Folia microbiologica最新文献_第5页

Nanobodies: a new frontier in influenza virus neutralization. 纳米体：流感病毒中和的新前沿。

IF 3.1 4区生物学

Folia microbiologica Pub Date : 2025-08-01 Epub Date: 2025-07-23 DOI: 10.1007/s12223-025-01303-2

Mohamed J Saadh, Waleed K Abdulsahib, Ashok Kumar Bishoyi, Suhas Ballal, Abhayveer Singh, Suman Saini, Khasankhodja Abidov, Kamal Kant Joshi, Munther Kadheem, Manizhe Jozpanahi, Mohammad Darvishi

{"title":"Nanobodies: a new frontier in influenza virus neutralization.","authors":"Mohamed J Saadh, Waleed K Abdulsahib, Ashok Kumar Bishoyi, Suhas Ballal, Abhayveer Singh, Suman Saini, Khasankhodja Abidov, Kamal Kant Joshi, Munther Kadheem, Manizhe Jozpanahi, Mohammad Darvishi","doi":"10.1007/s12223-025-01303-2","DOIUrl":"10.1007/s12223-025-01303-2","url":null,"abstract":"Recurrent epidemics and pandemics caused by seasonal human influenza viruses result in substantial morbidity and are a significant public health burden worldwide annually. Antiviral drugs are used to treat influenza infections but have several limitations.. Therefore, monoclonal antibody therapy is an exciting and promising approach. Nanobodies, also known as single-domain antibodies, are a new class derived from heavy-chain-only antibodies found in camelids like alpacas, llamas, and camels. These antibodies neutralize influenza viruses by targeting various proteins through multiple mechanisms. For example, they can target the hemagglutinin protein to prevent its functions. By focusing on conserved epitopes, they can neutralize a variety of influenza subtypes, including seasonal flu strains and possible pandemic variants. Additionally, these antibodies can neutralize free-floating viruses in the extracellular environment, preventing them from infecting cells. They can reduce the viral load and limit the spread of the infection. Using nanobodies to neutralize influenza viruses provides numerous advantages compared to conventional antibodies. Thanks to their unique properties, nanobodies play a crucial role in fighting influenza, improving disease management, and strengthening public health responses. In this review, we summarize the role of nanobodies in influenza virus neutralization.","PeriodicalId":12346,"journal":{"name":"Folia microbiologica","volume":" ","pages":"739-751"},"PeriodicalIF":3.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144689765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunological orchestration and dysregulation in COVID-19 pneumonia: from viral pathogenesis to precision therapeutics in the post-pandemic era. COVID-19肺炎的免疫协调与失调：从病毒发病机制到后大流行时代的精准治疗

IF 3.1 4区生物学

Folia microbiologica Pub Date : 2025-08-01 Epub Date: 2025-08-18 DOI: 10.1007/s12223-025-01315-y

Yun Qin, Chaofan Li, Xingxing Yuan, Zhuying Li

{"title":"Immunological orchestration and dysregulation in COVID-19 pneumonia: from viral pathogenesis to precision therapeutics in the post-pandemic era.","authors":"Yun Qin, Chaofan Li, Xingxing Yuan, Zhuying Li","doi":"10.1007/s12223-025-01315-y","DOIUrl":"10.1007/s12223-025-01315-y","url":null,"abstract":"The COVID-19 pandemic revolutionized our understanding and treatment of pneumonia, particularly highlighting its complex immunological aspects. In this review, we synthesized recent research on COVID-19 clinical management, shedding light on the immune-related landscape of pneumonia in the post-pandemic era. We explored key features of SARS-CoV-2, such as transmission dynamics, emerging variants, and infection mechanisms, before delving into the host immune response following viral exposure. Our discussion emphasized the critical role of immune cells, inflammatory cytokines, and cytokine storms in pneumonia development, alongside immune-mediated lung damage and thrombotic complications. Clinically, we summarized evolving diagnostic methods, treatment approaches, and intensive care protocols, all with a focus on the pivotal role of immunology in pneumonia management. Looking forward, we advocated for a comprehensive approach to addressing ongoing pneumonia challenges, including strengthening epidemic surveillance and advancing immunotherapy research to target abnormal immune responses. Additionally, refining vaccine strategies for durable immunity against evolving viral strains was deemed essential. Overall, this review underscored the central role of immunology in shaping pneumonia management post-COVID-19, aiming to enhance our understanding of disease mechanisms and immunological responses in the post-pandemic era.","PeriodicalId":12346,"journal":{"name":"Folia microbiologica","volume":" ","pages":"779-795"},"PeriodicalIF":3.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144872266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vector-borne diseases and their role in COVID-19 dynamics and death rates: focus on India. 媒介传播疾病及其在COVID-19动态和死亡率中的作用：重点关注印度。

