Frontiers in Chemistry最新文献

{"title":"Highly sensitive electrochemical immunosensor based on methylene blue-reduced graphene oxide nanocomposites as signal probes for IL-6 detection in gingival crevicular fluid samples.","authors":"Changfeng Zhu, Hongxin Wang, Jiyang Liu","doi":"10.3389/fchem.2025.1549927","DOIUrl":"https://doi.org/10.3389/fchem.2025.1549927","url":null,"abstract":"<p><p>As an important inflammatory cytokine, interleukin-6 (IL-6) can mediate the entire pathological process of periodontitis and is closely associated with the degree of inflammation. Therefore, it is critical to develop convenient quantitative methods for monitoring IL-6 quantity in gingival crevicular fluid. In this study, methylene blue (MB)-decorated reduced graphene oxide (rGO) is employed as signal probe to further support the antibody-enabling specific recognition of IL-6. Due to π-π stacking and electrostatic interactions, rGO-MB nanocomposites can be stably obtained. rGO with good conductivity and large surface area characteristics promotes the redox signals of MB on the glassy carbon electrode (GCE). In addition, through the simple <i>in situ</i> self-polymerization of dopamine, the polydopamine (PDA) obtained can be not only directly used as a biological crosslinking agent for covalent immobilization of anti-IL-6 antibody but can also be regarded as a protective layer to enhance the stability of rGO-MB on the GCE surface. Such a designed PDA/rGO-MB/GCE-based immunosensor enables specific binding with IL-6 and produces a decreased electrochemical signal for MB, realizing the selective and sensitive quantitative measurement of IL-6. Consequently, our fabricated PDA/rGO-MB/GCE-based electrochemical immunosensor has an excellent linear relationship with IL-6 ranging from 1 pg/mL to 100 ng/mL, with a limit of detection as low as 0.48 pg/mL. Moreover, our as-prepared sensing strategy shows accurate monitoring of the IL-6 quantity in gingival crevicular fluid samples.</p>","PeriodicalId":12421,"journal":{"name":"Frontiers in Chemistry","volume":"13 ","pages":"1549927"},"PeriodicalIF":3.8,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12000011/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"4-Aminoquinoline: a comprehensive review of synthetic strategies.","authors":"Francisco Delgado, Andrés Benítez, Lourdes Gotopo, Angel H Romero","doi":"10.3389/fchem.2025.1553975","DOIUrl":"https://doi.org/10.3389/fchem.2025.1553975","url":null,"abstract":"<p><p>4-Aminoquinoline is an important scaffold due to its variety of applications in medicinal, synthetic organic, and industrial chemistry. It has gained great relevance for the development of selective and potent leishmanicidal agents targeting parasite mitochondria, agonists and antagonists of Toll-like receptors (TLRs), antimalarials, and anticancer agents. As a consequence of the importance of 4-aminoquinoline as leishmanicidal, the present mini-review article aims to give comprehensive information about the different synthetic alternatives for the synthesis of 4-aminoquinolines, including (i) reactions based on nucleophilic aromatic substitution via conventional heating, microwave, and ultrasound; (ii) one-pot metal-free or metal-catalyzed reactions of inter- and intramolecular cyclization/annulation; (iii) miscellaneous reactions including the dehydrogenative amination of dihydroquinolin-4(<i>1H</i>)one and amination via Hartwig-Buchwald cross-coupling or rearrangement reactions.</p>","PeriodicalId":12421,"journal":{"name":"Frontiers in Chemistry","volume":"13 ","pages":"1553975"},"PeriodicalIF":3.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12023255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healing and leishmanicidal activity of <i>Zanthoxylum rhoifolium</i> Lam.","authors":"Juliana Correa-Barbosa, Heliton Patrick Cordovil Brígido, Bibiana Franzen Matte, Paloma Santos De Campos, Marcelo Lazzaron Lamers, Daniele Ferreira Sodré, Pedro Henrique Costa Nascimento, Gleison Gonçalves Ferreira, Valdicley Vieira Vale, Andrey Moacir do Rosário Marinho, José Edson De Sousa Siqueira, Márlia Regina Coelho-Ferreira, Marta Chagas Monteiro, Maria Fâni Dolabela","doi":"10.3389/fchem.2025.1504998","DOIUrl":"https://doi.org/10.3389/fchem.2025.1504998","url":null,"abstract":"<p><p><i>Zanthoxylum rhoifolium</i> is used in folk medicine as an antiparasitic agent. Therefore, this study evaluated the phytochemical aspects and biological activities of <i>Z. rhoifolium</i>. For this, the ethanolic extract (EE) was obtained by macerating the peel with ethanol and subjected to acid-base partition to obtain the neutral fractions (FN) and alkaloid fractions (FA). These samples were analyzed using chromatography techniques. From this, a substance was isolated from FN and identified by nuclear magnetic resonance. For biological activity, strains of <i>Leishmania amazonensis</i> were used for leishmanicidal activity. For cytotoxicity, cell viability methods were used and finally, the selectivity index (SI) was determined. Cell