Food Bioscience最新文献

{"title":"Advances in CRISPR/Cas9-driven strategies for microbial production and optimization of sugar polyols for food applications: A review","authors":"Manoj Kumar ,&nbsp;Sumit Totade ,&nbsp;Kanika Sharma ,&nbsp;Ajinath Dukare ,&nbsp;K. Pandiyan ,&nbsp;Sujata Saxena","doi":"10.1016/j.fbio.2025.106553","DOIUrl":"10.1016/j.fbio.2025.106553","url":null,"abstract":"<div><div>Sugar polyols, including xylitol, erythritol, mannitol and sorbitol are vital nutritional sweeteners having significant applications across various sectors like food, pharmaceuticals, and cosmetics. Metabolic engineering in microbes is a center of attraction to produce value-added products from the lignocellulosic biomass. Clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 has emerged as a powerful and transformative platform in molecular biology, offering innovative solutions for enhancing the biosynthesis of sugar polyols, paving the way for more efficient and cost-effective production methods. This review aims to offer a thorough overview of CRISPR/Cas9 technology and its role in enhancing production of sugar polyols in microbial systems. It focuses on recent advancements and optimization strategies for improving polyol biosynthesis and productivity through CRISPR/Cas9 based gene editing and fermentation process optimization. The review highlights several successful implementations of CRISPR/Cas9 technology in modifying biosynthetic pathways for sugar polyol production in microbes. Continued research and development in this area are likely to lead to further improvements in efficiency and scalability, benefiting various industries particularly food and pharmaceutical industry that rely on these valuable compounds.</div></div>","PeriodicalId":12409,"journal":{"name":"Food Bioscience","volume":"68 ","pages":"Article 106553"},"PeriodicalIF":4.8,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143843153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review on the biological activities of key carotenoids: Structures, sources, market, economical features, and stability","authors":"Kolsoum Gholipour-Varnami ,&nbsp;Sonia Mohamadnia ,&nbsp;Omid Tavakoli ,&nbsp;Mohammad Ali Faramarzi","doi":"10.1016/j.fbio.2025.106529","DOIUrl":"10.1016/j.fbio.2025.106529","url":null,"abstract":"<div><div>Bioactive compounds present in marine species are abundant, and marine carotenoids in particular have drawn interest due to their potential benefits for health. Because of their unique characteristics, marine carotenoids always have a special appeal among the hundreds of carotenoids that are isolated from various natural biomass. Due to their distinctive colors and various bioactivities, these carotenoids are well known for improving the nutritional content and visual appeal of food products. Consequently, they are essential components in driving the development of the food industry. This review presents the chemistry and classification of all carotenoids and the nutraceutical effects of six widely used carotenoids, lycopene, lutein, astaxanthin, β-carotene, fucoxanthin, and canthaxanthin, on human health. Their production by natural resources such as algae and their various uses in the global market are also discussed. In addition, pioneering companies involved in the production of carotenoids have also been investigated. Furthermore, the stability of valuable pigments can be enhanced by the used techniques in entrapment methods, such as spray drying, supercritical micronization, emulsification, etc. was described. In this regard, the emulsion technique was superior to other techniques owing to its higher availability, safety, and low energy consumption.</div></div>","PeriodicalId":12409,"journal":{"name":"Food Bioscience","volume":"68 ","pages":"Article 106529"},"PeriodicalIF":4.8,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143817032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brazil nut or not? Uncovering the best source of selenium for chronic non-communicable disease","authors":"Renata Cristina Bezerra Rodrigues ,&nbsp;Danielle Nascimento ,&nbsp;Jessyca Brito ,&nbsp;Ligia Soares Lima ,&nbsp;Julie C. Lobo ,&nbsp;Ludmila F.M.F. Cardozo ,&nbsp;Denise Mafra","doi":"10.1016/j.fbio.2025.106520","DOIUrl":"10.1016/j.fbio.2025.106520","url":null,"abstract":"<div><div>Selenium, an essential micronutrient known for its antioxidant and anti-inflammatory