Experimental Brain Research最新文献

{"title":"Predictable transcranial magnetic stimulation suppresses corticospinal excitability: a TMS experiment.","authors":"Napat Sriutaisuk, Elizabeth A Franz","doi":"10.1007/s00221-025-07091-y","DOIUrl":"10.1007/s00221-025-07091-y","url":null,"abstract":"<p><p>Motor skill learning plays a crucial role in human functioning and is often studied using transcranial magnetic stimulation (TMS) to assess corticospinal excitability (CSE). CSE, which reflects the motor system's responsiveness, is compared across experimental conditions to determine whether a factor facilitates or inhibits motor skill learning. However, variability in stimulation predictability may confound interpretation of CSE measures. In this study, we examined the impact of TMS predictability on CSE by comparing motor-evoked potential (MEP) responses under predictable and unpredictable conditions. Twenty right-handed participants underwent TMS-EMG recordings while observing either a predictable visual cue (a moving white bar) or an unpredictable visual cue (a static white bar). MEP amplitudes were recorded from the first dorsal interosseous (FDI) muscle and normalized across participants. Results showed that unpredictable TMS produced significantly larger MEP amplitudes compared to predictable stimulation. The findings suggest that the predictability of TMS substantially modulates CSE, potentially confounding the results in previous TMS studies on action observation and motor facilitation. Ensuring consistent stimulation predictability across experimental conditions is therefore essential for accurately interpreting TMS-induced CSE changes.</p>","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"243 6","pages":"134"},"PeriodicalIF":1.7,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12050229/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143981847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of CaMKII/CREB pathway in rapid-antidepressant-like effect: comparison of ketamine with rapastinel.","authors":"Ceyda Özler, Esra Özkan, Narges Shomalizadeh, Judy Kesibi, Selin Sapancı, Fatmanur Akpunar Salman, Ege Anıl Uçar, Yasemin Gürsoy-Özdemir","doi":"10.1007/s00221-025-07085-w","DOIUrl":"10.1007/s00221-025-07085-w","url":null,"abstract":"<p><p>Recent studies in mouse models have demonstrated that ketamine and rapastinel induce rapid-acting and sustained antidepressant effects in major depressive disorder (MDD). However, it remains unclear how ketamine's and rapastinel's opposing mechanisms of action-NMDAR antagonist and NMDAR positive allosteric modulator, respectively-result in similar antidepressant-like effects. Furthermore, although the CaMKII/CREB pathway plays a crucial role in BDNF synthesis and synaptic plasticity, its involvement in rapastinel- or ketamine-induced antidepressant effects has not been studied in detail. The main purpose of this study was to analyze the link between BDNF levels and CaMKII/CREB activity in the antidepressant-like effects of rapastinel and ketamine treatments. This study used 46 male mice subjected to the chronic unpredictable mild stress (CUS) model for 28 days. Based on their experimental groups, the animals were administered the CaMKII inhibitor TatCN21 (5 mg/kg i.p.), ketamine (10 mg/kg i.p.), or rapastinel (3 mg/kg i.p.), either alone or in combination. Behavioral tests and molecular analyses were performed. The CUS model significantly reduced weight gain, decreased sucrose preference in the sucrose preference test (SPT), and increased immobility time in the forced swim test (FST) compared to the control group. BDNF concentrations in the prefrontal cortex (PFC) and hippocampus were significantly reduced following chronic stress. Both ketamine and rapastinel reduced anhedonia and passive coping behavior, demonstrating their antidepressant-like effects. Treatment with ketamine or rapastinel after chronic stress significantly increased BDNF concentrations in the PFC and hippocampus 24 h post-injection. Similarly, TatCN21 significantly increased BDNF levels in the PFC and hippocampus and reduced immobility time in the FST. Interestingly, when the CaMKII inhibitor was administered before ketamine or rapastinel, it had opposing effects on their antidepressant-like actions. TatCN21 enhanced rapastinel's effects while blocking the antidepressant-like effects of ketamine, suggesting that the CaMKII pathway may play a differential role in mediating these effects. Overall, this study provides insights into the potential mechanisms underlying the antidepressant-like effects of ketamine and rapastinel. Understanding these mechanisms could aid in developing new treatments for depression that are both rapid-acting and long-lasting, without the side effects associated with current medications.