Free Radical Research最新文献_第7页

The selective NOX4 inhibitor GLX7013159 decreases blood glucose concentrations and human beta-cell apoptotic rates in diabetic NMRI nu/nu mice transplanted with human islets. 选择性NOX4抑制剂GLX7013159降低了移植人胰岛的糖尿病NMRI nu/nu小鼠的血糖浓度和人β细胞凋亡率。

IF 3.3 3区生物学

Free Radical Research Pub Date : 2023-05-01 Epub Date: 2023-12-26 DOI: 10.1080/10715762.2023.2284637

Andris Elksnis, Nils Welsh, Per Wikström, Joey Lau, Per-Ola Carlsson

引用次数: 0

Molecular dissection of anti-colon cancer activity of NARI-29: special focus on H₂O₂ modulated NF-κB and death receptor signaling. NARI-29抗结肠癌活性的分子解剖:特别关注H2O2调节NF-κB和死亡受体信号传导。

IF 3.3 3区生物学

Free Radical Research Pub Date : 2023-04-01 DOI: 10.1080/10715762.2023.2243029

Syamprasad Np, Bishal Rajdev, Siddhi Jain, Jagadeesh Kumar Gangasani, Jayathirtha Rao Vaidya, Vgm Naidu

{"title":"Molecular dissection of anti-colon cancer activity of NARI-29: special focus on H2O2 modulated NF-κB and death receptor signaling.","authors":"Syamprasad Np, Bishal Rajdev, Siddhi Jain, Jagadeesh Kumar Gangasani, Jayathirtha Rao Vaidya, Vgm Naidu","doi":"10.1080/10715762.2023.2243029","DOIUrl":"https://doi.org/10.1080/10715762.2023.2243029","url":null,"abstract":"Accumulating evidence attributes the role of aldose reductase (AR) in modulating ROS and inflammation which are the main factor responsible for cancer progression and drug resistance. Epalrestat is the only AR inhibitor being used in Asian countries. It did not make it to the markets of the USA and Europe due to marginal efficacy as an antioxidant and anti-inflammatory agent owing to difficulty reaching intracellular targets. In our previous studies, we attempted to synthesize the epalrestat analogs and reported that the compound 4-((Z)-5-((Z)-2-Cyano-3-phenylallylidene)-4-oxo-2-thioxothiazolidin-3-yl) benzoic acid named as NARI-29 has potent AR inhibition compared to epalrestat. In the current study, we aimed to find the effect of NARI-29 on ROS-induced cancer progression and TRAIL resistance in colon cancer in vitro models. In the first part of the study, we demonstrated that the NARI-29 has specific AKR1B1 inhibition and superior drug-like properties than epalrestat using bioinformatics tools. In the second part of the study, it was proven that NARI-29 has induced the hydrogen peroxide-triggered TRAIL-induced apoptosis in the colon cancer cells via modulating the AKR1B1/4HNE/FOXO3a/DR axis. The selective cytotoxicity of NARI-29 (10-fold) compared to epalrestat (4-fold) toward cancer cells is due to its differential ROS regulation and anti-inflammatory activities. Altogether, these data show that NARI-29 may be a potential candidate for AR inhibitors, which will be used to prevent colon cancer progression and as adjuvant therapy for preventing TRAIL resistance.","PeriodicalId":12411,"journal":{"name":"Free Radical Research","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10285010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Dissecting the potential role of ferroptosis in liver diseases: an updated review. 剖析铁下垂在肝脏疾病中的潜在作用:最新综述。

IF 3.3 3区生物学

Free Radical Research Pub Date : 2023-04-01 DOI: 10.1080/10715762.2023.2232941

Gaoyue Guo, Wanting Yang, Chao Sun, Xiaoyu Wang

引用次数: 2

Formation of free radicals in Chi-aroma Baijiu during aging process with fat pork. 肥猪陈酿中Chi-aroma白酒中自由基的形成。

