Fortschritte Der Neurologie Psychiatrie最新文献

{"title":"[Acute kidney injury during treatment with clozapine].","authors":"Ralf Kozian, Olga Bengel","doi":"10.1055/a-2537-9539","DOIUrl":"https://doi.org/10.1055/a-2537-9539","url":null,"abstract":"","PeriodicalId":12353,"journal":{"name":"Fortschritte Der Neurologie Psychiatrie","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143613690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flimsy but handy: Devising an algorithm as a novel approach to the pharmacotherapy of cocaine addiction.","authors":"Sebastian Karl Maximilian Fischer, Jochen Mutschler","doi":"10.1055/a-2537-9595","DOIUrl":"https://doi.org/10.1055/a-2537-9595","url":null,"abstract":"<p><p>Cocaine addiction is a devastating disorder, not only for the individual but also for society. Due to the rapid increase in cocaine consumption worldwide, cocaine and its deleterious psychiatric and physical consequences have increasingly become a major focus of addiction medicine. Unfortunately, advances in the treatment of cocaine addiction cannot keep pace with the surging demand for effective, fast-acting, readily available and affordable therapies. Psychosocial and psychotherapeutic measures are still the mainstay of therapy, but many patients do not have access to or benefit sufficiently from these treatment modalities. To date, there is no pharmacotherapy that has been approved or shown to be consistently effective for cocaine addiction. Nonetheless, a fair number of promising candidate substances can be extracted from a large pool of studies and there exists enough evidence to justify the assumption that many patients are likely to benefit from at least one of these substances. We have thoroughly analyzed the literature and contributed our own research results in order to integrate clinically relevant findings into an algorithm that enables the clinician to make the current state of knowledge usable in routine practice.</p>","PeriodicalId":12353,"journal":{"name":"Fortschritte Der Neurologie Psychiatrie","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The Attitude of the Public Concerning Coercive Measures in Psychiatric Patients].","authors":"Christian G Huber, Sahar Steiger, Julian Möller, Undine E Lang","doi":"10.1055/a-2036-7780","DOIUrl":"10.1055/a-2036-7780","url":null,"abstract":"<p><strong>Objective: </strong>To examine the attitude of the general public in Basel concerning the use of coercive measures while dealing with psychiatric patients. The common population indirectly governs the use of coercive measures in psychiatry by its stigmatization of people with psychiatric illnesses, and its attitude towards treatment in psychiatry and by local opinion leaders and reactions of social networks.</p><p><strong>Methods: </strong>The answers of 1,112 persons from a representative population survey were evaluated. Participants were mailed case vignettes and questionnaires, and asked if they considered involuntary admission, coercive medication, and/or seclusion as acceptable measures in dealing with psychiatric patients.</p><p><strong>Results: </strong>When symptoms of a psychotic disorder were present, 31.5% approved of at least one coercive measure, with 22% approval in the case of a borderline personality disorder, and 20.7% in the case of alcohol dependency. However, the overall rejection of coercive measures by the general public in Basel was high. The differential approval of the examined coercive measures depending on psychiatric symptoms was in line with professional medical and ethical guidelines.</p><p><strong>Conclusion: </strong>Public attitudes have an indirect influence on the local use of coercive measures and should be included in the specialist psychiatric discourse.</p>","PeriodicalId":12353,"journal":{"name":"Fortschritte Der Neurologie Psychiatrie","volume":" ","pages":"86-94"},"PeriodicalIF":0.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11903099/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9290105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Metabolic adverse drug reactions related to psychotropic drugs].","authors":"Maximilian Gahr","doi":"10.1055/a-2405-5087","DOIUrl":"10.1055/a-2405-5087","url":null,"abstract":"<p><p>Metabolic adverse drug reactions (mADR) related to psychotropic drugs have significant health-related effects including weight gain, impaired glucose tolerance, diabetes mellitus and dyslipidemia as well as economic relevance. Nearly all antipsychotics (AP) and many antidepressants (AD) and mood stabilisers may induce weight gain. Weight development in the first weeks or months after the beginning of the therapy is the strongest predictor for weight gain related to AP and AD. The most important risk factors for mADR are antagonistic effects at H₁-, 5-HT_2C- und M₃-receptors and antidopaminergic effects. However, several other systems are also relevant. Systematic monitoring of metabolic parameters is recommended in all patients treated with substances that are associated with an increased risk of mADR. Lifestyle modification, dietary measures, exercise therapy, dose reduction, change and discontinuation of the substance, and additional treatment with metformin and topiramate are evidence-based treatment options for AP-associated weight gain. GLP-1 receptor agonists such as liraglutide are also promising.</p>","PeriodicalId":12353,"journal":{"name":"Fortschritte Der Neurologie Psychiatrie","volume":" ","pages":"95-103"},"PeriodicalIF":0.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142307476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neue Studiendaten zur Primär- und Sekundärprävention des Schlaganfalls.","authors":"Hans Christoph Diener, Matthias Endres, Gerrit M Große, Götz Thomalla, Stefan Schwab","doi":"10.1055/a-2465-8151","DOIUrl":"https://doi.org/10.1055/a-2465-8151","url":null,"abstract":"","PeriodicalId":12353,"journal":{"name":"Fortschritte Der Neurologie Psychiatrie","volume":"93 3","pages":"104-115"},"PeriodicalIF":0.