Experimental Brain Research最新文献

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Analysis of frequency domain features for the classification of evoked emotions using EEG signals.
IF 1.7 4区 医学
Experimental Brain Research Pub Date : 2025-02-14 DOI: 10.1007/s00221-025-07002-1
Samannaya Adhikari, Nitin Choudhury, Swastika Bhattacharya, Nabamita Deb, Daisy Das, Rajdeep Ghosh, Souvik Phadikar, Ebrahim Ghaderpour
{"title":"Analysis of frequency domain features for the classification of evoked emotions using EEG signals.","authors":"Samannaya Adhikari, Nitin Choudhury, Swastika Bhattacharya, Nabamita Deb, Daisy Das, Rajdeep Ghosh, Souvik Phadikar, Ebrahim Ghaderpour","doi":"10.1007/s00221-025-07002-1","DOIUrl":"10.1007/s00221-025-07002-1","url":null,"abstract":"<p><p>Emotion is a natural instinctive state of mind that greatly influences human physiological activities and daily life decisions. Electroencephalogram (EEG) signals created from the central nervous system are very useful for emotion recognition and classification. In this study, EEG signals of individuals are analyzed by the variational mode decomposition (VMD) for frequency domain features to recognize visual stimuli-based evoked emotions (happy, sad, fear). After cleaning EEG signals from artifacts, VMD is employed to decompose the signal into its respective intrinsic mode functions (IMFs). A sliding windowing approach is adopted to calculate the power distributions in each of the predefined frequency bands. The results reveal that extracting frequency domain features using a sliding window of 3 s significantly enhances the efficiency of analyzing induced emotions in subjects. The random forest model shows promising results in classifying various emotions, achieving an accuracy of 99.57% for validation and 99.36% for testing. Moreover, it is observed that the fifth IMF has a strong relationship with emotion elicited from visual stimuli. In addition, the features of the trained model are analyzed by Shapley additive explanations.</p>","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"243 3","pages":"65"},"PeriodicalIF":1.7,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11828826/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143424491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Environmental enrichment attenuates sevoflurane anesthesia-induced learning deficits in aged mice through regulating TTBK1 and phosphorylated Tau expression.
IF 1.7 4区 医学
Experimental Brain Research Pub Date : 2025-02-14 DOI: 10.1007/s00221-025-07017-8
Xuenan Chang, Xiaoli Zhuang, Jingyu Feng, Yonghao Yu, Yang Yu
{"title":"Environmental enrichment attenuates sevoflurane anesthesia-induced learning deficits in aged mice through regulating TTBK1 and phosphorylated Tau expression.","authors":"Xuenan Chang, Xiaoli Zhuang, Jingyu Feng, Yonghao Yu, Yang Yu","doi":"10.1007/s00221-025-07017-8","DOIUrl":"10.1007/s00221-025-07017-8","url":null,"abstract":"<p><p>Perioperative neurocognitive disorders (PND) are a prevalent complication in elderly patients undergoing surgery with general anesthesia. Sevoflurane, a commonly used anesthetic, has been associated with cognitive impairment and neurotoxicity. In this study, we aim to explore the mechanisms through which sevoflurane impairs cognitive function in aged mice and hence identify potential therapeutic strategies. Female C57BL/6 J mice were treated with 2-h-daily Environmental enrichment (EE) for 4 weeks before being exposed to single 3% sevoflurane plus 60% oxygen inhalation for 2 h. WHI-P180, a TTBK1 inhibitor, was administered 5 min prior to anesthesia. Cognitive function, TTBK1, Tau p-Ser422, AT8 (Tau p-Ser202/p-Thr205), TNF-ɑ, IL-6, and IL-1β were measured. The results indicated that sevoflurane inhalation induced cognitive dysfunction, elevated TTBK1 expression and phosphorylated Tau levels, and increased inflammatory factors in the hippocampus of aged mice. However, EE treatment reduced elevated TTBK1, phosphorylated Tau, and inflammatory factor levels in the hippocampus. Additionally, EE alleviated cognitive impairment caused by sevoflurane in aged mice. Furthermore, WHI-P180 mitigated cognitive dysfunction by decreasing Tau phosphorylation and inflammatory cytokine levels in the hippocampus of aged mice. In conclusion, TTBK1 plays a crucial role in cognitive impairment induced by sevoflurane in aged mice, and EE mitigates sevoflurane-induced cognitive dysfunction by inhibiting TTBK1 and Tau protein phosphorylation in the hippocampus of old mice. These findings suggest that EE could be a potential therapeutic strategy for preventing or treating PND in elderly patients undergoing general surgery with sevoflurane anesthesia.</p>","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"243 3","pages":"67"},"PeriodicalIF":1.7,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143424493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Saikosaponins alleviate depression-like behaviors of chronic unpredictable mild stress exposed mice through ERK signaling pathway.