IF 3.3 3区生物学

Free Radical Research Pub Date : 2023-04-01 DOI: 10.1080/10715762.2023.2232095

Fengjiao Zhang, Renjie Zhang, Songgui He, Jingyi Guan, Zhaoxing Feng, Zhenqiang Wu

{"title":"Formation of free radicals in Chi-aroma Baijiu during aging process with fat pork.","authors":"Fengjiao Zhang, Renjie Zhang, Songgui He, Jingyi Guan, Zhaoxing Feng, Zhenqiang Wu","doi":"10.1080/10715762.2023.2232095","DOIUrl":"https://doi.org/10.1080/10715762.2023.2232095","url":null,"abstract":"Soaking aged fat pork is a special aging process in the production of Chi-aroma Baijiu considered to involve the formation of free radicals. This study aimed to investigate the free radicals' formation pathway in Chi-aroma Baijiu during aged fat pork soaking by using electron paramagnetic resonance (EPR) and spin trapping with 5,5-dimethyl-1-pyrrolin-n-oxide (DMPO). The alkyl radical adducts (DMPO-R) and hydroxyl radical adducts (DMPO-OH) were detected in Baijiu after soaking the fat pork for aging. During the preparation process of aged fat pork, alkoxy radicals adduct (DMPO-RO) were mainly detected since lipid oxidation. Oleic acid and linoleic acid, the two main unsaturated fatty acids in fat pork, produced alkoxy radicals in the oxidation process. The total amounts of spins in linoleic acid and oleic acid after 4-month oxidation treatment increased by 248.07 ± 26.65% and 34.17 ± 0.72% than 0-month. It indicated that the free radicals in aged Chi-aroma Baijiu were mainly derived from the two main unsaturated fatty acids in aged fat pork and linoleic acid had a stronger ability to produce free radicals than oleic acid. Alkoxy radicals (RO·) from fat pork reacted with ethanol in Baijiu to form alkyl radicals (R·). The peroxide bond of hydroperoxides from the oxidation of unsaturated fatty acid was cleaved to form hydroxyl radicals (·OH) that were transferred to Baijiu. The results provide theoretical guidance for the subsequent work of free radicals scavenging.","PeriodicalId":12411,"journal":{"name":"Free Radical Research","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10627987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DhHP-6 alleviates inflammation and reduces vascular permeability by eliminating reactive oxygen species. DhHP-6通过消除活性氧减轻炎症，降低血管通透性。

IF 3.3 3区生物学

Free Radical Research Pub Date : 2023-04-01 DOI: 10.1080/10715762.2023.2243030

Fanwei Meng, Junfeng Ke, Feng Guo, Jiaqing Yan, Liping Wang

{"title":"DhHP-6 alleviates inflammation and reduces vascular permeability by eliminating reactive oxygen species.","authors":"Fanwei Meng, Junfeng Ke, Feng Guo, Jiaqing Yan, Liping Wang","doi":"10.1080/10715762.2023.2243030","DOIUrl":"https://doi.org/10.1080/10715762.2023.2243030","url":null,"abstract":"Inflammation is a defensive immune response to external stimuli. However, uncontrolled inflammation may cause potential damage to the host. Therefore, timely control of uncontrolled inflammation is particularly important. Previous studies have found that small molecules with antioxidant activity, such as peroxidase mimic enzymes, can inhibit the development of inflammation. DhHP-6 is a new peptide mimic of peroxidase previously designed by our laboratory. Here, we explored its anti-inflammatory activity in vitro and in vivo. Our results showed that treatment with DhHP-6 significantly reduced the production of reactive oxygen species (ROS), NO, IL-6, and TNF-α in RAW264.7 cells induced by lipopolysaccharides (LPS); in addition, it also blocked the phosphorylation of extracellularly regulated kinase 1 and 2 (ERK1/2) and ribosomal s6 kinase 1 (RSK1), thereby blocking the phosphorylation and degradation of IκBα, and inhibiting the nuclear translocation of p65. Interestingly, treatment with DhHP-6 blocked the phosphorylation of ERK1/2 and myosin light chain kinase (MLCK) in HUVECs induced by LPS. Finally, we found that DhHP-6 treatment significantly reduced the infiltration of immune cells in balloon model rats. Therefore, we believe that DhHP-6 is a potent inhibitor of inflammation.","PeriodicalId":12411,"journal":{"name":"Free Radical Research","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10281012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of circulatory PCSK-9 with biomarkers of redox imbalance and inflammatory cascades in the prognosis of diabetes and associated complications: a pilot study in the Indian population. 循环PCSK-9与氧化还原失衡和炎症级联的生物标志物在糖尿病和相关并发症预后中的相关性：一项在印度人群中的试点研究。

