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Significant role of pyocyanin and exotoxin A in the pathogenesis of Pseudomonas aeruginosa isolated from hospitalized patients. 从住院病人体内分离出的铜绿假单胞菌的致病机理中，脓蓝蛋白和外毒素 A 起着重要作用。
Folia medica Pub Date : 2024-02-29 DOI: 10.3897/folmed.66.e111038
Zahra Panahi, Mina Owrang, Hamid Reza Goli
{"title":"Significant role of pyocyanin and exotoxin A in the pathogenesis of <i>Pseudomonas aeruginosa</i> isolated from hospitalized patients.","authors":"Zahra Panahi, Mina Owrang, Hamid Reza Goli","doi":"10.3897/folmed.66.e111038","DOIUrl":"10.3897/folmed.66.e111038","url":null,"abstract":"<p><strong>Aim: </strong>Due to the importance of exotoxin A and pyocyanin in the pathogenicity of this bacterium, we decided to evaluate the prevalence of genes encoding these virulence factors in clinical isolates of P.aeruginosa.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"66 1","pages":"88-96"},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139996091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anti-inflammatory and in vitro antioxidant activities of Satureja montana dry extract. Satureja montana 干提取物的抗炎和体外抗氧化活性。
Folia medica Pub Date : 2024-02-29 DOI: 10.3897/folmed.66.e115800
Natalia Vilmosh, Maria Georgieva-Kotetarova, Ilin Kandilarov, Hristina Zlatanova-Tenisheva, Mariana Murdjeva, Veselina Kirina, Stela Dimitrova, Mariana Katsarova, Petko Denev, Ivanka Kostadinova
{"title":"Anti-inflammatory and in vitro antioxidant activities of <i>Satureja montana</i> dry extract.","authors":"Natalia Vilmosh, Maria Georgieva-Kotetarova, Ilin Kandilarov, Hristina Zlatanova-Tenisheva, Mariana Murdjeva, Veselina Kirina, Stela Dimitrova, Mariana Katsarova, Petko Denev, Ivanka Kostadinova","doi":"10.3897/folmed.66.e115800","DOIUrl":"10.3897/folmed.66.e115800","url":null,"abstract":"<p><strong>Introduction: </strong>Many chronic somatic and psychiatric diseases are associated with oxidative stress and inflammation, both of which have detrimental effects on human health.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"66 1","pages":"114-122"},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139996061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of body mass index on urinary lithogenic factors in urinary system stone patients. 体重指数对泌尿系统结石患者排尿成石因子的影响
Folia medica Pub Date : 2024-02-29 DOI: 10.3897/folmed.66.e114369
Yavuz Güler
{"title":"Effects of body mass index on urinary lithogenic factors in urinary system stone patients.","authors":"Yavuz Güler","doi":"10.3897/folmed.66.e114369","DOIUrl":"10.3897/folmed.66.e114369","url":null,"abstract":"<p><strong>Aim: </strong>Obesity and metabolic syndrome are becoming more prevalent these days. In addition, we know that urinary stone disease is also on the rise. In this study, we wanted to examine if body mass index (BMI) had a negative effect on the stone disease by evaluating 24-hour urinalysis in stone patients and recurrence rates in our region.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"66 1","pages":"80-87"},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139996064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Guardians of immunity: NK cell-mediated defense in COVID-19 and post-COVID scenarios. 免疫守护者：COVID-19 和后 COVID 情况下 NK 细胞介导的防御。
Folia medica Pub Date : 2024-02-29 DOI: 10.3897/folmed.66.e113356
Steliyan Petrov, Hristo Taskov, Marianna Murdjeva
{"title":"Guardians of immunity: NK cell-mediated defense in COVID-19 and post-COVID scenarios.","authors":"Steliyan Petrov, Hristo Taskov, Marianna Murdjeva","doi":"10.3897/folmed.66.e113356","DOIUrl":"10.3897/folmed.66.e113356","url":null,"abstract":"<p><p>The COVID-19 pandemic has left a lasting impact on global health, challenging communities, healthcare systems, and researchers worldwide. As we navigate this unprecedented crisis, this paper embarks on a multifaceted exploration of the pivotal role played by natural killer (NK) cells in the context of COVID-19. A significant portion of this paper is devoted to dissecting the nuanced role that NK cells assume in the context of COVID-19. From the initial acute infection to post-recovery immunity, NK cells emerge as critical players. We scrutinize the activation and dysregulation of NK cells during SARS-CoV-2 infection, shedding light on their potential contribution to disease severity. Moreover, we explore the fascinating