IF 1.7 4区 医学
Experimental Brain Research Pub Date : 2025-02-12 DOI: 10.1007/s00221-025-07011-0
Min Chen, Min Li, Liwei Ma, Huiling Hou, Meiling Tang, Qiang Li
{"title":"Saikosaponins alleviate depression-like behaviors of chronic unpredictable mild stress exposed mice through ERK signaling pathway.","authors":"Min Chen, Min Li, Liwei Ma, Huiling Hou, Meiling Tang, Qiang Li","doi":"10.1007/s00221-025-07011-0","DOIUrl":"10.1007/s00221-025-07011-0","url":null,"abstract":"<p><p>Depressive disorder is the most common mental disorder with limited treatments. The aim of this study was to investigate the antidepressant effects of saikosaponins (SS) and its mechanism. The depression-like behaviors of chronic unpredictable mild stress (CS)-exposed mice were evaluated by sucrose preference test, forced swimming test (FST), and open field test (OFT). The proteome profiler mouse phospho-kinase array kit was used to reveal possible phosphorylated kinases and signaling nodes that SS treatment affected. TUNEL staining of brain tissues and protein levels of brain-derived neurotrophic factor (BDNF) and caspase-3 were combined to evaluate cell apoptosis. The U0126 was applied to pharmacologically inhibit ERK signaling pathway to verify the regulatory role of SS treatment on depression-like behaviors and cell apoptosis was achieved through ERK pathway. SS ameliorated chronic unpredictable mild stress‑induced depressive‑like behaviors by prominently increasing the sucrose preference, total traveling distance, standing number, and grooming number, and decreasing immobility time. SS also inhibited apoptosis of hippocampal neurons by down-regulating caspase-3 protein and up-regulating BDNF protein levels. SS treatment specifically up-regulated the phosphorylation of ERK through the proteome profiler mouse phospho-kinase array analysis. Moreover, the ERK inhibitor, U0126, pharmacological inhibited the phosphorylation levels of ERK induced by SS treatment, and further weakened the treatments of SS on depression-like behaviors and cell apoptosis. SS alleviates depression-like behaviors and protects neuron by activating the ERK signaling pathway, indicating that SS may be a potential therapeutic drug for treatment of depression.</p>","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"243 3","pages":"63"},"PeriodicalIF":1.7,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Standing balance responses and habituation to sinusoidal optic flow virtual reality perturbations.
IF 1.7 4区 医学
Experimental Brain Research Pub Date : 2025-02-12 DOI: 10.1007/s00221-025-07014-x
Minal Ahuja, Trevor A Day, Nicholas D J Strzalkowski
{"title":"Standing balance responses and habituation to sinusoidal optic flow virtual reality perturbations.","authors":"Minal Ahuja, Trevor A Day, Nicholas D J Strzalkowski","doi":"10.1007/s00221-025-07014-x","DOIUrl":"10.1007/s00221-025-07014-x","url":null,"abstract":"<p><p>This study investigated the effects of prolonged virtual reality (VR) optic flow exposure on standing balance, focusing on how optic flow parameters influence balance responses and the potential for habituation. While short-term responses to optic flow are well-documented, the impact of extended VR immersion (up to 60 min) on balance remains poorly understood. Twenty healthy young adults were exposed to sinusoidal optic flow stimuli in a novel VR environment, with different velocities (0.1, 1, 10 m/s) and frequencies (0.125, 0.25, 0.5 Hz). Balance responses were assessed using a force plate to measure anteroposterior centre of pressure (CoP) velocity (AP-Vel) and mean power frequency (MPF). VR optic flow elicited significantly greater AP-Vel (P < 0.0001) and MPF (P < 0.0001) compared to non-VR eyes open conditions, with higher optic flow velocities and frequencies inducing greater balance responses (AP-Vel: P = 0.0322; MPF: P = 0.0027). Despite prolonged VR exposure, no evidence of habituation was observed within 90-second trials (P > 0.2110) or over the 40-60-minute experiment (P > 0.6724). Participants reported increased physical (P = 0.0010) and mental fatigue (P = 0.0005) by the end of the experiment, though this did not affect balance. These findings highlight the sensitivity of standing balance to VR optic flow parameters and the stability of balance responses over prolonged VR exposure, even with perceived fatigue. This research advances our understanding of sensory integration in postural control and informs the use of VR for research, rehabilitation, and entertainment.</p>","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"243 3","pages":"64"},"PeriodicalIF":1.7,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gamma-frequency transcranial alternating current stimulation over the left posterior parietal cortex enhances the long-term retention of associative memory.
