Food Bioscience最新文献

{"title":"Cinnamaldehyde triggers fungal apoptosis in Fusarium solani by impairing cell structures and antioxidant defense through restricting glucose availability","authors":"Chao Pan ,&nbsp;Yan Ye ,&nbsp;Yingchun Ma ,&nbsp;Shuolong Li ,&nbsp;Yixue Zhu ,&nbsp;Yanzi Chu ,&nbsp;Fajuan Wang ,&nbsp;Ling Shen ,&nbsp;Jun Tian","doi":"10.1016/j.fbio.2025.106889","DOIUrl":"10.1016/j.fbio.2025.106889","url":null,"abstract":"<div><div><em>Fusarium solani</em> is the primary causative agent of <em>Fusarium</em> root rot, one of major postharvest diseases of sweet potato. Cinnamaldehyde (CA) is a natural product isolated from cinnamon essential oil (EO). To combat the damage caused by <em>F. solani</em>, it is necessary to assess the antifungal activity of CA. The minimum inhibitory concentration (MIC) of CA against <em>F. solani</em> spores was 0.12 g/L, while addition of 2 % glucose increased the MIC to 0.16 g/L. A volatile concentration of CA at 0.12 g/L suppressed <em>F. solani</em>-induced root rot in sweet potatoes. Glucose addition alleviated CA-induced structural damage to cell walls and membranes. Moreover, CA reduced intracellular levels of glucose and glucose-6-phosphate (G6P), promoted oxidative stress, and induced cell apoptosis. However, glucose addition enhanced the gene expression of <em>hexokinase</em> and contents of glucose and G6P, thereby potentiating glycolytic flux. Further, sufficient glucose increased the gene expression of <em>glutathione</em> (<em>GSH</em>) <em>reductase</em>, GSH level, catalase activity, and decreased the contents of reactive oxygen species (ROS) and malondialdehyde in the presence of CA. Inhibition of glucose utilization using hexokinase inhibitor lonidamine (0.25 g/L) promoted ROS accumulation and exacerbated the reduction in cell viability of <em>F. solani</em> caused by 0.08 g/L CA. Altogether, these findings demonstrated that CA triggers fungal apoptosis by disrupting cell structures and antioxidant defense in <em>F. solani</em> mediated by glucose metabolism interference. Therefore, CA holds promise as a green preservative for sweet potato roots, and inhibition of glucose metabolism can serve as a novel strategy for enhancing the antifungal efficacy of EOs.</div></div>","PeriodicalId":12409,"journal":{"name":"Food Bioscience","volume":"69 ","pages":"Article 106889"},"PeriodicalIF":4.8,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144134381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Supercritical CO2 extraction and fractionation of turmeric polyphenols: Antioxidant capacity and inhibition of lipid oxidation in sunflower oil","authors":"Hoang Le Tan,&nbsp;Giovanna Ferrentino,&nbsp;Ksenia Morozova,&nbsp;Maria Concetta Tenuta,&nbsp;Matteo Scampicchio","doi":"10.1016/j.fbio.2025.106906","DOIUrl":"10.1016/j.fbio.2025.106906","url":null,"abstract":"<div><div>Turmeric (<em>Curcuma longa</em>) is a rich source of antioxidants, including polyphenols and curcuminoids. This study investigates the antioxidant capacity and oxidative stability of a polyphenol-rich fraction obtained via supercritical fluid extraction (SFE) with supercritical CO₂. Optimized extraction conditions (300 bar, 40 °C, CO₂ flow rate: 1 L/h, 20 % w/w ethanol) yielded 11.4 ± 0.3 % (w/w) crude extract. Fractionation separated a hydrophilic Fraction B, rich in polyphenol and weak in curcuminoids, and a Fraction C, weak in polyphenol and rich in curcuminoids. Fraction B showed the highest total phenolic content (476 ± 6 mmol/L GAE/g dry matter) and superior antioxidant activity in DPPH, ABTS, and ORAC assays. HPLC-MS identified curcumin, demethoxycurcumin, bis-demethoxycurcumin, phenolics, and phenolic terpenoid hybrids, highlighting their potential contributions to antioxidant efficiency and the synergistic radical-scavenging interactions that influence oxidative stability. Turmeric fractions were added to the stripped sunflower oil. Isothermal calorimetry confirmed that an oil enriched with Fraction B prolonged the induction period of lipid oxidation (11.4 ± 0.3 h) at 30 °C in the presence of AIBN (20 mmol/L) as a free radical initiator, outperforming Fraction C. These findings highlight the potential application of turmeric extracts in functional foods and nutraceuticals to increase their stability against oxidation.