proliferation assay (SRB method) was also performed, such as a wound healing assay. After analysis, it was inferred that in chromatography, EE, FN and FA presented peaks suggestive of alkaloids, and the alkaloid chelerythrine was isolated from FN. In antiparasitic activity against promastigotes, EE, FN and FA were active. Against amastigotes, the infection inhibition index was dose dependent for EE and FN. In the cytotoxicity test (J774), EE and FN showed moderate cytotoxicity, while FA demonstrated cytotoxicity. In VERO strain, EE and FA showed moderate cytotoxicity, while FN was not cytotoxic. Finally, considering the SI, EE, FN and FA showed high selectivity. Furthermore, EE and FN increased cell proliferation and FN promoted a healing effect. Thus, it is highlighted that the specie <i>Z. rhoifolium</i> presented antileishmanial activity and selectivity for the parasite, and its FN presented healing potential.</p>","PeriodicalId":12421,"journal":{"name":"Frontiers in Chemistry","volume":"13 ","pages":"1504998"},"PeriodicalIF":3.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11996901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143988896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DABCO-modified magnetic core-shell as an efficient nanocatalyst for synthesizing polyhydroquinoline derivatives.","authors":"Mozhgan Esfandiari, Alireza Salimi Beni","doi":"10.3389/fchem.2025.1557628","DOIUrl":"https://doi.org/10.3389/fchem.2025.1557628","url":null,"abstract":"<p><p>The fabrication of core-shell structured magnetic resorcinol-formaldehyde composites has garnered considerable attention within the scientific community in recent years. A key area of focus has been the immobilization of homogeneous catalysts onto the surfaces of these materials and transforming them into heterogeneous catalysts. In this study, a novel quaternary ammonium salt catalyst was synthesized by immobilizing 1,4-diazabicyclo [2.2.2] octane (DABCO) on resorcinol-formaldehyde-modified Fe₃O₄ nanocomposite as a support (Fe₃O₄@RF/Pr-DABCO). The Fe₃O₄@RF/Pr-DABCO nanocomposite was characterized using various physicochemical techniques, including FT-IR, VSM, SEM, XRD, and TGA. The Fe₃O₄@RF/Pr-DABCO nanocomposite was employed as a power nanocatalyst in the Hantzsch reaction for synthesizing polyhydroquinoline derivatives using aromatic aldehydes, ammonium acetate, dimedone and ethyl acetoacetate. Various aromatic aldehydes were used as substrates in the presence of 0.003 g of Fe₃O₄@RF/Pr-DABCO under solvent-free condution at 60 °C, achieving high to excellent yields (90-99%) within short reaction times (5-15 min). Furthermore, this nanocatalyst showed excellent reusability and maintained its catalytic activity for at least eight consecutive cycles without a significant decrease in efficiency. These results demonstrate the potential of the Fe₃O₄@RF/Pr-DABCO nanocomposite as an efficient and sustainable catalyst for the synthesis of polyhydroquinoline derivatives via the Hantzsch reaction.</p>","PeriodicalId":12421,"journal":{"name":"Frontiers in Chemistry","volume":"13 ","pages":"1557628"},"PeriodicalIF":3.8,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11994587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143994896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Co-pyrolysis and combustion characteristics of polylactic acid and acrylonitrile-butadiene-styrene: insights into interactions, kinetics and synergistic effects.","authors":"Xujuan Wu, Yunpeng Yang, Yuanyuan Zhan, Kaiyuan Li, Fei Xiao","doi":"10.3389/fchem.2025.1552814","DOIUrl":"https://doi.org/10.3389/fchem.2025.1552814","url":null,"abstract":"<p><p>Polylactic acid (PLA) and acrylonitrile-butadiene-styrene (ABS) are the most commonly used filaments in 3D printing. To enable filament materials to withstand higher stresses, PLA and ABS are often blended (PLA/ABS). In this work, the co-pyrolysis and combustion properties of PLA/ABS blends of various ratios (75%/25%, 50%/50%, and 25%/75%) were analyzed. Thermogravimetric analysis showed that the catalytic pyrolysis of the blends became more intense as the proportion of PLA in PLA/ABS increased. Cone calorimetry tests indicated that the pyrolysis of ABS determines the peak heat release rate of the PLA/ABS blend. The higher amount of PLA allows the blend to pyrolyze at lower temperatures and the combustion reaction becomes more violent. The theoretical heat of combustion was calculated by correlating the average and maximum HRR with the heat flux through theoretical analysis. The theoretical heat of combustion obtained from the maximum HRR data is more reliable than from the average HRR data. This study has implications for the efficient utilization and fire protection of materials based on PLA/ABS.