IF 3.1 4区生物学

Folia microbiologica Pub Date : 2025-08-01 Epub Date: 2025-08-09 DOI: 10.1007/s12223-025-01313-0

Satyananda Patel, Maneesh Kumar, Ganesh Chandra Sahoo, Sushil Kumar Sahu

{"title":"Vector-borne diseases and their role in COVID-19 dynamics and death rates: focus on India.","authors":"Satyananda Patel, Maneesh Kumar, Ganesh Chandra Sahoo, Sushil Kumar Sahu","doi":"10.1007/s12223-025-01313-0","DOIUrl":"10.1007/s12223-025-01313-0","url":null,"abstract":"As one of the most significant global health emergencies, COVID-19 has placed extraordinary demands on healthcare systems worldwide. In India, its widespread transmission has been influenced by the country's diverse climatic conditions, geo-ecological complexity, and dense population. This, vector-borne diseases (VBDs)-including malaria, dengue, kala azar, Japanese encephalitis, and chikungunya-have long posed additional challenges to public health infrastructure. Intriguingly, prior exposure to these diseases may shape immune responses, potentially conferring cross-protection against multiple pathogens. A cross-sectional study aimed at assessing the role of VBDs in COVID-19 incidence and mortality revealed a multifaceted relationship. Prior dengue exposure was linked to an increased risk of SARS-CoV-2 infection and mortality, whereas kala azar, Japanese encephalitis, and chikungunya appeared to have protective influences. Notably, malaria had statistically significant protective effects against both SARS-CoV-2 infection and mortality (p < 0.04). These findings suggest that immune mechanisms-such as cross-reactive antibodies or immune regulation-may alter susceptibility to COVID-19. Given the substantial protective effect of malaria, further investigation is warranted to clarify the underlying biological processes involved. Insights from this study could guide public health strategies, optimize resource allocation, and refine intervention measures in regions where both COVID-19 and VBDs remain major concerns.","PeriodicalId":12346,"journal":{"name":"Folia microbiologica","volume":" ","pages":"899-906"},"PeriodicalIF":3.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144811925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A rare and first report of Ochrobactrum intermedium co-infection in coxsackievirus-A24-infected acute hemorrhagic conjunctivitis patients. 柯萨奇病毒- a24感染急性出血性结膜炎患者中中嗜铬杆菌合并感染的罕见报道。

IF 3.1 4区生物学

Folia microbiologica Pub Date : 2025-08-01 Epub Date: 2025-07-14 DOI: 10.1007/s12223-025-01300-5

Sthita Pragnya Behera, Pooja Bhardwaj, Prashansha Srivastava, Shashikant Tiwari, Manoj Kumar, Nalini Mishra, Ritesh Kumar, Nirbhay Singh, Rajeev Singh, Hari Shanker Joshi, Gaurav Raj Dwivedi

