Folia medica最新文献_第5页

Clinical value of causative pathogen identification in one-stage revision for periprosthetic joint infection. 假体周围关节感染一期翻修中病原鉴定的临床价值。

Folia medica Pub Date : 2026-06-17 DOI: 10.3897/folmed.68.e182189

Georgi Lukanov, Atanas Panev, Lubomir Tzvetanov, Kevork Kaykchian, Alexander Gerchev, Plamen Kinov, Slaveyko Djambazov

{"title":"Clinical value of causative pathogen identification in one-stage revision for periprosthetic joint infection.","authors":"Georgi Lukanov, Atanas Panev, Lubomir Tzvetanov, Kevork Kaykchian, Alexander Gerchev, Plamen Kinov, Slaveyko Djambazov","doi":"10.3897/folmed.68.e182189","DOIUrl":"10.3897/folmed.68.e182189","url":null,"abstract":"Introduction: Total hip arthroplasty is one of the most successful modern surgical procedures, yet periprosthetic joint infection (PJI) remains a serious complication associated with disability and increased postoperative mortality.\u0000\u0000Aim: This study highlights the importance of identifying the causative microorganism and its antibiotic susceptibility profile for the successful application of a one-stage revision protocol in treating PJI.\u0000\u0000Materials and methods: Between October 2017 and July 2023, 33 patients underwent one-stage revision total hip arthroplasty. Preoperative joint aspiration and intraoperative periprosthetic tissue sampling were performed in all cases, with microbiological analysis conducted. The study group consisted of 15 men and 18 women, with a mean postoperative follow-up of 33 months (range 2–66 months).\u0000\u0000Results: A pathogen was identified in 31 patients. Staphylococcus epidermidis was the most common microorganism, responsible for 44.1% of infections. Staphylococcus aureus was found in 14.7% of cases. Enterococcus faecalis was isolated in three patients, and Serratia marcescens in two. No infection recurrence was recorded during follow-up. Complications included two postoperative dislocations, both managed with closed reduction, and one death due to pulmonary embolism. Functional outcomes improved, with the mean Harris Hip Score increasing from 54.3 preoperatively to 72.3 postoperatively.\u0000\u0000Conclusion: In this selected cohort, one-stage revision was associated with favorable short- to mid-term outcomes. These findings suggest that, when guided by precise microbiological diagnosis and multidisciplinary management, one-stage revision may be a viable option for carefully selected patients with periprosthetic hip infection.","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"68 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148864375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of hand disinfection of dentists in interrupting cross-transmission of infections in dental practice. 牙医手部消毒在阻断牙科执业感染交叉传播中的作用。

Folia medica Pub Date : 2026-06-17 DOI: 10.3897/folmed.68.e173454

Veselina Kondeva, Velina Stoeva, Yordan Kalchev

{"title":"Role of hand disinfection of dentists in interrupting cross-transmission of infections in dental practice.","authors":"Veselina Kondeva, Velina Stoeva, Yordan Kalchev","doi":"10.3897/folmed.68.e173454","DOIUrl":"10.3897/folmed.68.e173454","url":null,"abstract":"Introduction: It is mandatory to perform meticulous hygienic disinfection of dentists’ hands. Dental personnel unintentionally transfer microorganisms from the patient’s mouth to adjacent surfaces, and vice versa.\u0000\u0000Aim: The aim of the present study was to determine the presence of resident and transient skin microbiota on the hands of dentists after performing hygienic hand disinfection.\u0000\u0000Materials and methods: A prospective epidemiological and microbiological study was conducted among 60 dentists in Plovdiv from May to June 2025. A short survey was also administered to assess basic knowledge of hygienic hand disinfection. After hand disinfection with alcohol-containing antiseptic, samples were collected with a dry sterile swab before donning gloves and manipulating the specimen.\u0000\u0000Results: Coagulase-negative staphylococci in microbial counts below 105 colony-forming units (CFU) were detected in 26% (n=16) and above 105 CFU in 20% (n=12). Gram-negative enteric bacteria were cultured in microbial counts below 105 CFU in 13.3% (n=8) and at 105 CFU in 1.7% (n=1). Molds were also grown in 3.3% (n=2).\u0000\u0000Conclusion: The presence of coagulase-negative staphylococci and Gram-negative bacteria in high microbial counts raises concerns about the disinfection quality. Regular and proper disinfection significantly reduces the risk of contamination and protects both the patient and the dental staff.","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"68 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148864388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The emerging function of MYPT1 as a biomarker and therapeutic target. MYPT1作为生物标志物和治疗靶点的新功能。

