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A gastric metastasis from ovarian carcinoma mimicking GIST - a case report. 模仿GIST的卵巢癌胃转移1例报告。
Folia medica Pub Date : 2026-08-06 DOI: 10.3897/folmed.68.e153213
Teodor Sofiyanski, Elena Popova, Sonya Sergieva, Bozhil Robev, Boryana Ilcheva, Albena Fakirova
{"title":"A gastric metastasis from ovarian carcinoma mimicking GIST - a case report.","authors":"Teodor Sofiyanski, Elena Popova, Sonya Sergieva, Bozhil Robev, Boryana Ilcheva, Albena Fakirova","doi":"10.3897/folmed.68.e153213","DOIUrl":"10.3897/folmed.68.e153213","url":null,"abstract":"<p><p>Ovarian cancer has the highest mortality rate among gynecological malignancies. Metastatic sites are most commonly found in the peritoneum, pelvic organs, and lymph nodes, followed by the liver, distant lymph nodes, lungs, bones, and brain. There have only been a few reports of distant metastases in the stomach.\u0000\u0000Herein, we present a rare case of a 59-year-old woman with high-grade serous ovarian carcinoma with a single metastasis in the stomach. The post-surgery follow-up was performed with 18F-FDG PET/CT. The patient remained recurrence-free for 3 years. On a routine follow-up PET/CT scan, an intramural hypermetabolic lesion in the stomach, suggestive of GIST, was detected. A biopsy confirmed a metastasis from high-grade serous ovarian carcinoma. A “Reverse Krukenberg” tumor—a gastric metastasis from ovarian cancer—is extremely uncommon. The exact mechanism of spreading to the stomach is still unknown. Even though gastric metastasis from ovarian carcinoma is uncommon, we advise clinicians to stay mindful of the potential for gastric metastasis in patients with a history of ovarian cancer.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"68 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148863860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunoscore as a prognostic marker in colorectal cancer. 免疫评分作为结直肠癌的预后指标。
Folia medica Pub Date : 2026-08-06 DOI: 10.3897/folmed.68.e163476
Yanislav Grishev Iliev, Vladimir Nikolov Andonov, Elena Galabova Poryazova-Markova
{"title":"Immunoscore as a prognostic marker in colorectal cancer.","authors":"Yanislav Grishev Iliev, Vladimir Nikolov Andonov, Elena Galabova Poryazova-Markova","doi":"10.3897/folmed.68.e163476","DOIUrl":"10.3897/folmed.68.e163476","url":null,"abstract":"<p><p>Introduction: Colorectal cancer is a leading cause of morbidity and mortality worldwide. Immunoscore provides important prognostic information in early-stage colorectal cancer, beyond traditional TNM staging.\u0000\u0000Aim: To investigate the Immunoscore in early-stage colorectal cancer and its prognostic value.\u0000\u0000Patients and methods: A retrospective pilot cohort of 35 patients was evaluated for recurrence, survival, toxicity, and clinical correlations with Immunoscore.\u0000\u0000Results: High Immunoscore was associated with better outcomes, including zero recurrence. Immunoscore showed trends by tumor location, with stronger associations in younger patients. There was no correlation with carcinoembryonic antigen levels.\u0000\u0000Conclusion: Our findings support the incorporation of Immunoscore into future colorectal cancer staging models.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"68 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148864309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Solitary benign thyroid nodule in an elderly female cadaver. 老年女性尸体单发良性甲状腺结节。
Folia medica Pub Date : 2026-08-06 DOI: 10.3897/folmed.68.e154612
Dibakar Borthakur, Jayashree Raja, Silka Agarwal, Seema Singh
{"title":"Solitary benign thyroid nodule in an elderly female cadaver.","authors":"Dibakar Borthakur, Jayashree Raja, Silka Agarwal, Seema Singh","doi":"10.3897/folmed.68.e154612","DOIUrl":"10.3897/folmed.68.e154612","url":null,"abstract":"<p><p>A thyroid nodule (TN) is a structurally discrete lesion within the thyroid gland that can be readily distinguished from the adjoining normal thyroid parenchyma. TNs are more frequently detected these days because of the widespread use of high-resolution imaging techniques for various neck pathologies. A well-circumscribed macroscopic lesion measuring 17 mm ×14 mm ×12 mm was observed in the left lobe of the thyroid gland during routine dissection performed on an embalmed elderly female cadaver for undergraduate teaching. It was firm to the touch and greyish brown in color. In the histological examination, the lesion appeared intensely stained and encapsulated by a thick fibrous capsule having various sizes of thyroid follicles lined by cuboidal to low-columnar epithelium with focal areas of calcification and hemorrhages. There was no sign of local tissue or vascular invasion by the lesion. No nuclear atypia was observed. The lesion was identified as a benign follicular adenoma. This report underscores the significance of recognizing that a thyroid gland that appears to be within normal limits may, in fact, harbor a thyroid nodule of considerable size. The identification of such nodules is of paramount importance, as a significant proportion of benign thyroid lesions found in geriatric women have a high propensity to undergo malignant transformation.