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Recurrent total knee arthroplasty aseptic loosening in a patient with hypophosphatasia: are they related? A case report. 低磷酸盐患者复发性全膝关节置换术无菌性松动：两者是否相关？一份病例报告。
Folia medica Pub Date : 2026-06-25 DOI: 10.3897/folmed.68.e158848
Giulia Lazzeri, Damiano Antognetti, Nicola Piolanti, Vittoria Bettarini, Paolo Domenico Parchi, Vanna Bottai
{"title":"Recurrent total knee arthroplasty aseptic loosening in a patient with hypophosphatasia: are they related? A case report.","authors":"Giulia Lazzeri, Damiano Antognetti, Nicola Piolanti, Vittoria Bettarini, Paolo Domenico Parchi, Vanna Bottai","doi":"10.3897/folmed.68.e158848","DOIUrl":"10.3897/folmed.68.e158848","url":null,"abstract":"<p><p>Hypophosphatasia (HPP) is a rare metabolic bone disease caused by deficient alkaline phosphatase activity, leading to impaired mineralization. While total knee arthroplasty (TKA) is a common treatment for end-stage knee arthritis, its outcomes in patients with metabolic bone disorders like HPP are poorly documented.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"68 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148864398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of the efficacy of native radiography and computed tomography in the evaluation of the closed reduction in developmental dysplasia of the hip. 本机x线摄影和计算机断层摄影在评估髋关节发育不良闭合复位中的疗效比较。
Folia medica Pub Date : 2026-06-25 DOI: 10.3897/folmed.68.e182430
Milena Bogojevska Doksevska, Zoran Bozinovski, Daniela Georgieva, Roza Dzoleva Tolevska, Marta Foteva, Nenad Atanasov, Vilijam Velkovski, Ilir Shabani, Milan Samardziski
{"title":"Comparison of the efficacy of native radiography and computed tomography in the evaluation of the closed reduction in developmental dysplasia of the hip.","authors":"Milena Bogojevska Doksevska, Zoran Bozinovski, Daniela Georgieva, Roza Dzoleva Tolevska, Marta Foteva, Nenad Atanasov, Vilijam Velkovski, Ilir Shabani, Milan Samardziski","doi":"10.3897/folmed.68.e182430","DOIUrl":"https://doi.org/10.3897/folmed.68.e182430","url":null,"abstract":"<p><strong>Introduction: </strong>Developmental dysplasia of the hip (DDH) is a common orthopedic disorder in infants, and accurately assessing the success of reduction is critical for achieving positive outcomes. While native radiography has traditionally been the standard postoperative imaging modality, its diagnostic limitations have prompted consideration of computed tomography (CT) as an alternative.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"68 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148864416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Digital approach to rehabilitating partially edentulous arch using advanced fabrication techniques for precision attachments in cast partial dentures: a case report. 数字方法修复部分无牙弓使用先进的制造技术精密附件铸造部分义齿：一个案例报告。
Folia medica Pub Date : 2026-06-25 DOI: 10.3897/folmed.68.e162497
Manu Rathee, Mathiyazhagan Stalin, Sarthak Singh Tomar, Divakar Santhanam, Senthilvelpalani Balavignesh, Nang Nalika Moungkhom
{"title":"Digital approach to rehabilitating partially edentulous arch using advanced fabrication techniques for precision attachments in cast partial dentures: a case report.","authors":"Manu Rathee, Mathiyazhagan Stalin, Sarthak Singh Tomar, Divakar Santhanam, Senthilvelpalani Balavignesh, Nang Nalika Moungkhom","doi":"10.3897/folmed.68.e162497","DOIUrl":"10.3897/folmed.68.e162497","url":null,"abstract":"<p><p>The integration of digital technologies in removable prosthodontics has significantly enhanced the precision, efficiency, and predictability of cast partial denture (CPD) fabrication. Conventional methods, often involving multiple manual steps, are prone to inaccuracies and technical errors that may compromise the prosthesis fit, patient comfort, and long-term clinical success. The advent of computer-aided design and computer-aided manufacturing (CAD/CAM), along with direct metal laser sintering (DMLS), has enabled the fabrication of high-precision frameworks and extracoronal precision attachments with improved biomechanical and esthetic outcomes. This case report presents the digital rehabilitation of a partially edentulous maxillary arch classified as Kennedy Class II Modification 2, utilizing a CAD/CAM-designed and DMLS-fabricated cast partial denture. The digital workflow encompassed intraoral scanning, virtual framework design, and additive manufacturing of the prosthesis with integrated precision attachments. Clinical outcomes demonstrated enhanced accuracy of fit, improved retention, and increased patient satisfaction, with a reduction in chairside adjustments. This report highlights the transformative impact of digital technologies on enhancing clinical standards and fostering personalized, patient-centered care in removable prosthodontics.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"68 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148864393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Selection bias and inferential validity in fever of unknown origin studies. Comment on: Poposki et al. Visceral leishmaniasis as a leading cause of fever of unknown origin in immunocompetent adults. 不明原因发热研究的选择偏倚和推断效度。点评：Poposki等人。内脏利什曼病是免疫正常成人不明原因发热的主要原因。
Folia medica Pub Date : 2026-06-24 DOI: 10.3897/folmed.68.e184403
