Frontiers in Chemistry最新文献

{"title":"Next-generation nanomedicine for cancer therapy: advances, challenges, and future perspectives.","authors":"Biswajit Mohanty, Puja Saikia, Piyush Pandey, Chira R Bhattacharjee","doi":"10.3389/fchem.2026.1920337","DOIUrl":"https://doi.org/10.3389/fchem.2026.1920337","url":null,"abstract":"<p><p>In recent times, permeation of nanotechnology to modern medicine has revolutionized transformation, especially in the case of cancer diagnosis and therapy, positioning nanomedicine as a key pillar of next-generation healthcare. Tuning the physicochemical properties of nanoparticles such as size, morphology, and surface charge, enables controlled targeted drug delivery, increased cellular uptake and controlled therapeutic release. Nanomedicine-based platforms can improve certain drawbacks associated with conventional therapies including poor aqueous solubility, unfavorable pharmacokinetics, systemic toxicity and low bioavailability for specific therapeutic agents. While consistent tumor-specific accumulation, intratumoral heterogeneity, drug resistance, and long-term therapeutic outcomes remains challenging and highly formulation- and patient-dependent. This review paper besides, focussing on individual nanocarrier classes or specific therapeutic modalities, also provide an integrated and critical perspective on next-generation nanomedicine by connecting nanocarrier design with tumor-specific accumulation, intracellular trafficking, stimuli-responsive drug release, combination therapy and clinical translation. Recent advances in polymeric, lipid-based, inorganic, biological, and hybrid nanocarriers are systematically discussed, with particular stress on surface engineering, ligand-mediated targeting, multifunctional delivery systems and nanoengineered cancer medicine. The potential of these platforms for elevating therapeutic precision, overcoming biological barriers, multidrug resistance and enabling site-specific delivery is critically studied. In addition, major translational challenges, including large-scale fabrication, reproducibility, long-term safety, regulatory barriers, and nanotoxicological concerns are also addressed. Finally, emerging directions involving personalized nanomedicine, combination therapies, and artificial intelligence-assisted nanoparticle design are highlighted to provide perspectives toward safer, more effective, and patient-concentrated cancer therapy.</p>","PeriodicalId":12421,"journal":{"name":"Frontiers in Chemistry","volume":"14 ","pages":"1920337"},"PeriodicalIF":5.3,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13627390/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149106890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Active porous ZIF-8 based hybrid catalysts for solvent-free reactions.","authors":"César D Sampaio, Luís Dias, Isabel Santos-Vieira, Eulália Pereira, Luís Cunha-Silva, Fátima Mirante, Salete S Balula","doi":"10.3389/fchem.2026.1894924","DOIUrl":"https://doi.org/10.3389/fchem.2026.1894924","url":null,"abstract":"<p><p>Hybrid heterogeneous polymeric catalysts were prepared by distinct methodologies to evaluate their catalytic ability, stability and recycling capacity to promote the ring-opening reaction of styrene oxide with aniline resulting as main product the 2-Amino-1,2-diphenylethanol. These composites were based on porous metal-organic frameworks (MOFs), specifically the zinc-based ZIF-8, activated catalytically by the incorporation of Keggin-type phosphomolybdic acid (PMo₁₂). The resulting composite denoted as PMo₁₂@ZIF-8 was prepared via impregnation and <i>in-situ</i> methods (PMo₁₂ loadings of 0.149 and 0.194 mmol/g were obtained via <i>in-situ</i> and impregnation procedures). Both materials were characterized by FTIR-ATR, PXRD, SEM, EDS, and ICP-OES. The catalytic performance evaluation revealed that both composites exhibited high conversion rates under a sustainable solvent-free system (98% of conversion was achieved after 24 h), and high selectivity toward 2-Amino-1,2-diphenylethanol, along with notable robustness and recyclability.</p>","PeriodicalId":12421,"journal":{"name":"Frontiers in Chemistry","volume":"14 ","pages":"1894924"},"PeriodicalIF":5.3,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13627323/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149106724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hierarchically porous Co-N-C catalysts from bimetallic Zn/Co zeolitic imidazolate frameworks for selective CO₂ electroreduction to CO.","authors":"Zhaoyu Meng","doi":"10.3389/fchem.2026.1940515","DOIUrl":"https://doi.org/10.3389/fchem.2026.1940515","url":null,"abstract":"<p><p>The conversion of CO₂ to CO using electrochemistry requires the use of earth abundant catalysts with high selectivity, rapid reaction rate, and durability. In this work, hierarchically porous Co-N-C catalysts were synthesized via co-pyrolysis of a bimetallic zeolitic imidazolate framework (Zn/Co) and the dicyandiamide (DCD) followed by acid etching. By systematically adjusting the pyrolysis temperature (800 °C-1,000 °C) and the Co feed ratio (5-20 mol%), volcano-type activity relationships are found, which are controlled by the interplay of the three factors graphitization, nitrogen retention, and the density of Co-N_x sites. The optimized catalyst CoNC-900 achieves a Faradaic efficiency of CO of 94.9% ± 1.0% at -0.75 V vs. RHE in CO₂-saturated 0.5 M KHCO₃ with a CO partial current density of 16.0 mA cm^-2, a lower bound turnover frequency of ≥0.33 s^-1 and ≈11% current decay FE_CO retained above 92% over 24 h. The observed selectivity can be rationalized, as the density functional theory calculations indicate that the barrier of the rate-determining step, namely the formation of COOH is lowered on the Co-N₄ moiety (0.42 eV, whereas ≥1.79 eV on the metal-free nitrogen sites). A transferable design rule is developed for CO₂ electrolysis that relates bimetallic MOF precursor chemistry, hierarchical porosity, and M-N_x site engineering.