</p>","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"243 6","pages":"138"},"PeriodicalIF":1.7,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Testing the effectiveness of combined attention modification training with right dorso-lateral prefrontal cortex theta-burst stimulation on reducing levels of anxiety and attentional bias.","authors":"Maria Sikki, Katerina Konikkou, Nikos Kostantinou, Kostas A Fanti","doi":"10.1007/s00221-025-07040-9","DOIUrl":"10.1007/s00221-025-07040-9","url":null,"abstract":"<p><p>Neurostimulation techniques, such as continuous theta-burst stimulation (cTBS), over the dorsolateral prefrontal cortex (DLPFC) have been associated with improvements in anxiety symptoms and emotion processing. The aim of this feasibility study was the evaluation of the effectiveness of cTBS over the right DLPFC combined with Attention Modification Training (AMT) on reducing levels of anxiety and attentional bias. A 40s-cTBS session (real or sham) over the right DLPFC was administrated at 8 treatment sessions over a 2-week period, and each cTBS treatment was followed by computer-based AMT (real or control). Eighty-nine participants (Mage = 21.29, SD = 2.06, 50.56% females) differentiated on levels of anxiety were randomly assigned to the following treatment groups (i) cTBS and AMT, (ii) cTBS and control AMT, and (iii) sham cTBS and AMT. Findings suggested that cTBS combined with AMT treatment was not superior to sham cTBS and AMT on reducing self-reported anxiety symptoms. However, combined cTBS and AMT was associated with increased attention towards positive stimuli and increased gaze fixation in the mouth region of happy facial expressions. Current results provide promising evidence for the effectiveness of AMT in reducing anxiety symptoms and contribute to existing knowledge on how inhibitory stimulation over the right DLPFC combined with AMT may influence emotion processing. Present findings can inform future treatments designed to address the attention mechanisms leading to anxiety symptoms.</p>","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"243 6","pages":"137"},"PeriodicalIF":1.7,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12050235/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143980649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do the enhanced errors impact visuomotor adaptation in children with autism spectrum disorder?","authors":"Jin Bo, Bo Shen, YanLi Pang, Jiayou Shen, Patricia Lasutschinkow, Alina Dillahunt","doi":"10.1007/s00221-025-07067-y","DOIUrl":"10.1007/s00221-025-07067-y","url":null,"abstract":"<p><p>Children with autism spectrum disorders (ASD) often exhibit challenges with visuomotor adaptation. This study explored whether enlarged visual error feedback could enhance motor adaptability in children with and without ASD. Thirty-five children, ages 6 to 10, completed two center-out computerized adaptation tasks. In these tasks, the visual feedback of their hand movement error was provided in either a regular (gain = 1:1) or enhanced (gain = 1:2) ratio. Results indicated that children with ASD had reduced visuomotor adaptability compared to their peers during the regular feedback task. However, in the enhanced feedback task, children with ASD showed positive after-effects on a key motor planning measure, implying that they might be capable of adapting to visual distortions. Despite this, the lack of significant differences between the tasks suggests that while enhanced visual feedback may offer some benefits, it is unlikely to fully offset the compromised visuomotor adaptability. Meanwhile, the ASD group demonstrated an association between fine motor skills and visuomotor adaptability during the regular task. Further approaches beyond enhancing visual feedback need to be explored for a better understanding of the mechanisms behind kinematic adaptation in ASD.</p>","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"243 6","pages":"135"},"PeriodicalIF":1.7,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of stepping practice and functional electrical stmulation on neuromotor excitability in able bodied young adults.","authors":"Jacob Spencer, Fisayo K Aloba, Alexandra Slusarenko, Taylor Leone, Jay Patel, Lily Eyvazzadeh, Anna-Lee Lynch, Michael R Borich, Trisha M Kesar","doi":"10.1007/s00221-025-07042-7","DOIUrl":"10.1007/s00221-025-07042-7","url":null,"abstract":"<p><p>The neural processes underlying gait retraining interventions that combine stepping practice with electrical stimulation are poorly understood. The purpose of this study was to compare acute changes in corticomotor excitability measured by motor evoked potential (MEP) amplitude, monosynaptic stretch reflex excitability measured by H/M ratio, and propulsive force generation during gait measured by anterior ground reaction forces (AGRF), induced by 30-minutes of fast walking (Fast) and 30-minutes of fast walking with functional electrical stimulation of the ankle plantarflexors and dorsiflexors (FastFES) in 14 able-bodied young adults. Our results showed that FastFES, but not Fast elicited a significant acute decrease in tibialis anterior MEP amplitude (p = .01). Furthermore, the practice-induced acute decrease in tibialis anterior MEP amplitudes was significantly larger for FastFES than Fast (p = .04). FastFES also elicited a statistically significant increase in the AGRF in the tested limb (p = .01), which was significantly larger than the change induced by Fast (p = .04). Additionally, baseline soleus MEP amplitude was positively correlated with within-session change in AGRF (p = .04, r² = 0.16). Acute decrease in tibialis anterior MEP amplitude for the FastFES condition relative to the Fast condition may be caused by fatigue, while the greater increase in AGRF for the FastFES condition signify that stepping practice facilitated alterations of gait patterns. More research is needed to confirm neural mechanisms and investigate the acute as well as long-term effects of Fast and FastFES on clinical populations.