American Journal of Transplantation最新文献_第7页

Stepping stones: Hepatitis C virus infection and pediatric kidney transplantation.

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2025-03-01 DOI: 10.1016/j.ajt.2025.02.017

Sharon Bartosh, Chris Callaghan

引用次数: 0

Is operational tolerance induction finally safe and feasible for some kidney transplant recipients: a breakthrough to a new horizon?

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2025-02-22 DOI: 10.1016/j.ajt.2025.02.013

Edward K Geissler, Birgit Sawitzki

引用次数: 0

Direct and indirect allorecognition-not so different after all?

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2025-02-22 DOI: 10.1016/j.ajt.2025.02.014

Gavin J Pettigrew

引用次数: 0

DCDD HEART TRANSPLANTATION WITH THORACO-ABDOMINAL NORMOTHERMIC REGIONAL PERFUSION AND STATIC COLD STORAGE: THE EXPERIENCE IN SPAIN.

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2025-02-22 DOI: 10.1016/j.ajt.2025.02.006

Alicia Pérez-Blanco, Francisco González-Vilchez, José González-Costello, Mario Royo-Villanova, Eduardo Miñambres, José J Cuenca, Sergio J Cánovas, Iris P Garrido, Gabriel Moreno-González, Fabrizio Sbraga, Antonio García-Quintana, Vicente J Peña, Francisco A Portela, Luis Almenar-Bonet, Juan Martínez-León, Ana Tur, Ángel Ruiz-Arranz, Pedro Caravaca-Pérez, Elena Sandoval, Manuel Gómez-Bueno, Marina Pérez-Redondo, Susana Villar, Manuel Cobo, J Francisco Nistal, Beatriz Domínguez-Gil

{"title":"DCDD HEART TRANSPLANTATION WITH THORACO-ABDOMINAL NORMOTHERMIC REGIONAL PERFUSION AND STATIC COLD STORAGE: THE EXPERIENCE IN SPAIN.","authors":"Alicia Pérez-Blanco, Francisco González-Vilchez, José González-Costello, Mario Royo-Villanova, Eduardo Miñambres, José J Cuenca, Sergio J Cánovas, Iris P Garrido, Gabriel Moreno-González, Fabrizio Sbraga, Antonio García-Quintana, Vicente J Peña, Francisco A Portela, Luis Almenar-Bonet, Juan Martínez-León, Ana Tur, Ángel Ruiz-Arranz, Pedro Caravaca-Pérez, Elena Sandoval, Manuel Gómez-Bueno, Marina Pérez-Redondo, Susana Villar, Manuel Cobo, J Francisco Nistal, Beatriz Domínguez-Gil","doi":"10.1016/j.ajt.2025.02.006","DOIUrl":"https://doi.org/10.1016/j.ajt.2025.02.006","url":null,"abstract":"Heart transplantation from donors after the circulatory determination of death (DCDD) is expanding worldwide. Thoraco-abdominal normothermic regional perfusion (TA-NRP) allows the validation and recovery of the DCDD heart, but there is limited evidence on the results of heart transplants performed with this approach. This multicenter, nationwide, prospective study describes the short-term outcomes of adult patients receiving a DCDD heart transplant obtained via TA-NRP followed by static cold storage in Spain. Recipients of hearts from donors after the neurological determination of death (DNDD) were used as controls. The primary outcome was a composite of 1-year all-cause death or severe primary graft failure (PGF). During 2020-2023, 98 adult DCDD and 347 DNDD heart transplants were performed across 11 centers. The primary outcome was met by 21 (21.4%) and 77 (22.2%) patients, respectively (p=0.87). Thirty-day and 1-year survival were 94.9% and 88.8% in the DCDD vs 93.7% and 87.3% in the DNDD group (p=0.70). Severe PGF was observed in 13 (13.3%) vs 52 (15.0%) patients (p=0.67). By inverse probability weighting, the DCDD heart was not associated with the primary outcome (HR 0.97;95%CI 0.58-1.62;p=0.91). In conclusion, adult DCDD heart transplantation based on TA-NRP and static cold storage provides similar short-term outcomes than DNDD heart transplants.","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":" ","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perioperative C1-esterase inhibitor therapy to allow transplantation in a highly sensitized lung transplant candidate: Three case reports.

