Fortschritte Der Neurologie Psychiatrie最新文献

{"title":"Depressionen: funktionelle Konnektivität zur Zielplanung der Magnetstimulation","authors":"","doi":"10.1055/a-2080-1554","DOIUrl":"https://doi.org/10.1055/a-2080-1554","url":null,"abstract":"Die repetitive transkranielle Magnetstimulation (rTMS) ist ein Verfahren zur Therapie schwerer Depressionen, bei dem Magnetimpulse die Erregbarkeit von Nervenzellen beeinflussen. Obgleich heutige Protokolle die funktionelle Konnektivität des subgenuellen anterioren cingulären Kortex (sgACC) nutzen, bleibt die Studienlage unklar. Elbau et al. haben daher funktionelle Konnektivität der Stimulationsstelle und Stimulationsoutcome überprüft.","PeriodicalId":12353,"journal":{"name":"Fortschritte Der Neurologie Psychiatrie","volume":"128 6","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135564292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Telemedicine Care of Dementia Patients During the COVID-19 Pandemic].","authors":"Stefan Brodoehl, Franziska Wagner, Carsten Klingner, Annie Srowig, Kathrin Finke","doi":"10.1055/a-2073-3947","DOIUrl":"10.1055/a-2073-3947","url":null,"abstract":"<p><p>In our multidisciplinary memory center at Jena University Hospital, we initiated a regular video consultation for patients at risk of developing dementia or with dementia disease and their relatives at the beginning of the SARS-CoV2 pandemic in spring 2020.Over a 12-month period, we conducted a systematic survey of satisfaction among patients in regular face-to-face contact (F2F) and video consultations (VC).The aim of this study was to evaluate the potential use of telemedicine in older people with incipient cognitive deficits in the context of dementia. In particular, we aimed to evaluate patient satisfaction and feasibility.Initial presentations to our memory center for suspected dementia were evaluated in a standardized regular on-site setting (n=50) and in a standardized video consultation (n=40). In both settings, a neuropsychologist's and a physician's consultation were performed consecutively. Both groups were similarly distributed in terms of age and sex (71.4 vs. 72.3 years, 52 vs. 50% female (F2F vs. VC)). Cognitive status was slightly better in the VC group (ACE III significant, MMST not significant).In the survey of the patients using a 12-question inventory (patient satisfaction, rated 1 to 5), there was no significant difference between the two groups overall. However, the F2F tended to be rated slightly better here in terms of advice. More than 80% of the physicians and neuropsychologists rated the technical process of VC as good/very good.A general assessment of the cognitive deficits by physicians and neuropsychologists correlated extremely highly with the results of the subsequent specific testing (MMST and ACE) in F2F and VC. With a tendency to better agreement in VC, the difference between the correlations was not significant.Overall, we could not find any significant differences in patients' satisfaction between VC and classical F2F presentation. Technical aspects in the preparation of a VC and during a VC were less problematic than initially anticipated.</p>","PeriodicalId":12353,"journal":{"name":"Fortschritte Der Neurologie Psychiatrie","volume":" ","pages":"444-454"},"PeriodicalIF":0.6,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635742/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9866998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Demenzrisiko bei fokaler Epilepsie","authors":"","doi":"10.1055/a-2163-2292","DOIUrl":"https://doi.org/10.1055/a-2163-2292","url":null,"abstract":"Die Epilepsie-Erkrankung stellt mit einer Inzidenz von 30 000/Jahr und einer Prävalenz von 400 000–80 000 Betroffenen in Deutschland eine der häufigsten neurologischen Erkrankungen dar [1]. Inzidenzgipfel bestehen vor dem ersten und nach dem 65. Lebensjahr, wobei die Erstmanifestationen im höheren Alter primär durch fokale Epilepsien z. B. nach Schlaganfall, post-traumatischen Defekten oder im Rahmen von Hirnmetastasen und -tumoren bedingt wird. Dies begründet auch die zuletzt steigenden Prävalenzzahlen (4,7/1000 in 1995 auf 5,5/1000 in 2010 ) [1], nachdem angesichts des demographischen Wandels der Bevölkerungsanteil >65 Jahre von 15,6% im Jahr 1995 auf 20,7% im Jahr 2010 angestiegen ist. Eine weitere Zunahme ist zu erwarten, nachdem der Anteil der über 65-Jährigen nach Auskunft des Statistischen Bundesamtes 