Folia medica最新文献_第10页

Neuroendocrine regulation of appetite. 食欲的神经内分泌调节。

Folia medica Pub Date : 2026-01-30 DOI: 10.3897/folmed.68.e156353

Nikolay Botushanov, Aleksandar Botushanov, Albena Botushanova

引用次数: 0

Micro-scratch and wear resistance of restorative dental materials: an in vitro study. 牙体修复材料的微划伤和耐磨性的体外研究。

Folia medica Pub Date : 2026-01-30 DOI: 10.3897/folmed.68.e161188

Valeriya Aleksandrova, Neshka Manchorova, Veselina Todorova, Lyubomir Vangelov, Svetlin Alexandrov

引用次数: 0

Assessment of attitudes and practices regarding human papillomavirus vaccines among Medical University students: preliminary results. 医科大学学生对人乳头瘤病毒疫苗的态度和做法的评估：初步结果。

Folia medica Pub Date : 2026-01-30 DOI: 10.3897/folmed.68.e160562

Meri Hristamyan

{"title":"Assessment of attitudes and practices regarding human papillomavirus vaccines among Medical University students: preliminary results.","authors":"Meri Hristamyan","doi":"10.3897/folmed.68.e160562","DOIUrl":"10.3897/folmed.68.e160562","url":null,"abstract":"Introduction: Human papillomavirus (HPV) infections are highly prevalent and are linked to a range of health conditions, from benign lesions to several oncological diseases. Safe and highly effective HPV vaccines have been developed; however, vaccination rates remain suboptimal in many countries, including Bulgaria. As future medical professionals, the attitudes and practices of healthcare students toward HPV vaccination are of extreme importance.\u0000\u0000Aim: To evaluate the attitudes and practices of university healthcare students regarding HPV vaccines.\u0000\u0000Materials and methods: An anonymous online survey was administered to a total of 245 medical, dental, and pharmacy students at the Medical University of Plovdiv, Bulgaria. Statistical analyses were performed using SPSS v. 24; p<0.05 was considered significant.\u0000\u0000Results: The majority of participants (86.5%, n=212) had not been vaccinated against HPV, but more than half (n=121) expressed a willingness to be vaccinated. The proportion of vaccinated individuals increased with the number of sexual partners reported in the previous year (χ2=10.44, p=0.033). Approximately two-thirds of the individuals surveyed (n=157) would recommend vaccination, with a higher likelihood among women (U=1848.5, p<0.001). Vaccinated respondents tended to have greater distrust of the myth regarding reproductive consequences (U=1926.0, p=0.002). Embarrassment was not perceived as a major barrier, but 21.2% (n=52) stated that cost was. There was a consensus among all majors on the necessity for enhanced awareness, which is particularly pronounced among medical students (H=13.13, p<0.001). Unvaccinated respondents had a higher interest in gaining more knowledge (U=1971.0, p=0.003), just like first- to third-year students (H=9.37, p=0.017).\u0000\u0000Conclusion: While overall vaccine confidence and attitudes are high, addressing specific concerns (such as safety, personal risk, and cost) could improve HPV vaccine uptake and acceptance.","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"68 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147510689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rare constellation of unilateral superficial ulnar artery, variant common interosseous artery, and unilateral agenesis of palmaris longus. 罕见的单侧尺浅动脉星座，变异的骨间总动脉，和单侧掌长肌发育不全。

Folia medica Pub Date : 2025-12-29 DOI: 10.3897/folmed.67.e145015

Prabhjot Singh, Hare Krishna, Kumar Sambhav, Surajit Ghatak

引用次数: 0

Identifying potential novel biomarkers for varicocele: A bioinformatics approach to genomics analysis. 鉴定精索静脉曲张潜在的新型生物标志物：基因组学分析的生物信息学方法。