IF 3.3 3区生物学

Free Radical Research Pub Date : 2023-04-01 Epub Date: 2023-07-22 DOI: 10.1080/10715762.2023.2237180

Mohd Waiz, Sahir Sultan Alvi, M Salman Khan

{"title":"Association of circulatory PCSK-9 with biomarkers of redox imbalance and inflammatory cascades in the prognosis of diabetes and associated complications: a pilot study in the Indian population.","authors":"Mohd Waiz, Sahir Sultan Alvi, M Salman Khan","doi":"10.1080/10715762.2023.2237180","DOIUrl":"10.1080/10715762.2023.2237180","url":null,"abstract":"AbstractsBesides the profound role of proprotein convertase subtilisin/kexin type-9 (PCSK-9) in LDL-C regulation, its association with other metabolic complications cannot be disregarded. The co-existence of redox imbalance and inflammatory cascades has greatly reflected the etiology of hyperglycemia. Therefore, we studied the association of PCSK-9 with inflammation and oxidative stress biomarkers to predict its role in the prognosis of diabetes and its associated complications in the Indian population. This pilot study examined a total of n = 187 subjects: healthy controls (HC; n = 50), diabetic without complication (T2DM; n = 49), diabetic nephropathy (T2DM-N; n = 43), and diabetic dyslipidemic (T2DM-DL; n = 45) subjects. The relationship between circulatory PCSK-9 levels and inflammation and redox imbalance biomarkers has been explored. The significant positive association of elevated PCSK-9 level with the inflammatory (i.e. IL-1β, IL-6, TNF-α, and CRP) and oxidative stress marker (i.e. XOD, CD, LOOH, and MDA) was observed in T2DM-N and T2DM-DL subjects. Whereas single regression analysis depicted that PCSK-9 was inversely associated with the FRAP and PON-1 in T2DM-N and T2DM-DL subjects. Furthermore, no significant correlation was detected in both T2DM and HC subjects. We found a significant relationship between these prognostic biomarkers with an elevated level of PCSK-9 in T2DM-N and T2DM-DL subjects. PCSK-9 is a nontraditional biomarker in diabetes that may help identify patients at risk of developing secondary complications of diabetes in the Indian population. However, further large cohort validation studies are needed.","PeriodicalId":12411,"journal":{"name":"Free Radical Research","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10283074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Antioxidant and prooxidant modulation of lipid peroxidation by integral membrane proteins. 整体膜蛋白对脂质过氧化的抗氧化和促氧化调节。