IF 1.7 4区 医学
Experimental Brain Research Pub Date : 2025-02-07 DOI: 10.1007/s00221-025-07009-8
Shunxiang Sun, Hiroki Annaka, Tomonori Nomura
{"title":"Gamma-frequency transcranial alternating current stimulation over the left posterior parietal cortex enhances the long-term retention of associative memory.","authors":"Shunxiang Sun, Hiroki Annaka, Tomonori Nomura","doi":"10.1007/s00221-025-07009-8","DOIUrl":"10.1007/s00221-025-07009-8","url":null,"abstract":"<p><p>Transcranial alternating current stimulation (tACS) has been reported to improve associative memory (AM) by modulating the frequency of neural oscillations in the brain; however, whether gamma-frequency (> 30 Hz) tACS in the left posterior parietal lobe (PPC) can enhance memory retention in AM remains unclear. This study aimed to investigate whether memory retention in AM could be improved after gamma-frequency tACS of the left PPC. We used a randomly assigned, double-blind, repeated-measures, sham-control design, in which 28 healthy adult participants were assigned to receive a single 20-min session of gamma-frequency (60 Hz) tACS or sham stimulation. The memory learning task consisted of studying and testing 50 unrelated word pairs three times on day 1. The number of correct responses in the cued recall task was measured at three time points: days 1, 7, and 28. The results revealed a significant difference in the number of correct responses between the interventions on day 7 and day 28. These data suggest that gamma-frequency tACS stimulation of the left PPC enhances the long-term retention of AM in healthy adults.</p>","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"243 3","pages":"62"},"PeriodicalIF":1.7,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Attention and control of posture: the effects of light touch on the center-of-pressure time series regularity and simple reaction time task.
IF 1.7 4区 医学
Experimental Brain Research Pub Date : 2025-02-06 DOI: 10.1007/s00221-025-07007-w
Anna Brachman, Justyna Michalska, Bogdan Bacik
{"title":"Attention and control of posture: the effects of light touch on the center-of-pressure time series regularity and simple reaction time task.","authors":"Anna Brachman, Justyna Michalska, Bogdan Bacik","doi":"10.1007/s00221-025-07007-w","DOIUrl":"10.1007/s00221-025-07007-w","url":null,"abstract":"<p><p>The stabilizing influence of a light touch (LT) on a postural sway has been consistently shown in the literature, however there is still no consensus in what way attentional resources are used when adopting LT during standing. To better elucidate the underlying mechanisms we introduced additional feedback (LT), which seems to distracts from postural control, and verified it by center of pressure (COP) regularity level and simple reaction time task. 25 healthy students randomly performed eight postural tasks, four without (NoRT)/ four with simple reaction task (RT). COP displacements were measured on a force plate in two visual conditions: eyes open/closed and two sensory conditions: without (NoLT)/with light touch (LT). Participants were asked to consider the postural task as the primary task. Although simple reaction time did not differ between postural conditions (p > 0.05), LT decreased postural sway velocity in anteroposterior direction (p < 0.001, η2 = 0.86) and decreased standard deviation (p < 0.001, η2 = 0.91) in both, reaction and visual conditions. Interestingly, RT task modified subjects behavior in NoLT conditions and caused slower COP velocity (p < 0.001, η2 = 0.53) without changes in signal regularity. Results also showed a significant increase in irregularity during standing with LT (p < 0.001, η2 = 0.86) in both vision and reaction conditions, suggesting that the signal was more random. Current results suggests that providing LT enhance postural steadiness and also seem to redirect attention externally, as shown by increased signal irregularity. Hence, LT possibly reduce the attention invested in the postural task itself. A RT task can be not sensitive enough to detect such subtle changes.</p>","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"243 3","pages":"60"},"PeriodicalIF":1.7,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of unilateral knee restraint on symmetry adaptation and double-support phase dynamic stability during split-belt walking.