Folia medica Pub Date : 2025-12-18 DOI: 10.3897/folmed.67.e168906

Muhammad Farid, Hanin Fitri Aqilanisa

{"title":"Identifying potential novel biomarkers for varicocele: A bioinformatics approach to genomics analysis.","authors":"Muhammad Farid, Hanin Fitri Aqilanisa","doi":"10.3897/folmed.67.e168906","DOIUrl":"10.3897/folmed.67.e168906","url":null,"abstract":"Introduction: Varicocele, characterized by the enlargement of scrotal veins, is a common contributor to male infertility, but its genetic underpinnings remain largely unknown.\u0000\u0000Aim: The goal of this study is to identify potential biomarkers associated with varicocele in order to better understand its molecular mechanisms.\u0000\u0000Materials and methods: Using the three primary databases, NCBI, DisGeNET, and OpenTarget, we analyzed gene variants and found 79 pertinent genes associated with varicocele. Protein-protein interaction analysis was performed using STRING and visualized with Cytoscape. Molecular Complex Detection (MCODE) and CytoHubba tools helped identify significant protein clusters.\u0000\u0000Results: The gene ontology analysis shows that there are 79 proteins involved in the inflammatory process, the regulation of gene expression, and cellular components that play a role in oxidative stress and angiogenesis. Our results revealed three key biomarkers: Interleukin-1 beta (IL1B), B-cell lymphoma 2 (BCL2), and matrix metalloproteinase-9 (MMP-9). These proteins are involved in critical processes, such as inflammation, oxidative stress, angiogenesis, and vascular damage, that are central to the pathophysiology of varicocele.\u0000\u0000Conclusion: The identification of IL1B, BCL2, and MMP-9 offers new insights into varicocele’s molecular mechanisms and suggests potential targets for diagnostic and therapeutic strategies, advancing personalized treatment approaches for fertility restoration.","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"67 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145854978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of anthropometric parameters, white blood cell count, and morphological changes of red blood cells in a pristane-induced rheumatoid arthritis rat model. 评测人体测量参数，白细胞计数和红细胞形态学变化的大鼠模型的前列腺素诱导的类风湿关节炎。

Folia medica Pub Date : 2025-12-18 DOI: 10.3897/folmed.67.e152994

Samir Mehmedagić, Muhamed Katica, Dina Kapić, Aida Bešić, Nadža Kapo-Dolan, Almir Fajkić, Asija Začiragić, Nermina Klapuh-Bukvić, Amela Dervišević

{"title":"Evaluation of anthropometric parameters, white blood cell count, and morphological changes of red blood cells in a pristane-induced rheumatoid arthritis rat model.","authors":"Samir Mehmedagić, Muhamed Katica, Dina Kapić, Aida Bešić, Nadža Kapo-Dolan, Almir Fajkić, Asija Začiragić, Nermina Klapuh-Bukvić, Amela Dervišević","doi":"10.3897/folmed.67.e152994","DOIUrl":"10.3897/folmed.67.e152994","url":null,"abstract":"Introduction: Rheumatoid arthritis (RA) is an autoimmune disease characterized by a complex pathophysiological mechanism. The adipose tissue, blood and its cellular components are less-studied extra-articular manifestations of RA.\u0000\u0000Aim: In this study, we used a pristane-induced RA rat model to assess the impact of RA-induced inflammation on anthropometric parameters, obesity indices, white blood cell differentiation, and morphological changes in red blood cells.\u0000\u0000Materials and methods: The randomized controlled, prospective, experimental study involved 20 adult female Wistar rats, aged 12-13 weeks, with body weights ranging from 180 to 220 grams. The rats were randomly assigned to two groups: an experimental RA-induced group (PIA group; n=10) and a control group of healthy animals (n=10). Rheumatoid arthritis was induced by intradermal injection of 150 μL of pristane at the dorsal base of the tail.\u0000\u0000Results: Rats in the PIA group exhibited significantly lower values of body weight (p=0.002), abdominal circumference (p=0.011), and BMI (p=0.028) compared to those in the control group. The number of neutrophils (p<0.001) and eosinophils (p<0.001) in the PIA group was significantly higher than in the control group, while the number of lymphocytes (p=0.001) was lower. Peripheral blood smear analysis showed a significant increase in the number of dacryocytes (p=0.003), anulocytes (p=0.002), spherocytes (p<0.001), and reticulocytes (p<0.001) in the PIA group compared to the control group.\u0000\u0000Conclusion: This study demonstrates that the pathological processes in rheumatoid arthritis are reflected in the anthropometric parameters, the distribution of specific leukocyte types, and the morphological characteristics of erythrocytes. These factors collectively contribute to the complexity of disease progression in RA.","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"67 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145855004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical analysis in older patients with a first-ever, second, third, and recurrent strokes. 老年患者首次、第二次、第三次和复发性脑卒中的临床分析。