</p>","PeriodicalId":12421,"journal":{"name":"Frontiers in Chemistry","volume":"14 ","pages":"1940515"},"PeriodicalIF":5.3,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13627418/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149106839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Copper nanomaterial antimicrobial coatings: ion release, transparency, and wash durability across biomedical, textile, and packaging applications.","authors":"Nurhidayatul Warda Muhamad Shuhaimi, Jei Vincent, Kam Sheng Lau, Siew Xian Chin, Shahariar Chowdhury, Theerakamol Pengsakul, Chin Hua Chia","doi":"10.3389/fchem.2026.1949389","DOIUrl":"https://doi.org/10.3389/fchem.2026.1949389","url":null,"abstract":"<p><p>Healthcare-associated infections remain a major burden on health systems, with 8.9 million episodes estimated annually across EU/EEA hospitals and long-term care facilities and approximately 518,000 in US acute care hospitals in 2023, driving demand for persistent antimicrobial surface coatings. Copper nanomaterials (CuNMs) offer multi-mechanism bactericidal and virucidal activity, including membrane disruption, reactive oxygen species generation, and photothermal hyperthermia, at an approximately 150-fold lower feedstock cost than silver, yet commercial deployment remains limited. This review synthesises 498 Scopus-indexed articles (2015-2026) on CuNM antimicrobial coatings to identify the structural barrier to translation. A critical trilemma emerges: no published system simultaneously achieves optical transmittance >80% at 550 nm, ≥2-log bacterial reduction, and durability over ≥50 home launderings or ≥3 months continuous efficacy. The five principal CuNM forms, Cu⁰, Cu₂O, CuO, CuS, and Cu-MOFs, occupy distinct niches in the efficacy-transparency-stability design space. Copper sulfide nanoparticles and sub-0.5 wt% Cu-MOFs are the most promising candidates for transparent applications. Polydopamine anchoring establishes a wash-durability benchmark of 40 laundering cycles at 90% efficacy retention. Stimulus-responsive pH- and NIR-triggered release systems extend functional lifetime while limiting cytotoxic overexposure. An 8-parameter Minimum Reporting Standard is proposed to resolve heterogeneous reporting that currently impedes cross-study comparison, regulatory assessment, and commercial investment.</p>","PeriodicalId":12421,"journal":{"name":"Frontiers in Chemistry","volume":"14 ","pages":"1949389"},"PeriodicalIF":5.3,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13625678/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149106830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of natural TLR4 modulators through network pharmacology and molecular modeling in SARS-CoV-2 <i>Acinetobacter baumannii</i> co-infection.","authors":"Mebarka Ouassaf, Shafi Ullah Khan, Kannan R R Rengasamy, Nada S Alhaggass, Bader Y Alhatlani","doi":"10.3389/fchem.2026.1916568","DOIUrl":"https://doi.org/10.3389/fchem.2026.1916568","url":null,"abstract":"<p><p>Viral-bacterial co-infection with SARS-CoV-2 and <i>Acinetobacter baumannii</i> exacerbates hyperinflammation via Toll-like receptor 4 (TLR4)-mediated immune pathways. Using network pharmacology, an integrated protein-protein interaction network identified 30 key inter-species hubs comprising viral, bacterial, and human host proteins, with TLR4 achieving a high MCC score (722), highlighting its high topological centrality as a host immune target. Virtual screen of 2,820 natural compounds against the TLR4/MD-2 complex identified three top candidates, CID5898023, CID5403474, and CID74977829, with docking scores of -10.46, -10.02, and -9.58 kcal/mol, respectively, compared with -9.10 kcal/mol for the reference antagonist Eritoran. CID5898023 (curcumin-derived) exhibited a more favorable docking score and stable binding behavior during the molecular dynamics simulation compared with the reference antagonist Eritoran. CID74977829 (baicalin-derived) showed stable binding but lower intestinal absorption, while CID5403474 (chrysin-derived) lacked conformational stability despite favorable docking scores. These computational findings prioritize curcumin- and baicalin-derived scaffolds as potential TLR4/MD-2 modulators for further experimental investigation in the context of co-infection-associated inflammation.