properties, has been extensively studied for its potential health benefits, especially in reducing oxidative stress and inflammation frequently observed in patients with noncommunicable diseases. The ongoing discussion about optimal selenium intake has led to two main approaches in scientific research: supplementation through selenium capsules and dietary intake via natural food sources such as Brazil nut (<em>Bertholletia excelsa</em>). Brazil nut is recognized as the richest known food source of selenium, with just one nut often fulfilling the Recommended Dietary Allowance of Selenium. However, while some studies support controlled selenium supplementation through capsules to ensure precise dosages, others emphasize the benefits of consuming whole foods like Brazil nuts, which also provide additional nutrients and health advantages. This narrative review investigates the ongoing discussion between these methods, highlighting the differences in bioavailability, potential health outcomes, and practical considerations for individuals. Capsule supplementation and dietary intake via Brazil nuts exhibit possible benefits; however, additional advantages connected to Brazil nut consumption have been noted. Further research is essential to determine the most suitable option for each specific noncommunicable disease and to address the complexities of dosage control, safety, and overall nutritional impact.</div></div>","PeriodicalId":12409,"journal":{"name":"Food Bioscience","volume":"68 ","pages":"Article 106520"},"PeriodicalIF":4.8,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143817031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanisms of fatigue and molecular diagnostics: The application of bioactive compounds in fatigue relief research","authors":"Xinxin Si ,&nbsp;Yanyan Si ,&nbsp;Zhen Lu ,&nbsp;Tian Zhong ,&nbsp;Ying Xiao ,&nbsp;Zhenyu Wang ,&nbsp;Xi Yu","doi":"10.1016/j.fbio.2025.106523","DOIUrl":"10.1016/j.fbio.2025.106523","url":null,"abstract":"<div><div>Fatigue represents a complex biopsychological phenomenon encompassing two distinct yet interrelated dimensions: mental fatigue (subjective perception) and physical fatigue (objective performance) that emerge during sustained cognitive exertion and intensive physical training regimens. Rapid fatigue can negatively impact work efficiency and quality of life, which is especially problematic for particular groups, such as those doing heavy mental work, athletes, astronauts, and soldiers. Furthermore, persistent fatigue increases the likelihood of developing a disease or reduces lifespan. Bioactive compounds (polysaccharides, peptides, polyphenols, saponins, etc.) from natural products offer easily accessible resources for effectively relieving fatigue. This review summarizes the potential molecular mechanisms of fatigue, including the regulation of Ca²⁺, energy substance depletion, the inflammatory factor storm, and the oxidative stress reaction. In addition, bioactive compounds in natural products that can relieve fatigue, as well as the underlying pathophysiological mechanisms, are discussed. Understanding the mechanism of fatigue development and its consequences can help prolong the time for fatigue occurrence, alleviate the severity of fatigue, reduce the duration of persistent fatigue, and allow the prediction of fatigue based on biomarker detection. Ultimately, effective ways to relieve fatigue can be identified through the mechanism of fatigue and offer insights for the development of functional foods and beverages.</div></div>","PeriodicalId":12409,"journal":{"name":"Food Bioscience","volume":"68 ","pages":"Article 106523"},"PeriodicalIF":4.8,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143817034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolation, characterization, and bioactive properties of strawberry-derived nanoparticles","authors":"Fang Yuan ,&nbsp;Songlin Ye ,&nbsp;Xiaotong Wang ,&nbsp;Xudong Xia ,&nbsp;Yingying Li ,&nbsp;Qiuping Chen","doi":"10.1016/j.fbio.2025.106483","DOIUrl":"10.1016/j.fbio.2025.106483","url":null,"abstract":"<div><div>Strawberries are nutrient-rich fruits with antioxidant function; however, research on strawberry-derived nanoparticles remains limited. In this study, nanoparticles were successfully isolated and extracted from strawberry juice. The antioxidant properties and active components of these nanoparticles were