IF 1.7 4区 医学
Experimental Brain Research Pub Date : 2025-02-06 DOI: 10.1007/s00221-025-07006-x
Keisuke Hirata, Hiroki Hanawa, Taku Miyazawa, Naohiko Kanemura
{"title":"Impact of unilateral knee restraint on symmetry adaptation and double-support phase dynamic stability during split-belt walking.","authors":"Keisuke Hirata, Hiroki Hanawa, Taku Miyazawa, Naohiko Kanemura","doi":"10.1007/s00221-025-07006-x","DOIUrl":"10.1007/s00221-025-07006-x","url":null,"abstract":"<p><p>The split-belt treadmill task is an effective tool for studying walking adaptation, particularly the symmetry adaptation of spatiotemporal parameters such as step length and double support time. This study aimed to evaluate the relationship between symmetry adaptation of spatiotemporal parameters and dynamic stability during the double-support phase in split-belt walking. We hypothesized that restraining fast-side knee extension, which is necessary for step lengthening during adaptation, would decrease dynamic stability during the double-support phase. Ten able-bodied male participants performed split-belt walking tasks under three conditions: control, fast-side knee restraint, and slow-side knee restraint. Our findings revealed that slow-side knee restraint disrupted symmetry in double support time and significantly decreased stability on the fast side during the early and late adaptation phases. Contrary to our hypothesis, fast-side knee restraint did not have a statistically significant effect on dynamic stability or symmetry. These results suggest that decreased dynamic stability during the double-support phase, particularly due to limitations in the movement of the trailing leg, may hinder the adaptation process. This study highlights the importance of dynamic stability control during the double-support phase for successful walking adaptation. Future studies with larger sample sizes and varying speed conditions are recommended to generalize these findings and develop targeted interventions to improve walking adaptability and dynamic stability.</p>","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"243 3","pages":"61"},"PeriodicalIF":1.7,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute effects of anodal transcranial direct current stimulation on endurance and maximal voluntary contraction in lower limbs: a systematic review and meta-analysis. 阳极经颅直流电刺激对下肢耐力和最大自主收缩的急性影响:系统回顾和荟萃分析。
IF 1.7 4区 医学
Experimental Brain Research Pub Date : 2025-02-05 DOI: 10.1007/s00221-025-07008-9
Geanny Zanirate Flor, Walace Monteiro, Ramdel Caldas Ferreira da Silva, Bruno Ribeiro Ramalho de Oliveira, Gonzalo Marquez, Eduardo Lattari
{"title":"Acute effects of anodal transcranial direct current stimulation on endurance and maximal voluntary contraction in lower limbs: a systematic review and meta-analysis.","authors":"Geanny Zanirate Flor, Walace Monteiro, Ramdel Caldas Ferreira da Silva, Bruno Ribeiro Ramalho de Oliveira, Gonzalo Marquez, Eduardo Lattari","doi":"10.1007/s00221-025-07008-9","DOIUrl":"10.1007/s00221-025-07008-9","url":null,"abstract":"<p><strong>Purpose: </strong>To examine the effects of single-dose anodal tDCS on isometric maximal voluntary contraction (MVC) and isometric endurance performance in lower limb exercises with healthy adults.</p><p><strong>Methods: </strong>For this systematic review and meta-analysis, we searched PubMed, ISI Web of Science, Scopus, and CINAHL for studies published between database inception and June 11, 2024. All randomized controlled trials on anodal tDCS interventions for MVC and isometric endurance in lower limb exercises were included, with no date restrictions. The quality of the evidence was assessed using the Jadad Scale, and the certainty of evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation approach. The Open Science Framework registered the protocol in June 2024 (DOI https://doi.org/10.17605/OSF.IO/AG93M ).