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2025-02-18 DOI: 10.1016/j.ajt.2025.02.009

Jérôme Devaquet, Benjamin Coiffard, Xavier Demant, François Parquin, Magali Devriese, Edouard Sage, Pascal Pedini, Clément Picard, Florence Daviet, Xavier Benoit D'Journo, Gwendaline Guidicelli, Natalia Belousova, Antoine Roux

引用次数: 0

Gut microbiome alterations precede graft rejection in kidney transplantation patients.

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2025-02-18 DOI: 10.1016/j.ajt.2025.02.010

Johannes Holle, Rosa Reitmeir, Felix Behrens, Dharmesh Singh, Daniela Schindler, Olena Potapenko, Victoria McParland, Harithaa Anandakumar, Nele Kanzelmeyer, Claudia Sommerer, Steffen Hartleif, Joachim Andrassy, Uwe Heemann, Michael Neuenhahn, Sofia K Forslund-Startceva, Markus Gerhard, Jun Oh, Nicola Wilck, Ulrike Löber, Hendrik Bartolomaeus

{"title":"Gut microbiome alterations precede graft rejection in kidney transplantation patients.","authors":"Johannes Holle, Rosa Reitmeir, Felix Behrens, Dharmesh Singh, Daniela Schindler, Olena Potapenko, Victoria McParland, Harithaa Anandakumar, Nele Kanzelmeyer, Claudia Sommerer, Steffen Hartleif, Joachim Andrassy, Uwe Heemann, Michael Neuenhahn, Sofia K Forslund-Startceva, Markus Gerhard, Jun Oh, Nicola Wilck, Ulrike Löber, Hendrik Bartolomaeus","doi":"10.1016/j.ajt.2025.02.010","DOIUrl":"10.1016/j.ajt.2025.02.010","url":null,"abstract":"Kidney transplantation (KT) is the best treatment for end-stage kidney disease, with graft survival critically affected by the recipient's immune response. The role of the gut microbiome in modulating this immune response remains underexplored. Our study investigates how microbiome alterations might be associated with allograft rejection by analyzing the gut microbiome using 16S rRNA gene amplicon sequencing of a multicenter prospective study involving 562 samples from 245 individuals of whom 217 received KT. Overall, gut microbiome composition showed gradual recovery post-KT, mirroring chronic kidney disease (CKD)-to-health transition as indicated by an increase in Shannon diversity. Prior to graft rejection, we observed a decrease in microbial diversity and short-chain fatty acid-producing taxa. Functional analysis highlighted a decreased potential for short-chain fatty acid production in patients preceding the rejection event, validated by quantitative PCR for the production potential of propionate and butyrate. Postrejection analysis revealed normalization of these microbiome features. Comparison to published microbiome signatures from CKD patients demonstrated a partial overlap of the microbiome alterations preceding graft rejection with the alterations typically found in CKD. Our findings suggest that alterations in gut microbiome composition and function may precede and influence KT rejection, suggesting potential implications as biomarkers or for early therapeutic microbiome-targeting interventions.","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":" ","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between out-of-sequence allocation and deceased donor kidney nonuse across organ procurement organizations.

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2025-02-17 DOI: 10.1016/j.ajt.2025.02.005

Joel T Adler, David C Cron, Arnold E Kuk, Miko Yu, Sumit Mohan, S Ali Husain, Layla Parast

引用次数: 0

Longer travel and traffic are associated with adult liver transplant waitlist mortality in the United States.

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2025-02-17 DOI: 10.1016/j.ajt.2025.02.002

Kali Zhou, Robert Albertian, Christopher Wong, Leane S Kuo, Laura K Thompson, Jennifer L Dodge, Neil Mehta, Norah A Terrault, Myles G Cockburn

