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Leveraging machine learning and molecular docking techniques to predict novel melanocortin-4 receptor agonists. 利用机器学习和分子对接技术预测新的黑素皮质素-4受体激动剂。
Folia medica Pub Date : 2025-06-06 DOI: 10.3897/folmed.67.e150583
Stavroula Giakoumopoulou, Paris Christodoulou, Minos-Timotheos Matsoukas, Vasilis Panagiotopoulos, Dionisis Cavouras, Eftichia Kritsi
{"title":"Leveraging machine learning and molecular docking techniques to predict novel melanocortin-4 receptor agonists.","authors":"Stavroula Giakoumopoulou, Paris Christodoulou, Minos-Timotheos Matsoukas, Vasilis Panagiotopoulos, Dionisis Cavouras, Eftichia Kritsi","doi":"10.3897/folmed.67.e150583","DOIUrl":"https://doi.org/10.3897/folmed.67.e150583","url":null,"abstract":"<p><strong>Introduction: </strong>Monogenic obesity caused by mutations in the melanocortin-4 receptor (MC4R) gene remains a significant health challenge, despite numerous efforts to discover effective treatments. The MC4R has emerged as a promising target for drug development due to its role in energy homeostasis and adipose tissue formation.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"67 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Giant vulvar polyp in a postmenopausal woman: a rare clinical case. 绝经后妇女巨大外阴息肉一例罕见临床病例。
Folia medica Pub Date : 2025-06-02 DOI: 10.3897/folmed.67.e139838
Krum Vladov, Ekaterina Uchikova, Maria Koleva-Ivanova, Kamen Yamakov, Veselin Belovezhdov, Gita Yamakova-Vladova, Eleonora Hristova-Atanasova
{"title":"Giant vulvar polyp in a postmenopausal woman: a rare clinical case.","authors":"Krum Vladov, Ekaterina Uchikova, Maria Koleva-Ivanova, Kamen Yamakov, Veselin Belovezhdov, Gita Yamakova-Vladova, Eleonora Hristova-Atanasova","doi":"10.3897/folmed.67.e139838","DOIUrl":"10.3897/folmed.67.e139838","url":null,"abstract":"<p><p>The increased frequency of precancerous lesions and malignant diseases of the vulva is a hallmark of the postmenopausal period. However, the development of fibroepithelial polyps, which are benign neoplasms, is also possible. The exact etiology and pathogenesis remain unclear. These mesenchymal neoplasms are mostly diagnosed in women who received hormone replacement therapy or those who are of reproductive age, with pregnancy being a predisposing factor. We present a clinical case in which surgical treatment was the first choice, and histopathological examination confirmed the diagnosis.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"67 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predictive value of neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in patients with vaginitis: nested case-control study. 中性粒细胞-淋巴细胞比值和血小板-淋巴细胞比值在阴道炎患者中的预测价值：巢式病例对照研究。
Folia medica Pub Date : 2025-06-02 DOI: 10.3897/folmed.67.e146769
Ali Mohammed Ali Al-Nuaimi
{"title":"Predictive value of neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in patients with vaginitis: nested case-control study.","authors":"Ali Mohammed Ali Al-Nuaimi","doi":"10.3897/folmed.67.e146769","DOIUrl":"https://doi.org/10.3897/folmed.67.e146769","url":null,"abstract":"<p><strong>Aim: </strong>To investigate the value of the hematological indices to differentiate bacterial vaginosis (BV) from vulvovaginal candidiasis (VVC) and predict treatment response.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"67 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Infiltration level of CPP-ACFP (MI Varnish™), self-assembling peptide P11-4 (Curodont™ Repair), and newly synthesized fluorinated self-assembling peptides in artificial enamel initial carious lesions on smooth surfaces assessed by laser confocal microscopy - an in vitro study. 用激光共聚焦显微镜评估光滑表面人工牙釉质初始龋齿病变中pcp - acfp （MI Varnish™）、自组装肽P11-4 （curodon™Repair）和新合成的氟化自组装肽的浸润水平
Folia medica Pub Date : 2025-06-02 DOI: 10.3897/folmed.67.e151396
Irina Uzunova-Raycheva, Tanya Nihtyanova, Ralitsa Raycheva, Dancho Danalev, Petya Romanova, Ani Belcheva-Krivorova
{"title":"Infiltration level of CPP-ACFP (MI Varnish™), self-assembling peptide P<sub>11</sub>-4 (Curodont™ Repair), and newly synthesized fluorinated self-assembling peptides in artificial enamel initial carious lesions on smooth surfaces assessed by laser confocal microscopy - an in vitro study.","authors":"Irina Uzunova-Raycheva, Tanya Nihtyanova, Ralitsa Raycheva, Dancho Danalev, Petya Romanova, Ani Belcheva-Krivorova","doi":"10.3897/folmed.67.e151396","DOIUrl":"https://doi.org/10.3897/folmed.67.e151396","url":null,"abstract":"<p><strong>Aim: </strong>The aim of this study was to compare the lesion depth and level of penetration of CPP-ACFP, SAP P11-4 and 2 newly synthesized self-assembling peptides by measuring the linear depth of fluorescence.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"67 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Extramedullary CNS myeloma. 髓外中枢神经系统骨髓瘤。
Folia medica Pub Date : 2025-06-02 DOI: 10.3897/folmed.67.e156417
Alessandro Gozzetti
{"title":"Extramedullary CNS myeloma.","authors":"Alessandro Gozzetti","doi":"10.3897/folmed.67.e156417","DOIUrl":"10.3897/folmed.67.e156417","url":null,"abstract":"<p><p>NA.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"67 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Types and biological effects of titanium alloys in prosthodontics. 钛合金在口腔修复中的种类及生物学效应。
Folia medica Pub Date : 2025-05-27 DOI: 10.3897/folmed.67.e152720
Atanas Chonin, Radka Cholakova, Zlatina Tomova, Angelina Vlahova, Mariana Dimova-Gabrovska