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"68 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148864333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Circulating microRNAs in the context of the lifestyle intervention program MultiPill-Exercise: a pilot study. 在生活方式干预方案MultiPill-Exercise的背景下循环microrna：一项试点研究。
Folia medica Pub Date : 2026-06-30 DOI: 10.3897/folmed.68.e176338
Rebecca Bankamp, Angelika Schmitt, Annunziata Fragasso, Simone Schweda, Manuel Widmann, Andreas Nieß, Inga Krauß, Barbara Munz
{"title":"Circulating microRNAs in the context of the lifestyle intervention program MultiPill-Exercise: a pilot study.","authors":"Rebecca Bankamp, Angelika Schmitt, Annunziata Fragasso, Simone Schweda, Manuel Widmann, Andreas Nieß, Inga Krauß, Barbara Munz","doi":"10.3897/folmed.68.e176338","DOIUrl":"https://doi.org/10.3897/folmed.68.e176338","url":null,"abstract":"<p><strong>Introduction: </strong>Multimorbidity is a common finding in the context of lifestyle-related diseases, such as obesity, hypertonia, diabetes mellitus type 2, or osteoarthritis. However, little is known about the effects of exercise on subjects with multimorbidity. Biomarkers, such as microRNAs (miRs), might be useful tools in this context.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"68 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148864380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gastric DLBCL presenting as multiple gastric ulcers: a case report. 胃DLBCL表现为多发性胃溃疡1例。
Folia medica Pub Date : 2026-06-30 DOI: 10.3897/folmed.68.e155005
Wulyo Rajabto, Lugyanti Sukrisman, Agnes Stephanie Harahap, Maria Pyrhadistya, Ainun Safitri
{"title":"Gastric DLBCL presenting as multiple gastric ulcers: a case report.","authors":"Wulyo Rajabto, Lugyanti Sukrisman, Agnes Stephanie Harahap, Maria Pyrhadistya, Ainun Safitri","doi":"10.3897/folmed.68.e155005","DOIUrl":"https://doi.org/10.3897/folmed.68.e155005","url":null,"abstract":"<p><p>Gastric diffuse large B-cell lymphoma (DLBCL) comprises most of all gastrointestinal lymphomas, accounting for approximately 55%-65% of all cases. This condition predominantly affects male patients and those older than 50 years and is usually aggressive. The clinical presentations are nonspecific and can mimic other diseases. In this report, we present a case of a 66-year-old male patient with a history of hematemesis and melena, with significant weight loss for 3 months. Esophagogastroduodenoscopy (EGD) revealed multiple stomach ulcers. A biopsy taken during EGD, which was followed by immunohistochemical staining, confirmed the diagnosis of non-Hodgkin lymphoma, specifically germinal center B-cell (GCB)-subtype DLBCL. A positron emission tomography (PET) scan was performed, revealing the involvement of the mesenteric lymph nodes and an infiltrative lesion that extended from the stomach to the pancreas. Based on the Ann Arbor staging system, the diagnosis was identified to be stage IV gastric DLBCL. Following diagnosis, we administered rituximab, cyclophosphamide, hydroxydaunorubicin, vincristine, and prednisone (R-CHOP) to the patient.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"68 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148864405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biochemical profiling of salivary monosodium glutamate in relation to dental caries: An observational analytical study. 唾液味精与龋齿的生化分析：一项观察性分析研究。
Folia medica Pub Date : 2026-06-30 DOI: 10.3897/folmed.68.e173421
Pravallika Kakada, Monal Yuwanati
{"title":"Biochemical profiling of salivary monosodium glutamate in relation to dental caries: An observational analytical study.","authors":"Pravallika Kakada, Monal Yuwanati","doi":"10.3897/folmed.68.e173421","DOIUrl":"https://doi.org/10.3897/folmed.68.e173421","url":null,"abstract":"<p><strong>Introduction: </strong>Monosodium glutamate (MSG) is extensively used in processed foods to enhance umami flavor, and its lingering presence in the oral cavity may influence salivary composition and microbial activity.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"68 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148864442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Contemporary materials for the prevention of occlusal carious lesions. 预防牙合龋齿的现代材料。