</p><p><strong>Results: </strong>20 interventions were included, comprising 15 for MVC and 5 for 'Time to Task Failure' (TTF), which refers to isometric endurance performance measured in seconds. The findings showed no difference in the MVC (SMD = 0.06; 95% CI = - 0.14, 0.25; P = 0.57) and TTF performance (WMD = 0.07; 95% CI = - 0.26, 0.40; P = 0.68).</p><p><strong>Conclusion: </strong>The current meta-analysis indicated that anodal tDCS did not increase isometric MVC and isometric endurance performance in lower limb exercises in healthy adults.</p>","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"243 3","pages":"57"},"PeriodicalIF":1.7,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Paraxanthine enhances memory and neuroplasticity more than caffeine in rats. 更正:副黄嘌呤比咖啡因更能增强大鼠的记忆力和神经可塑性。
IF 1.7 4区 医学
Experimental Brain Research Pub Date : 2025-02-05 DOI: 10.1007/s00221-025-06996-y
Ralf Jäger, Sidney Abou Sawan, Marco Orrú, Grant M Tinsley, Martin Purpura, Shawn D Wells, Kylin Liao, Ashok Godavarthi
{"title":"Correction: Paraxanthine enhances memory and neuroplasticity more than caffeine in rats.","authors":"Ralf Jäger, Sidney Abou Sawan, Marco Orrú, Grant M Tinsley, Martin Purpura, Shawn D Wells, Kylin Liao, Ashok Godavarthi","doi":"10.1007/s00221-025-06996-y","DOIUrl":"10.1007/s00221-025-06996-y","url":null,"abstract":"","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"243 3","pages":"59"},"PeriodicalIF":1.7,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11799065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reaction time distribution analysis of bimanual movements with spatial and symbolic cues. 利用空间和符号线索分析双臂动作的反应时间分布。
IF 1.7 4区 医学
Experimental Brain Research Pub Date : 2025-02-05 DOI: 10.1007/s00221-025-07010-1
Jarrod Blinch, Catherine E Gooch, Allison R Clark, Bryce Murrin, Kathryn Bayouth
{"title":"Reaction time distribution analysis of bimanual movements with spatial and symbolic cues.","authors":"Jarrod Blinch, Catherine E Gooch, Allison R Clark, Bryce Murrin, Kathryn Bayouth","doi":"10.1007/s00221-025-07010-1","DOIUrl":"10.1007/s00221-025-07010-1","url":null,"abstract":"<p><p>The movement preparation of bimanual asymmetric reaching movements is longer than bimanual symmetric movements. This bimanual asymmetric cost is small for spatially cued movements and large with symbolic cues. Previous research on these bimanual asymmetric costs has relied on mean reaction time. The goal of the present study was to better understand the sensorimotor mechanisms of spatially and symbolically cued bimanual asymmetric costs by employing reaction time distribution analysis. Reaction time distributions were described with the ex-Gaussian parameters of [Formula: see text], [Formula: see text], and [Formula: see text]. Forty-eight young adults made bimanual symmetric and asymmetric reaching movements that were spatially or symbolically cued. With spatial cues, there was a small cost to [Formula: see text] for bimanual asymmetric movements compared to symmetric ones. This was depicted as a 4.8 ms rightward shift to the reaction time distribution. The bimanual asymmetric cost with spatial cues is likely caused by the temporal coupling of bimanual asymmetric movements. With symbolic cues, there was a large cost to [Formula: see text] and small costs to [Formula: see text] and [Formula: see text]. This was depicted as the Gaussian and exponential components of the distribution having longer and more disperse reaction time for asymmetric movements. The bimanual asymmetric cost with symbolic cues is likely caused by two factors: stimulus-response translation of two different symbolic cues and temporal coupling of bimanual asymmetric movements. The bimanual asymmetric cost to µ with symbolic cues is likely a combination of both factors, with stimulus-response translation contributing more than temporal coupling. The bimanual asymmetric costs to σ and τ are exclusively caused by stimulus-response translation.</p>","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"243 3","pages":"58"},"PeriodicalIF":1.7,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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