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Association between the time for contrast to pass through the myocardium, risk profile and hemodynamic parameters. 造影剂通过心肌的时间、风险概况和血流动力学参数之间的关系。
Folia medica Pub Date : 2025-08-29 DOI: 10.3897/folmed.67.e152244
Rozen K Grigorov, Stefan Yambolov, Daniel Tsvetkov, Ivaylo Borisov, Svetoslav Georgiev
{"title":"Association between the time for contrast to pass through the myocardium, risk profile and hemodynamic parameters.","authors":"Rozen K Grigorov, Stefan Yambolov, Daniel Tsvetkov, Ivaylo Borisov, Svetoslav Georgiev","doi":"10.3897/folmed.67.e152244","DOIUrl":"https://doi.org/10.3897/folmed.67.e152244","url":null,"abstract":"<p><strong>Introduction: </strong>The time for contrast to pass through the myocardium (TCPM) is a novel fluoroscopic method proposed for the assessment of coronary microcirculation in patients with non-significant epicardial coronary artery disease.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"67 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144948862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrosion resistance of cobalt-chromium alloys for metal ceramic dental restorations. 金属陶瓷牙体修复用钴铬合金的耐腐蚀性能。
Folia medica Pub Date : 2025-08-29 DOI: 10.3897/folmed.67.e150425
Zlatina Tomova
{"title":"Corrosion resistance of cobalt-chromium alloys for metal ceramic dental restorations.","authors":"Zlatina Tomova","doi":"10.3897/folmed.67.e150425","DOIUrl":"https://doi.org/10.3897/folmed.67.e150425","url":null,"abstract":"<p><strong>Introduction: </strong>The corrosion of dental alloys can have undesirable consequences. The corrosion properties may be modified by the alloy production method, composition, method of prosthetic restoration manufacturing, and oral conditions.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"67 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144948802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing diagnostic delay in Ewing sarcoma: A single tertiary center analysis. 评估尤文氏肉瘤的诊断延迟：单三级中心分析。
Folia medica Pub Date : 2025-08-29 DOI: 10.3897/folmed.67.e153324
Yordan S Ivanov, Ivo V Ivanov, Karina A Atanasova-Ivanova
{"title":"Assessing diagnostic delay in Ewing sarcoma: A single tertiary center analysis.","authors":"Yordan S Ivanov, Ivo V Ivanov, Karina A Atanasova-Ivanova","doi":"10.3897/folmed.67.e153324","DOIUrl":"https://doi.org/10.3897/folmed.67.e153324","url":null,"abstract":"<p><strong>Introduction: </strong>Ewing sarcoma is a rare and highly aggressive primary malignant bone tumor. Early diagnosis is difficult, especially in the early stages of the disease, which often results in delays in diagnosis.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"67 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144948860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetic variability of CYP2D6, CYP2C19, and CYP1A2 in patients with treatment resistance to antipsychotics and antidepressants. 抗精神病药和抗抑郁药治疗耐药患者CYP2D6、CYP2C19和CYP1A2的遗传变异
Folia medica Pub Date : 2025-08-29 DOI: 10.3897/folmed.67.e149527
Tatiana A Zhiganova, Evgenia A Radkova
{"title":"Genetic variability of CYP2D6, CYP2C19, and CYP1A2 in patients with treatment resistance to antipsychotics and antidepressants.","authors":"Tatiana A Zhiganova, Evgenia A Radkova","doi":"10.3897/folmed.67.e149527","DOIUrl":"https://doi.org/10.3897/folmed.67.e149527","url":null,"abstract":"<p><strong>Aim: </strong>The study objective was to assess the frequency of gene alleles responsible for the metabolism and elimination of drugs in treatment-resistant patients to antipsychotics and/or antidepressants.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"67 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144948877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reference values of human epididymis protein 4 in the Bulgarian population - assessment of the influence of age, menopause, pregnancy, and renal function. 保加利亚人口中人类附睾蛋白4的参考值——年龄、更年期、妊娠和肾功能影响的评估
Folia medica Pub Date : 2025-08-29 DOI: 10.3897/folmed.67.e155013
Vesselina Koleva-Topova, Sevim Shefket
{"title":"Reference values of human epididymis protein 4 in the Bulgarian population - assessment of the influence of age, menopause, pregnancy, and renal function.","authors":"Vesselina Koleva-Topova, Sevim Shefket","doi":"10.3897/folmed.67.e155013","DOIUrl":"https://doi.org/10.3897/folmed.67.e155013","url":null,"abstract":"<p><strong>Introduction: </strong>Human epididymis protein 4 (HE4) is increasingly utilized in diagnosing pelvic masses and monitoring patients with ovarian or endometrial carcinoma. However, various publications and diagnostic kit manufacturers report a wide range of reference and threshold values, complicating accurate clinical interpretation and reducing the marker's clinical utility. This study aimed to establish reference values for HE4 in the Bulgarian female population and investigate the impact of physiological factors such as age, menopause, and pregnancy, as well as pathological conditions like impaired renal function, on marker levels.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"67 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144948841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Orthoplastic approach to limb salvage surgery in oncology: types of flaps and surgical timing. 肿瘤保肢手术的整形入路：皮瓣的类型和手术时机。
Folia medica Pub Date : 2025-08-15 DOI: 10.3897/folmed.67.e145385
Michela Saracco, Maria Grazia Cerrone, Gianmarco Vavalle, Raffaele Vitiello, Omar El Ezzo, Giulio Maccauro, Elisabetta Pataia