{"title":"Types and biological effects of titanium alloys in prosthodontics.","authors":"Atanas Chonin, Radka Cholakova, Zlatina Tomova, Angelina Vlahova, Mariana Dimova-Gabrovska","doi":"10.3897/folmed.67.e152720","DOIUrl":"https://doi.org/10.3897/folmed.67.e152720","url":null,"abstract":"<p><p>Recent EU regulations recommend restriction of the use of medical devices in which cobalt content exceeds 0.1%. Commercially pure titanium (cpTi) and titanium alloys appear to be excellent alternatives to cobalt-based alloys in the fields of implantology and prosthodontics. The narrative review summarizes the structure and types of titanium alloys and the methods of their processing. The high biocompatibility of titanium is explained in terms of corrosion, ion release, and interaction with the biological environment. An analysis of existing studies on the mechanical properties of titanium prosthetic restorations is presented, and future perspectives are outlined.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"67 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolic storm in psoriatic arthritis: a cardiovascular time bomb? 银屑病关节炎中的代谢风暴：心血管定时炸弹？
Folia medica Pub Date : 2025-05-27 DOI: 10.3897/folmed.67.e153667
Eugeniu Russu, Mircea Betiu, Alexandru Corlateanu, Lia Chislari, Larisa Rotaru, Liliana Groppa
{"title":"Metabolic storm in psoriatic arthritis: a cardiovascular time bomb?","authors":"Eugeniu Russu, Mircea Betiu, Alexandru Corlateanu, Lia Chislari, Larisa Rotaru, Liliana Groppa","doi":"10.3897/folmed.67.e153667","DOIUrl":"10.3897/folmed.67.e153667","url":null,"abstract":"<p><strong>Introduction: </strong>Psoriatic arthritis (PsA) is a chronic immune-mediated disease that extends beyond joint and skin involvement, being strongly associated with metabolic disturb ances and increased cardiovascular risk. Chronic inflammation, adipokine imbalance, and endothelial dysfunction contribute to accelerated atherosclerosis in this population.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"67 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Management of patients with combined height injury - a case report. 合并高度损伤患者的处理- 1例报告。
Folia medica Pub Date : 2025-05-27 DOI: 10.3897/folmed.67.e137950
Vanya Anastasova, Stanislav Karamitev, Aleksandar Georgiev, Petar Kiskinov, Elena Krasteva, Elean Zanzov
{"title":"Management of patients with combined height injury - a case report.","authors":"Vanya Anastasova, Stanislav Karamitev, Aleksandar Georgiev, Petar Kiskinov, Elena Krasteva, Elean Zanzov","doi":"10.3897/folmed.67.e137950","DOIUrl":"10.3897/folmed.67.e137950","url":null,"abstract":"<p><p>Combined musculoskeletal traumas (MST) are complex injuries that can lead to life-threatening conditions and high mortality rates, particularly in men under 45 and women under 35. Recent increases in multiple trauma incidence highlight the need for timely intervention and effective management strategies. The concept of damage control orthopedics emphasizes the importance of stabilizing life-threatening injuries first, followed by staged surgical interventions once the patient's condition is stabilized.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"67 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunodiagnostic potential of the RANK/RANKL/OPG ratio in gingival crevicular fluid for periodontitis. 龈沟液RANK/RANKL/OPG比值对牙周炎的免疫诊断价值
Folia medica Pub Date : 2025-05-16 DOI: 10.3897/folmed.67.e144949
Thuraya K Alwandawi
{"title":"Immunodiagnostic potential of the RANK/RANKL/OPG ratio in gingival crevicular fluid for periodontitis.","authors":"Thuraya K Alwandawi","doi":"10.3897/folmed.67.e144949","DOIUrl":"10.3897/folmed.67.e144949","url":null,"abstract":"<p><strong>Introduction: </strong>Periodontitis and apical periodontitis are multifactorial inflammatory diseases involving microbial activity and host responses that lead to tissue destruction. Biomarkers such as receptor activator of nuclear factor-kappa B (RANK), its ligand (RANKL), and the osteoprotegerin (OPG) system in gingival crevicular fluid (GCF) have been investigated for their diagnostic and prognostic roles in these conditions.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"67 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of the impact of sex on some biochemical markers in end-stage renal disease patients on hemodialysis (comparison between hyperuricemia and normouricemia). 评价性别对终末期肾病血液透析患者某些生化指标的影响（高尿酸血症与正常尿酸血症的比较）。
Folia medica Pub Date : 2025-05-16 DOI: 10.3897/folmed.67.e152461
Rawaa Shareef, Bashaer Muhammad-Baqir, Evan Hameed, Mustafa Ahmed
{"title":"Evaluation of the impact of sex on some biochemical markers in end-stage renal disease patients on hemodialysis (comparison between hyperuricemia and normouricemia).","authors":"Rawaa Shareef, Bashaer Muhammad-Baqir, Evan Hameed, Mustafa Ahmed","doi":"10.3897/folmed.67.e152461","DOIUrl":"https://doi.org/10.3897/folmed.67.e152461","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic kidney disease is characterized by the damage or dysfunction of the kidneys for a duration of at least three months, depending on its cause. End-stage kidney disease is defined by a glomerular filtration rate (GFR) of less than 15 mL/min/1.73 m2 or the need for long-term renal replacement therapy irrespective of GFR.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"67 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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