</p>","PeriodicalId":12421,"journal":{"name":"Frontiers in Chemistry","volume":"13 ","pages":"1552814"},"PeriodicalIF":3.8,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11994657/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Hosomi-Sakurai allylation reaction in total synthesis of biologically active natural products.","authors":"Justice Akwensi, Robert T Kumah, Dorcas Osei-Safo, Richard K Amewu","doi":"10.3389/fchem.2025.1527387","DOIUrl":"https://doi.org/10.3389/fchem.2025.1527387","url":null,"abstract":"<p><p>The Hosomi-Sakurai allylation reaction has been widely applied in the total synthesis of biologically active natural products, especially in synthesising complex polycyclic compounds containing multi-stereogenic centres since its discovery in 1976. The Hosomi-Sakurai allylation is the allylation of ketones and aldehyde with nucleophilic allylsilanes catalyzed with Lewis acid mainly used to extend the C-C bond in a molecule and also create a new site for manipulation due to the facile transformation of the <i>pi</i> (π) bond at the end of its chain. This review highlights only portions of natural product synthetic works that feature the Hosomi-Sakurai allylation reaction or its modification as a key transformation in the synthetic route.</p>","PeriodicalId":12421,"journal":{"name":"Frontiers in Chemistry","volume":"13 ","pages":"1527387"},"PeriodicalIF":3.8,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986726/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143988524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis, bioactivity, and molecular docking studies: novel arylpiperazine derivatives as potential new-resistant AR antagonists.","authors":"Hua Jiang, Haowei Chen, Ya Wang, Huaxin Xu, Hong Chen","doi":"10.3389/fchem.2025.1557275","DOIUrl":"https://doi.org/10.3389/fchem.2025.1557275","url":null,"abstract":"<p><p>The majority of patients with androgen-dependent prostate cancer (PCa) develop resistance to hormone therapy after approximately 18-24 months of androgen deprivation therapy treatment. During this process, PCa cells progressively lose their sensitivity to androgens and evolve into castration-resistant prostate cancer leading to uncontrolled tumor growth and ultimately the failure of endocrine therapy. To develop potential anti-prostate cancer agents, in this study, we identified a novel ether-type arylpiperazine derivative as a potent androgen receptor (AR) antagonist, uncovering a series of effective antiproliferative compounds. The derivatives (<b>7, 11, 17, 19, 20, 21, 22, 23</b>, and <b>24</b>) demonstrated strong cytotoxicity against cancer cells, with <b>17, 19, 20</b>, and <b>23</b> showing significant androgen receptor antagonistic activity (Inhibition% >60) and robust AR binding affinities. The structure-activity relationship (SAR) of these developed derivatives was discussed based on data. Docking study suggested that the compound <b>19</b> mainly bind to AR ligand binding pocket site through Van der Waals' force interactions. This research presents a promising lead compound for developing anticancer agents targeting prostate cancer therapy.</p>","PeriodicalId":12421,"journal":{"name":"Frontiers in Chemistry","volume":"13 ","pages":"1557275"},"PeriodicalIF":3.8,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11985751/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the therapeutic mechanism of curcumin in spinal cord injury treatment based on network pharmacology, molecular dynamics simulation, and experimental validation.","authors":"Yongzhi He, Jiachun Lu, Yushan Luo, Rizhao Pang, Xiaoming Hu, Lijuan Ding, Hua Xiao, Yunyun Wang, Wenchun Wang","doi":"10.3389/fchem.2025.1568551","DOIUrl":"https://doi.org/10.3389/fchem.2025.1568551","url":null,"abstract":"<p><strong>Introduction: </strong>Curcumin, a natural active compound derived from plants, is widely used as a pigment across the globe. Research has demonstrated that curcumin possesses neuroprotective properties in spinal cord injuries (SCIs); however, its specific mechanisms of action remain unclear. This study aimed to elucidate the potential mechanisms underlying curcumin's therapeutic effects in SCI.</p><p><strong>Methods: </strong>We screened the targets of curcumin in the treatment of spinal cord injury using network pharmacology across a variety of public databases. The interaction between the compound and the target was analyzed through bioinformatics analysis, molecular docking, and molecular dynamics simulation. Finally, the prediction results were verified by simulating spinal cord injury through oxygen-glucose deprivation (OGD) injury in PC12 cells.</p><p><strong>Results: </strong>Initial screening indicated 13 core targets involved in mitigating SCI. Curcumin may regulate the HIF pathway, immune cells, inflammation, oxidative stress, and other processes. Matrix metalloproteinase-9 (MMP9), tumor necrosis factor (TNF), interleukin-1β (IL-1β), signal transducer and activator of transcription 3 (STAT3), and caspase 3 (CASP3) were identified as key targets of curcumin in SCI regulation. Molecular docking results demonstrated that curcumin exhibited favorable affinity with the core targets, with MMP9 showing the highest binding affinity (-8.76 kcal/mol). Further studies confirmed that curcumin stably binds with MMP9, and the binding site was located at residues 220-225. Cell counting kit-8 (CCK8) assay results showed that curcumin exerted a good therapeutic effect. Western blot results showed that curcumin inhibited the expression of MMP9 protein but had no significant effect on the expression of TNF-α.