Experimental Brain Research最新文献_第10页

Grasping type affects configural encoding in visual working memory. 抓握类型影响视觉工作记忆的构形编码。

IF 1.6 4区医学

Experimental Brain Research Pub Date : 2025-12-27 DOI: 10.1007/s00221-025-07208-3

Shinhae Ahn, Richard A Abrams

{"title":"Grasping type affects configural encoding in visual working memory.","authors":"Shinhae Ahn, Richard A Abrams","doi":"10.1007/s00221-025-07208-3","DOIUrl":"10.1007/s00221-025-07208-3","url":null,"abstract":"Previous research has shown that different grasping actions selectively influence the processing of simple visual features based on their relevance to the specific action. However, it remains uncertain if this interaction extends to higher-order information, such as the global configuration extracted from an array of visual elements. The present study investigated the impact of different grasping types on the processing of configural shape information in visual working memory (VWM). In Experiment 1, participants engaged in a VWM change detection task while producing either power- or precision-grasping actions. The availability of configural shape information was manipulated through the presence or absence of surrounding circles around oriented bars. The results showed that configural shape information in the memory array overall benefited participants' change detection performance. Importantly, the effect of configural shape on memory performance was modulated by grasping type, with a greater configural benefit under precision-grasping compared to power-grasping. Experiment 2 replicated those findings under different task demands that required maintaining the grasp postures, while controlling for differences in the physical appearance of stimuli across conditions. Together, the findings highlight the role of grasping type in modulating the processing of configural shape information: different grasping actions influence how configural shape information is encoded and maintained in visual working memory.","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"244 1","pages":"19"},"PeriodicalIF":1.6,"publicationDate":"2025-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145846385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of instructions regarding gaze direction on stability of movements and accuracy of trajectory control during cycling. 注视方向指示对骑行过程中运动稳定性和轨迹控制精度的影响。

IF 1.6 4区医学

Experimental Brain Research Pub Date : 2025-12-27 DOI: 10.1007/s00221-025-07213-6

Takashi Kojima, Masahiro Kokubu

引用次数: 0

ERP evidence of attentional selection outside of effective oculomotor range. 有效动眼力范围外注意选择的ERP证据。

IF 1.6 4区医学

Experimental Brain Research Pub Date : 2025-12-23 DOI: 10.1007/s00221-025-07219-0

Wiktor Więcławski, Jakub Paszulewicz

引用次数: 0

Evaluation of hand muscle strength, deficiency and hand sensation in individuals with type 2 diabetes. 2型糖尿病患者手部肌肉力量、缺乏和手感的评估。

IF 1.6 4区医学

Experimental Brain Research Pub Date : 2025-12-23 DOI: 10.1007/s00221-025-07212-7

Ahmet Furkan Doğan, Fatma Erdeo, Hilal Akay Çizmecioğlu, Neslihan Altuntaş Yılmaz

{"title":"Evaluation of hand muscle strength, deficiency and hand sensation in individuals with type 2 diabetes.","authors":"Ahmet Furkan Doğan, Fatma Erdeo, Hilal Akay Çizmecioğlu, Neslihan Altuntaş Yılmaz","doi":"10.1007/s00221-025-07212-7","DOIUrl":"10.1007/s00221-025-07212-7","url":null,"abstract":"The aim of this study was to evaluate hand muscle strength, dexterity and hand sensation in individuals with type 2 diabetes with and without peripheral neuropathy. The study was completed with a total of 57 patients with diabetic peripheral neuropathy (DPN+) (n = 31) and without diabetic peripheral neuropathy (DPN-) (n = 26). Semmes-Weinstein Monofilament Test (SWMT) was used for light touch sensation, 128 Hz tuning fork for vibration sensation, esthesiometer for two-point discrimination sensation, Baseline hydraulic hand dynamometer for rough grip strength, Baseline pinch meter for finger pinch strength, and 9-hole peg test (NHPT) for manual dexterity. When light touch sensation was examined in DPN+ and DPN- groups, a significant difference was found between the groups (p < 0.05). When two-point discrimination sense was evaluated between the DPN+ and DPN- groups, it was found to be significant in favor of the DPN+ group in the 1st finger of the right hand and 2nd and 3rd fingers of the left hand (p < 0.05). Rough grip strength values were found to be significantly lower in the DPN+ group in both hands (p < 0.05). In the DPN+ group, left 1st and 2nd finger pinch strength values were found to be statistically significant (p < 0.05). Manual dexterity values were significantly higher in the DPN+ group (p < 0.05). Peripheral sensory nerve involvement in diabetic patients reduces hand grip strength and hand function. Understanding these connections between diabetes, sensation, and muscle strength is important for developing targeted interventions and rehabilitation strategies to help diabetic patients maintain their quality of life.","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"244 1","pages":"15"},"PeriodicalIF":1.6,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145810052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of lateralization bias of pain on pain, anxiety and cognition in mice. 疼痛偏侧性对小鼠疼痛、焦虑和认知的影响。