{"title":"Orthoplastic approach to limb salvage surgery in oncology: types of flaps and surgical timing.","authors":"Michela Saracco, Maria Grazia Cerrone, Gianmarco Vavalle, Raffaele Vitiello, Omar El Ezzo, Giulio Maccauro, Elisabetta Pataia","doi":"10.3897/folmed.67.e145385","DOIUrl":"https://doi.org/10.3897/folmed.67.e145385","url":null,"abstract":"<p><p>Extremities are a very common site for the development of malignant tumors. A multidisciplinary approach is essential for the proper management of extremity tumors, ensuring complete surgical resection with clear margins, proper management of tissue loss, and optimal functional recovery following reconstruction. Up to 95% of patients undergo successful limb-sparing treatments, avoiding amputation. We will discuss the advantages and disadvantages of using various flaps to reconstruct upper and lower extremities. We will also explore the applications of microvascular surgery and free flaps in this context and conclude with a reflection on the timing of reconstructions.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"67 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144948811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pediatric tracheotomy: insights from a single-center study. 儿科气管切开术：来自单中心研究的见解。
Folia medica Pub Date : 2025-08-15 DOI: 10.3897/folmed.67.e151098
Stoyan S Markov, Petya P Markova, Karen B Dzhambazov, Elizabet K Dzhambazova
{"title":"Pediatric tracheotomy: insights from a single-center study.","authors":"Stoyan S Markov, Petya P Markova, Karen B Dzhambazov, Elizabet K Dzhambazova","doi":"10.3897/folmed.67.e151098","DOIUrl":"https://doi.org/10.3897/folmed.67.e151098","url":null,"abstract":"<p><strong>Introduction: </strong>Over the years, pediatric tracheotomy has evolved significantly, and ongoing debates regarding its indications, timing, surgical techniques, and decannulation protocols persist. In most cases, management decisions are based on the medical team's clinical experience and existing literature, as there are no universally accepted guidelines.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"67 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144948813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Congenital bronchial atresia: a case report. 先天性支气管闭锁1例。
Folia medica Pub Date : 2025-08-15 DOI: 10.3897/folmed.67.e140562
Kostadin Ketev, Ivanka Karavelikova, Daniela Milanova-Ilieva
{"title":"Congenital bronchial atresia: a case report.","authors":"Kostadin Ketev, Ivanka Karavelikova, Daniela Milanova-Ilieva","doi":"10.3897/folmed.67.e140562","DOIUrl":"10.3897/folmed.67.e140562","url":null,"abstract":"<p><p>We present the case of a 12-year-old boy with congenital bronchial atresia exacerbated by recurrent pulmonary infections. Born prematurely at seven months, the patient experienced recurring respiratory symptoms and persistent chest pain. Despite a month of broad-spectrum antibiotics, his symptoms persisted, and imaging tests, including computed tomography, revealed bronchial atresia. Reviewing the patient's imaging results and clinical course underscores the importance of considering congenital abnormalities when treating patients with chronic pulmonary symptoms that do not respond to traditional treatment. Early recognition of congenital bronchial atresia is vital for implementing timely therapeutic interventions. This proactive approach can help patients avoid complications, improve respiratory function, and achieve better long-term health outcomes.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"67 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144948855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Marginal integrity evaluation of resin pit and fissure sealant with different application techniques. 不同应用工艺下树脂坑缝密封胶边缘完整性评价。
Folia medica Pub Date : 2025-08-15 DOI: 10.3897/folmed.67.e153322
Krasimir Hristov, Ralitsa Bogovska-Gigova, Nedana Georgieva
{"title":"Marginal integrity evaluation of resin pit and fissure sealant with different application techniques.","authors":"Krasimir Hristov, Ralitsa Bogovska-Gigova, Nedana Georgieva","doi":"10.3897/folmed.67.e153322","DOIUrl":"https://doi.org/10.3897/folmed.67.e153322","url":null,"abstract":"<p><strong>Introduction: </strong>Marginal integrity can be defined as the ability of a sealant to establish a robust and resilient bond at the interface between the sealant and the tooth surface, preventing microleakage, discoloration, the formation of voids and cracks, and the subsequent development of caries lesions.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"67 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144948783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative analysis of clinical characteristics of gout patients. 痛风患者临床特点的比较分析。
Folia medica Pub Date : 2025-08-15 DOI: 10.3897/folmed.67.e147838
Larisa Rotaru, Liliana Groppa, Eugeniu Russu, Svetlana Agachi, Larisa Spinei, Ludmila Negruța, Emil Ceban, Alexandru Corlateanu, Cristina Pamfil, Elena Sprincean, Cornelia Cornea
{"title":"Comparative analysis of clinical characteristics of gout patients.","authors":"Larisa Rotaru, Liliana Groppa, Eugeniu Russu, Svetlana Agachi, Larisa Spinei, Ludmila Negruța, Emil Ceban, Alexandru Corlateanu, Cristina Pamfil, Elena Sprincean, Cornelia Cornea","doi":"10.3897/folmed.67.e147838","DOIUrl":"https://doi.org/10.3897/folmed.67.e147838","url":null,"abstract":"<p><strong>Aim: </strong>Given the documented rise in the incidence and prevalence of gout over the past decade, this study aims to comparatively assess patients of different ages affected by gout in Romania and the Republic of Moldova.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"67 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144948880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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