</p>","PeriodicalId":12421,"journal":{"name":"Frontiers in Chemistry","volume":"14 ","pages":"1916568"},"PeriodicalIF":5.3,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13625435/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149106907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"QSPR analysis using stress sum based topological indices for predicting physicochemical properties of Hodgkin lymphoma drugs.","authors":"A Sivaranjani, K Bharani Dharan, S Radha","doi":"10.3389/fchem.2026.1936029","DOIUrl":"10.3389/fchem.2026.1936029","url":null,"abstract":"<p><p>Molecular graph theory has been widely used to represent the structure of chemical compounds and to study their physicochemical properties. In this work, we introduce a set of stress sum-based indices and examine their usefulness in describing the structural characteristics of drugs used in Hodgkin lymphoma treatment. Eight stress sum-based indices were calculated for thirteen selected drug molecules. Their relationships with seven physicochemical properties, namely boiling point, complexity, molecular weight, molar refraction, polar surface area, polarizability, and heavy atom count, were examined using Quantitative Structure-Property Relationship (QSPR) analysis. The correlation analysis of various indices supports the fact that the stress sum-based indices are efficient to capture the pertinent structural features of drug molecules and their application as molecular descriptors in QSPR studies. Additionally, these indices provide meaningful insights into the structural and physicochemical properties of drugs associated with Hodgkin lymphoma treatment. The findings of this study show promise for practical applications for drug design, structural optimization, and the repurposing of existing therapeutic compounds in the broader efforts of cancer pharmacology research.</p>","PeriodicalId":12421,"journal":{"name":"Frontiers in Chemistry","volume":"14 ","pages":"1936029"},"PeriodicalIF":5.3,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13619894/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149080276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence modeling of small molecule pharmaceutical solubility in supercritical fluid and comparative analysis under temperature and pressure variations.","authors":"Haolin Wu, Hadil Faris Alotaibi, Ahmed Salah Fahem, Saeed Shirazian","doi":"10.3389/fchem.2026.1947884","DOIUrl":"10.3389/fchem.2026.1947884","url":null,"abstract":"<p><p>Enhancing the dissolution behavior of poorly water-soluble pharmaceuticals remains an important challenge in drug formulation and manufacturing, since limited aqueous solubility can substantially restrict therapeutic performance. Supercritical-fluid technologies provide a promising route for addressing this limitation, particularly through the production of nanoscale drug formulations with improved dissolution characteristics. In the present work, the ternary solubility of Nystatin in the SC-CO₂-ethanol system was modeled as a function of temperature and pressure. Four regression approaches-K-nearest neighbors, linear regression, multilayer perceptron (MLP), and Theil-Sen regression-were examined as individual learners and subsequently incorporated into AdaBoost-based ensemble models. Model-specific hyperparameters were tuned using Glowworm Swarm Optimization whose population-based search strategy is suitable for exploring heterogeneous optimization spaces containing different parameter types. The developed ensemble configurations demonstrated strong agreement with the experimental solubility data, as reflected by high coefficients of determination and low root mean square errors. Among all evaluated models, the AdaBoost-MLP configuration provided the most favorable predictive performance, achieving an <i>R</i> ² of 0.99412 together with the lowest root mean square error.</p>","PeriodicalId":12421,"journal":{"name":"Frontiers in Chemistry","volume":"14 ","pages":"1947884"},"PeriodicalIF":5.3,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13619376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149080325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From state estimation to active intelligence: safety-aware battery management for electric vehicles.","authors":"Feng Li, Yuan Li, Wenqi Wu, Huaying Qiao, Lihua Jiang","doi":"10.3389/fchem.2026.1960882","DOIUrl":"10.3389/fchem.2026.1960882","url":null,"abstract":"<p><p>Battery management systems (BMSs) are increasingly required to convert incomplete electrical and thermal measurements into safe control actions rather than merely report battery states. This Mini Review focuses on two deployment questions that connect electrochemistry with control: how electrochemical states can be made observable with affordable diagnostics, and how charging, thermal, balancing, and health objectives can be arbitrated when their constraints conflict. We compare physics-based, equivalent-circuit, and data-driven representations using reported quantitative benchmarks, and show why cross-dataset accuracy alone is insufficient evidence of deployability. Particular attention is given to electrochemical impedance spectroscopy (EIS), distribution of relaxation times (DRT), galvanostatic intermittent titration technique (GITT), and active pulse diagnostics as routes for linking measurable responses to interfacial kinetics, resistance growth, and transport limitations. A layered vehicle-edge-cloud architecture is proposed in which a deterministic safety supervisor enforces voltage, temperature, lithium-plating, power, imbalance, and uncertainty limits before performance optimization. The same framework is then examined for solid-state, lithium-sulfur, and sodium-ion batteries, where pressure, observability, and chemistry-specific calibration introduce new constraints. We conclude with a testable short-, mid-, and long-term roadmap centered on uncertainty calibration, pack-level validation, electrochemical observability, version-controlled learning, and safety-case evidence.