IF 3.3 3区生物学

Free Radical Research Pub Date : 2023-02-01 DOI: 10.1080/10715762.2023.2201391

Parvana Hajieva, Roman Abrosimov, Sascha Kunath, Bernd Moosmann

{"title":"Antioxidant and prooxidant modulation of lipid peroxidation by integral membrane proteins.","authors":"Parvana Hajieva, Roman Abrosimov, Sascha Kunath, Bernd Moosmann","doi":"10.1080/10715762.2023.2201391","DOIUrl":"https://doi.org/10.1080/10715762.2023.2201391","url":null,"abstract":"Lipid peroxidation is a biochemically adverse phenomenon with key involvement in many different diseases including premature infant blindness, nonalcoholic steatohepatitis, or Parkinson's disease. Moreover, lipid peroxidation may be the most important universal driver of the biological aging process. Canonic lipid peroxidation is a free radical chain reaction consisting of three kinetically independent steps, initiation, propagation, and termination. During the bulk propagation phase, only lipids and oxygen are consumed as substrates and maintain the chain reaction. In native biological membranes, however, lipid peroxidation takes place in direct vicinity to high concentrations of inserted membrane proteins with their exposed hydrophobic amino acid side chains. In the following, we review the evidence that redox-active intramembrane amino acid residues have a profound impact on the course and extent of lipid peroxidation in vivo. Specifically, tyrosine and tryptophan are concluded to be chain-breaking antioxidants that effectuate termination, whereas cysteine is a chain-transfer catalyst that accelerates propagation and thereby promotes lipid peroxidation. Methionine, in turn, is highly accumulated in mitochondrial membrane proteins of animal species with high metabolic rates and imminent danger of lipid peroxidation, though its specific role has not been entirely defined. Potentially, it interferes with initiation on the membrane protein surface. Nevertheless, all four residues are distinguished by their clear relevance to lipid peroxidation as deduced from either experimental or genetic and comparative data. The latter have uncovered distinct evolutionary pressures in favor or against each residue in lipid membranes and have shed light on formerly unacknowledged chemical mechanisms.","PeriodicalId":12411,"journal":{"name":"Free Radical Research","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9678386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Current understanding of plasma-activated solutions for potential cancer therapy. 目前对潜在癌症治疗的血浆活化溶液的了解。

IF 3.3 3区生物学

Free Radical Research Pub Date : 2023-02-01 DOI: 10.1080/10715762.2023.2193308

Nobuhisa Yoshikawa, Kae Nakamura, Hiroaki Kajiyama

{"title":"Current understanding of plasma-activated solutions for potential cancer therapy.","authors":"Nobuhisa Yoshikawa, Kae Nakamura, Hiroaki Kajiyama","doi":"10.1080/10715762.2023.2193308","DOIUrl":"https://doi.org/10.1080/10715762.2023.2193308","url":null,"abstract":"Cancer therapy consists of multidisciplinary treatment combining surgery, chemotherapy, radiotherapy, and immunotherapy. Despite the elucidation of cancer mechanisms by comprehensive genomic and epigenomic analyses and the development of molecular therapy, drug resistance and severe side effects have presented challenges to the long-awaited development of new therapies. With the rapid technological advances in the last decade, there are now reports concerning potential applications of non-equilibrium atmospheric pressure plasma (NEAPP) in cancer therapy. Two approaches have been tried: direct irradiation with NEAPP (direct plasma) and the administration of a liquid (e.g. culture medium, saline, Ringer's lactate) activated by NEAPP (plasma-activated solutions: PAS). Direct plasma is a unique treatment method in which various active species, charged ions, and photons are delivered to the affected area, but the direct plasma approach has physical limitations related to the device used, such as a limited depth of reach and limited irradiation area. PAS is a liquid that contains reactive oxygen species generated by PAS, and it has been confirmed to have antitumor activity that functions in the same manner as direct plasma. This review introduces recent studies of PAS and informs researchers about the potential of PAS for cancer therapy.","PeriodicalId":12411,"journal":{"name":"Free Radical Research","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9677883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Hydroperoxyl radical (HOO^•) as a reducing agent: unexpected synergy with antioxidants. A review. 氢过氧自由基(HOO•)作为还原剂:与抗氧化剂意想不到的协同作用。复习一下。