</p><p><strong>Conclusion: </strong>Curcumin exerts its effects on SCI through multiple targets and pathways. Its specific mechanisms involve the inhibition of inflammation, prevention of apoptosis and ferroptosis, and promotion of neuronal repair. MMP9 may be a key target mediating curcumin's protective effects against SCI. These findings provide scientific evidence for further research and development of drugs.</p>","PeriodicalId":12421,"journal":{"name":"Frontiers in Chemistry","volume":"13 ","pages":"1568551"},"PeriodicalIF":3.8,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11985754/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in electrochemical biosensors for the detection of tumor-derived exosomes.","authors":"Jun Chen, Zhou Zhao, Honglin Zhu, Xiaobing Li","doi":"10.3389/fchem.2025.1556595","DOIUrl":"https://doi.org/10.3389/fchem.2025.1556595","url":null,"abstract":"<p><p>Exosomes, released from diverse cells as nanoscale lipid bilayer vesicles, mediate intercellular communication and participate in various physiological and pathological processes. Thereinto, tumor-derived exosomes (T-EXOs) with molecular cargoes of parent tumor cells act as attractive biomarkers for tumor liquid biopsy. The amount of T-EXOs and their levels of contained specific proteins and nucleic acids are closely associated with cancer burden and classification. Nevertheless, the nanoscale size and relatively low abundance of exosomes, as well as complex body liquid matrix pose daunting challenges for efficient isolation and sensitive detection of T-EXOs. Biosensing as fast, convenient and accurate method, has been widely employed for the detection of biomarkers over the past decades. Among them, electrochemical sensors can sensitively detect biomarkers by measuring of the change of electrical signal caused by oxidation or reduction at the working electrode surface. This review aims to summarize the recent advance in electrochemical biosensors for quantification, and protein and RNA analysis of exosomes. Further, challenges and future perspectives for exosome-based liquid biopsy have been discussed.</p>","PeriodicalId":12421,"journal":{"name":"Frontiers in Chemistry","volume":"13 ","pages":"1556595"},"PeriodicalIF":3.8,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11978826/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structure-based identification of bioactive phytochemicals targeting kallikrein-related peptidase 2 for prostate cancer therapy.","authors":"Deeba Shamim Jairajpuri, Afzal Hussain, Mohamed F Alajmi, Taj Mohammad, Anas Shamsi, Md Imtaiyaz Hassan","doi":"10.3389/fchem.2025.1553987","DOIUrl":"https://doi.org/10.3389/fchem.2025.1553987","url":null,"abstract":"<p><p>Kallikrein-related peptidase 2 (KLK2) is a serine protease exhibiting antiangiogenic properties through proteolytic activity. KLK2 is overexpressed in prostate cancer and plays a pivotal role in cancer progression, establishing it as a potential therapeutic target. Despite the promising results of small molecule inhibitors targeting KLK2 in prostate cancer treatment, there are still many challenges in the development and application of these inhibitors. As a consequence, very few KLK2 inhibitors have advanced to clinical trials because of issues with specificity and selectivity. Moreover, the precise mechanisms underlying KLK2's interactions with small molecule inhibitors remain inadequately understood. This study used structure-based virtual screening of a phytochemical library and found three compounds, Phaseolin, Withaphysalin D, and Nicandrenone, as potential KLK2 inhibitors. These compounds exhibited high binding affinities (-8.9 to -8.8 kcal/mol), favorable pharmacokinetic profiles, and stable interactions with KLK2's catalytic residues (including His65) in docking studies. Their binding was further validated through MM-PBSA free energy calculations, which confirmed energetically favorable interactions with KLK2. The findings suggest that these phytochemicals have a high potential to be exploited as novel KLK2 inhibitors with improved efficacy. While experimental validation of enzymatic inhibition and antitumor efficacy is required, this study provides a structural and mechanistic foundation for advancing these candidates into preclinical testing. These results also highlight the use of phytochemical libraries and dynamics-driven virtual screening in developing targeted therapies for prostate cancer.</p>","PeriodicalId":12421,"journal":{"name":"Frontiers in Chemistry","volume":"13 ","pages":"1553987"},"PeriodicalIF":3.8,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11979280/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}