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143614005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[What are the consequences of the new drug approval for Alzheimer's dementia?]","authors":"Jens Kuhn, Joachim Klosterkötter","doi":"10.1055/a-2502-9556","DOIUrl":"https://doi.org/10.1055/a-2502-9556","url":null,"abstract":"","PeriodicalId":12353,"journal":{"name":"Fortschritte Der Neurologie Psychiatrie","volume":"93 3","pages":"82-85"},"PeriodicalIF":0.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143614003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Treatment-refractory chronic depression in a CADASIL patient with a symptom-free somatic course: a case report].","authors":"Sebastian Wurthmann, Oliver Kastrup, Cornelius Wurthmann, Norbert Scherbaum, Patrik Roser","doi":"10.1055/a-2512-7605","DOIUrl":"https://doi.org/10.1055/a-2512-7605","url":null,"abstract":"<p><p>Depressive disorders are very common psychiatric disorders that are usually well treatable. However, special attention is required if the depressive symptoms do not improve despite guideline-compliant treatment and if brain structural changes can be detected on neuroimaging.We report on a genetically newly diagnosed 63-year-old patient with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) with a two-decade course of severe affective symptoms in the absence of classical somatic disease characteristics although we found a pathogenic variant in the EGFr 4 domain of the NOTCH3 protein.CADASIL is a rare inherited disease of the small cerebral vessels which is caused by mutations in the NOTCH3 gene. The disease typically begins in young adulthood and is characterized by ischemic strokes, migraine-like headaches, psychiatric disturbance, and cognitive decline. Pathogenic variants in NOTCH3 EGFr domains 1-6 are associated with a more severe somatic phenotype. Our case report highlights the phenotypic heterogeneity of CADASIL with only psychiatric symptoms despite mutation within EGFr domain 4; therefore, CADASIL should be considered in the presence of affective disorders, lack of response to antidepressants and typical MR changes.</p>","PeriodicalId":12353,"journal":{"name":"Fortschritte Der Neurologie Psychiatrie","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143370623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Diagnostic utility of the MTA-Score depending on age and cerebral microangiopathy in times of automated volumetry].","authors":"Pauline Klara Sander, Cathrin Sauer, Arne Grey, Pawel Krukowski, Jennifer Linn, Moritz D Brandt, Robert Haussmann","doi":"10.1055/a-2512-7931","DOIUrl":"https://doi.org/10.1055/a-2512-7931","url":null,"abstract":"<p><p>  To investigate the diagnostic value of the MTA score according to age, cerebral small vessel disease and in times of automated volumetry.  Retrospective analysis of patients with subjective cognitive decline (SCD), amnestic mild cognitive impairment (aMCI), Alzheimer's disease (AD) and mixed dementia (MD) who presented to our outpatient dementia clinic between February 2018 and October 2020. Patients underwent cranial magnetic resonance imaging (MRI) including specific MRI sequences needed for automated volumetry. MRI data sets were analyzed regarding MTA score, Fazekas score, hippocampal und temporal lobe percentile and total white matter lesion volume.  Within the study period, 242 patients (100 male, 142 female, mean age 74.7±9.9 years) with SCD (n=20), aMCI (n=110), AD (n=62) and MD (n=50) were analyzed. MTA score strongly correlated with age (ρ=0.545; p<0.001), especially regarding the aMCI and AD group. MTA score differentiated only between prodromal and dementia stages (aMCI vs. AD: p=0.005), whereas hippocampal percentile also showed a trend in differentiating between SCD and aMCI. There was a correlation between MTA score and hippocampal percentile (ρ=-0.385; p<0.001), which, on a single group level, could only be shown for the aMCI and AD group. There was significant correlation between MTA score with hippocampal and temporal lobe percentile. MTA score also correlated with Fazekas score (ρ=0.451; p<0.001) which again could only be detected within the aMCI and AD group. But there was no correlation between hippocampal percentile and total white matter lesion volume.  When interpreting the MTA score, patient's age needs to be taken into consideration. Especially, in early dementia diagnostics, automated volumetric procedures might be advantageous, but due to the strong correlation of MTA score with hippocampal percentile, the MTA score still is a valid diagnostic marker. Whether hippocampal atrophy is modulated by cerebral small vessel disease still needs to be elucidated.</p>","PeriodicalId":12353,"journal":{"name":"Fortschritte Der Neurologie Psychiatrie","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Neurological evaluation of \"post-COVID-19 syndrome\" (PCS)].","authors":"Jens D Rollnik","doi":"10.1055/a-2465-3570","DOIUrl":"https://doi.org/10.1055/a-2465-3570","url":null,"abstract":"<p><p>The so-called \"post-COVID-19 syndrome\" (PCS) includes a variety of subjective complaints and represents a challenge to medical evaluation. The review focuses on symptom validation of the most common neurological, neuropsychiatric and neuropsychological PCS symptoms like fatigue, loss of smell and taste, problems speaking or communicating, cognitive disorders, dysaesthesia and persistent muscle pain.</p>","PeriodicalId":12353,"journal":{"name":"Fortschritte Der Neurologie Psychiatrie","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Correction: The pioneers Schwerin and Brandenburg-Görden in the development of alcohol use disorder therapy in the GDR].","authors":"Nadja Pontzen, Holger Steinberg","doi":"10.1055/a-2503-2447","DOIUrl":"https://doi.org/10.1055/a-2503-2447","url":null,"abstract":"","PeriodicalId":12353,"journal":{"name":"Fortschritte Der Neurologie Psychiatrie","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142964437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}