</p>","PeriodicalId":12421,"journal":{"name":"Frontiers in Chemistry","volume":"14 ","pages":"1960882"},"PeriodicalIF":5.3,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13619866/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149080303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanomedicine against antimicrobial resistance: mechanistic insights and next-generation therapeutic potential.","authors":"Vishal L Handa, Benedict B Vyas, Abhishek Padhi, Ashwini Agarwal, B R M Vyas","doi":"10.3389/fchem.2026.1915145","DOIUrl":"10.3389/fchem.2026.1915145","url":null,"abstract":"<p><p>Antimicrobial resistance (AMR) has emerged as one of the most critical global health threats, severely limiting the effectiveness of existing therapies against bacterial, fungal, and viral infections. The increasing prevalence of multidrug-resistant pathogens is largely driven by rapid genetic evolution, which promotes multiple resistance mechanisms such as drug degradation, target-site alteration, reduced intracellular drug accumulation, and biofilm formation, leading to persistent infections and rising mortality. These challenges highlight the urgent need for alternative therapeutic strategies beyond conventional antimicrobials. Nanomedicine has gained considerable attention due to its unique physicochemical properties, enabling improved drug stability, targeted delivery, controlled release, enhanced pathogen penetration, and multimodal antimicrobial action. This review comprehensively examines resistance mechanisms across major microbial pathogens and discusses the evolution of nanomedicine as an advanced platform for combating AMR. Particular emphasis is placed on green biogenic synthesis of nanoparticles using biological resources, offering environmentally sustainable and biocompatible antimicrobial nanomaterials. The synergistic interactions between nanomaterials and conventional antimicrobial agents that enhance therapeutic efficacy and restore susceptibility in resistant pathogens. Emerging next-generation antimicrobial nanomedicine platforms, including biomimetic nanoparticles, antimicrobial peptide delivery systems, CRISPR-enabled nanocarriers, and stimuli-responsive systems, are also highlighted for their potential in precision infection management. Finally, key challenges involving toxicity, biosafety, microbiome disruption, environmental impact, manufacturing scalability, regulatory and clinical translation. Addressing these barriers will be essential for advancing safe and effective nanomedicine-based solutions against AMR.</p>","PeriodicalId":12421,"journal":{"name":"Frontiers in Chemistry","volume":"14 ","pages":"1915145"},"PeriodicalIF":5.3,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13617642/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149074222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative review of dopant strategies for efficient photo-electrocatalytic water splitting: 3d transition metal oxides vs. carbon-based materials.","authors":"Mamoona Saeed, Mohsin Javed, Sana Mansoor, Adeeb Shehzad, Sajid Mahmood, Reem Alreshidi, Salah Knani, Shahid Iqbal","doi":"10.3389/fchem.2026.1886951","DOIUrl":"10.3389/fchem.2026.1886951","url":null,"abstract":"<p><p>Photocatalytic water splitting is an essential technology in the production of hydrogen on a sustainable basis, to combat the energy limits the world is facing by conserving solar energy in chemical bonds. Nevertheless, an inefficient visible light absorption and recombination of charges usually restrict the efficiency of semiconductor photocatalysts. This review is comparative analysis of two prominent dopant-based methods to overcome these limitations, namely, Transition Metal Oxides (TMOs) and Carbon-Based Materials (CBMs). We debate on the latest advancements in TMO dopants including Sc, V, Cr, Co, Ni and Cu, which is a TMO dopant but acts by decreasing bandgaps and altering electronic band structures in order to reach visible light. On the other hand, CBMs as graphene, carbon nanotubes (CNTs), and carbon quantum dots (CQDs), are electron sinks, as well as, conductive scaffolds, which enable separation of charge, and charge movement. This review emphasizes the trade-off between TMO-based bandgap engineering and CBM-based charge-mobility optimization. Additionally, we are referring to the combination of these strategies into hybrid systems that combine the optical benefits of TMOs and kinetic benefits of CBMs. The current review gives a design rulebook to the next-generation of high-efficiency photocatalysts in that it outlines some of the special conditions under which each type of dopant can work effectively<b>.</b></p>","PeriodicalId":12421,"journal":{"name":"Frontiers in Chemistry","volume":"14 ","pages":"1886951"},"PeriodicalIF":5.3,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13616573/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149069468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}