</div></div>","PeriodicalId":12409,"journal":{"name":"Food Bioscience","volume":"69 ","pages":"Article 106906"},"PeriodicalIF":4.8,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144124452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-omics evaluation of feeding strategies on yak meat quality: insights from eDNA, metagenomics, and metabolomics","authors":"Zhengwen Wang,&nbsp;Haitao Yu,&nbsp;Yuxin Meng,&nbsp;Suxing Liu,&nbsp;Rong Dai,&nbsp;Xiayan Zhou,&nbsp;Shangli Shi,&nbsp;Wenxia Cao","doi":"10.1016/j.fbio.2025.106909","DOIUrl":"10.1016/j.fbio.2025.106909","url":null,"abstract":"<div><div>This study investigates how seasonal grazing and housed feeding regimes alter the rumen microbiome and metabolite networks in yaks, thereby influencing meat quality. We evaluated the effects of these feeding strategies on Warner-Bratzler shear force (WBSF) and other key meat quality parameters using an integrated approach combining eDNA-metagenomics and metabolomics. This study revealed that warm-season forages, which are abundant in n-3 polyunsaturated fatty acids (n-3 PUFA), promote rumen metabolites associated with PUFA retention. This process resulted in an increased n-3 PUFA content in yak meat. Housed yaks fed high-energy diets exhibited increased Bacillota abundance and acetate biosynthesis, changes that enhanced IMF and crude protein levels, thereby improving meat tenderness and marbling. In contrast, cold-season grazing yaks ingested a higher proportion of Fabaceae and Ranunculaceae species. A high-fibre diet increased the abundance of <em>Prevotella</em> and <em>Fibrobacter</em>, genera that mitigate cold stress through enhanced propionate production and fatty acid catabolism. However, this dietary pattern led to a reduction in key meat quality indicators. In conclusion, the yak rumen microbiome employs distinct adaptive strategies under different feeding systems, thereby exerting differential effects on meat quality.</div></div>","PeriodicalId":12409,"journal":{"name":"Food Bioscience","volume":"69 ","pages":"Article 106909"},"PeriodicalIF":4.8,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144124358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-osteoporotic effects of peptide PASTGAAK derived from black-boned silky fowl on ovariectomized mice","authors":"Yang Qiu ,&nbsp;Jiaxin Guo ,&nbsp;Jie Zhang ,&nbsp;Chenxu Xue ,&nbsp;Wanjun He ,&nbsp;Jiajin Zhu","doi":"10.1016/j.fbio.2025.106908","DOIUrl":"10.1016/j.fbio.2025.106908","url":null,"abstract":"<div><div>This study investigated the anti-osteoporotic effects of the peptide PASTGAAK (P11) on ovariectomized (OVX) mice. <em>In vitro</em> gastrointestinal stability assays demonstrated that P11 resisted enzymatic degradation by trypsin and pepsin, retaining its osteogenic activity post-digestion. <em>In vivo</em>, P11 administration (8 weeks) significantly reversed OVX-induced bone loss, as evidenced by improved trabecular bone microstructure, as well as the enhanced biomechanical properties. Serum analysis revealed P11 was beneficial for upregulating bone formation markers. Gene expression profiling indicated P11 stimulated osteogenic differentiation via upregulation of Runx2, Osterix, ALP and Col1a1. Gut microbiota analysis showed P11 restored OVX-induced reductions in microbial richness, modulated the Firmicutes/Bacteroidota ratio and increased key genera (<em>Akkermansia</em>). Serum metabolomics identified P11-mediated restoration of lipid metabolism (α-linolenic acid pathway) and inhibition of serotonin synthesis. Correlation analysis revealed that the aforementioned metabolic changes induced by P11 were closely associated with the enrichment of <em>Akkermansia</em> in the gut. These findings highlighted P11 as a safe natural agent for osteoporosis treatment, acting via osteogenic promotion, gut microbiota modulation and metabolic pathway regulation.