{"title":"Longer travel and traffic are associated with adult liver transplant waitlist mortality in the United States.","authors":"Kali Zhou, Robert Albertian, Christopher Wong, Leane S Kuo, Laura K Thompson, Jennifer L Dodge, Neil Mehta, Norah A Terrault, Myles G Cockburn","doi":"10.1016/j.ajt.2025.02.002","DOIUrl":"10.1016/j.ajt.2025.02.002","url":null,"abstract":"Transportation to transplant centers is a barrier to liver transplantation (LT). We analyzed the impact of travel metrics on LT waitlist outcomes in the United States. A total of 83 640 adult LT candidates in the Scientific Registry of Transplant Recipients database (2013-2021) were included. Google Distance Matrix application programming interface estimated driving time from patients' residing ZIP code to listing center. Effect of travel time (short [<1 hour], medium [1 to < 3 hours], or long [3 to < 6 hours]), traffic congestion in metropolitan areas, and center mismatch (defined as listing at a center >1 hour from nearest center) on waitlist mortality were examined using multivariable competing risk regression with adjustment for confounders. Compared to short travel, medium (HR 1.09 [95% CI: 1.05-1.13]) and long travel times (HR 1.14 [95% CI: 1.08-1.20]) were associated with higher waitlist mortality. Both high (HR 1.09 [95% CI: 1.01-1.12]) and moderate traffic (HR 1.09 [95% CI 1.02-1.15]) was also associated with higher waitlist mortality compared to low traffic. Lastly, there was no relationship between center mismatch (9.1% of listed) and waitlist deaths. Longer travel and traffic congestion are associated with greater waitlist mortality for adult LT candidates. Strategies to address these underrecognized spatial barriers to LT are needed.","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":" ","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143456340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Breaking barriers: successful outcomes of hepatitis C virus D⁺/R^- Transplants in HIV⁺ Recipients.

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2025-02-15 DOI: 10.1016/j.ajt.2025.02.007

Saima Aslam, Sarah Hussain, Brandy Haydel, Sander S Florman, Alexander J Gilbert, Marcus R Pereira, Nahel Elias, Jonathan Hand, Kristin Mekeel, Gabriel Schnickel, Mita Shah, Veeral Ajmera, Aaron A R Tobian, Jonah Odim, Allan Massie, Dorry L Segev, Christine M Durand, Meenakshi Rana

{"title":"Breaking barriers: successful outcomes of hepatitis C virus D+/R- Transplants in HIV+ Recipients.","authors":"Saima Aslam, Sarah Hussain, Brandy Haydel, Sander S Florman, Alexander J Gilbert, Marcus R Pereira, Nahel Elias, Jonathan Hand, Kristin Mekeel, Gabriel Schnickel, Mita Shah, Veeral Ajmera, Aaron A R Tobian, Jonah Odim, Allan Massie, Dorry L Segev, Christine M Durand, Meenakshi Rana","doi":"10.1016/j.ajt.2025.02.007","DOIUrl":"10.1016/j.ajt.2025.02.007","url":null,"abstract":"Transplantation from donors with hepatitis C virus (HCV) viremia to recipients without HCV-viremia (HCV D+/R-) is common, but no data exist for recipients with HIV or donors with HCV/HIV coinfection. We assessed outcomes of HCV D+/R- transplants within 3 HIV Organ Policy Equity Act studies of HIV+ abdominal transplantation to recipients with HIV between 2017 and 2023. Eighteen kidney and 6 liver transplant recipients with HIV received organs from 19 donors with HCV viremia, including 7 with HCV/HIV coinfection. Median recipient age was 58 years, 96% were male, and median waitlist time was 1 year. All recipients had undetectable HIV RNA at time of transplant with median cluster of differentiation 4 count 499 cells/mm3. HCV/HIV-coinfected donors had median cluster of differentiation 4 count 210 cells/mm3, and 4 of the 7 had detectable HIV RNA. HCV treatment with direct-acting antivirals was initiated at median 33 days after transplant and sustained virologic response was achieved in 23 of the 23 treated recipients without HCV-related adverse events; data unavailable for 1 participant. Kaplan-Meier survival analysis demonstrated 100% 1-year and 96% 3-year survival. Graft survival was 96% at 1 and 3 years. HCV D+/R- abdominal transplantation, including donors with HCV/HIV coinfection, demonstrates favorable patient and graft survival in recipients with HIV and is a viable strategy to increase organ utilization.","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":" ","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From flawed to fairer: reducing blood type bias in lung transplant allocation.

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2025-02-13 DOI: 10.1016/j.ajt.2025.02.003

Isaac S Alderete, Matthew G Hartwig

引用次数: 0