{"title":"A rare and first report of Ochrobactrum intermedium co-infection in coxsackievirus-A24-infected acute hemorrhagic conjunctivitis patients.","authors":"Sthita Pragnya Behera, Pooja Bhardwaj, Prashansha Srivastava, Shashikant Tiwari, Manoj Kumar, Nalini Mishra, Ritesh Kumar, Nirbhay Singh, Rajeev Singh, Hari Shanker Joshi, Gaurav Raj Dwivedi","doi":"10.1007/s12223-025-01300-5","DOIUrl":"10.1007/s12223-025-01300-5","url":null,"abstract":"Epidemic form of acute hemorrhagic conjunctivitis was reported from different geographical locations of the world, during 2023. Since the viral agents are well established behind acute hemorrhagic conjunctivitis outbreaks, this study aims to investigate the bacterial agent associated with the acute hemorrhagic conjunctivitis outbreak that occurred in the eastern Uttar Pradesh region of India. The bacterial infection was investigated in 91 conjunctival swabs collected from acute hemorrhagic conjunctivitis patients during the outbreak. Total nucleic acid was extracted from the ocular swab collected from acute hemorrhagic conjunctivitis patients, followed by the detection of human adenovirus and pan-enterovirus using PCR. Further, the isolation of bacteria was performed using these clinical samples. Characterization of the bacterial isolates was done using the VITEK-2 system and 16S ribosomal RNA sequencing. Of 64 conjunctival swabs positive for coxsackievirus-A24 samples, two clinical specimens showed bacterial growth. Both isolates were identified as Ochrobactrum anthropi via VITEK-2 with 93% and 95% confidence levels. While 16S ribosomal RNA analysis characterized the isolates as Ochrobactrum intermedium. Ochrobactrum intermedium is an emerging multidrug-resistant bacterium and is reported to cause a variety of clinical infections. This study first reported the Ochrobactrum intermedium infection in two coxsackievirus-A24 infected acute hemorrhagic conjunctivitis patients.","PeriodicalId":12346,"journal":{"name":"Folia microbiologica","volume":" ","pages":"891-897"},"PeriodicalIF":3.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isolation and assessment of probiotic potential of Acidipropionibacterium acidipropionici C03B-STR from goat milk with cholesterol-lowering capability. 从具有降低胆固醇能力的山羊奶中分离酸性丙酸杆菌 C03B-STR 并评估其益生菌潜力

IF 3.1 4区生物学

Folia microbiologica Pub Date : 2025-08-01 Epub Date: 2024-11-06 DOI: 10.1007/s12223-024-01222-8

Sirikhwan Tinrat, Onnicha Jiraprasertwong

{"title":"Isolation and assessment of probiotic potential of Acidipropionibacterium acidipropionici C03B-STR from goat milk with cholesterol-lowering capability.","authors":"Sirikhwan Tinrat, Onnicha Jiraprasertwong","doi":"10.1007/s12223-024-01222-8","DOIUrl":"10.1007/s12223-024-01222-8","url":null,"abstract":"Elevated levels of cholesterol or triglycerides in the blood are one of the major risk factors for coronary heart disease, which is the foremost leading cause of death across the world. The aims of this study were to isolate and verify the potential probiotic strain and cholesterol-lowering capability from goat milk. The C03B-STR isolate had a broad-spectrum antibacterial property and exhibited remarkable bacteriostatic activity against Klebsiella pneumoniae ATCC 13883 (27.00 ± 1.73 mm), Pseudomonas aeruginosa ATCC 27853 (19.33 ± 0.57 mm) and Staphylococcus aureus ATCC 10832 (19.00 ± 1.00 mm) by agar well diffusion assay. This isolate is closely related to the 16S rDNA sequence of Acidipropionibacterium acidipropionici. Acidipropionibacterium acidipropionici C03B-STR can survive under acidic conditions (60.51 ± 0.02% of survival rate at pH 3.0 for 3 h) and was as bile-tolerant strain (> 80% of survival rate at 0.30% bile salts after 3 h of incubation). Furthermore, it showed significantly high cell surface hydrophobicity (74.36 ± 0.23%) and aggregation capability (> 83%) (p ≤ 0.05) but displayed low to moderate co-aggregation ability (44-61%). This strain can also be regarded as strongly adhesive (73.69 ± 0.74%) and inhibit pathogen attachment to the Caco-2 cell lines (39.20 ± 0.59-69.01 ± 0.29%). A. acidipropionici C03B-STR appeared to be safe (non-haemolytic) and controllable (sensitive to various antibiotics). Notably, it had the potential to suppress cholesterol uptake in Caco-2 cells (approximately 45%) and also reduced cholesterol level above 84% during the exponential phase under acidic conditions. Thus, A. acidipropionici C03B-STR from goat milk may be a promising novel potential cholesterol-lowering probiotic strain for application in functional foods and biotherapeutics.","PeriodicalId":12346,"journal":{"name":"Folia microbiologica","volume":" ","pages":"823-840"},"PeriodicalIF":3.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142582105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Navigating bacterial motility through chemotaxis: from molecular mechanisms to physiological perspectives. 通过趋化性引导细菌运动：从分子机制到生理角度。

