Food Bioscience最新文献

{"title":"Piperine confers protection against pulmonary arterial hypertension by targeting IL-6/STAT3 signaling pathway","authors":"Qinghao Li ,&nbsp;Chunzhen Zhou ,&nbsp;Hamza Imtiaz ,&nbsp;Xun Tan","doi":"10.1016/j.fbio.2025.107037","DOIUrl":"10.1016/j.fbio.2025.107037","url":null,"abstract":"<div><div>Pulmonary arterial hypertension (PAH) is a chronic, progressive vasculopathy characterized by a sustained elevation in pulmonary vascular resistance and remodeling of pre-capillary pulmonary arterioles, leading to right ventricular failure and often death. This study explores the potential of piperine, a bioactive dietary alkaloid, in mitigating PAH pathogenesis using a broiler chicken model. Network pharmacology analysis identified the IL-6/STAT3 signaling pathway as key anti-PAH targets of piperine. <em>In vivo</em> experiments demonstrated that piperine treatment significantly reduced PAH-associated mortality, suppressed inflammatory cytokine production, and attenuated pulmonary vascular remodeling in the chicken model. Mechanistically, the observed protective effects were linked to the downregulation of IL-6 expression and STAT3 phosphorylation, along with the suppression of NF-κB p65 activation. Furthermore, piperine inhibited hypoxia-induced proliferation and migration of pulmonary arterial smooth muscle cells (PASMCs) <em>in vitro</em>, reinforcing its role in preventing vascular remodeling. Collectively, these findings underscore the potential of piperine as a functional food component with cardiopulmonary protective properties, proposing its utility as a potential dietary intervention for the management of PAH.</div></div>","PeriodicalId":12409,"journal":{"name":"Food Bioscience","volume":"70 ","pages":"Article 107037"},"PeriodicalIF":4.8,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144279648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation, In vitro evaluation of calcium transport, and chelation mechanism of rice bran peptide-calcium chelate","authors":"Hongyan Li ,&nbsp;Weirong Guan ,&nbsp;Youjia Guo ,&nbsp;Gengjie Cui ,&nbsp;Meng Du ,&nbsp;Yangyang Wen ,&nbsp;Jing Wang ,&nbsp;Baoguo Sun","doi":"10.1016/j.fbio.2025.107030","DOIUrl":"10.1016/j.fbio.2025.107030","url":null,"abstract":"<div><div>Peptide-calcium chelates have been shown to enhance calcium absorption. In this study, rice bran peptide-calcium chelate (RBP-Ca) was synthesized from rice bran protein, and its calcium transport efficiency was evaluated using a Caco-2 monolayer cell model. Additionally, the chelation mechanism of RBP-Ca was explored. Results indicated that alcalase was the optimal enzyme for producing RBP-Ca, yielding a calcium-binding capacity of 102.42 mg/g. Furthermore, RBP-Ca significantly increased calcium transport, with a transport amount 2.49-fold higher than that of CaCl₂ at a concentration of 0.1 mg/mL. X-ray diffraction (XRD) and particle size distribution analysis revealed that a chemical reaction occurred between the peptide and CaCl₂, resulting in the formation of chelates with larger particle sizes. Ultraviolet–visible (UV–vis) spectroscopy, Fourier transform infrared (FTIR) spectroscopy, and Zeta potential measurements suggested that the carboxyl and amide groups of the rice bran peptide (RBP) interact with calcium during chelation. Amino acid composition and liquid chromatography-tandem mass (LC-MS/MS) analysis indicated that aspartic acid (Asp) and glutamic acid (Glu) played crucial roles in the chelation process. These research findings provide a scientific basis for the development of efficient calcium supplements and the enhanced utilization of rice bran protein.