American Journal of Transplantation最新文献_第7页

Machine learning for personalized and prediction of longitudinal COVID-19 vaccine responses in transplant recipients. 用于个性化和预测移植受者COVID-19纵向疫苗反应的机器学习。

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2025-01-08 DOI: 10.1016/j.ajt.2025.01.001

Hinpetch Daungsupawong, Viroj Wiwanitkit

引用次数: 0

Treatment of rapid recurrence of severe steatosis with combined glucagon-like peptide-1 agonist and growth hormone therapy in a pediatric patient transplanted for metabolic dysfunction-associated steatohepatitis cirrhosis in the setting of hypopituitarism. GLP-1激动剂和生长激素联合治疗1例垂体功能低下的儿童代谢功能障碍相关脂肪性肝炎肝硬化移植患者中严重脂肪变性的快速复发

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2025-01-08 DOI: 10.1016/j.ajt.2025.01.002

Stephanie R Saaybi, Henry Shiau, Goo Lee, Babak John Orandi, Luz Helena Gutierrez Sanchez

{"title":"Treatment of rapid recurrence of severe steatosis with combined glucagon-like peptide-1 agonist and growth hormone therapy in a pediatric patient transplanted for metabolic dysfunction-associated steatohepatitis cirrhosis in the setting of hypopituitarism.","authors":"Stephanie R Saaybi, Henry Shiau, Goo Lee, Babak John Orandi, Luz Helena Gutierrez Sanchez","doi":"10.1016/j.ajt.2025.01.002","DOIUrl":"10.1016/j.ajt.2025.01.002","url":null,"abstract":"<p><p>The association between hypopituitarism and metabolic dysfunction-associated steatotic liver disease is increasingly recognized, although data about therapies targeting recurrence posttransplant is limited. An 8-year-old with hypopituitarism-associated metabolic dysfunction-associated steatotic liver disease underwent a liver transplant due to rapid progression of metabolic dysfunction-associated steatohepatitis. Hepatosteatosis recurred within weeks. Her therapeutic plan included a glucagon-like peptide-1 agonist and growth hormone replacement. Her transaminases normalized in 2.5 months, and her macrosteatosis significantly improved on the 1-year surveillance biopsy. This case highlights one of the youngest reported children with hypopituitarism to have undergone transplantation for rapidly progressing metabolic dysfunction-associated steatohepatitis and its recurrence post-operatively. We observed that steatosis improved with growth hormone replacement and glucagon-like peptide-1 agonist therapy. If started early, this combination could help delay recurrence of steatosis post-transplantation. Further research is needed to determine long-term effects and establish protocols.</p>","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":" ","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142963427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Kidney graft directly implanted on endovascular stent in external iliac artery: A preliminary experience. 髂外动脉血管内支架直接植入肾移植；初步的经验。

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2025-01-02 DOI: 10.1016/j.ajt.2024.12.279

Julia S Slagter, Hendikus J A N Kimenai, Jorg L de Bruin, Hence J M Verhagen, Marie-Josee van Rijn, Joke M Hendriks, Michiel G H Betjes, Sander Ten Raa, Robert C Minnee

引用次数: 0

Long-term persistence of seroprotection against measles following measles-mumps-rubella vaccination administered before and after pediatric liver transplantation 小儿肝移植前后接种麻疹-流行性腮腺炎-风疹疫苗后对麻疹的血清保护作用的长期持续性。

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2025-01-01 DOI: 10.1016/j.ajt.2024.07.017

Laure F. Pittet , Renato Gualtieri , Charlotte M. Verolet , Arnaud G. L’Huillier , Barbara E. Wildhaber , Valérie A. McLin , Klara M. Posfay-Barbe