IF 3.1 4区生物学

Folia microbiologica Pub Date : 2025-08-01 Epub Date: 2025-08-09 DOI: 10.1007/s12223-025-01301-4

Isha Sharma, Sharon Nagpal, Alok Kumar Mishra

{"title":"Navigating bacterial motility through chemotaxis: from molecular mechanisms to physiological perspectives.","authors":"Isha Sharma, Sharon Nagpal, Alok Kumar Mishra","doi":"10.1007/s12223-025-01301-4","DOIUrl":"10.1007/s12223-025-01301-4","url":null,"abstract":"A ubiquitous property of bacteria is their ability to move toward more suitable environments, which can also facilitate host-associated activities like colonization and offer the cell several benefits such as bacteria moving towards a favorable gradient or away from a harmful gradient is known as chemotaxis. Bacteria achieve this by rotating flagella in clockwise and anticlockwise directions resulting in \"run\" and \"tumble.\" This ability of bacteria to sense and respond to any type of change in the environmental factors like pH, osmolarity, redox potential, and temperature is a standard signal transduction system that depends on coupling proteins, which is the bacterial chemotaxis system. There are two architectures for the coupling proteins in the chemotaxis system: CheW and CheV. Typically, a signal transduction system for chemotaxis to form a core signaling complex couples CheA activity to chemoreceptor control: two CheW coupling protein molecules span a histidine kinase CheA dimer and two chemoreceptors (also known as methyl-accepting chemotaxis protein, MCP) trimers of dimers which further transfer the signal to the flagellar motor through CheY. The current review summarizes and highlights the molecular mechanism involved in bacterial chemotaxis, its physiological benefits such as locating suitable nutrients and niches for bacterial growth, and various assay techniques used for the detection of chemotactic motility.","PeriodicalId":12346,"journal":{"name":"Folia microbiologica","volume":" ","pages":"753-777"},"PeriodicalIF":3.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144803933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biocontrol potential of Botrytis fabiopsis against the weeds of agricultural fields in the Qing-Tibetan Plateau. 拟褐飞虱对青藏高原农田杂草的生物防治潜力。

IF 3.1 4区生物学

Folia microbiologica Pub Date : 2025-08-01 Epub Date: 2024-11-12 DOI: 10.1007/s12223-024-01225-5

Haixia Zhu, Liang Cheng

{"title":"Biocontrol potential of Botrytis fabiopsis against the weeds of agricultural fields in the Qing-Tibetan Plateau.","authors":"Haixia Zhu, Liang Cheng","doi":"10.1007/s12223-024-01225-5","DOIUrl":"10.1007/s12223-024-01225-5","url":null,"abstract":"In screening biocontrol strains with broad-spectrum and high-efficiency herbicidal activities, a strain with strong pathogenicity, HY-021, was isolated from the leaves of Rumex acetosa, which was identified as Botrytis fabiopsis based on morphology and molecular biology. The herbicidal activities of the fermentation filtrate of strain HY-021 against nine weeds, including Chenopodium album L., Elsholtzia densa Benth., Malva verticillata L. var. Crispa, Polygonum lapathifolium L., Amaranthus retroflexus L., Avena fatua L., Thlaspi arvense L., Polygonum aviculare L., and Galium spurium L., were determined in vitro and in vivo. The results showed that the pathogenicity of strain HY-021 to the different weeds in vitro was as follows: E. densa > A. retroflexus > P. aviculare > P. lapathifolium > M. verticillata > T. arvense > G. spurium > A. fatua > C. album. Seven days after inoculation with the HY-021 strain, the incidences in nine weeds were in the range of 32.9-87.23%, and the disease index values of the nine weeds were 41.73-94.57%. The pathogenic effects from high to low were A. retroflexus > E. densa > A. fatua > G. spurium > C. album > M. verticillata > T. arvense > P. aviculare > P. lapathifolium. The crop safety test showed that the biocontrol strain HY-021 was safe to V. faba, P. sativum, H. vulgare, and T. aestivum, but had a slight effect on B. napus. Scanning electron microscopy showed that the mycelium of strain HY-021 invaded the tissue through the stomata of C. album leaves, parasitized and reproduced in the tissue, and gradually destroyed the tissue. The results of this study provide a basis for the development and utilization of new and efficient microbial source herbicides.","PeriodicalId":12346,"journal":{"name":"Folia microbiologica","volume":" ","pages":"851-859"},"PeriodicalIF":3.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular docking and antibacterial and antibiotic-modifying activities of synthetic chalcone (2E)-1-(3'-aminophenyl)-3-(4-dimethylaminophenyl)-prop-2-en-1-one in a MepA efflux pump-expressing Staphylococcus aureus strain. 合成查尔酮(2E)-1-(3'-氨基苯基)-3-(4-二甲基氨基苯基)-丙-2-烯-1-酮在表达 MepA 外排泵的金黄色葡萄球菌菌株中的分子对接及抗菌和抗生素修饰活性。

