Food and Agricultural Immunology最新文献_第4页

Annotation of genes involved in gamma-aminobutyric multiplication during coix germination by metabolome and transcriptome analysis 薏苡仁萌发过程中γ -氨基丁酸增殖相关基因的代谢组和转录组分析

IF 3 3区农林科学

Food and Agricultural Immunology Pub Date : 2023-08-11 DOI: 10.1080/09540105.2023.2241668

Xiao Zhang, Yuqin Ding, Yi Hao, Guoqing Dong, D. Du, D. Huo

{"title":"Annotation of genes involved in gamma-aminobutyric multiplication during coix germination by metabolome and transcriptome analysis","authors":"Xiao Zhang, Yuqin Ding, Yi Hao, Guoqing Dong, D. Du, D. Huo","doi":"10.1080/09540105.2023.2241668","DOIUrl":"https://doi.org/10.1080/09540105.2023.2241668","url":null,"abstract":"ABSTRACT Job’s tears (coix) is a widely used grain with rich and balanced nutritional value. In this study, a total of 71 metabolites, including amino acid metabolism, sugar metabolism and fatty acid metabolism, were significantly increased in the germinating coix through liquid chromatography tandem mass spectrometry (HPLC-MS/MS). Significant increase in gamma-aminobutyric (GABA) content during seed germination was detected in the metabolites detected. Transcript profiles generated through high-throughput RNA-sequencing data and 2431 differentially expressed genes (DEGs) were identified. The functional of DEGs were also significantly clustered in glucose metabolism and fatty acid metabolism. In the annotation of metabolite variation and differentially expressed genes, 23 regulatory genes and 10 significantly enriched metabolites for GABA content proliferation during coix germination were identified by association analysis. These results provided a theoretical basis for understanding the germination mechanism of coix and promoting its production and application.","PeriodicalId":12300,"journal":{"name":"Food and Agricultural Immunology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2023-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48954577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study on the mechanism of Lu’an GuaPian tea in treating heart failure based on network pharmacology and molecular docking 基于网络药理学和分子对接的六安瓜片茶治疗心力衰竭机制研究

IF 3 3区农林科学

Food and Agricultural Immunology Pub Date : 2023-08-03 DOI: 10.1080/09540105.2023.2231173

Fang Hua, Ling-li Shi, Pengcheng Zhou

引用次数: 0

Sodium butyrate alleviates potential Alzheimer’s disease in vitro by suppressing Aβ and tau activation and ameliorates Aβ-induced toxicity 丁酸钠通过抑制Aβ和tau的激活和改善Aβ诱导的毒性来减轻体外潜在的阿尔茨海默病

IF 3 3区农林科学

Food and Agricultural Immunology Pub Date : 2023-07-30 DOI: 10.1080/09540105.2023.2234100

A. B. Bayazid, Yeong Hwan Jeong, Soo Ah Jeong, B. Lim

{"title":"Sodium butyrate alleviates potential Alzheimer’s disease in vitro by suppressing Aβ and tau activation and ameliorates Aβ-induced toxicity","authors":"A. B. Bayazid, Yeong Hwan Jeong, Soo Ah Jeong, B. Lim","doi":"10.1080/09540105.2023.2234100","DOIUrl":"https://doi.org/10.1080/09540105.2023.2234100","url":null,"abstract":"ABSTRACT The number of Alzheimer’s disease (AD) affected patients is increasing without any effective cure and the etiology remains to be understood. Inflammations, oxidative stress, Aβ, and tauopathy are associated factors of AD. Sodium butyrate (NaB) is an HDAC inhibitor profoundly found to be neuroprotective. We have investigated the neuroprotective effects of NaB in SH-SY5Y cells stimulated with TNF-α/Aβ in SH-SY5Y cells and LPS-induced BV-2 cells. The cell viability and NO production were also investigated by MTT and Griess reagent assay. The expressions of APP/BACE, Aβ, and tau phosphorylation and the apoptotic regulators, including P-53, and caspase-1 were analysed by western blot analysis. Our findings exerted that NaB ameliorated cell death and inhibited NO production in Aβ-induced SH-SY5Y cells and LPS in BV-2 cells. NaB notably decreased the expression of tau hyperphosphorylation in TNF-α-stimulated SH-SY5Y and LPS-induced BV-2 cells. NaB remarkably attenuated APP/BACE and Aβ expressions in TNF-α-induced SH-SY5Y cells. Cell viability was restored by NaB and downregulated apoptotic proteins p-53, caspase-1 level in aggregated Aβ-induced SH-SY5Y cells. NaB increased Nrf-2/HO-1 expressions and substantially reversed the reactive oxygen species in Aβ-induced SH-SY5Y cells. Altogether, our results suggest that NaB could be a potential therapeutic agent against AD. GRAPHICAL ABSTRACT","PeriodicalId":12300,"journal":{"name":"Food and Agricultural Immunology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2023-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47445335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phillyrin attenuates airway inflammation and Th2 cell activities in a mouse asthma model Phillyrin在小鼠哮喘模型中减轻气道炎症和Th2细胞活性

