance. By exploring the benefits and limitations of this technique, we aim to contribute to the advancement of forensic science methodologies, ultimately aiding law enforcement in firearm-related cases.","PeriodicalId":12449,"journal":{"name":"Forensic Science, Medicine and Pathology","volume":" ","pages":"1230-1239"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of human remains in case of transgender individuals in forensic anthropology: a systematic review. 法医人类学中跨性别个体的遗骸鉴定：系统回顾。

IF 1.4 4区医学

Forensic Science, Medicine and Pathology Pub Date : 2025-09-01 Epub Date: 2025-06-10 DOI: 10.1007/s12024-025-01030-7

Viana Elisabetta, Selvaggi Gennaro, Milani Chantal

{"title":"Identification of human remains in case of transgender individuals in forensic anthropology: a systematic review.","authors":"Viana Elisabetta, Selvaggi Gennaro, Milani Chantal","doi":"10.1007/s12024-025-01030-7","DOIUrl":"10.1007/s12024-025-01030-7","url":null,"abstract":"During anthropological analysis of human skeletal remains, sex assessment is a key step in forensic identification of individuals. For transgender individuals, complications can arise during the estimation of biological sex, as physical characteristics may not correspond with the documented gender recorded at registration of the missing person with authorities. In this systematic review, we analyzed the current literature focusing on methods employed for state-of-the-art identification of skeletal remains of transgender and gender-diverse individuals in forensic anthropology, including the effects on the skeleton of gender-affirming hormone therapy and/or facial gender-affirmation surgery. Our findings support the need for additional studies using larger sample sizes and control groups involving different treatment regimens or longitudinal studies at different follow-up intervals. Furthermore, studies suggest that the impact of surgery involving the skull may provide identifying elements due either to the presence of surgical artifacts, traces of materials used for implants, or the possible incongruence with the pelvis in cases of sex estimation. Further studies are needed to investigate the impact of these anatomical aspects on outcomes related to forensic anthropology.","PeriodicalId":12449,"journal":{"name":"Forensic Science, Medicine and Pathology","volume":" ","pages":"1477-1494"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144265857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnosing milk aspiration as a cause of death in sudden unexpected infant death: forensic insights from post-mortem analysis impacting criminal investigations. 诊断吸奶为婴儿意外猝死的死因：影响刑事调查的验尸分析的法医见解。

IF 1.4 4区医学

Forensic Science, Medicine and Pathology Pub Date : 2025-09-01 Epub Date: 2025-01-31 DOI: 10.1007/s12024-025-00958-0

Alessandro Mauro Tavone, Francesca Servadei, Francesca Cazzato, Erica Giacobbi, Rita Bonfiglio, Antonio Oliva, Gian Luca Marella

{"title":"Diagnosing milk aspiration as a cause of death in sudden unexpected infant death: forensic insights from post-mortem analysis impacting criminal investigations.","authors":"Alessandro Mauro Tavone, Francesca Servadei, Francesca Cazzato, Erica Giacobbi, Rita Bonfiglio, Antonio Oliva, Gian Luca Marella","doi":"10.1007/s12024-025-00958-0","DOIUrl":"10.1007/s12024-025-00958-0","url":null,"abstract":"Sudden unexpected infant death (SUID) encompasses both explained and unexplained infant fatalities. When a comprehensive investigation yields inconclusive results, the case is classified as sudden infant death syndrome (SIDS). On the other hand, the most frequent non-SIDS diagnoses may be attributed to specific causes of death including a heterogeneous spectrum of conditions and disorders (e.g., trauma, asphyxia, suffocation, infection and metabolic diseases). Although rare, milk aspiration is a recognized cause of SUID that can lead to acute respiratory failure. This case report describes the death of a three-month-old infant found unresponsive in a traditional African baby carrier. Gross examination revealed no significant anomalies other than increased lung weight and the presence of milk-like material in the airways, alveoli, and stomach. Histological and ultrastructural analyses identified granular brownish material with birefringent globules in the lungs, consistent with aspirated milk. Immunohistochemical staining was positive for beta-lactoglobulin, confirming formula milk aspiration. This evidence was crucial in excluding maternal negligence as a cause of death, instead supporting an ante-mortem aspiration event resulting from regurgitation. This case highlights the diagnostic challenges associated with fatal milk aspiration and emphasizes the critical importance of a multidisciplinary approach. The integration of clinical history, autopsy findings, and advanced histopathological techniques is essential for accurately determining the cause of death and ensuring a sound legal assessment within the Courtroom setting.","PeriodicalId":12449,"journal":{"name":"Forensic Science, Medicine and Pathology","volume":" ","pages":"1327-1333"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12491373/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fractal wood burning remains a potentially lethal recreational activity. 分形焚烧木材仍然是一种可能致命的娱乐活动。

IF 1.4 4区医学

Forensic Science, Medicine and Pathology Pub Date : 2025-09-01 Epub Date: 2025-02-11 DOI: 10.1007/s12024-025-00948-2

Roger W Byard, Neil E I Langlois

引用次数: 0