{"title":"Long-term persistence of seroprotection against measles following measles-mumps-rubella vaccination administered before and after pediatric liver transplantation","authors":"Laure F. Pittet , Renato Gualtieri , Charlotte M. Verolet , Arnaud G. L’Huillier , Barbara E. Wildhaber , Valérie A. McLin , Klara M. Posfay-Barbe","doi":"10.1016/j.ajt.2024.07.017","DOIUrl":"10.1016/j.ajt.2024.07.017","url":null,"abstract":"<div><div>Liver transplantation (LT) recipients are susceptible to infections, including measles. Concerns about the safety and efficacy of live-attenuated vaccines, such as the measles-mumps-rubella (MMR) vaccine, have led to hesitancy among providers in administering them to immunocompromised patients. This 9-year interventional study assessed seroprotection against measles following MMR vaccination in pediatric LT recipients. Of 119 participants enrolled, 60 (50%) were seroprotected against measles after transplantation. Among the 59 nonseroprotected participants, 56 fulfilled safety criteria and received MMR vaccination with a seroprotection rate of 90% (95% confidence interval [CI], 73%-98%) after a first dose, 95% (95% CI, 85%-99%) after primary vaccination with 1 to 3 doses, comparable to nonimmunocompromized populations. However, measles antibodies declined over time, suggesting the need for regular monitoring, and booster doses. Half of the vaccinees (26/53, 49%) subsequently lost seroprotection. Among them, 23 received additional doses of MMR, with a high seroconversion rate. At their last follow-up (median, 6.1 years; interquartile range, 3.0-8.1 after inclusion), 63% (95% CI, 49%-75%) of all vaccinees were seroprotected against measles. In conclusion, MMR vaccination in pediatric LT recipients offers seroprotection against measles, but long-term immunity should be monitored closely.</div></div>","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":"25 1","pages":"Pages 170-180"},"PeriodicalIF":8.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141726523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identifying Plasma Biomarkers of Liver Cirrhosis Progression and Decompensation Using Top-Down Proteomics

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2025-01-01 DOI: 10.1016/j.ajt.2024.12.036

Paola Barrios, Eleonora Forte, Jes Sanders, Indira Pla, Micheal Hollas, Aniel Sanchez, Praneet Polineni, Alexander Huang, Julianna Doll, Zachary Dietch, Neil Kelleher, Daniela Ladner

引用次数: 0

Marginal zone B cells are required for optimal humoral responses to allograft 边缘区 B 细胞是对同种异体移植物产生最佳体液反应的必要条件。

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2025-01-01 DOI: 10.1016/j.ajt.2024.09.004

Victoria Gorbacheva, Ran Fan, Brian Gaudette, William M. Baldwin III, Robert L. Fairchild, Anna Valujskikh

{"title":"Marginal zone B cells are required for optimal humoral responses to allograft","authors":"Victoria Gorbacheva, Ran Fan, Brian Gaudette, William M. Baldwin III, Robert L. Fairchild, Anna Valujskikh","doi":"10.1016/j.ajt.2024.09.004","DOIUrl":"10.1016/j.ajt.2024.09.004","url":null,"abstract":"<div><div>Antibody-mediated rejection (AMR) is among the leading causes of graft failure in solid organ transplantation. However, AMR treatment options are limited by an incomplete understanding of the mechanisms underlying de novo donor-specific antibody (DSA) generation. The development of pathogenic isotype-switched DSA in response to transplanted allografts is typically attributed to follicular B cells undergoing germinal center reaction whereas the contribution of other B cell subsets has not been previously addressed. The current study investigated the role of recipient marginal zone B cells (MZ B cells) in DSA responses using mouse models of heart and renal allotransplantation. MZ B cells rapidly differentiate into antibody-secreting cells in response to allotransplantation. Despite the selective depletion of follicular B cells in heart allograft recipients, MZ B cells are sufficient for T-dependent IgM and early IgG DSA production. Furthermore, the presence of intact MZ B cell subset is required to support the generation of pathogenic isotype-switched DSA in renal allograft recipients containing donor-reactive memory helper T cells. These findings are the first demonstration of the role of MZ B cells in humoral alloimmune responses following solid organ transplantation and identify MZ B cells as a potential therapeutic target for minimizing de novo DSA production and AMR in transplant recipients.</div></div>","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":"25 1","pages":"Pages 48-59"},"PeriodicalIF":8.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142277484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Benefits of liver transplant in critically ill patients with acute-on-chronic liver failure: Implementation of an urgent living-donor program 急慢性肝功能衰竭重症患者接受肝脏移植的益处：实施紧急活体供体计划。