IF 3 3区农林科学

Food and Agricultural Immunology Pub Date : 2023-07-16 DOI: 10.1080/09540105.2023.2231182

Wen-Chung Huang, Shu-Ju Wu, Li-Wen Fang, Tzu-Yung Lin, Chian-Jiun Liou

{"title":"Phillyrin attenuates airway inflammation and Th2 cell activities in a mouse asthma model","authors":"Wen-Chung Huang, Shu-Ju Wu, Li-Wen Fang, Tzu-Yung Lin, Chian-Jiun Liou","doi":"10.1080/09540105.2023.2231182","DOIUrl":"https://doi.org/10.1080/09540105.2023.2231182","url":null,"abstract":"ABSTRACT Phillyrin is isolated from the fruit of Forsythia suspensa, and exhibits multiple pharmacological effects, including anti-tumor, anti-inflammation, and anti-oxidation activities. Here, we investigated whether phillyrin could alleviate airway hyperresponsiveness (AHR) and eosinophil infiltration in the lungs of asthmatic mice, and mitigate inflammatory responses in tracheal epithelial BEAS-2B cells. IL-4/TNF-α-stimulated BEAS-2B cells were treated with various phillyrin doses. Female BALB/c mice were sensitised and challenged with ovalbumin (OVA), and then treated with intraperitoneal injection different phillyrin doses. In IL-4/TNF-α-stimulated BEAS-2B cells, phillyrin effectively reduced proinflammatory cytokines, chemokines, and eotaxin (CCL11) levels. In the lungs of asthmatic mice, phillyrin treatment relieved AHR, airway inflammation, eosinophil infiltration, and goblet cell hyperplasia. Phillyrin also reduced serum OVA-IgE, and Th2-associated cytokine levels in splenocyte culture medium, and in bronchoalveolar lavage fluid of asthmatic mice. Our results indicate that phillyrin attenuated airway inflammation and eosinophil infiltration in asthmatic mice by suppressing Th2 cytokine production.","PeriodicalId":12300,"journal":{"name":"Food and Agricultural Immunology","volume":"1 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2023-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41761136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

IFN-γ mediated neuroinflammation and behaviour abnormality after maternal exposure to low dose mixture of food additives and pesticides IFN-γ介导的低剂量食品添加剂和农药混合物暴露后的神经炎症和行为异常

IF 3 3区农林科学

Food and Agricultural Immunology Pub Date : 2023-07-06 DOI: 10.1080/09540105.2023.2226841

Linyang Song, Xiaoyi He, Mengxia Wang, Lixia Li, Jing Liu, Guoying Li, Junhua Yang