</div></div>","PeriodicalId":12409,"journal":{"name":"Food Bioscience","volume":"71 ","pages":"Article 107030"},"PeriodicalIF":4.8,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144322705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial effect and mechanism of Sargassum carpophyllum extract against fish spoilage Pseudomonas sp. CL2","authors":"Xin Liu ,&nbsp;Qunjian Yin ,&nbsp;Fangchao Zhu ,&nbsp;Dewei Cheng ,&nbsp;Hongzhi Tang ,&nbsp;Naibin Yang ,&nbsp;Ying Liu","doi":"10.1016/j.fbio.2025.107041","DOIUrl":"10.1016/j.fbio.2025.107041","url":null,"abstract":"<div><div>Components of marine macroalgae have been considered as a novel source of antimicrobial and food preservatives. In the present study, the antibacterial activity and mechanism of <em>Sargassum carpophyllum</em> extract against fish spoilage <em>Pseudomonas</em> sp. CL2 has been studied. The minimum inhibitory concentration (MIC) of the extract was 3.20 mg dry mass (DM)/mL, and time-kill assay revealed that the antibacterial activity was dependent on the dose and treatment period. Changes in bacterial molecular composition have been revealed by Fourier transform infrared spectroscopy (FTIR). The protein and phospholipid structure of the bacteria have been altered, and leakage of nucleic acids was detected. These results were further confirmed by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) of membrane protein, fatty acid analysis and cell membrane permeability assays. The intensity of 25–30 kDa protein bands and ratio of unsaturated fatty acids to saturated fatty acids have been increased by the extract treatment, suggesting alterations in membrane protein and the fatty acid composition. Other than nucleic acid, leakage of proteins and small ions, as well as alkaline phosphatase (AKP) activity were also detected as the sign of increased cell membrane permeability. Scanning electron microscopy (SEM) images also evidenced the fact that <em>S</em>. <em>carpophyllum</em> extract has impaired the cell integrity and caused cell lysis. The results of the present study indicated that the extract could inhibit <em>Pseudomonas</em> sp. CL2 through damaging cell integrity and altering membrane permeability, which would provide important knowledge to understand the antibacterial mechanism and development of new antimicrobial product from <em>S. carpophyllum</em>.</div></div>","PeriodicalId":12409,"journal":{"name":"Food Bioscience","volume":"71 ","pages":"Article 107041"},"PeriodicalIF":4.8,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144331497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fungal xylomannan as a dietary supplement: Activates hepatic AMPK/HIF1α signaling to attenuate insulin resistance","authors":"Yuhan Meng,&nbsp;Xiushi Jia,&nbsp;Lujuan Zheng,&nbsp;Min Wang,&nbsp;Jing Xia,&nbsp;Mingming Li,&nbsp;Junzhu Wei,&nbsp;Yanchen Qi,&nbsp;Chen Meng,&nbsp;Jiaxing Sheng,&nbsp;Pengyu Ge,&nbsp;Yuying Fan,&nbsp;Yifa Zhou","doi":"10.1016/j.fbio.2025.107022","DOIUrl":"10.1016/j.fbio.2025.107022","url":null,"abstract":"<div><div>The global pandemic of type 2 diabetes mellitus (T2DM), driven by gene-environment interactions in obesogenic milieus, demands novel therapeutic strategies integrating nutritional biochemistry and metabolic regulation. We report the inaugural mechanistic elucidation of xylomannan (XM), a unique α-(1 → 3)-linked D-Man<em>p</em> with β-D-xyl<em>p</em> branching isolated from <em>Flammulina velutipes</em>, using a translational murine model of high-fat diet (HFD)/streptozotocin (STZ)-induced insulin resistance. XM administration (50 mg/kg/day) restored systemic insulin sensitivity, with a concomitant 46.5 % reduction in fasting hyperglycemia versus diabetic controls (<em>p</em> &lt; 0.001). Tracer-based biodistribution analysis demonstrated XM's gut-liver axis targeting, with oral bioavailability mediated through Peyer's patches. Kinase activity assays revealed XM's activation of hepatic AMPK (1.7-fold increased Thr172 phosphorylation) and HIF1α stabilization (nuclear accumulation increased by 52.4 %). This metabolic reprogramming transcriptionally upregulated glycolytic enzymes <em>Gck</em> and <em>Pfkl</em> by both 1.3-fold. Our findings establish XM as the inaugural fungal polysaccharide demonstrating AMPK/HIF-1α synergism, providing a biochemical rationale for developing edible mushroom-based functional foods.