2021 bereits 22% erreichte [2].","PeriodicalId":12353,"journal":{"name":"Fortschritte Der Neurologie Psychiatrie","volume":"130 12","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135564284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anstieg von GAP43 im Liquor deutet auf Alzheimer-Krankheit hin","authors":"","doi":"10.1055/a-2080-1347","DOIUrl":"https://doi.org/10.1055/a-2080-1347","url":null,"abstract":"Eine erhöhte präsynaptische Dysfunktion, die in der Zerebrospinalflüssigkeit (CSF) an Hand des als „Wachstums“- oder „Plastizitäts“-Protein bezeichneten Proteins GAP43 gemessen wird, kann bei der Alzheimer-Krankheit (AD) beobachtet werden. Wie aber ein Anstieg des GAP43-Liquors mit AD-Core-Pathologien, Neurodegeneration und kognitivem Abbau bei AD zusammenhängt, muss weiter untersucht werden.","PeriodicalId":12353,"journal":{"name":"Fortschritte Der Neurologie Psychiatrie","volume":"122 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135564308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depressionen: Veränderungen der funktionellen Konnektivität nach Remission?","authors":"","doi":"10.1055/a-2080-1540","DOIUrl":"https://doi.org/10.1055/a-2080-1540","url":null,"abstract":"Zur Therapie schwerer Depressionen stehen heute als Goldstandard 2 verschiedene Behandlungsansätze zur Verfügung: Pharmakotherapie und Psychotherapie. Dunlop und Kollegium haben nun mögliche Unterschiede der funktionellen Konnektivität des Gehirns im Ruhezustand nach Remission nach einer der beiden Behandlungen genauer analysiert, und kommen in ihrer funktionellen MRT-Studie mit über 130 Erwachsenen zu einem spannenden Ergebnis.","PeriodicalId":12353,"journal":{"name":"Fortschritte Der Neurologie Psychiatrie","volume":"128 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135564293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amyotrophe Lateralsklerose: Neuer Wirkstoff RNS60 gibt Hoffnung","authors":"","doi":"10.1055/a-2109-8907","DOIUrl":"https://doi.org/10.1055/a-2109-8907","url":null,"abstract":"Amyotrophe Lateralsklerose (ALS) ist eine tödlich verlaufende neurodegenerative Erkrankung, für die es bis heute keine kurativen Therapieverfahren gibt. Um die Progression bremsen und irgendwann eine Heilung ermöglichen zu können, läuft die Suche nach neuen Wirkstoffen auf Hochtouren. So haben Beghi et al. in einer Phase-II-Studie Sicherheit und Wirksamkeit des Medikamentes „RNS60“ untersucht und konnten dabei erste Erfolge erzielen.","PeriodicalId":12353,"journal":{"name":"Fortschritte Der Neurologie Psychiatrie","volume":"124 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135564299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parkinson: mit negativem Feedback Impulskontrollstörung prognostizieren","authors":"","doi":"10.1055/a-2080-1401","DOIUrl":"https://doi.org/10.1055/a-2080-1401","url":null,"abstract":"Spanische Neurowissenschaftler*innen versuchten zu bewerten, inwieweit die sogenannte Feedback-related Negativity (FRN) – ein neurophysiologischer Marker für die Anreizverarbeitung, die vor allem von negativem Feedback ausgelöst wird – verwendet werden kann, um die Entwicklung von Impulskontrollstörungen (ICDs) bei der Parkinson-Krankheit (PD) vorherzusagen.","PeriodicalId":12353,"journal":{"name":"Fortschritte Der Neurologie Psychiatrie","volume":"130 10","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135564285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Autism spectrum disorder in adulthood].","authors":"Hanna Thaler, Christine Falter-Wagner","doi":"10.1055/a-1898-5347","DOIUrl":"10.1055/a-1898-5347","url":null,"abstract":"<p><p>Autism is a neurodevelopmental disorder that starts in early childhood and persists over the lifespan. A combination of genetic factors and environmental factors around birth contribute to its etiology. Autistic individuals show differences and difficulties in social interaction and communication as well as repetitive, stereotypical behavior and interests. The diagnostic procedure is complex and should be carried out in a specialized assessment unit. Diagnostic assessment is based on behavioral observation and a careful evaluation of developmental history. A wide range of potential differential diagnoses should be considered. Autistic adults have a higher risk of developing psychiatric disorders such as anxiety and depression. Psychotherapeutic treatment that is adapted to autism-related difficulties can be helpful. Co-occurring conditions should be treated in accordance with disorder-specific guidelines. Psychopharmacological treatment of co-occurring conditions is, in most cases, only recommended as an addition to behavioral interventions. Autistic people often experience difficulties in social participation, which can be targeted with sociotherapeutic interventions.