Folia medica Pub Date : 2026-06-30 DOI: 10.3897/folmed.68.e177275
Nedana E Georgieva
{"title":"Contemporary materials for the prevention of occlusal carious lesions.","authors":"Nedana E Georgieva","doi":"10.3897/folmed.68.e177275","DOIUrl":"https://doi.org/10.3897/folmed.68.e177275","url":null,"abstract":"<p><p>Prevention of occlusal caries has been a longstanding challenge in dentistry, evolving appropriately from invasive mechanical techniques toward increasingly adhesive and bioactive strategies. Early attempts, such as the application of silver nitrate and preventive restorations, were limited by questionable efficacy and unnecessary removal of sound tooth structure. The advent of adhesive dentistry and the acid-etching technique enabled the development of resin-based sealants, providing a minimally invasive and effective method for fissure protection. Over time, sealant materials have evolved through four generations, introducing improved polymerization mechanisms, fillers, and fluoride release to enhance wear resistance, retention, and antibacterial properties.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"68 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148864407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sex and age effects on caudate nucleus size: implications for neurosurgery and neurodegenerative biomarkers. 性别和年龄对尾状核大小的影响：对神经外科和神经退行性生物标志物的影响。
Folia medica Pub Date : 2026-06-30 DOI: 10.3897/folmed.68.e180527
Shayan Yousufzai, Sajede Radmard, Yasaman Khandani, Nehleh Zareifard, Seyed Hamed Jafari, Reihane Yousefi, Maria Piagkou, George Triantafyllou, Fatemeh Karimi
{"title":"Sex and age effects on caudate nucleus size: implications for neurosurgery and neurodegenerative biomarkers.","authors":"Shayan Yousufzai, Sajede Radmard, Yasaman Khandani, Nehleh Zareifard, Seyed Hamed Jafari, Reihane Yousefi, Maria Piagkou, George Triantafyllou, Fatemeh Karimi","doi":"10.3897/folmed.68.e180527","DOIUrl":"10.3897/folmed.68.e180527","url":null,"abstract":"<p><strong>Introduction: </strong>The caudate nucleus (CN) plays a central role in motor control, cognition, and emotional regulation. Structural alterations of the CN have been associated with various neurodegenerative and psychiatric disorders. While volumetric magnetic resonance imaging (MRI) remains the standard for assessing CN morphology, linear morphometry offers a simpler and more accessible alternative that does not require advanced post-processing. Normative data on age- and sex-related variations in CN linear dimensions remain limited.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"68 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148864411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinicopathologic spectrum and outcomes analysis of Meckel's diverticulum in children. 儿童梅克尔憩室的临床病理特征及预后分析。
Folia medica Pub Date : 2026-06-30 DOI: 10.3897/folmed.68.e182087
Nandkishor Shinde, Sunil Kalaskar, Anup S Desai, Afia Kausar
{"title":"Clinicopathologic spectrum and outcomes analysis of Meckel's diverticulum in children.","authors":"Nandkishor Shinde, Sunil Kalaskar, Anup S Desai, Afia Kausar","doi":"10.3897/folmed.68.e182087","DOIUrl":"10.3897/folmed.68.e182087","url":null,"abstract":"<p><strong>Introduction: </strong>Meckel's diverticulum is the most common congenital anomaly of the gastrointestinal system. Although often asymptomatic, it can present with a wide range of complications in children. Early diagnosis remains challenging due to nonspecific symptoms and the limited sensitivity of imaging modalities.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"68 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148864383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical experience with chronic kidney disease in the HIV population: what have we learned? HIV人群慢性肾脏疾病的临床经验：我们学到了什么？
Folia medica Pub Date : 2026-06-25 DOI: 10.3897/folmed.68.e173506
Matea Rebrina, Josip Begovac, Mirjana Stupnisek
{"title":"Clinical experience with chronic kidney disease in the HIV population: what have we learned?","authors":"Matea Rebrina, Josip Begovac, Mirjana Stupnisek","doi":"10.3897/folmed.68.e173506","DOIUrl":"10.3897/folmed.68.e173506","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic kidney disease (CKD) represents a significant global public health issue among people living with HIV (PLWH). The use of antiretroviral therapy (ART) is associated with increased prevalence of CKD and decreased glomerular filtration rate (GFR).</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"68 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148864454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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