</div></div>","PeriodicalId":12409,"journal":{"name":"Food Bioscience","volume":"70 ","pages":"Article 107022"},"PeriodicalIF":4.8,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144279487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the prebiotic properties of mushrooms in improving gut health and related diseases","authors":"Francis Ayimbila ,&nbsp;Suttipun Keawsompong","doi":"10.1016/j.fbio.2025.107040","DOIUrl":"10.1016/j.fbio.2025.107040","url":null,"abstract":"<div><div>Edible mushrooms are increasingly recognized as a rich source of prebiotic polysaccharides, presenting a novel strategy to enhance gut health and combat non-communicable diseases (NCDs). This review explores the prebiotic potential of mushroom polysaccharides, emphasizing their ability to selectively promote beneficial gut bacteria and increase short-chain fatty acid (SCFA) production. It also highlights their potential in managing and preventing NCDs through gut microbiome modulation. It discusses the synergistic effects of mixed bioactive compounds in mushroom powders and extracts, their impact on gut microbiota composition, and the significance of polysaccharides from both intracellular and extracellular sources. Mushroom-derived polysaccharides demonstrated promising prebiotic benefits and significant immunomodulatory effects, indicating their potential as postbiotics. Advanced extraction methods enhance the efficiency and yield of these compounds. Additionally, research suggests these polysaccharides may help manage NCDs by reducing inflammation, improving glucose tolerance, and influencing lipid metabolism. These warrant future research, focusing on unravelling the mechanisms underlying the prebiotic effects of mushroom polysaccharides, optimizing extraction techniques, and conducting robust clinical trials to establish their therapeutic efficacy. Harnessing the prebiotic potential of edible mushrooms could open new avenues for improving gut health and addressing the growing burden of NCDs worldwide.</div></div>","PeriodicalId":12409,"journal":{"name":"Food Bioscience","volume":"70 ","pages":"Article 107040"},"PeriodicalIF":4.8,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144290472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights into the microbial cell chassis design and engineering for production of poly(3-hydroxybutyrate-co-3-hydroxyvalerate)","authors":"Wenjian Ma ,&nbsp;Jingwen Zhou ,&nbsp;Yaru Cao ,&nbsp;Jianli Wang ,&nbsp;Xiaoyuan Wang","doi":"10.1016/j.fbio.2025.107036","DOIUrl":"10.1016/j.fbio.2025.107036","url":null,"abstract":"<div><div>Poly(3-hydroxybutyrate-<em>co</em>-3-hydroxyvalerate) (PHBV), a completely biodegradable polymer, shows promising applications in food and health areas, and owns favorable characteristics due to introducing (<em>R</em>)-3-hydroxyvalerate (3HV) monomer units. Recently, advantages and potential of improving 3HV fraction of PHBV have attracted more attention, then many microbial cell factories and efficient engineering strategies emerged. This review focused on comparing different microbial producers for PHBV production, including <em>Escherichia coli</em>, halophiles, <em>Ralstonia eutropha</em>, <em>Corynebacterium glutamicum</em> and few other microorganisms. For these producers, different supplements of 3HV-related carbon source and metabolic engineering strategies to better form 3HV were summarized. Furthermore, the involved barriers and bottlenecks for PHBV biosynthesis were analyzed, thus some insights such as integrating global regulation engineering strategies and removing safety hazards for optimizing PHBV producers were proposed.</div></div>","PeriodicalId":12409,"journal":{"name":"Food Bioscience","volume":"71 ","pages":"Article 107036"},"PeriodicalIF":4.8,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144291587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The metabolic regulation mechanism of birchwood polysaccharides inducing Inonotus obliquus to synthesize bioactive polysaccharides","authors":"Feng Yan ,&nbsp;Xiaohong Lu ,&nbsp;Shisheng Tong ,&nbsp;Ruoyu Mi ,&nbsp;Xuan Zhang ,&nbsp;Ping Liu","doi":"10.1016/j.fbio.2025.107035","DOIUrl":"10.1016/j.fbio.2025.107035","url":null,"abstract":"<div><div>This study investigated the mechanism by which birch-derived polysaccharides induce extracellular polysaccharide synthesis in <em>Inonotus obliquus</em> under submerged fermentation conditions. Both cellulose-derived birch polysaccharide (C-48) and water-extracted hemicellulose polysaccharide (H-0) significantly increased α-glucosidase inhibitory activity of extracellular polysaccharide, with increases of 4.09 