</div></div>","PeriodicalId":12409,"journal":{"name":"Food Bioscience","volume":"69 ","pages":"Article 106908"},"PeriodicalIF":4.8,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144131239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the mechanism of fermentation induced antioxidant activity enhancement in asparagus juice: Metabolomic and transcriptomic insights into the functional role of Lactiplantibacillus plantarum JGS 49","authors":"Jinqing Huang ,&nbsp;Li Wang ,&nbsp;Xue Li ,&nbsp;Yao Zhang ,&nbsp;Bo Dong ,&nbsp;Shuai Hu ,&nbsp;Cailing Liu ,&nbsp;Dongwen Fu ,&nbsp;Lecheng Shen ,&nbsp;Guangxian Liu","doi":"10.1016/j.fbio.2025.106907","DOIUrl":"10.1016/j.fbio.2025.106907","url":null,"abstract":"<div><div>Fermentation has emerged as a pivotal strategy for improving the functional attributes of plant-based foods. This study demonstrates the biotransformation of asparagus juice through fermentation with <em>Lactiplantibacillus plantarum</em> JGS49, revealing systematic enhancements in nutritional and bioactive profiles. The process significantly elevated titratable acidity (1.56–10.26 g/L) and lactic acid content (10.29 g/L), while boosting total phenolic content and antioxidant capacity. Ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) analysis identified 1101 metabolites, with notable dynamic changes during fermentation. The fermentation process exhibited different substrate utilization patterns, characterized by the gradual consumption of small peptides, amino acids, nucleosides, and specific organic acids. The accumulation of characteristic bioactive metabolites was observed, among which metabolites such as phenylacetaldehyde, gentisic acid, 4-coumaric acid, homovanillic acid, indole-3-lactic acid, 3-phenyllactic acid, and DL-4-hydroxyphenyllactic acid became the signature biomarkers of the fermentation process. Transcriptome analysis disclosed substantial alterations in gene expression within <em>L. plantarum</em> JGS49 during fermentation, especially in the pathways related to translation and ribosomal function, peptide biosynthesis, and metabolic pathways. Differentially expressed genes were correlated with enriched metabolic pathways such as phenylalanine, tyrosine, and tryptophan biosynthesis, histidine metabolism, riboflavin metabolism, and glycerolipid metabolism in 0–12 h fermentation stage, while glycolysis/gluconeogenesis and pyruvate metabolism in 12–48 h fermentation stage. The integration of metabolomic and transcriptomic data clarified the mechanisms through which <em>L. plantarum</em> JGS49 enhances the nutritional quality and bioactivity of asparagus juice. This research laid a foundation for further exploration of <em>L. plantarum</em>-fermented asparagus juice as a functional food ingredient, emphasizing its potential to provide improved nutritional properties and health benefits.</div></div>","PeriodicalId":12409,"journal":{"name":"Food Bioscience","volume":"69 ","pages":"Article 106907"},"PeriodicalIF":4.8,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144131242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fe-MOF based turn-on fluorescence sensor for the rapid detection of foodborne pathogens in multiple matrices","authors":"Burcu Kabak ,&nbsp;Ali Soyuçok","doi":"10.1016/j.fbio.2025.106910","DOIUrl":"10.1016/j.fbio.2025.106910","url":null,"abstract":"<div><div>Ensuring food safety remains a global challenge because of the presence of foodborne pathogens, such as <em>Escherichia coli</em> and <em>Staphylococcus aureus</em>. In this study, we present a turn-on fluorescence biosensor based on an iron metal–organic framework (Fe-MOF) for the selective and rapid detection of two major foodborne pathogens, <em>E. coli</em> and <em>S. aureus</em>. Fe-MOF was synthesised via a solvothermal method and thoroughly characterised by Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy with energy-dispersive X-ray spectroscopy (SEM-EDX), and thermogravimetric analysis (TGA). Upon interaction with bacterial suspensions, the sensor exhibited significant fluorescence enhancement, which was attributed to electron transfer modulation triggered by bacterial surface components. The analytical performance was evaluated across three matrices—phosphate-buffered saline (PBS), drinking water, and milk—achieving detection limits as low as 0.464 log CFU/mL for <em>S. aureus</em> and 0.584 log CFU/mL for <em>E. coli</em>. The sensor enabled rapid detection within less than 1 h with high recovery rates (95–104 %) across all tested matrices, confirming its practical usability for real sample analysis. These findings address a critical gap in biosensor research by validating Fe-MOFs for practical food-safety applications in multiple real-world environments.