</p>","PeriodicalId":12353,"journal":{"name":"Fortschritte Der Neurologie Psychiatrie","volume":"91 11","pages":"466-478"},"PeriodicalIF":0.6,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72014090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Berthold Kihn (1895-1964) and the NS \"Euthanasia\": Profile of a Perpetrator].","authors":"Birgit Braun,&nbsp;Nikolaus Knoepffler","doi":"10.1055/a-2066-0207","DOIUrl":"https://doi.org/10.1055/a-2066-0207","url":null,"abstract":"<p><strong>Introduction: </strong>In historical sciences, there is no consensus on how to understand the transition from eugenic sterilization to \"euthanasia\". The aim of this article was to investigate this question based on the historical-critical method, using the example of the perpetrator profile of Berthold Kihn. His pseudoscientific way to \"euthanasia\", however, did not have an eugenic foundation.</p><p><strong>Methods: </strong>Literature- and archival studies were carried out. For the first time, attention was paid to relevant Franconian and familial archival sources. Moreover, documents of the Jena University Archive were compared to those of the concentration camps of Buchenwald and Oranienburg.</p><p><strong>Results: </strong>After professional as well as private dilemma, the neuroinfectiologist Kihn set a focus on the \"eradication of the inferiors\". Apart from Kihn's role in central \"euthanasia\" and \"childrens' euthanasia\", which has been clearly demonstrated, we found actual hints of his additional involvement in decentral \"euthanasia\". This is shown using the example of the prominent patient Felix von Papen.</p><p><strong>Discussion: </strong>Kihn was no racial hygienist, he did not make his mark as an eugenicist. His professional and private dilemma may - among other things - have motivated him, to join a politically promoted movement.</p><p><strong>Conclusion: </strong>Further comparative research in the profiling of NS perpetrators may contribute to a better differentiation of the transition from eugenics to \"euthanasia\".</p>","PeriodicalId":12353,"journal":{"name":"Fortschritte Der Neurologie Psychiatrie","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49689585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Forensic-Psychiatric Consultations in General Psychiatry].","authors":"Catharina Schmidt Schmidt,&nbsp;Natalia Anna Seeger,&nbsp;Nathalie Brackmann,&nbsp;Angela Guldimann,&nbsp;Elmar Habermeyer","doi":"10.1055/a-2182-6606","DOIUrl":"10.1055/a-2182-6606","url":null,"abstract":"<p><p>A subgroup of psychiatric patients are at increased risk of committing interpersonal violence, which may lead to placements in forensic-psychiatric institutions. The majority of patients treated in forensic hospitals have had contact with the general psychiatric care system years before being forensically committed due to an offence. Nevertheless, attempts to establish models related to violence prevention in general psychiatry have remained sparse. In the Canton of Zurich, the forensic psychiatric consultation liaison service provides the general psychiatric clinics with access to forensic psychiatric expertise. In this paper, we describe the consultation service's diagnostic and advisory offers and aim to characterize the patient population seen by the service. We compared the three most common diagnostic groups (schizophrenic, affective and personality disorders) regarding reason for consultation, history of violence and substance abuse. In addition, we analyzed content and kind of the recommendations made. From 2013 to 2021, 188 patients in general psychiatric clinics in Zurich have been examined after informed consent. Most patients had a positive history of violence (72.7%) and substance use (66.1%). Almost half of the patients (48.4%) had been diagnosed with schizophrenia or a related disorder.</p>","PeriodicalId":12353,"journal":{"name":"Fortschritte Der Neurologie Psychiatrie","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49689586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}