evaluated and compared using UV photometry and HPLC. SEM analysis revealed that the microstructure of the strawberry nanoparticles exhibit a vesicular microstructure. FTIR and NMR analyses indicated that the nanoparticles were primarily stabilized by hydrogen bonds. Furthermore, processing methods such as intense pulsed light treatment were found to influence molecular interactions during nanoparticle formation, enhancing π-π interactions and hydrophobicity. The <em>P</em>_app values and intestinal absorption rates of pelargonidin-3-glucoside (P3G) and cyanidin-3-glucoside (C3G) within the strawberry nanoparticles were significantly higher compared to their isolated forms. These findings provided valuable insights into the molecular interactions involved in nanoparticle formation and highlighted the physicochemical characteristics and enhanced functional properties of strawberry-derived nanoparticles.</div></div>","PeriodicalId":12409,"journal":{"name":"Food Bioscience","volume":"68 ","pages":"Article 106483"},"PeriodicalIF":4.8,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143748086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Lactobacillus fermentation on the composition, existing forms, digestive characteristics, and antioxidant activity of polyphenols in three kinds of bean milk","authors":"Zheng Zhang ,&nbsp;Jing-Li Wang ,&nbsp;Yun-Peng Hao ,&nbsp;Yue Meng ,&nbsp;Jun Meng ,&nbsp;Jia-Hui Chen ,&nbsp;Chang-He Ding ,&nbsp;Jun Xi","doi":"10.1016/j.fbio.2025.106482","DOIUrl":"10.1016/j.fbio.2025.106482","url":null,"abstract":"<div><div>Soy, peanut and chickpea contain polyphenols that have multiple beneficial biological activities. In this work, two <em>Lactobacillus</em> strains were employed to ferment the three kinds of bean milk and the effects of fermentation on the polyphenols in them were investigated. After fermentation with <em>L. fermentum</em> GD01 and <em>L. plantarum</em> BHP03, the total phenolic contents were increased by 16.90 % and 14.64 % in soy milk, 18.14 % and 24.28 % in peanut milk, 46.39 % and 51.91 % in chickpea milk, respectively. Specifically, the contents of free phenol, insoluble ester phenol, and insoluble glycosidic phenol increased, while the contents of soluble ester phenol and soluble glycosidic phenol reduced. These changes were positively associated with the antioxidant activities. Further, <em>Lactobacillus</em> fermentation also changed the contents and forms of monomeric phenols in bean milk, with the free monomeric phenols exhibiting the greatest diversity in types. In addition, the fermented bean milk demonstrated a higher release of phenols compared to the unfermented counterparts during simulated digestion, resulting in enhanced antioxidant activities. Notably, the most substantial increase in soluble phenols was detected in fermented chickpea milk (162.66 % by GD01, 137.48 % by BHP03), while the most significant increase in insoluble phenols was observed in fermented peanut milk (147.46 % by GD01, 150.53 % by BHP03). All the results confirmed that <em>Lactobacillus</em> fermentation could alter the structures, compositions, digestive characteristics of the polyphenols in the three kinds of bean milk, ultimately enhancing their antioxidant activities. These results offer a theoretical foundation for the advancement of fermented bean milk products with enhanced biological activity.</div></div>","PeriodicalId":12409,"journal":{"name":"Food Bioscience","volume":"68 ","pages":"Article 106482"},"PeriodicalIF":4.8,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143748084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical structures, antioxidant capacities, and immunostimulatory activities of pectic polysaccharides from jujube fruits collected from different producing areas","authors":"Jing Feng ,&nbsp;Xiao Luo ,&nbsp;Bo Li ,&nbsp;Xiao-Yan Yang ,&nbsp;Lin Zhang ,&nbsp;Jing-Wei Huang ,&nbsp;Yi-Chen Hu ,&nbsp;Liang Zou ,&nbsp;Ding-Tao Wu","doi":"10.1016/j.fbio.2025.106485","DOIUrl":"10.1016/j.fbio.2025.106485","url":null,"abstract":"<div><div>Pectic polysaccharides are well-recognized as the mainly functional components in jujube fruits, which have garnered considerable attentions to be exploited into functional food products. Nevertheless, the knowledge about the influence of the producing area on their fine structural features and biological functions is still scarce, which may restrict