IF 3.1 4区生物学

Folia microbiologica Pub Date : 2025-08-01 Epub Date: 2024-11-12 DOI: 10.1007/s12223-024-01221-9

Larissa da Silva, Cicera Alane Coelho Gonçalves, Antonio Henrique Bezerra, Cristina Rodrigues Dos Santos Barbosa, Janaina Esmeraldo Rocha, Yedda Maria Lobo Soares de Matos, Lígia Cláudia Castro de Oliveira, Hélcio Silva Dos Santos, Henrique Douglas Melo Coutinho, Francisco Assis Bezerra da Cunha

{"title":"Molecular docking and antibacterial and antibiotic-modifying activities of synthetic chalcone (2E)-1-(3'-aminophenyl)-3-(4-dimethylaminophenyl)-prop-2-en-1-one in a MepA efflux pump-expressing Staphylococcus aureus strain.","authors":"Larissa da Silva, Cicera Alane Coelho Gonçalves, Antonio Henrique Bezerra, Cristina Rodrigues Dos Santos Barbosa, Janaina Esmeraldo Rocha, Yedda Maria Lobo Soares de Matos, Lígia Cláudia Castro de Oliveira, Hélcio Silva Dos Santos, Henrique Douglas Melo Coutinho, Francisco Assis Bezerra da Cunha","doi":"10.1007/s12223-024-01221-9","DOIUrl":"10.1007/s12223-024-01221-9","url":null,"abstract":"Bacterial resistance has become a global concern for public health agencies. Various resistance mechanisms found in Staphylococcus aureus strains grant this bacterium resistance to a wide range of antibiotics, contributing to the rise in human mortality worldwide. Resistance mediated by efflux pumps is one of the most prevalent mechanisms in multi-resistant bacteria, which has aroused the interest of several researchers in the search for possible efflux pump inhibitors. In view of the aforementioned considerations, it is important that new strategies, such as the synthesis of chalcones, be made available as a viable strategy in antimicrobial therapy. In this study, the synthesized chalcone (2E)-1-(3'-aminophenyl)-3-(4-dimethylaminophenyl)-prop-2-en-1-one was tested for its antibacterial activity, focusing on antibiotic modification and the inhibition of the MepA efflux pump present in S. aureus strain K2068. The broth microdilution method, using microdilution plates, was employed in microbiological tests to determine the minimum inhibitory concentration of the chalcone, antibiotics, and ethidium bromide. The results show that while the chalcone did not exhibit direct antibacterial activity, it synergistically enhanced the effects of ciprofloxacin and ethidium bromide, as evidenced by the reduction in MICs. In addition, computer simulations of molecular docking demonstrate that the tested chalcone acts on the same binding site as the efflux pump inhibitor chlorpromazine, interacting with essentially the same residues. These data suggest that the chalcone may act as a MepA inhibitor.","PeriodicalId":12346,"journal":{"name":"Folia microbiologica","volume":" ","pages":"841-849"},"PeriodicalIF":3.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diversity of cultivable endophytic fungi in a decumbent subshrub endemic of the Brazilian tropical savanna. 巴西热带稀树草原特有的外倾亚灌木中可栽培内生真菌的多样性。