landscape of post-COVID immunity, where NK cells are known to interact with adaptive immune responses, providing a foundation for long-term protection. In light of their central role, we investigate therapeutic strategies targeting NK cells in COVID-19 management, presenting an overview of current research efforts and their promise in mitigating disease progression. Lastly, we draw attention to research gaps, emphasizing the need for further investigation into NK cell dynamics during COVID-19. These gaps represent opportunities for advancing our understanding of NK cell biology and, by extension, enhancing our strategies for combating this global health crisis. This comprehensive exploration not only highlights the intricate interplay between NK cells and the COVID-19 pandemic but also underscores the importance of these innate immune warriors in shaping both the acute response and long-term immunity, ultimately contributing to the broader discourse surrounding the pandemic's pathophysiology and therapeutic approaches.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"66 1","pages":"12-18"},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139996067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Initial experience with Bulgarian Arthroplasty Register. 保加利亚关节成形术注册的初步经验。
Folia medica Pub Date : 2024-02-29 DOI: 10.3897/folmed.66.e117165
Atanas Panev, Georgi Lukanov, Georgi Luchev, Slaveyko Dzhambazov, Stoyan Ivanov, Jean-Alain Epinette, Plamen Kinov
{"title":"Initial experience with Bulgarian Arthroplasty Register.","authors":"Atanas Panev, Georgi Lukanov, Georgi Luchev, Slaveyko Dzhambazov, Stoyan Ivanov, Jean-Alain Epinette, Plamen Kinov","doi":"10.3897/folmed.66.e117165","DOIUrl":"10.3897/folmed.66.e117165","url":null,"abstract":"<p><strong>Introduction: </strong>National arthroplasty registries date back to 1975, when the Swedish Knee Arthroplasty Register was founded. This method of database collecting has since been employed for both patient follow-up and the creation of annual statistical reports. In Bulgaria, there is currently no state-approved software that offers these features.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"66 1","pages":"41-45"},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139996068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Non-invasive stress estimation in simulative endoscopy setting: literature review. 模拟内窥镜检查环境中的无创压力估算：文献综述。
Folia medica Pub Date : 2024-02-29 DOI: 10.3897/folmed.66.e115645
Nikola Boyanov, Vladimir Andonov
{"title":"Non-invasive stress estimation in simulative endoscopy setting: literature review.","authors":"Nikola Boyanov, Vladimir Andonov","doi":"10.3897/folmed.66.e115645","DOIUrl":"10.3897/folmed.66.e115645","url":null,"abstract":"<p><p>One of the most common stressors is so-called \"occupational stress.\" It is defined as the sum of physical, mental and physiological responses to work in situations where the workload or stress associated with it intensifies for an extended period of time. It is a gradual process in which individual cognitive assessments of occupational stressors generate adverse health events and may lead to burnout. Since it has become a major problem in the medical field, studying, measuring and limiting it have been set as goals for the future.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"66 1","pages":"7-11"},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139996070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Platelet-rich plasma efficacy in alopecia areata patients with normal and elevated levels of antibodies against thyroglobulin and thyroid peroxidase. 富血小板血浆对甲状腺球蛋白和甲状腺过氧化物酶抗体水平正常和升高的斑秃患者的疗效。
Folia medica Pub Date : 2024-02-29 DOI: 10.3897/folmed.66.e115484
Tsvetana I Abadjieva, Lidiya N Todorova, Petya A Gardjeva, Mariana A Murdjeva
{"title":"Platelet-rich plasma efficacy in alopecia areata patients with normal and elevated levels of antibodies against thyroglobulin and thyroid peroxidase.","authors":"Tsvetana I Abadjieva, Lidiya N Todorova, Petya A Gardjeva, Mariana A Murdjeva","doi":"10.3897/folmed.66.e115484","DOIUrl":"10.3897/folmed.66.e115484","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate and compare the efficacy of platelet-rich plasma (PRP) therapy in alopecia areata (AA) patients with normal and with elevated levels of anti-thyroglobulin antibodies and/or anti-thyroid peroxidase antibodies.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"66 1","pages":"66-72"},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139996072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy and safety of quinolones as potential first line therapy in pulmonary tuberculosis: a meta-analysis. 喹诺酮类药物作为肺结核潜在一线疗法的疗效和安全性：一项荟萃分析。