</div></div>","PeriodicalId":12409,"journal":{"name":"Food Bioscience","volume":"69 ","pages":"Article 106910"},"PeriodicalIF":4.8,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144124456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Untargeted HPLC metabolomic profiling and antioxidant activity of wild rocket’s (Diplotaxis tenuifolia (L.) DC.) edible leaves influenced by biofortification, hybrid varieties and harvest time","authors":"Sofija Kilibarda,&nbsp;Danijel D. Milinčić,&nbsp;Sandra Vuković,&nbsp;Mirjana B. Pešić,&nbsp;Slavica Jelačić,&nbsp;Đorđe Moravčević,&nbsp;Aleksandar Ž. Kostić","doi":"10.1016/j.fbio.2025.106898","DOIUrl":"10.1016/j.fbio.2025.106898","url":null,"abstract":"<div><div><em>Diplotaxis tenuifolia</em> (L.) DC., commonly known as wild rocket, is a notable vegetable whose distinctive, pungent, leaf aroma has gained significant interest. This study aimed to investigate how the content and profile of pigments, phenolics, and glucosinolates in wild rocket leaves are influenced by varieties, biofortification, and consecutive harvests. The content of total pigments, and phytochemicals in the leaves of three hybrid varieties of wild rocket was determined together with antioxidant properties. Additionally, a detailed profile of phenolics and glucosinolates was assessed using an UHPLC Q-ToF-MS analysis. In total, 22 phenolics (mostly flavonols/phenolic acids derivatives) were quantified, as well as 4 glucosinolates, with glucosativin being the most predominant. Phytochemical levels fluctuated across hybrids, treatments and harvests. The harvest time influenced antioxidant properties. The UHPLC Q-ToF-MS analysis revealed varied phenolics influenced by hybrid/treatment, while glucosinolate profile remained unchanged. These findings highlight the potential of wild rocket as a functional food.</div></div>","PeriodicalId":12409,"journal":{"name":"Food Bioscience","volume":"69 ","pages":"Article 106898"},"PeriodicalIF":4.8,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144124454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of volatile flavor profiles and quantitative assessment of key physicochemical indicators for fermented bean curd using GC-IMS, E-nose and multi-channel colorimetric sensor array combined with chemometrics","authors":"Xiaorui Zhang ,&nbsp;Xingyi Huang ,&nbsp;Chunxia Dai ,&nbsp;Xiaoyu Tian ,&nbsp;Chengquan Wang ,&nbsp;Yi Ren ,&nbsp;Li Wang ,&nbsp;Shanshan Yu ,&nbsp;Joshua Harrington Aheto ,&nbsp;Xianhui Chang","doi":"10.1016/j.fbio.2025.106879","DOIUrl":"10.1016/j.fbio.2025.106879","url":null,"abstract":"<div><div>To elucidate the volatile flavor compositions and overall aroma profiles of fermented bean curd (FBC), the volatile organic compounds (VOCs) in six different FBC were detected and characterized using gas chromatography-ion mobility spectrometry (GC-IMS) and an electronic nose (E-nose) in this study. A total of 60 VOCs were identified by GC-IMS, of which esters, aldehydes, alcohols, and ketones constituted the major compounds. Among them, 17 VOCs were identified as key differentiating volatile compounds. In addition, the E-nose combined two algorithms, linear discriminant analysis (LDA) and k-nearest neighbor (KNN), to demonstrate its effectiveness in differentiating between different FBC samples. The results showed that the LDA model performed better than the KNN model. When the principal component number was 9, the recognition accuracies of the training and prediction sets for the LDA model were 94.44 % and 91.67 %, respectively. In addition, a multi-channel colorimetric sensor array (CSA) was constructed in this study for the quantitative prediction of key physicochemical indicators. The results showed that both partial least squares regression (PLSR) and support vector machine regression (SVR) achieved good prediction performance. Among them, for the SVR model, the prediction correlation coefficients for total acidity, reducing sugar, salinity, and amino acid nitrogen were 0.9033, 0.9170, 0.7298, and 0.9213, respectively. The results of this study indicate that GC-IMS, E-nose, and CSA are expected to be effective tools for characterizing FBC flavor as well as facilitating the rapid quantification of key physicochemical indicators, which may provide valuable insights for flavor and quality control in traditional fermented foods.