Kostadin Kostadinov
{"title":"Selection bias and inferential validity in fever of unknown origin studies. Comment on: Poposki et al. Visceral leishmaniasis as a leading cause of fever of unknown origin in immunocompetent adults.","authors":"Kostadin Kostadinov","doi":"10.3897/folmed.68.e184403","DOIUrl":"https://doi.org/10.3897/folmed.68.e184403","url":null,"abstract":"<p><p>The article by Poposki et al. on visceral leishmaniasis as a cause of fever of unknown origin presents clinically valuable observations but exhibits substantial methodological limitations. Differential exclusion of undiagnosed cases introduces selection bias and precludes generalizable prevalence estimates. The analytical strategy lacks etiological coherence by comparing a specific diagnosis against heterogeneous conditions. Multiple univariate comparisons without adjustment for family-wise error rate and absence of multivariable analysis to control confounding limit causal inference. The cross-sectional assessment of clinical features after diagnostic confirmation precludes temporal inference. Future studies would benefit from nested case-control designs, transparent reporting of diagnostic pathways, and appropriate statistical adjustment.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"68 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148864373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sinonasal oncocytic Schneiderian papilloma limited to the inferior turbinate: a rare case. 局限于下鼻甲的鼻窦嗜瘤性施耐德乳头状瘤1例。
Folia medica Pub Date : 2026-06-17 DOI: 10.3897/folmed.68.e170344
Constantinos Papadopoulos, Rafail Ioannidis, Anastasia Sarafidou, Konstantina Dinaki
{"title":"Sinonasal oncocytic Schneiderian papilloma limited to the inferior turbinate: a rare case.","authors":"Constantinos Papadopoulos, Rafail Ioannidis, Anastasia Sarafidou, Konstantina Dinaki","doi":"10.3897/folmed.68.e170344","DOIUrl":"https://doi.org/10.3897/folmed.68.e170344","url":null,"abstract":"<p><p>Sinonasal oncocytic papilloma is a rare benign epithelial tumor arising from the Schneiderian mucosa, accounting for 3%-5% of all sinonasal papillomas. We present a case of a 67-year-old man with a history of non-Hodgkin lymphoma who presented with a one-year history of frontal and parietal headache, nasal obstruction, and discharge. Endoscopic examination revealed a polypoid lesion arising from the right inferior turbinate-an exceptionally uncommon site. Computed tomography demonstrated a well-circumscribed mass confined to the inferior turbinate without bone erosion, while a positron emission tomography scan with a computed tomography revealed no fluorodeoxyglucose uptake. Histopathological evaluation confirmed the diagnosis of sinonasal oncocytic papilloma, characterized by oncocytic epithelium with eosinophilic cytoplasm and intraepithelial microcysts. The patient underwent endoscopic partial turbinectomy with complete excision of the lesion. Postoperative recovery was uneventful, and follow-up nasal endoscopy at one year showed complete mucosal healing without evidence of recurrence or polypoid degeneration. This case highlights an unusual localization of sinonasal oncocytic papilloma and underscores the diagnostic challenges associated with its differentiation from inflammatory and neoplastic lesions. It further emphasizes the importance of correlating histopathologic findings with imaging modalities, including a positron emission tomography scan with a computed tomography, in achieving an accurate diagnosis and optimal management of this rare entity.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"68 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148864420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A multidisciplinary team approach to a neonate with a rare primary mediastinal tumor: a case report. 一个多学科团队的方法与罕见的新生儿原发性纵隔肿瘤：一个病例报告。
Folia medica Pub Date : 2026-06-17 DOI: 10.3897/folmed.68.e173882
Stefka Stoichkova, Anna Kaneva-Nencheva, Radka Maslarska, Hristo Shivachev, Dimitar Pechilkov
{"title":"A multidisciplinary team approach to a neonate with a rare primary mediastinal tumor: a case report.","authors":"Stefka Stoichkova, Anna Kaneva-Nencheva, Radka Maslarska, Hristo Shivachev, Dimitar Pechilkov","doi":"10.3897/folmed.68.e173882","DOIUrl":"10.3897/folmed.68.e173882","url":null,"abstract":"<p><p>Primary mediastinal tumors in children are extremely rare, consisting of under 0.1% of neoplasms in this age group. Of these, teratomas represent 8%-16% of the cases. Clinical presentation depends primarily on the tumor's size, location, malignancy, and growth rate. Large tumor masses may compress structures in the thorax and cause respiratory distress syndrome, superior vena cava syndrome, or cardiac tamponade. This report describes a neonate with respiratory distress and heart failure shortly after birth due to a large mediastinal tumor mass. The child underwent successful surgery and has no signs of relapse during the 2-year follow-up. A complex approach and a multidisciplinary team are the cornerstone in the treatment of neonates with mediastinal tumors. Complete tumor resection is the gold standard treatment.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"68 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148864436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rare presentation of congenital cystic adenomatoid malformation type II detected in adulthood - a case report. 罕见的先天性囊性腺瘤样畸形II型发现于成年- 1例报告。