</p>","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"243 6","pages":"136"},"PeriodicalIF":1.7,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143976832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How psychological and descriptive narratives modulate the perception of facial emotional expressions: an event-related potentials (ERPs) study.","authors":"Daniela Altavilla, Valentina Deriu, Alessandra Chiera, Stefania Crea, Ines Adornetti, Francesco Ferretti","doi":"10.1007/s00221-025-07087-8","DOIUrl":"10.1007/s00221-025-07087-8","url":null,"abstract":"<p><p>The aim of the present study was to investigate whether stories with high and low narrative transport exert different effects on neural activation in response to facial emotional expressions. Thirty-one participants were randomly assigned to two groups based on the type of story they read: psychological narrative with high narrative transport (6 women and 10 men; age M = 34.38 ± 8.77); descriptive narrative with low narrative transport (9 women and 6 men; age M = 24.07 ± 7.38). The electroencephalographic activity of the participants in response to emotional facial expressions (joy, anger, fear, sadness) was recorded before (T0) and after (T1) the reading task. The findings indicated that the reading task modulated the early brain response (P1, N170) to emotional facial expressions, irrespective of the narrative type. However, only in the psychological narrative group was the amplitude of the P100 found to be positively associated with the extent to which an individual was transported into the narrative. In summary, the findings appear to indicate that an increased degree of transport into the narrative is associated with a greater internal simulation process of emotions and mental states. This, in turn, modulates the perception of the real social world after reading.</p>","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"243 6","pages":"133"},"PeriodicalIF":1.7,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of experimentally induced lumbar nociception on trunk motor control in the rat during locomotion.","authors":"Fangxin Xiao, Wendy Noort, Juliette Lévénez, Jia Han, Jaap H van Dieën, Huub Maas","doi":"10.1007/s00221-025-07041-8","DOIUrl":"10.1007/s00221-025-07041-8","url":null,"abstract":"<p><p>Nociception resulting in pain perception might be one of the factors contributing to the motor control changes in people with low-back pain. However, limited evidence exists regarding the effects of acute pain on trunk motor control during locomotion. This study aimed to evaluate the effects of hypertonic saline induced nociception on trunk movement and back muscle activity during locomotion in a rat model. Spine and pelvis kinematics, EMG signals from bilateral multifidus (MF) and medial longissimus (ML) muscles of the rats were collected during treadmill locomotion before and after hypertonic saline (5.8%) injection into the MF. We found that both the locomotion and EMG patterns remained unchanged after hypertonic saline injection. No significant changes were found in stride duration, pelvic, lumbar and spine angle changes, variability, or movement asymmetry. The overall EMG activation patterns and intermuscular coordination remained unchanged after hypertonic saline injection and there was synchronized activation of bilateral MF muscles with two peaks per stride cycle, and alternating activation of left and right ML. The only significant effects of hypertonic saline injection were the decrease in the normalized peak amplitude of the left MF and EMG variability in right ML, no effects were detected in other EMG outcomes or muscles. These results suggest that the changes in EMG activity reflect localized neuromuscular response to nociception rather than broader alterations in control of locomotion.</p>","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"243 5","pages":"132"},"PeriodicalIF":1.7,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12037427/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A wide-ranging review of galvanic vestibular stimulation: from its genesis to basic science and clinical applications.","authors":"Sarah Marchand, Alba Langlade, Quentin Legois, Alexandra Séverac Cauquil","doi":"10.1007/s00221-025-07079-8","DOIUrl":"10.1007/s00221-025-07079-8","url":null,"abstract":"<p><p>Galvanic vestibular stimulation (GVS) involves applying small electrical currents to the vestibular organs via electrodes placed on the mastoids, providing a powerful tool for investigating vestibular function. Despite its long history, GVS remains highly relevant for researchers due to its ability to probe the vestibular system's role in posture, gaze control, perception, and cortical processing. Recent technical advances have considerably expanded its application in both basic research and clinical practice. Despite the fact it is not realistic to cover all aspects of GVS within the constraints of a manuscript, this narrative review summarizes the history and neurophysiological mechanisms of GVS and provides new insights and perspectives for current and future studies, both in fundamental and clinical applications. We synthesize the main findings from neurophysiological, behavioral, and neuroimaging studies, focusing on the effects of GVS on postural control, ocular responses, cortical activity, and self-motion perception. Then diagnostic and therapeutic applications are explored in balance disorders, stroke rehabilitation, and neurodegenerative diseases. Clinical approaches could benefit from greater reliance on laboratory research to refine stimulation protocols, for maximum efficacy in its therapeutic use. A final discussion summarizes what is currently well-established with regard to GVS and opens up new and exciting perspectives in basic science and clinical applications.