IF 1.6 4区医学

Experimental Brain Research Pub Date : 2025-12-23 DOI: 10.1007/s00221-025-07217-2

Xuechun Cai, Xueli Lv, Baojian Zhao

{"title":"The effect of lateralization bias of pain on pain, anxiety and cognition in mice.","authors":"Xuechun Cai, Xueli Lv, Baojian Zhao","doi":"10.1007/s00221-025-07217-2","DOIUrl":"10.1007/s00221-025-07217-2","url":null,"abstract":"The transmission of pain signals through the spinal cord can cause structural and functional changes in the brain, which may contribute to diverse symptoms. Since the early 19th century, researchers have been studying hemispheric asymmetries in the brain and their effects across different species. However, it remains unclear whether pain-related emotional and cognitive changes are differently affected by left- and right-sided pain. To address this question, we conducted a study comparing the performance of chronic neuropathic mice with left or right spared nerve injury (SNI) in various behavioral tests. We evaluated their behaviors in the open field (OF), Y-maze, novel object recognition, and fear conditioning tests, and compared their performance to that of sham mice. Compared with sham mice, SNI mice manifested mechanical allodynia. In the OF test, SNI-L mice showed an increased anxiety-like profile compared to the other groups. Both left- and right- sided SNI mice showed cognitive deficits to a similar degree in memory tasks. Our results revealed that unilateral chronic neuropathic pain differentially affected anxiety condition, but not pain threshold and cognitive function.","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"244 1","pages":"17"},"PeriodicalIF":1.6,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145810005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of competing grouping patterns and tonal coherence in neural synchronization to musical meter. 竞争分组模式和调性连贯在神经与乐律同步中的作用。

IF 1.6 4区医学

Experimental Brain Research Pub Date : 2025-12-23 DOI: 10.1007/s00221-025-07216-3

Ferran Mayayo, Alexandre Celma-Miralles, Peter E Keller, Juan M Toro

{"title":"The role of competing grouping patterns and tonal coherence in neural synchronization to musical meter.","authors":"Ferran Mayayo, Alexandre Celma-Miralles, Peter E Keller, Juan M Toro","doi":"10.1007/s00221-025-07216-3","DOIUrl":"10.1007/s00221-025-07216-3","url":null,"abstract":"Musical meter emerges from the hierarchical organization of beats, which is influenced by both external acoustic cues and internally driven processes. This study examines neural and behavioral responses to auditory sequences when two simultaneous grouping patterns, melodic repetition and intensity accents, are candidates to establish a ternary or quaternary metrical representation. We also investigated how tonal coherence and tempo affect these metrical representations. To do so, we recorded finger tapping responses and electroencephalograms (EEG) from musically-naïve participants while they listened to musical sequences. The frequency-tagging analyses of the EEG indicated that melodic repetition, compared to intensity accents, enhances neural synchronization to metrical groupings. In contrast, disrupting tonal coherence with microtonal intervals reduces neural responses to both grouping patterns. No neural synchronization to any of these patterns was observed during a grouping-continuation imagery task. Behavioral data from the tapping task revealed a strong preference for quaternary over ternary groupings. These findings provide evidence that a repeating melodic pattern can establish neural responses to its periodicity, which likely scaffolds a metrical representation of the rhythmic sequences in the brain through complex interactions between bottom-up and top-down mechanisms in the formation of musical meter.","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"244 1","pages":"18"},"PeriodicalIF":1.6,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145810014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Training-induced plasticity for processing auditory temporal cues in dancers. 训练诱导的舞者处理听觉时间线索的可塑性。

IF 1.6 4区医学

Experimental Brain Research Pub Date : 2025-12-20 DOI: 10.1007/s00221-025-07198-2

Thomas M D Augereau, Daniel Paromov, Nicia John, Victoria Duda, François Champoux

引用次数: 0

USP19 restores mitochondrial function in neurons by deubiquitinating FUS to alleviate trigeminal neuralgia. USP19通过去泛素化FUS，恢复神经元线粒体功能，减轻三叉神经痛。