IF 3.1 4区生物学

Folia microbiologica Pub Date : 2025-08-01 Epub Date: 2024-11-19 DOI: 10.1007/s12223-024-01226-4

Jefferson Brendon Almeida Dos Reis, Jadson Diogo Pereira Bezerra, Helson Mario Martins do Vale

{"title":"Diversity of cultivable endophytic fungi in a decumbent subshrub endemic of the Brazilian tropical savanna.","authors":"Jefferson Brendon Almeida Dos Reis, Jadson Diogo Pereira Bezerra, Helson Mario Martins do Vale","doi":"10.1007/s12223-024-01226-4","DOIUrl":"10.1007/s12223-024-01226-4","url":null,"abstract":"The diversity of cultivable endophytic fungi in native subshrubs of the Brazilian Cerrado is largely unknown. This study investigated the cultivable endophytic mycobiome of stems, leaves, and flowers of Peltaea polymorpha (Malvaceae). In total, 208 endophytic fungi were isolated, 95 from stems, 65 from leaves, and 48 from flowers. The isolates were classified as ascomycetes belonging to three classes, eight orders, ten families, 12 genera, and 31 species. Diaporthe, Nigrospora, and Colletotrichum were the dominant genera in the three analyzed organs. The richness estimators suggested that the number of species might be slightly higher than observed. The highest values for the Shannon and Simpson diversity indices were observed in stems. Beta diversity showed overlapping of fungal communities in different organs, with a high rate of sharing of taxa. Furthermore, the dominant primary fungal lifestyles were plant pathogens and saprobes. Our findings show that the cultivable endophytic fungal community of P. polymorpha is species-rich and that communities in different organs share genera and species.","PeriodicalId":12346,"journal":{"name":"Folia microbiologica","volume":" ","pages":"861-873"},"PeriodicalIF":3.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142667653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation and mechanism of the antioxidant activity of lactic acid bacteria. 乳酸菌抗氧化活性的评价及机制研究。

IF 3.1 4区生物学

Folia microbiologica Pub Date : 2025-08-01 Epub Date: 2025-06-07 DOI: 10.1007/s12223-025-01277-1

Yuyang Xiao, Jian Yang, Xupeng Zhang, Meng Yang, Yuexiang Qin, Pinfang Huang, Dan Liu

{"title":"Evaluation and mechanism of the antioxidant activity of lactic acid bacteria.","authors":"Yuyang Xiao, Jian Yang, Xupeng Zhang, Meng Yang, Yuexiang Qin, Pinfang Huang, Dan Liu","doi":"10.1007/s12223-025-01277-1","DOIUrl":"10.1007/s12223-025-01277-1","url":null,"abstract":"Lactic acid bacteria (LABs) have emerged as a significant area of study within the field of probiotics due to their diverse health benefits and wide application. This review examines the various methods used to evaluate the antioxidant activity of LABs, including in vitro chemical evaluation methods, cell model evaluation methods, and in vivo evaluation methods. Comprehensive overview of the various assessment techniques employed to elucidate the multifaceted roles of LABs in enhancing the body's natural defenses against oxidative damage. Moreover, this review emphasizes several pivotal aspects of the antioxidant effects of LABs, including the activation of the antioxidant signal pathway, the induction of antioxidative enzymes, the formation of a ROS-binding system, the production of metabolites, the enhancement of intestinal barrier integrity, the activation of the oxidative damage repair system, and the assurance of mitochondrial function. These represent the key antioxidant effects of LABs. The synthesis of this information advances our understanding of the dynamic and diverse antioxidant effects of LABs, providing a foundation for further research into their therapeutic applications in combating oxidative stress-related disorders. Future research should employ multi-omics technologies, genetic engineering, studies on synergistic effects, and large-scale clinical trials to further elucidate the molecular mechanisms underlying the antioxidant effects of LABs. This will promote their application in functional foods, pharmaceuticals, and cosmetics, providing a scientific basis for the development of more efficient antioxidant products.","PeriodicalId":12346,"journal":{"name":"Folia microbiologica","volume":" ","pages":"711-727"},"PeriodicalIF":3.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0