Folia medica Pub Date : 2025-12-18 DOI: 10.3897/folmed.67.e164775

Dimitar Maslarov, Jane Maslarova-Gelov, Ivan Gelov, Natasha Angelova, Blagovesta Dafkova, Simona Nikolova, Desislava Drenska

引用次数: 0

Our experience in the management of Fournier's gangrene - a single-center retrospective study. 我们在富尼耶坏疽治疗中的经验-一项单中心回顾性研究。

Folia medica Pub Date : 2025-12-18 DOI: 10.3897/folmed.67.e155274

Velizar Hadzhiminev, Georgi Markov, Aleksandar Sarpanov, Lyubomir Paunov, Stanislav Karamitev, Aleksandrina Topalova-Shishmanova, Krasi Kalacheva, Atanas Batashki

{"title":"Our experience in the management of Fournier's gangrene - a single-center retrospective study.","authors":"Velizar Hadzhiminev, Georgi Markov, Aleksandar Sarpanov, Lyubomir Paunov, Stanislav Karamitev, Aleksandrina Topalova-Shishmanova, Krasi Kalacheva, Atanas Batashki","doi":"10.3897/folmed.67.e155274","DOIUrl":"10.3897/folmed.67.e155274","url":null,"abstract":"Introduction: Fournier’s gangrene (FG) is a rare and potentially life-threatening infection that leads to necrosis of soft tissue. This condition constitutes a medical emergency, necessitating prompt surgical intervention to mitigate the potential consequences.\u0000\u0000Aim: To analyze the demographic and clinical characteristics of a small cohort of patients with FG.\u0000\u0000Patients and methods: The present retrospective study included 31 patients with Fournier’s gangrene who were hospitalized in the Department of General Surgery from January 2020 to December 2023. A comprehensive examination of the patients’ demographic characteristics, comorbidities, presence of diabetes mellitus, microbial agents involved, and methods used for wound management was conducted.\u0000\u0000Results: The study found that men, particularly those over the age of 55, were more commonly affected than women. Escherichia coli was identified as the predominant microbial agent. The prevalence of diabetes mellitus was found to be higher among female patients. All patients received prompt surgery according to established protocols. Enzyme proteolysis was our method of choice for wound management. Ten patients underwent adjunctive surgery while seven patients had reconstructive procedures. The mortality rate registered was 25.8%. The mean length of hospital stay was 12.8 days.\u0000\u0000Conclusion: Fournier’s gangrene has a high mortality and complication rate despite the current treatment options. Wound management with enzyme proteolysis yielded promising results.","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"67 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145855090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Papillary fibroelastoma in an unusual location: arising from the left atrial endocardium. 不寻常位置的乳头状纤维弹性瘤：起源于左房心内膜。

Folia medica Pub Date : 2025-12-18 DOI: 10.3897/folmed.67.e145258

Assen S Keltchev, Kristiyanna M Mavrodieva

引用次数: 0

The role of improved molecular genetic testing in the diagnosis of cystic fibrosis - a case series. 改进的分子基因检测在囊性纤维化诊断中的作用-一个病例系列。

Folia medica Pub Date : 2025-12-18 DOI: 10.3897/folmed.67.e145379

Nadezhda Yaneva, Mila Baycheva, Dimitrinka Miteva, Guergana Petrova

引用次数: 0