American Journal of Transplantation最新文献_第8页

Preformed donor-specific class II DQ antibodies are associated with graft loss after liver transplantation: A prospective multicenter study. 预形成的供体特异性II类DQ抗体与肝移植后移植物损失相关：一项前瞻性多中心研究

IF 8.1 2区医学

American Journal of Transplantation Pub Date : 2026-09-03 DOI: 10.1016/j.ajt.2026.08.019

Andreas Arendtsen Rostved, Helle Bruunsgaard, Carl Jorns, Bo Göran Ericzon, William Bennet, Andreas Schult, Arno Nordin, Helena Isoniemi, Carina Lund Sørensen, Allan Rasmussen

{"title":"Preformed donor-specific class II DQ antibodies are associated with graft loss after liver transplantation: A prospective multicenter study.","authors":"Andreas Arendtsen Rostved, Helle Bruunsgaard, Carl Jorns, Bo Göran Ericzon, William Bennet, Andreas Schult, Arno Nordin, Helena Isoniemi, Carina Lund Sørensen, Allan Rasmussen","doi":"10.1016/j.ajt.2026.08.019","DOIUrl":"10.1016/j.ajt.2026.08.019","url":null,"abstract":"The aim of this study was to assess whether preformed donor-specific human leukocyte antigen antibodies (DSAs) are associated with graft loss after liver transplantation. We conducted a prospective multicenter study at 4 liver transplant centers. Presence of preformed donor-specific antibodies was analyzed using a single-antigen bead assay and a virtual crossmatch unknown to clinicians at a central laboratory. Graft survival was assessed using Kaplan-Meier analysis and Cox regression during a 2-year follow-up. Class I DSAs were observed in 106 of 832 patients (13%) and showed no association with graft loss. Class II DSAs were detected in 131 of 831 patients (16%), and DQ in 79 (10%). Class II DQ subtype was the only independent predictor of graft loss (adjusted hazard ratio 2.0, 95% confidence interval [CI]: 1.1-3.6, P = .02) with a 2-year graft loss rate of 23% (95% CI: 15%-34%) compared to 10% (95% CI: 8%-12%) without class II DSAs and 7% (95% CI: 2%-20%) for DR-specific antibodies (log-rank P = .002). Mean fluorescence intensity was not independently associated with graft loss after adjustment for DQ status. Preformed class II DQ DSAs are independently associated with an increased risk of graft loss even at low mean fluorescence intensity.","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148885738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regional disparities in living donor kidney transplantation: An analysis of transplant referral networks. 活体肾移植的地区差异：移植转诊网络分析。

IF 8.1 2区医学

American Journal of Transplantation Pub Date : 2026-09-03 DOI: 10.1016/j.ajt.2026.08.020

Lachlan C McMichael, Nick Cross, Kate Wyburn, Philip A Clayton, Melanie Wyld

{"title":"Regional disparities in living donor kidney transplantation: An analysis of transplant referral networks.","authors":"Lachlan C McMichael, Nick Cross, Kate Wyburn, Philip A Clayton, Melanie Wyld","doi":"10.1016/j.ajt.2026.08.020","DOIUrl":"10.1016/j.ajt.2026.08.020","url":null,"abstract":"Living donor kidney transplantation (LDKT) is the preferred standard of care for most patients with kidney failure. We sought to quantify the variation in access to living donor transplantation across referral networks for patients in Australia and New Zealand. We included adults who initiated kidney replacement therapy between 2002 and 2022. Each patient was mapped to a transplant referral network. For each network, we calculated a standardized living donor transplant ratio by comparing the observed number of living donor transplants within 12 months with the expected number. The expected number was estimated using multivariable Poisson regression with a random effect for each referral network. Overall, 53 313 patients were included. The ratio of observed to expected living donor transplants ranged from 0.36 to 2.11. Of 21 networks, 4 (19%) performed below expected. Initiating treatment at a center with direct transplant unit affiliation, nonmetropolitan residence, and timely nephrology referral were associated with increased LDKT. Access to LDKT varies substantially across transplant referral networks in Australia and New Zealand. Identifying center-level barriers and facilitators underpinning this variation will be critical to developing targeted center-based strategies to enhance living donation rates.","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148885748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rank Order of Candidates for Heart Transplantation in France: An Explainable Machine Learning Analysis 法国心脏移植候选者的排名顺序：一个可解释的机器学习分析

IF 8.8 2区医学

American Journal of Transplantation Pub Date : 2026-09-01 DOI: 10.1016/j.ajt.2026.09.012

Benoit Audry,Martin Prodel,Carine Jasseron,Christian Jacquelinet,Naissa Bacar,Pascal Leprince,Laurent Sebbag,Andre Vincentelli,Dahbia Horchi,Benoit Averland,William F. Parker,Michel Tsimaratos,Camille Legeai,Richard Dorent

引用次数: 0

Open Recovery Of The Vascularized Composite Bladder Allograft For Bladder Transplantation 带血管的同种异体复合膀胱移植开放恢复的研究

IF 8.8 2区医学

American Journal of Transplantation Pub Date : 2026-09-01 DOI: 10.1016/j.ajt.2026.09.002