{"title":"IFN-γ mediated neuroinflammation and behaviour abnormality after maternal exposure to low dose mixture of food additives and pesticides","authors":"Linyang Song, Xiaoyi He, Mengxia Wang, Lixia Li, Jing Liu, Guoying Li, Junhua Yang","doi":"10.1080/09540105.2023.2226841","DOIUrl":"https://doi.org/10.1080/09540105.2023.2226841","url":null,"abstract":"ABSTRACT People often simultaneously expose to acceptable/tolerable daily intake of food additives and pesticides in daily life. Exposure in adult rodents to acceptable/tolerable daily intake of food additives and pesticides chemical mixtures (AFACM) is reported to cause health damage. Our recently study reported that AFACM exposure of pregnant mice resulted in neuroinflammation and abnormal emotional behaviours in offspring. Here, we found that neutralising IFN-γ with neutralising antibodies completely blocked the influences induced by maternal AFACM exposure, including the increased IFN-γ level in serum, increased IFN-γ, interleukin-6 and tumour necrosis factor-α levels in prefrontal cortex(PFC) in offspring on postnatal day(PND)7, the abnormal emotional behaviours in offspring on PND56, and the decreased of ATPase phospholipid flippase 8A2(ATP8A2) in the PFC of offspring on PND7. In sum, maternal AFACM exposure induced the PFC neuroinflammation, abnormal emotional behaviours and decreased PFC ATP8A2 expression through increasing systemic IFN-γ in offspring.","PeriodicalId":12300,"journal":{"name":"Food and Agricultural Immunology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42783017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exosomes derived from berberine-treated bone marrow mesenchymal stem cells ameliorate inflammatory arthritis in rats with collagen-induced rheumatoid arthritis 黄连素处理的骨髓间充质干细胞外泌体改善胶原诱导的类风湿性关节炎大鼠的炎症性关节炎

IF 3 3区农林科学

Food and Agricultural Immunology Pub Date : 2023-07-06 DOI: 10.1080/09540105.2023.2220566

Fei Sun, Yuxia Ma, Fa-Xin Li, Congcong Li, Zhaowen Yang

{"title":"Exosomes derived from berberine-treated bone marrow mesenchymal stem cells ameliorate inflammatory arthritis in rats with collagen-induced rheumatoid arthritis","authors":"Fei Sun, Yuxia Ma, Fa-Xin Li, Congcong Li, Zhaowen Yang","doi":"10.1080/09540105.2023.2220566","DOIUrl":"https://doi.org/10.1080/09540105.2023.2220566","url":null,"abstract":"ABSTRACT To evaluate the effect of exosomes secreted by berberine-treated bone marrow-derived mesenchymal stem cells (BMSCs) on synovial inflammation in collagen-induced arthritis (CIA) model. Exosomes were isolated from berberine-treated BMSCs (Ber-BMSC-EXs) and untreated BMSCs (BMSC-EXs). CIA rats were developed and treated with Ber-BMSC-EXs or BMSC-EXs. Clinical arthritis index was measured, activation of fibroblast-like synoviocytes (FLSs) were evaluated, and response and frequency of T helper 17 (Th17) and regulatory T (Treg) cells as well as cytokine levels in synovial fluid were determined. Ber-BMSC-EXs (with a superior effect than BMSC-EXs) significantly alleviated RA clinical score and paw inflammation, balanced Th17 and Treg cells’ responses and population, modulated levels of pro-inflammatory and anti-inflammatory cytokines in joint synovial fluid, and inhibited FLS activation in CIA rats. Ber-BMSC-EXs (with a significantly greater effect than BMSC-EXs) could significantly ameliorate synovial joint inflammation and clinical symptoms of arthritis in CIA rats, showing that berberine can reinforce anti-arthritic effects of BMSC-EXs.","PeriodicalId":12300,"journal":{"name":"Food and Agricultural Immunology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44607338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Immunostimulatory activity of Paeonia lactiflora through TLR4-dependent activation of p38, JNK, and ERK1/2 in mouse macrophages, RAW264.7 cells 通过tlr4依赖性激活小鼠巨噬细胞、RAW264.7细胞中的p38、JNK和ERK1/2的免疫刺激活性

IF 3 3区农林科学

Food and Agricultural Immunology Pub Date : 2023-07-06 DOI: 10.1080/09540105.2023.2222930

Min Yeong Choi, So-Jung Park, J. Jeong

引用次数: 0

Oral administration of vermicompost tea ameliorates eczema skin inflammation via regulation of Th2 immune response 口服粉丝茶通过调节Th2免疫反应改善湿疹皮肤炎症

IF 3 3区农林科学

Food and Agricultural Immunology Pub Date : 2023-07-06 DOI: 10.1080/09540105.2023.2223366

Huijiao Wen, Ci Lu, Runmen Hu, W. Shi, Libang Zhou, Puzhao Wen, Shan Jiang, Y. Lo

引用次数: 0

Serotype and antimicrobial resistance of Salmonella from poultry meats in 2021 in Shanghai, China 2021年上海禽肉中沙门氏菌的血清型和耐药性