</p>","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"243 5","pages":"131"},"PeriodicalIF":1.7,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12034599/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143981763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the role of brain renin angiotensin system in vascular dementia: mechanisms and therapeutic perspectives.","authors":"Kuldeep Kumar, Sonal Aggarwal, Ayush Kandpal, Ramanpreet Kaur, Amteshwar S Jaggi, Harlokesh Narayan Yadav, Dhandeep Singh, Dimple Chopra, Nirmal Singh","doi":"10.1007/s00221-025-07072-1","DOIUrl":"10.1007/s00221-025-07072-1","url":null,"abstract":"<p><p>Dementia is a heterogeneous syndrome characterized by the progressive deterioration of various brain functions, severely impacting cognitive, emotional, and social abilities. According to a World Health Organization (WHO) report, dementia represents a pressing global health concern, with the number of affected individuals projected to triple by 2050. Among its various subtypes, vascular dementia (VD) stands as the second most common form, following Alzheimer's disease (AD). Despite ongoing efforts in drug development, no pharmaceutical entity has yet received approval from the U.S. Food and Drug Administration (FDA) for the treatment of VD. Emerging evidence underscores the critical involvement of the brain's Renin-Angiotensin System (RAS) in the pathogenesis of multiple neurodegenerative disorders, including VD. The intricate roles of RAS components include regulating vascular tone, neuronal growth and survival, regulating cerebral blood flow and endothelial dysfunction, increasing neuroinflammation (by increasing release of IL-1, IL-6, TNF-α, microglial activation), oxidative stress and destruction of BBB integrity, mainly through Angiotensin II type 1 (AT1) and type 2 (AT2) receptors, are of significant interest in the pathophysiology of VD. However, disruptions in these signaling pathways are believed to contribute substantially to the progression of VD. This review addresses the limitations of current therapeutic approaches for VD while emphasizing the untapped potential of RAS-targeted interventions. We systematically explore the neurophysiological mechanisms of brain RAS, their role in promoting neuronal health, and the factors that compromise these pathways, ultimately leading to cognitive decline. By elucidating these mechanisms and challenges, the review offers novel insights into designing innovative RAS-based therapeutic strategies, paving the way for effective clinical management of VD. This work aspires to stimulate further research and development in this underexplored yet promising domain.</p>","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"243 5","pages":"130"},"PeriodicalIF":1.7,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Darbepoetin alpha has neuroprotective effects in the hippocampus against long-term intermittent ethanol administration.","authors":"Emine Uygur, Hafize Uzun, Matem Tuncdemir, Aysim Buge Oz, Elif Polat, Ahsen Yilmaz, Elif Yaman, Hakki Oktay Seymen","doi":"10.1007/s00221-025-07073-0","DOIUrl":"10.1007/s00221-025-07073-0","url":null,"abstract":"<p><p>The consumption of ethanol has detrimental effects on several organs, including the brain. One of the most important targets of ethanol toxicity in the brain is the hippocampus. The aim of our study was to investigate the neuroprotective effects of darbepoetin alpha against neuronal damage caused by long-term intermittent ethanol exposure in the hippocampus. Forty male Wistar albino rats were divided into four groups: control (C), ethanol (E), darbepoetin alpha (DA), and ethanol + darbepoetin alpha (E + DA). In this study, oxidative stress and antioxidant markers, S100-β and neuron specific enolase (NSE) were investigated in both brain tissue and serum. Additionally, brain tissues were examined using histopathological methods. S100-β and NSE levels were significantly elevated in the E group compared to the C group in both the brain tissue and serum. Furthermore, catalase (CAT) and glutathione reductase (GR) levels, glutathione peroxidase (GPx) enzyme activities were significantly lower in both brain tissue and serum, while superoxide dismutase (SOD) enzyme activity in brain tissue was significantly reduced, and malondialdehyde (MDA) levels in brain tissue were markedly elevated in the E group. In the E + DA group, S100-β levels in both brain tissue and serum, NSE levels in serum, and MDA levels in brain tissue were significantly lower. Additionally, GPx activity in brain tissue and CAT levels in serum were significantly higher in the E + DA group compared to the E group. Histopathologically, the E group showed moderate neurodegeneration in the dentate gyrus, while the E + DA group exhibited mild neurodegeneration. In conclusion, DA reversed the degenerative effects of long-term intermittent ethanol exposure on the hippocampus by improving oxidative stress parameters and reducing neuronal injury.</p>","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"243 5","pages":"128"},"PeriodicalIF":1.7,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144001701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}