IF 1.6 4区医学

Experimental Brain Research Pub Date : 2025-12-16 DOI: 10.1007/s00221-025-07210-9

Xianhai Fang, Yujing Fan, Nan Liu, Shaopeng Huang

{"title":"USP19 restores mitochondrial function in neurons by deubiquitinating FUS to alleviate trigeminal neuralgia.","authors":"Xianhai Fang, Yujing Fan, Nan Liu, Shaopeng Huang","doi":"10.1007/s00221-025-07210-9","DOIUrl":"10.1007/s00221-025-07210-9","url":null,"abstract":"Deubiquitinating enzymes of the ubiquitin-specific peptidase (USP) family have been increasingly recognized for their roles in modulating neuropathic pain. In this study, bioinformatic analysis identified USP19 as a downregulated gene in trigeminal neuralgia (TN). Using a mouse model of TN induced by foramen lacerum impingement of the trigeminal nerve (FLIT), we demonstrated that adeno-associated virus-mediated overexpression of USP19 in the cerebral cortex significantly alleviated anxiety-like and pain-like behaviors. USP19 overexpression promoted deubiquitination and stabilization of fused in sarcoma (FUS), as confirmed by Western blotting, actinomycin D treatment, and ubiquitination assays. In HT22 and SH-SY5Y cells exposed to lipopolysaccharide to induce mitochondrial dysfunction, USP19 restored mitochondrial membrane potential, reduced mitochondrial reactive oxygen species, suppressed DRP1 phosphorylation, and upregulated CYTB and ND4 levels. These effects were reversed by FUS knockdown, both in vitro and in vivo. Moreover, FUS silencing abolished USP19-mediated improvements in NAD⁺/NADH ratio and mitochondrial function, as well as its analgesic and anxiolytic benefits in TN mice. These findings suggest that USP19 alleviates TN by enhancing FUS deubiquitination and preserving mitochondrial integrity in neurons. This study reveals a novel USP19/FUS signaling axis in the regulation of mitochondrial homeostasis and provides a promising therapeutic target for the treatment of TN.","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"244 1","pages":"13"},"PeriodicalIF":1.6,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145762678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional brain network analysis of VR motion sickness. VR晕动病的脑功能网络分析。

IF 1.6 4区医学

Experimental Brain Research Pub Date : 2025-12-15 DOI: 10.1007/s00221-025-07207-4

Geng Yuehua, Wang Wendi, Li Yongjian, Zhai Xiang, Xu Guizhi

{"title":"Functional brain network analysis of VR motion sickness.","authors":"Geng Yuehua, Wang Wendi, Li Yongjian, Zhai Xiang, Xu Guizhi","doi":"10.1007/s00221-025-07207-4","DOIUrl":"10.1007/s00221-025-07207-4","url":null,"abstract":"This study aims to explore the neural impact of virtual reality (VR) motion sickness on individuals from the perspective of brain functional networks, analyze the relationship between changes in Electroencephalogram (EEG) frequency bands and VR motion sickness, and provide a new perspective for evaluating the neural excitation mechanism of VR motion sickness. Twenty-six subjects were grouped based on their sensitivity to VR by a subjective evaluation scale. EEG signals were recorded before and after VR experiment. Functional brain networks were constructed and the changes in perspective of network topological characteristic parameters were analyzed. Participants in the sensitive group exhibited increased clustering coefficients and local efficiencies in the Delta band, as well as increased characteristic path lengths in the Alpha band. Conversely, subjects in the insensitive group exhibited no substantial alterations in brain network parameters before and after the VR experiment, and no significant changes in other frequency bands. The result indicate that alterations in the Delta and Alpha frequency bands play a crucial role in the mechanism of VR-induced motion sickness. These changes reflect an augmentation of the brain's local information processing capacity in response to VR motion sickness, as well as modifications in the efficiency of the global network in processing visual stimuli and modulating attention. These findings provide theoretical underpinnings for the neurological effects of VR motion sickness and establish a foundational framework for future research.","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"244 1","pages":"12"},"PeriodicalIF":1.6,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145755647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early life stress alters microglia in ventral hippocampus and dorsal CA2 associated with anxiety-like behavior in adolescent male rats. 早期生活压力改变青春期雄性大鼠腹侧海马和背侧CA2中与焦虑样行为相关的小胶质细胞。

IF 1.6 4区医学

Experimental Brain Research Pub Date : 2025-12-08 DOI: 10.1007/s00221-025-07204-7

Kezzia Jones, Lindsay Teliska, Martine M Mirrione, Adrienne J Betz

引用次数: 0