Nima Nassiri,Lauren Schafrank,Jolie Shen,Erik Lum,Inderbir S. Gill

引用次数: 0

Regulating cell and xeno-transplants: learning from medical device oversight 调节细胞和异种移植：从医疗设备监管中学习

IF 8.8 2区医学

American Journal of Transplantation Pub Date : 2026-09-01 DOI: 10.1016/j.ajt.2026.09.011

Ali B. Abbasi,Robert M. Califf

引用次数: 0

Proteinuria after pig kidney xenotransplantation: A potential unifying hypothesis linking mechanical, innate, and adaptive injury pathways. 猪肾异种移植后蛋白尿：连接机械、先天和适应性损伤途径的潜在统一假说。

IF 8.1 2区医学

American Journal of Transplantation Pub Date : 2026-09-01 DOI: 10.1016/j.ajt.2026.08.015

Shikhar Tripathi, Maho Terashita, Ivy Rosales, David K C Cooper

{"title":"Proteinuria after pig kidney xenotransplantation: A potential unifying hypothesis linking mechanical, innate, and adaptive injury pathways.","authors":"Shikhar Tripathi, Maho Terashita, Ivy Rosales, David K C Cooper","doi":"10.1016/j.ajt.2026.08.015","DOIUrl":"10.1016/j.ajt.2026.08.015","url":null,"abstract":"Persistent proteinuria remains a major barrier to successful pig-to-nonhuman primate kidney xenotransplantation and may become an important issue in clinical renal xenotransplantation. However, published human renal xenotransplant reports to date have not established severe proteinuria as a consistent clinical finding, and its relevance in living human recipients should, therefore, be regarded as an important unresolved question. In pig-to-nonhuman primate models, severe proteinuria may also be accompanied by urinary loss of therapeutic monoclonal antibodies, including anti-CD154, potentially compromising rejection prophylaxis. Proteinuria in this setting may occur in association with heterogeneous and overlapping patterns of immune-mediated and nonimmune-mediated injury, including rejection-associated endothelial, microvascular, and humoral lesions such as thrombotic microangiopathy, capillaritis, C4d deposition, and xenograft glomerulopathy. Hemodynamic mismatch should currently be regarded as a possible but unproven contributor rather than a dominant initiating trigger. We, therefore, propose a unifying hypothesis based on an evidence-informed, testable framework rather than a definitive causal cascade, which we hope will stimulate discussion. Clarifying the dominant mechanisms in individual cases, correlating proteinuria with biopsy findings, and prospectively monitoring urinary drug loss will be essential for developing rational preventive and therapeutic strategies.","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148872470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiomic analyses in xenotransplantation: Hypothesis generation and the path toward precision diagnostics 异种移植的多组分析：假设的产生和精确诊断的途径

IF 8.8 2区医学

American Journal of Transplantation Pub Date : 2026-09-01 DOI: 10.1016/j.ajt.2026.09.027

Joseph M. Ladowski,Aurélie Sannier,Alexandre Loupy,Raphael P.H. Meier

引用次数: 0

Temporal Changes in the Recovery and Utilization of Kidneys Donated After Circulatory Death in the United States 美国循环性死亡后捐赠肾脏恢复和利用的时间变化

IF 8.8 2区医学

American Journal of Transplantation Pub Date : 2026-09-01 DOI: 10.1016/j.ajt.2026.09.014

Syed Ali Husain,Laura Zeiser,Tanveen Ishaque,Babak J. Orandi,Macey L. Levan,Jeffrey M. Stern,Jennifer D. Motter,Bonnie E. Lonze,Barbara E. Coons,Marissa K. Lipton,Philip M. Sommer,Sunjae Bae,Brendan Parent,Dorry L. Segev,Allan B. Massie,Darren E. Stewart

引用次数: 0

Transplant Business Best Practices: An American Society of Transplant Surgeons Business Practice Services Committee Opinion on Reimbursement, Cost Accounting, and Professional Coding in Modern Transplant Practice 移植业务最佳实践：美国移植外科医生协会商业实践服务委员会关于现代移植实践中的报销、成本会计和专业编码的意见

IF 8.8 2区医学

American Journal of Transplantation Pub Date : 2026-09-01 DOI: 10.1016/j.ajt.2026.09.025

Rajeev Sharma,Chris Freise,Liise Kayler,Kenneth Chavin,Ashesh Shah,Giuliano Testa,Sunil Geevargheese,Zoe Stewart Lewis,Al-Faraaz Kassam,Vincent Casingal,Nahel Elias,Joy Allen-Joseph,Kiran Dhanireddy,Tomoaki Kato

引用次数: 0

Which should be the preferable clinical setting to administer Treg therapies in transplantation? 在移植中应用Treg治疗的最佳临床环境是什么？

IF 8.8 2区医学

American Journal of Transplantation Pub Date : 2026-09-01 DOI: 10.1016/j.ajt.2026.09.035

Maegan Fleming,Marc Martinez-Llordella,Giovanna Lombardi,Alberto Sanchez-Fueyo

引用次数: 0