and 3.44-fold, respectively. C-48 also accelerated the synthesis of extracellular polysaccharides. These differences can be attributed to their differential capacities to activate polysaccharide-synthesizing enzymes and regulate metabolic pathways after absorption by growing mycelia. The addition of both polysaccharides inhibited phosphoglucose isomerase (PGI) activity while enhancing the activities of phosphoglucomutase and Uridine Diphosphate (UDP) -glucose pyrophosphorylase, thereby promoting metabolic flux toward UDP-glucose synthesis and increasing the production of bioactive glucans. Transcriptomic analysis revealed that polysaccharide supplementation led to downregulation of key genes involved in glycolysis and the tricarboxylic acid (TCA) cycle, while upregulating genes associated with gluconeogenesis. These regulatory shifts suppressed glucose catabolism and optimized polysaccharide biosynthesis in <em>I. obliquus</em>. In the C-48 group, regulation of key enzyme genes in the mannose and pentose phosphate pathways promoted the generation of polysaccharide precursors. In contrast, the H-0 group regulated genes involved in pentose interconversion, glycoside hydrolysis, and glycolysis, thereby indirectly influencing glucose metabolism and facilitating extracellular polysaccharide production. These distinct regulatory effects indicate that polysaccharides critically influence the synthesis of bioactive polysaccharides, underscoring their potential as metabolic activators.</div></div>","PeriodicalId":12409,"journal":{"name":"Food Bioscience","volume":"71 ","pages":"Article 107035"},"PeriodicalIF":4.8,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144306520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic antifungal activity of Melaleuca alternifolia oil and terpinen-4-ol in stored rice","authors":"Somenath Das","doi":"10.1016/j.fbio.2025.107038","DOIUrl":"10.1016/j.fbio.2025.107038","url":null,"abstract":"<div><div>The present investigation aimed to evaluate synergistic antifungal activity of <em>Melaleuca alternifolia</em> essential oil (MAEO) and terpinen-4-ol (MAEO-ter) against <em>Aspergillus flavus</em> and <em>Fusarium proliferatum</em> infestation along with aflatoxin B₁ (AFB₁), fumonisin B₁ (FB₁), and fumonisin B₂ (FB₂) production in stored rice (<em>Oryza sativa</em> L.) samples. The mechanism of antifungal activity of synergistic formulation was based on the assessment of plasma membrane. Results showed that the MAEO-ter synergistic formulation improved the anti-aflatoxigenic and anti-fumonisin efficacy at lower doses than individual application of MAEO and terpinen-4-ol. The impairment in ergosterol production along with enhanced release of cell contents and high propidium iodide fluorescence intensity suggested plasma membrane as possible target site of action. Moreover, the retardation in methylglyoxal biosynthesis and <em>in silico</em> modeling of terpinen-4-ol with Omt-A, Ver-1, Fum-1, and Fum-6 proteins unveiled the biochemical and molecular mechanism of anti-aflatoxigenic and anti-fumonisin activity. The <em>in situ</em> results exhibited promising efficacy of MAEO-ter synergistic formulation towards the inhibition of AFB₁, FB₁, and FB₂ production along with the suppression of lipid peroxidation, and loss of carbohydrate and protein content (p &lt; 0.05) in rice samples. The acceptable scores of organoleptic properties and favorable safety profile in mice suggested the efficacy of MAEO-ter synergistic formulation as an effective antifungal and anti-mycotoxigenic agent in managing the loss of stored rice samples.