their rational use in the functional food sector. Therefore, the structural and biological properties of pectic polysaccharides from jujube fruits (JP) collected from different producing areas were compared. The results showed that JP's physicochemical properties (e.g., total uronic acids, total bound polyphenols, molecular mass distributions, and ratios of constituent monosaccharides) varied significantly depending on the producing area. However, the primary chemical structures of JPs obtained from various producing areas were largely similar, predominantly composing of homogalacturonan and rhamnogalacturonan-I regions. Furthermore, JP's antioxidant and immunostimulatory effects also varied remarkedly depending on the producing area, primarily attributed to variations in their physicochemical properties. Particularly, JP's antioxidant activity demonstrated a significantly positive correlation with the levels of total uronic acids and total bound polyphenols, and similarly, its immunostimulatory activity was highly dependent on the level of total uronic acids. Moreover, mechanistic investigations revealed that JP could enhance immune responses via activating the Toll-like receptor 4 mediated nuclear factor-κB signaling pathway in RAW 264.7 macrophages. Collectively, the current findings could provide valuable insights for the rational application of jujube fruits and JP in the functional food sector.</div></div>","PeriodicalId":12409,"journal":{"name":"Food Bioscience","volume":"68 ","pages":"Article 106485"},"PeriodicalIF":4.8,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143748021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plant hormones mediated temperature-induced anthocyanin accumulation in blood oranges (Citrus sinensis L. Osbeck)","authors":"Jin Chen ,&nbsp;Jianle Chen ,&nbsp;Yujing Sun ,&nbsp;Wenjun Wang ,&nbsp;Yanyun Zhu ,&nbsp;Shiguo Chen ,&nbsp;Xingqian Ye ,&nbsp;Donghong Liu ,&nbsp;Zhongxiang Fang ,&nbsp;Huan Cheng","doi":"10.1016/j.fbio.2025.106473","DOIUrl":"10.1016/j.fbio.2025.106473","url":null,"abstract":"<div><div>Anthocyanins are enriched in blood oranges (<em>Citrus sinensis</em> L. Osbeck) in response to external environmental stimulation during postharvest storage, while the role of plant hormones in anthocyanin accumulation in response to low-temperature inducement is still poorly studied. Here, we investigated the anthocyanin profiles and fruit quality of blood oranges treated with different temperatures and then further focused on the mechanisms of plant hormone-mediated anthocyanin biosynthesis induced by low temperatures using proteomics. Total and individual anthocyanins were significantly increased in blood oranges under the low-temperature storage at 8 °C, among which cyanidin 3-glucoside and cyanidin 3-(6″-malonylglucoside) were increased by 6.51 and 6.77 times at the end of storage, respectively. Low temperature effectively delayed the weight loss and maintained the water status. For flavor changes, high levels of sucrose, citric acid, and malic acid were observed in fruits stored at 8 °C, and low temperature delayed the changes of overall volatile flavor compounds, in which aroma-active compounds were closer to those in fresh fruit. The proteomic analysis found that differentially expressed proteins between fruit stored at 8 and 25 °C were enriched in “Phenylalanine metabolism”, “Flavonoid biosynthesis”, “Brassinosteroid biosynthesis” and “Cysteine and methionine metabolism” pathways, indicating that low temperature induced the biosynthesis and signal transduction of brassinosteroids and ethylene (CYP90A1, CYP90C1/D1, CYP92A6, SAMS, ACC oxidase, ETR1), upregulated the expression of anthocyanin-related proteins (PAL, 4CL, CHS1, CHS2, F3′5′H, DFR, ANS, and UFGT), and ultimately promoted anthocyanin accumulation in the postharvest blood oranges.