Folia medica Pub Date : 2026-06-08 DOI: 10.3897/folmed.68.e166432

Victor Velyanov, Nikola Lazarov, Lubomir Lubomirov, Kameliya Bratoeva

引用次数: 0

The association between psoriasis and body mass index: an observational retrospective study of 184 patients. 牛皮癣与体重指数的关系：184例患者的观察性回顾性研究

Folia medica Pub Date : 2026-06-08 DOI: 10.3897/folmed.68.e167943

Dzhamile Kamber, Klimentina Gospodinova, Veronika Gincheva, Ivelina Yordanova, Dimitar Gospodinov

引用次数: 0

Increased interleukin-6 and hepcidin-25 are associated with restless legs syndrome in rheumatoid arthritis patients. 白细胞介素-6和hepcidin-25的增加与类风湿性关节炎患者的不宁腿综合征有关。

Folia medica Pub Date : 2026-06-08 DOI: 10.3897/folmed.68.e193784

Krasimir Avramov, Snezhana Terziyska, Ivan Yakov, Todor Georgiev, Aneliya Draganova, Kiril Terziyski

引用次数: 0

Ten years of clinical experience with spinal cord stimulation for chronic pain: a retrospective cohort study and review of evolving stimulation paradigms. 十年脊髓刺激治疗慢性疼痛的临床经验：一项回顾性队列研究和不断发展的刺激范式的回顾。

Folia medica Pub Date : 2026-06-08 DOI: 10.3897/folmed.68.e177992

Dimitar Slavkov, Svetoslava Troyanova-Slavkova

引用次数: 0

Altered sleep architecture in chronic insomnia and its phenotypes: polysomnographic correlates and associations with insomnia severity and depressive symptoms. 慢性失眠的睡眠结构改变及其表型：多导睡眠图与失眠严重程度和抑郁症状的相关性

Folia medica Pub Date : 2026-04-30 DOI: 10.3897/folmed.68.e193687

Todor Georgiev, Kiril Terziyski

引用次数: 0

CXCL8 and CXCR4 expression in synchronous bone metastasis in nasopharyngeal cancer. CXCL8和CXCR4在鼻咽癌同步骨转移中的表达。

Folia medica Pub Date : 2026-04-30 DOI: 10.3897/folmed.68.e168480

Rahmat Cahyanur, Cosphiadi Irawan, Lisnawati Rachmadi, Marlinda Adham, Achmad Fauzi Kamal, Ahmad Rusdan Handoyo Utomo, Mardiah Suci Hardianti, Thariqah Salamah, Muchtaruddin Mansyur

引用次数: 0

Changing the treatment paradigm in beta thalassemia. 改变地中海贫血的治疗模式。

Folia medica Pub Date : 2026-04-30 DOI: 10.3897/folmed.68.e180627

Katya Sapunarova

{"title":"Changing the treatment paradigm in beta thalassemia.","authors":"Katya Sapunarova","doi":"10.3897/folmed.68.e180627","DOIUrl":"https://doi.org/10.3897/folmed.68.e180627","url":null,"abstract":"Beta-thalassemia is a hereditary disease that affects the synthesis of β-globin, resulting in ineffective erythropoiesis, chronic anemia, and iron overload. Although the traditional treatment approach, which includes hypertransfusion and chelation therapy, has increased patient survival, it does not address the underlying disease mechanisms. Improving erythroid maturation, increasing fetal hemoglobin synthesis, lowering iron burden, and modifying the disease's genetic background are the goals that have resulted in the development of several therapeutic classes and treatment options. Erythroid maturation modifiers have been shown to significantly reduce transfusion requirements in patients with beta-thalassemia, and inducers of fetal hemoglobin and hepcidin agonists show promise in controlling ineffective erythropoiesis and secondary iron overload. Gene therapy using lentiviral vectors or CRISPR/Cas9 genome editing has the potential to provide a significant proportion of patients with long-term transfusion independence. These therapeutic advances could significantly improve the quality of life and long-term survival of patients with beta-thalassemia. However, long-term studies are still needed to establish their safety profiles, refine patient selection criteria, and ensure greater access to these innovative treatments.","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"68 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148864242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling molecular dynamics: the effects of functional mandibular advancement and a one-month recovery period on myostatin and myosin-1c gene expression in masticatory muscles of young male Wistar rats. 揭示分子动力学：下颌功能推进和1个月恢复期对年轻雄性Wistar大鼠咀嚼肌肌生长抑制素和肌球蛋白-1c基因表达的影响。

Folia medica Pub Date : 2026-04-20 DOI: 10.3897/folmed.68.e169836

Sonakshi Sharma, Amol Patil, Shruti Biyani, Shivangini Swarnkar, Meydha Gera

引用次数: 0