Folia medica Pub Date : 2026-06-17 DOI: 10.3897/folmed.68.e157932
Michał Miciak, Patrycja Paszenda, Agnieszka Kowalik, Konrad Pawełczyk, Maciej Rutkiewicz, Adam Rzechonek, Piotr Błasiak
{"title":"Rare presentation of congenital cystic adenomatoid malformation type II detected in adulthood - a case report.","authors":"Michał Miciak, Patrycja Paszenda, Agnieszka Kowalik, Konrad Pawełczyk, Maciej Rutkiewicz, Adam Rzechonek, Piotr Błasiak","doi":"10.3897/folmed.68.e157932","DOIUrl":"10.3897/folmed.68.e157932","url":null,"abstract":"<p><p>Congenital cystic adenomatoid malformation (CCAM) is a very rare innate pulmonary disorder characterized by the formation of cysts and abnormal dilatation of the respiratory bronchioles. The etiology of the disease remains unknown. CCAM is most commonly diagnosed prenatally or during the neonatal period, and diagnosis in adulthood is extremely rare. The condition is classified into subtypes based on the morphology of the cysts and the extent of pulmonary parenchymal involvement. Clinical symptoms are nonspecific. The aim of this study is to present a case of CCAM type II diagnosed de novo in an adult. A 43-year-old patient was admitted to the clinic due to an abnormal finding on a chest X-ray. A large conglomerate of lesions was located in the inferior lobe of the left lung, and the patient had a history of recurrent pneumonia. After initial diagnostic tests and confirmation of the lesion's location on chest computed tomography, the patient was qualified for surgical intervention. The lesion was removed via video-assisted thoracoscopic surgery, and histopathological examination confirmed the diagnosis of CCAM type II. At the six-month follow-up visit, no recurrence was detected, and treatment was completed. Although it is extremely rare, CCAM type II can also occur in adult patients. This condition should be considered in the differential diagnosis, and such patients should be monitored for potential malignant pulmonary transformation.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"68 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148864434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Silent case of a gigantic high-grade glioma in the left temporoparietal region of the brain. 脑左颞顶区巨大高级别胶质瘤的沉默病例。
Folia medica Pub Date : 2026-06-17 DOI: 10.3897/folmed.68.e144993
Marina Coelho, Henrique Sousa, Tiago Mascarenhas, Pedro Avelar, Beatriz Marques, Carla Henriques
{"title":"Silent case of a gigantic high-grade glioma in the left temporoparietal region of the brain.","authors":"Marina Coelho, Henrique Sousa, Tiago Mascarenhas, Pedro Avelar, Beatriz Marques, Carla Henriques","doi":"10.3897/folmed.68.e144993","DOIUrl":"https://doi.org/10.3897/folmed.68.e144993","url":null,"abstract":"<p><p>High-grade gliomas are aggressive primary brain tumors that are extremely malignant, especially isocitrate dehydrogenase (IDH) wildtype glioblastoma. This case concerns a male 54-year-old with a history of substance abuse who was undervalued and diagnosed with a large glioblastoma following several months of inappropriate behavior. Although there has been some recent progress, a tumor of this size is still considered incurable and is currently a rare diagnosis in Western countries.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"68 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148864378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of prosthetic parameters for validating an AI designed crown. 假体参数在验证人工智能设计的冠中的作用。
Folia medica Pub Date : 2026-06-17 DOI: 10.3897/folmed.68.e177266
Aleksandar V Naydenov, Todor T Uzunov, Georgi Kostadinov
{"title":"Role of prosthetic parameters for validating an AI designed crown.","authors":"Aleksandar V Naydenov, Todor T Uzunov, Georgi Kostadinov","doi":"10.3897/folmed.68.e177266","DOIUrl":"https://doi.org/10.3897/folmed.68.e177266","url":null,"abstract":"<p><strong>Aim: </strong>To investigate the relationship between the angles describing the emergence profile of an implant crown and the metric data used to validate the digital design modeled via a 3D GAN.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"68 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148864400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Uric acid as a biomarker in patients with COPD and CKD. 尿酸作为COPD和CKD患者的生物标志物。
Folia medica Pub Date : 2026-06-17 DOI: 10.3897/folmed.68.e190088
Elena D Borisova, Snezhanka T Ivankovska, Plamen S Pavlov, Pavlina T Glogovska
{"title":"Uric acid as a biomarker in patients with COPD and CKD.","authors":"Elena D Borisova, Snezhanka T Ivankovska, Plamen S Pavlov, Pavlina T Glogovska","doi":"10.3897/folmed.68.e190088","DOIUrl":"10.3897/folmed.68.e190088","url":null,"abstract":"<p><strong>Introduction: </strong>High uric acid level is a risk factor for the development of CKD. It is also a biomarker associated with exacerbations, severity, and progression of COPD.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"68 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148863085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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