</div></div>","PeriodicalId":12409,"journal":{"name":"Food Bioscience","volume":"69 ","pages":"Article 106879"},"PeriodicalIF":4.8,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144124357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation of K-carrageenan /polylactic acid nanofiber membranes encapsulating Vitamin C/ Hydroxypropyl-beta-cyclodextrin inclusion complexes by electrostatic spinning for blueberry preservation","authors":"Lingling Bai ,&nbsp;Yurui Wu ,&nbsp;Huijin Xu ,&nbsp;Jiyuan Yang ,&nbsp;Yiting Lu ,&nbsp;Wenge Yang ,&nbsp;Yonghong Hu","doi":"10.1016/j.fbio.2025.106894","DOIUrl":"10.1016/j.fbio.2025.106894","url":null,"abstract":"<div><div>In this study, K-carrageenan (KC)/poly(lactic acid) (PLA) composite nanofiber membranes loaded with vitamin C (VC)/2-hydroxypropyl-β-cyclodextrin (HP-β-CD) inclusion complexes were prepared by electrostatic spinning for blueberry preservation. A scanning electron microscope, electronic universal testing machine, and other instruments were used to analyze the apparent and mechanical properties of the membrane as well as the physicochemical indexes of blueberries during the preservation process. The loading of the inclusion raised the average diameter of the nanofibers membrane, reduced the crystallinity, and hydrophobicity, and improved the thermal stability of the fibers membrane. The release curves showed that encapsulating the inclusion complex in KC/PLA significantly prolonged the release time of VC. The membranes exhibited better antimicrobial properties as well as higher antioxidant properties in <em>vitro</em> and in <em>vivo</em>. These results indicate that the developed antimicrobial membrane has good application prospects in food packaging.</div></div>","PeriodicalId":12409,"journal":{"name":"Food Bioscience","volume":"69 ","pages":"Article 106894"},"PeriodicalIF":4.8,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144115457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting oncogenic signaling pathways in lung Cancer: The emerging role of nobiletin, a flavonoid from citrus peel","authors":"Newton Suwal ,&nbsp;Rajan Thapa ,&nbsp;Saroj Bashyal ,&nbsp;Vrashabh V. Sugandhi ,&nbsp;Sapana Subedi ,&nbsp;Nisha Panth ,&nbsp;Nadia Amorim ,&nbsp;Jaesung P. Choi ,&nbsp;Madhu Gupta ,&nbsp;Sobia Idrees ,&nbsp;Kamal Dua ,&nbsp;Keshav Raj Paudel","doi":"10.1016/j.fbio.2025.106887","DOIUrl":"10.1016/j.fbio.2025.106887","url":null,"abstract":"<div><div>Lung cancer continues to have a high incidence rate, exhibiting a five-year overall survival percentage of merely 18.6 %. Despite advancements in conventional therapeutic approaches, drug resistance and treatment-associated toxicities remain major challenges. Recent research has focused on plant-derived molecules as promising therapeutic alternatives due to their low toxicity and significant anticancer effects. Nobiletin, a flavonoid enriched with polymethoxylated groups present in citrus peel, has exhibited diverse therapeutic properties, including antioxidants, immunomodulatory, neuroprotective, and antitumor activities. This review highlights anti-lung cancer activity of nobiletin by modulating critical tumor-promoting signaling pathways thereby suppressing cancer cell proliferation, infiltration, and metastasis. Most importantly, nobiletin triggers cancer cell apoptosis by caspase-3 activation and poly-(ADP-ribose) polymerase cleavage and functions as a key regulator in mitigating drug resistance by regulating various signaling pathways. However, its medical use is constrained by poor aqueous solubility and limited bioavailability. To mitigate these challenges, advanced drug delivery systems have been explored, including polymeric nanoparticles, nano-dispersed solids, micelles, and nano emulsions. Nanotechnology-based formulations such as self-micro emulsifying drug delivery systems, chitosan-based microemulsions, and liposomal encapsulation have significantly improved the nobiletin's stability, solubility, and targeted delivery. These approaches enhance its therapeutic efficacy, positioning nobiletin as a potential therapeutic strategy for lung cancer treatment.</div></div>","PeriodicalId":12409,"journal":{"name":"Food Bioscience","volume":"69 ","pages":"Article 106887"},"PeriodicalIF":4.8,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144154881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}