</div></div>","PeriodicalId":12409,"journal":{"name":"Food Bioscience","volume":"68 ","pages":"Article 106473"},"PeriodicalIF":4.8,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143747277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cordia africana fruit hydrocolloid alleviates sodium dextran sulfate-induced colitis in mice","authors":"Maria Isabela Ferreira de Araújo ,&nbsp;Francisca Crislândia Oliveira Silva ,&nbsp;Ana Fernandes ,&nbsp;Soraia Pires Silva ,&nbsp;José Josenildo Batista ,&nbsp;Elisabete Coelho ,&nbsp;Manuel António Coimbra ,&nbsp;Viviani Mendes de Almeida ,&nbsp;Angélica Thomaz Vieira ,&nbsp;Jacinto da Costa Silva Neto ,&nbsp;Luzia de Abilio da Silva ,&nbsp;Paulo Antônio Galindo Soares ,&nbsp;Clarisse Nobre ,&nbsp;Maria Tereza dos Santos Correia","doi":"10.1016/j.fbio.2025.106463","DOIUrl":"10.1016/j.fbio.2025.106463","url":null,"abstract":"<div><div><em>Cordia africana</em> fruit contains a mucilaginous pulp rich in hydrocolloid with nutraceutical potential, whose composition and bioactive potential remain uncertain. This study evaluated its structural characterization, toxicity and ability to prevent DSS-induced ulcerative colitis in mice. The hydrocolloid was extracted with hot water and precipitated with ethanol (1:3 <em>v/v</em>), yielding 7.2 % (<em>w/w</em>). The extracted hydrocolloid was administered for 15 days to study its preventive effect on ulcerative colitis, which was subsequently induced by the administration of DSS (3 %) in drinking water. The hydrocolloid (65 kDa) was composed mainly of negatively charged polysaccharides (glucans and uronic acids) with a high degree of esterified phenolic acids, preventing their degradation during digestion (6.6 ± 0.5 and 13.2 ± 0.5 mg GAE/g free and bound, respectively, including syringic, hydroxybenzoic, and dihydrocaffeic acids). At a dose of 2000 mg/kg, the hydrocolloid did not induce systemic toxic effects <em>in vivo</em> and alleviated DSS-induced colitis, reducing clinical symptoms such as colon inflammation. These effects were associated with lower disease activity indices, increased colon length, enhanced myeloperoxidase and eosinophil peroxidase activity, as well as preservation of microvilli and a reduction of inflammatory infiltrate (with a pretreatment dose of 100 mg/kg hydrocolloid). The hydrocolloid has potential as a prebiotic, as it increased the proliferation of probiotic <em>Lactobacillus</em> and <em>Bifidobacterium</em> and reduced Acetobacteraceae and stimulated short-chain fatty acids synthesis in the gut microbiota of mice subjected to colitis. These findings highlight <em>C. africana</em> hydrocolloid's potential as a functional ingredient with prebiotic and anti-inflammatory properties for maintaining colon health.</div></div>","PeriodicalId":12409,"journal":{"name":"Food Bioscience","volume":"68 ","pages":"Article 106463"},"PeriodicalIF":4.8,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143747278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lemon-derived exosome-like nanovesicles: A promising avenue for drug delivery system and therapeutic applications in biomedical science","authors":"Mansi Khadilkar ,&nbsp;Sanchit Arora ,&nbsp;Rohan Chand Sahu ,&nbsp;Satyavati Rawat ,&nbsp;Dinesh Kumar ,&nbsp;Ashish Kumar Agrawal","doi":"10.1016/j.fbio.2025.106474","DOIUrl":"10.1016/j.fbio.2025.106474","url":null,"abstract":"<div><div>Extracellular vesicles (EVs) are naturally occurring, phospholipid bilayer-enclosed vesicles that offer high bioavailability and minimal invasiveness, making them promising candidates for disease treatment, drug delivery vectors, and effective biomarkers for disease detection and diagnosis. As researchers continue to discover and characterize EVs from various origins and biogenesis, their role in intercellular communication for diagnostic and therapeutic purposes becomes increasingly clear. Plant-derived exosome-like nanovesicles (PELNs) are of particular interest due to their compatibility, low toxicity, high bioavailability, ease of absorption, and inherent therapeutic activities. Among the diverse plant sources, lemons stand out for their high nutritional value and wealth of phytochemicals and bioactive components. Recently, there has been significant research into PELNs, focusing on their pharmacological properties and potential applications in drug delivery. This review centres on lemon-derived exosome-like nanovesicles (LELNs), exploring their extraction methods, biological and therapeutic potential, and applications as effective drug delivery systems. By highlighting these aspects, we aim to encourage further research into LELNs to uncover additional properties and potential biomedical applications.</div></div>","PeriodicalId":12409,"journal":{"name":"Food Bioscience","volume":"68 ","pages":"Article 106474"},"PeriodicalIF":4.8,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143747274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}