IF 3.3 3区生物学

Free Radical Research Pub Date : 2023-02-01 DOI: 10.1080/10715762.2023.2212121

Andrea Baschieri, Zongxin Jin, Riccardo Amorati

{"title":"Hydroperoxyl radical (HOO•) as a reducing agent: unexpected synergy with antioxidants. A review.","authors":"Andrea Baschieri, Zongxin Jin, Riccardo Amorati","doi":"10.1080/10715762.2023.2212121","DOIUrl":"https://doi.org/10.1080/10715762.2023.2212121","url":null,"abstract":"Abstract This review highlights the progress made in recent years in harnessing the peculiar chemistry of the hydroperoxyl, or perhydroxyl, radical (HOO•) during lipid peroxidation, particularly with regard to its interaction with antioxidants. The HOO• radical, the protonated form of superoxide, plays an important role in the propagation and termination of lipid peroxidation in nonaqueous systems. However, differently from alkylperoxyl (ROO•) radicals that have only oxidizing ability, HOO• has a two-faced oxidizing and reducing activity. The HOO• radical can reduce the radical of the antioxidant (phenols and aromatic amines) by H-atom transfer (A• + HOO• ⟶ AH + O2) thus increasing the length of the inhibition period and the effectiveness of the antioxidant. The simultaneous presence of HOO• and ROO• radicals triggers the catalytic antioxidant activity of quinones and nitroxides and explains the antioxidant activity of melanin-like polymers. The HOO• radical can be formed by fragmentation of ROO• radicals deriving from amines, alcohols, substituted alkenes and may be present at low concentrations in many oxidizing systems. Pro-aromatic compounds, like the natural essential oil component γ-terpinene, are the most effective sources of HOO• and behave as co-antioxidants in the presence of nitroxides or quinones. The future developments and applications of HOO• chemistry in the context of the inhibition of autoxidation are also discussed.","PeriodicalId":12411,"journal":{"name":"Free Radical Research","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9616476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Trafficking of oxidative stress-generated lipid hydroperoxides: pathophysiological implications. 氧化应激产生的脂质氢过氧化物的运输：病理生理学意义。

IF 3.3 3区生物学

Free Radical Research Pub Date : 2023-02-01 Epub Date: 2023-05-16 DOI: 10.1080/10715762.2023.2213817

Albert W Girotti, Witold Korytowski

{"title":"Trafficking of oxidative stress-generated lipid hydroperoxides: pathophysiological implications.","authors":"Albert W Girotti, Witold Korytowski","doi":"10.1080/10715762.2023.2213817","DOIUrl":"10.1080/10715762.2023.2213817","url":null,"abstract":"Lipid hydroperoxides (LOOHs) are reactive intermediates that arise during peroxidation of unsaturated phospholipids, glycolipids and cholesterol in biological membranes and lipoproteins. Non-physiological lipid peroxidation (LPO) typically occurs under oxidative stress conditions associated with pathologies such as atherogenesis, neurodegeneration, and carcinogenesis. As key intermediates in the LPO process, LOOHs are susceptible to one-electron versus two-electron reductive turnover, the former exacerbating membrane or lipoprotein damage/dysfunction and the latter diminishing it. A third possible LOOH fate is translocation to an acceptor membrane/lipoprotein, where one- or two-electron reduction may then ensue. In the case of cholesterol (Ch)-derived hydroperoxides (ChOOHs), translocation can be specifically stimulated by StAR family trafficking proteins, which are normally involved in Ch homeostasis and Ch-mediated steroidogenesis. In this review, we discuss how these processes can be impaired by StAR-mediated ChOOH and Ch co-trafficking to mitochondria of vascular macrophages and steroidogenic cells, respectively. The protective effects of endogenous selenoperoxidase, GPx4, are also discussed. This is the first known example of detrimental ChOOH transfer via a natural Ch trafficking pathway and inhibition thereof by GPx4.","PeriodicalId":12411,"journal":{"name":"Free Radical Research","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10405667/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10003189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0