IF 3 3区农林科学

Food and Agricultural Immunology Pub Date : 2023-06-18 DOI: 10.1080/09540105.2023.2220568

Quan Xiao, Ying Yu, Biyao Xu, Zhixin Fang, Wenjie Chen, Jun Feng, Yanqi Zhu, Yue Liu, Qifang Gu, Jiayuan Luo, X. Song, Zengfeng Zhang, Min Chen, Hongzhi Zhang

{"title":"Serotype and antimicrobial resistance of Salmonella from poultry meats in 2021 in Shanghai, China","authors":"Quan Xiao, Ying Yu, Biyao Xu, Zhixin Fang, Wenjie Chen, Jun Feng, Yanqi Zhu, Yue Liu, Qifang Gu, Jiayuan Luo, X. Song, Zengfeng Zhang, Min Chen, Hongzhi Zhang","doi":"10.1080/09540105.2023.2220568","DOIUrl":"https://doi.org/10.1080/09540105.2023.2220568","url":null,"abstract":"ABSTRACT Salmonella is a major cause of food poisoning, and its infection and antimicrobial resistance vary regionally due to different sanitary standards and the use of antimicrobials. The aim of this study is to evaluate the microbiological contamination and antimicrobial resistance of Salmonella in Shanghai, providing references for supervision over food safety and clinical treatment. This study analysed the distribution of serotypes, the distribution of antimicrobial resistance in different poultry meats and serotype of Salmonella, the correlation between different antimicrobial resistance, and multiple drug resistance (MDR) of 139 strains of Salmonella from poultry meats. The results showed that the proportion of Salmonella detected in pigeons was high, which could cause severe diseases to humans. The most common resistance was observed to TET (about 60%), and resistance was even found to IPM. Resistance to two or more antimicrobials was accounted for 75.5%, indicating a wide spreading MDR.","PeriodicalId":12300,"journal":{"name":"Food and Agricultural Immunology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2023-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47480889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of a novel polyclonal antibody against bovine αS1-casein IgE epitopes for prediction of potential allergenicity of milk in foods 一种新的抗牛αS1酪蛋白IgE表位多克隆抗体的开发用于预测牛奶在食品中的潜在致敏性

IF 3 3区农林科学

Food and Agricultural Immunology Pub Date : 2023-06-18 DOI: 10.1080/09540105.2023.2222932

Shengfa He, Caiyun Long, Liming Li, Yan Yan, Jinyu Li, Meng Xiong, Jiangqiang Zhao, Ziling Feng, Yang Li, Yaping Dong, Xin Li, Hongbing Chen

{"title":"Development of a novel polyclonal antibody against bovine αS1-casein IgE epitopes for prediction of potential allergenicity of milk in foods","authors":"Shengfa He, Caiyun Long, Liming Li, Yan Yan, Jinyu Li, Meng Xiong, Jiangqiang Zhao, Ziling Feng, Yang Li, Yaping Dong, Xin Li, Hongbing Chen","doi":"10.1080/09540105.2023.2222932","DOIUrl":"https://doi.org/10.1080/09540105.2023.2222932","url":null,"abstract":"ABSTRACT Bovine αS1-casein (αS1-CN) is the main allergen in cow's milk, and immunoglobulin E (IgE) epitopes are the material basis to trigger allergic reactions. Thus, IgE epitopes could be as key targets for precise αS1-CN detection and allergenicity assessment. Here, we designed a tandem containing nine IgE linear epitopes of αS1-CN (tαS1-CN), expressed the recombinant tαS1-CN in Escherichia coli, and prepared the rabbit polyclonal antibody against recombinant tαS1-CN (pAb-tαS1-CN). The obtained recombinant tαS1-CN had a purity of 94.43% and retained the antigenicity and potential allergenicity of IgE epitopes. The pAb-tαS1-CN could recognize the nine IgE epitopes of αS1-CN, and also showed high specificity. The ability of pAb-tαS1-CN to evaluate the potential allergenicity of milk in foods was validated by sera from cow's milk allergy patients. These findings indicate that our prepared pAb-tαS1-CN may represents a valuable tool for the evaluation of milk allergenicity in processed foods.","PeriodicalId":12300,"journal":{"name":"Food and Agricultural Immunology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2023-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43287676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0