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2025-01-01 DOI: 10.1016/j.ajt.2024.08.008

Hye-Mee Kwon , Jae Hwan Kim , Sung-Hoon Kim , In-Gu Jun , Jun-Gol Song , Deok-Bog Moon , Gyu-Sam Hwang

{"title":"Benefits of liver transplant in critically ill patients with acute-on-chronic liver failure: Implementation of an urgent living-donor program","authors":"Hye-Mee Kwon , Jae Hwan Kim , Sung-Hoon Kim , In-Gu Jun , Jun-Gol Song , Deok-Bog Moon , Gyu-Sam Hwang","doi":"10.1016/j.ajt.2024.08.008","DOIUrl":"10.1016/j.ajt.2024.08.008","url":null,"abstract":"<div><div>We evaluated the liver transplantation (LT) criteria in acute-on-chronic liver failure (ACLF), incorporating an urgent living-donor LT (LDLT) program. Critically ill patients with a Chronic Liver Failure Consortium (CLIF-C) ACLF score (CLIF-C_ACLF_score) ≥65, previously considered unsuitable for LT, were included to explore the excess mortality threshold of the CLIF-C_ACLF_score (CLIF-C_ACLF_score_threshold). We followed 854 consecutive patients with ACLF (276 ACLF grade 2 and 215 ACLF grade 3) over 10 years among 4432 LT recipients between 2008 and 2019. For advanced ACLF patients without immediate deceased-donor (DD) allocation, an urgent LDLT program was expedited. The CLIF-C_ACLF_score_threshold was determined by the metrics of transplant survival benefit: >60% 1-year and >50% 5-year survival rate. In predicting post-LT mortality, the CLIF-C_ACLF_score outperformed the (model for end-stage liver disease-sodium) MELD-Na and (model for end-stage liver disease) MELD-3.0 scores but was comparable to the Sundaram ACLF-LT-mortality score. A CLIF-C_ACLF_score ≥65 (n = 54) demonstrated posttransplant survival benefits, with 1-year and 5-year survival rates of 66.7% and 50.4% (<em>P</em> < .001), respectively. Novel CLIF-C_ACLF_score_threshold for 1-year and 5-year mortalities was 70 and 69, respectively. A CLIF-C_ACLF_score–based nomogram for predicting survival probabilities, integrating cardiovascular disease, diabetes, and donor type (LDLT vs DDLT), was generated. This study suggests reconsidering the criteria for unsuitable LT with a CLIF-C_ACLF_score ≥65. Implementing a timely salvage LT strategy, and incorporating urgent LDLT, can enhance survival rates.</div></div>","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":"25 1","pages":"Pages 150-163"},"PeriodicalIF":8.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141998930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prolonged Time from Cross Clamp until Normothermic Machine Perfusion Start is Associated with Increased Risk of Early allograft Dysfunction Following DCD Liver Transplant

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2025-01-01 DOI: 10.1016/j.ajt.2024.12.022

Charles Lee , Amit Mathur , Julie Heimbach , C. Burcin Taner , Bashar Aqel , Shennen Mao , Kristopher Croome

引用次数: 0

Perceptions of Alcohol Use Disorder Support Among Liver Transplant Recipients, A Survey of Strategies and Challenges

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2025-01-01 DOI: 10.1016/j.ajt.2024.12.101

Maria Cote, Natalia Rodriguez-Payan, Leigh Anne Dageforde

引用次数: 0

Renal Transplant Graft Survival After Normothermic Regional Perfusion Is Comparable To Other Standard Procurement Methods

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2025-01-01 DOI: 10.1016/j.ajt.2024.12.062

Caroline Godfrey , Kathryn Kraft , Scott Rega , Irene Feurer , Wali Johnson , David Shaffer , Rachel Forbes , Laura Hickman

引用次数: 0