</div></div>","PeriodicalId":12409,"journal":{"name":"Food Bioscience","volume":"71 ","pages":"Article 107038"},"PeriodicalIF":4.8,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144306521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glycyrrhizic acid, a natural sweetener, through KLRC2/ZAP70/MAPK pathway attenuates spleen deficiency syndrome in ratsnew","authors":"Xiaojing Zhang ,&nbsp;Tingting Li ,&nbsp;Wenxin Xia ,&nbsp;Xueyan Fu","doi":"10.1016/j.fbio.2025.107032","DOIUrl":"10.1016/j.fbio.2025.107032","url":null,"abstract":"<div><div>Glycyrrhizic acid, derived from licorice, is a natural sweetener and widely used in the food industry. In traditional Chinese medicine, licorice is a classic herb used to strengthen the spleen and invigorate qi. However, which monomer components of licorice play a role in the treatment of spleen deficiency syndrome and its regulatory mechanism is still unclear. Based on the SD rat model of spleen deficiency syndrome, this study first determined glycyrrhizic acid (GA) is the active component of licorice for alleviating spleen deficiency syndrome in SD rats by regulating the KLRC2/ZAP70/MAPK pathway. Transcriptomic data indicated that the NK cell receptor KLRC2 might be the target of GA. Molecular docking and BLI experiments determined that KLRC2, ZAP70, and GRB2 were proteins that could bind to GA. The data obtained from animal experiments indicated that GA could decrease the level of apoptotic factors to varying degrees. Overexpression of KLRC2 could significantly enhance the cytotoxicity of NK cells against K562 target cells. Inspired by this result, further animal experiments showed that the expression levels of KLRC2, p-ZAP70, p-MAPK, TNF-α, and GZMB in spleen deficiency rats all increased to varying degrees, and GA could down-regulate the expression levels of these proteins. This provides high-quality experimental evidence for its spleen-strengthening efficacy and enhances the market value and application scope of GA, a traditional sweetener.</div></div>","PeriodicalId":12409,"journal":{"name":"Food Bioscience","volume":"71 ","pages":"Article 107032"},"PeriodicalIF":4.8,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144313070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Constructing a synthetic microbial community by analyzing the microorganisms responsible for the core flavor substances of Zhenjiang aromatic vinegar and their interaction","authors":"Yongjian Yu ,&nbsp;Jiaxin Liu ,&nbsp;Yuanyuan Zhu,&nbsp;Ke Wang,&nbsp;Yuqin Wang,&nbsp;Dong Han,&nbsp;Zhen Yu,&nbsp;Siyuan Cheng,&nbsp;Nan Zhang,&nbsp;Shuaiwei Dou,&nbsp;Shiyuan Lin,&nbsp;Ziyi Kang","doi":"10.1016/j.fbio.2025.107025","DOIUrl":"10.1016/j.fbio.2025.107025","url":null,"abstract":"<div><div>The traditional Zhenjiang aromatic vinegar brewing process relies on natural fermentation driven by spontaneous microbial activities, resulting in variability in flavor and quality between batches. This variability makes it difficult to achieve consistent characteristic flavor compounds. To address this, identifying key microbial species and designing fermentation starters can enhance fermentation efficiency and flavor consistency. High-throughput sequencing and cultivation experiments identified <em>Acetobacter pasteurianus</em> A-3, <em>Lactobacillus acetotolerans</em> L-72, and <em>Bacillus licheniformis</em> B-3122 as core functional microorganisms in the fermentation process. Co-culture experiments revealed a commensal relationship between <em>A. pasteurianus</em> A-3 and <em>L. acetotolerans</em> L-72, and an amensal relationship between <em>A. pasteurianus</em> A-3 and <em>B. licheniformis</em> B-3122. The co-culture promoted the accumulation of acids, organic acids, and volatile flavor compounds. The synthetic microbial community, consisting of these three microorganisms, showed improved fermentation characteristics compared to traditional seed <em>pei</em>, including higher temperature, increased total acids, and faster sugar consumption. The vinegar <em>pei</em> also had higher levels of organic acids and volatile flavor substances. Transcriptomics analysis revealed that the interaction between <em>A. pasteurianus</em> A-3 and <em>L. acetotolerans</em> L-72 enhanced the acid production of <em>A. pasteurianus</em> and influenced the metabolism of <em>L. acetotolerans</em>. The interaction between <em>A. pasteurianus</em> and <em>B. licheniformis</em> increased the sugar utilization rate and improved acid tolerance in <em>A. pasteurianus</em>, while also affecting the amino acid and sugar metabolism in <em>B. licheniformis</em>.</div></div>","PeriodicalId":12409,"journal":{"name":"Food Bioscience","volume":"71 ","pages":"Article 107025"},"PeriodicalIF":4.8,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144313073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}