Folia medica Pub Date : 2024-02-29 DOI: 10.3897/folmed.66.e115239
Aqyl Hanif Abdillah, Ahmad Aziz Multazam Rangkuti, Dimas Pangestu, Salsabila Az-Zahra, Supiono Supiono
{"title":"Efficacy and safety of quinolones as potential first line therapy in pulmonary tuberculosis: a meta-analysis.","authors":"Aqyl Hanif Abdillah, Ahmad Aziz Multazam Rangkuti, Dimas Pangestu, Salsabila Az-Zahra, Supiono Supiono","doi":"10.3897/folmed.66.e115239","DOIUrl":"10.3897/folmed.66.e115239","url":null,"abstract":"<p><strong>Introduction: </strong>Tuberculosis is an infectious disease that continues to plague the world today, causing concerns due to its high mortality rate. The therapy regimens used for the treatment of tuberculosis today have demonstrated high efficacy and safety, potentially reducing the disease's burden, but the use of some standardized medications has caused many resistances to emerge. Over the last decade, researchers have been looking for suitable alternatives, with quinolones emerging as the most promising candidate due to their efficacy, safety, and availability. However, their efficacy as a first-line treatment remains debatable.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"66 1","pages":"26-34"},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139996065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predictors of a severe course and mortality in patients with COVID-19-associated pneumonia. COVID-19 相关肺炎患者严重病程和死亡率的预测因素。
Folia medica Pub Date : 2024-02-29 DOI: 10.3897/folmed.66.e111124
Vesela Blagoeva, Vladimir Hodzhev, Rositsa Dimova, Rumyana Stoyanova, Dimitar Bahariev
{"title":"Predictors of a severe course and mortality in patients with COVID-19-associated pneumonia.","authors":"Vesela Blagoeva, Vladimir Hodzhev, Rositsa Dimova, Rumyana Stoyanova, Dimitar Bahariev","doi":"10.3897/folmed.66.e111124","DOIUrl":"10.3897/folmed.66.e111124","url":null,"abstract":"<p><strong>Introduction: </strong>Severe and critical forms of SARS-CoV-2 pneumonia are associated with high morbidity and mortality. Numerous research studies have been conducted around the world to investigate various variables (demographic, clinical, laboratory, etc.) in an attempt to understand the relationships between them and the course and outcome of patients with COVID-19 infection and pneumonia.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"66 1","pages":"59-65"},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139996073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A 3D-simulation study of the deformation, tension, and stress of 3D-printed and conventional denture base materials after immersion in artificial saliva. 关于三维打印和传统义齿基托材料在人工唾液中浸泡后的变形、张力和应力的三维模拟研究。
Folia medica Pub Date : 2024-02-29 DOI: 10.3897/folmed.66.e118377
Mariya Dimitrova, Angelina Vlahova, Raycho Raychev, Bozhana Chuchulska, Rada Kazakova
{"title":"A 3D-simulation study of the deformation, tension, and stress of 3D-printed and conventional denture base materials after immersion in artificial saliva.","authors":"Mariya Dimitrova, Angelina Vlahova, Raycho Raychev, Bozhana Chuchulska, Rada Kazakova","doi":"10.3897/folmed.66.e118377","DOIUrl":"10.3897/folmed.66.e118377","url":null,"abstract":"<p><strong>Introduction: </strong>The worldwide application of digital technology has presented dentistry with transformative opportunities. The concept of digital dentures, incorporating computer-aided design (CAD) and computer-aided manufacturing (CAM) techniques, holds the promise of improved precision, customization, and overall patient satisfaction. However, the shift from traditional dentures to their digital counterparts should not be taken lightly, as the intricate interplay between oral physiology, patient comfort, and long-term durability requires thorough examination.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"66 1","pages":"104-113"},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139996060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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