Experimental Brain Research最新文献_第10页

Reliability of transcranial magnetic stimulation-evoked responses on knee extensor muscles during cycling. 骑自行车时膝关节伸肌的经颅磁刺激诱发反应的可靠性。

IF 1.7 4区医学

Experimental Brain Research Pub Date : 2024-07-01 Epub Date: 2024-05-28 DOI: 10.1007/s00221-024-06859-y

Jenny Zhang, Zachary J McClean, Neda Khaledi, Sophie-Jayne Morgan, Guillaume Y Millet, Saied Jalal Aboodarda

{"title":"Reliability of transcranial magnetic stimulation-evoked responses on knee extensor muscles during cycling.","authors":"Jenny Zhang, Zachary J McClean, Neda Khaledi, Sophie-Jayne Morgan, Guillaume Y Millet, Saied Jalal Aboodarda","doi":"10.1007/s00221-024-06859-y","DOIUrl":"10.1007/s00221-024-06859-y","url":null,"abstract":"Transcranial magnetic stimulation (TMS) measures the excitability and inhibition of corticomotor networks. Despite its task-specificity, few studies have used TMS during dynamic movements and the reliability of TMS paired pulses has not been assessed during cycling. This study aimed to evaluate the reliability of motor evoked potentials (MEP) and short- and long-interval intracortical inhibition (SICI and LICI) on vastus lateralis and rectus femoris muscle activity during a fatiguing single-leg cycling task. Nine healthy adults (2 female) performed two identical sessions of counterweighted single-leg cycling at 60% peak power output until failure. Five single pulses and ten paired pulses were delivered to the motor cortex, and two maximal femoral nerve stimulations (Mmax) were administered during two baseline cycling bouts (unfatigued) and every 5 min throughout cycling (fatigued). When comparing both baseline bouts within the same session, MEP·Mmax-1 and LICI (both ICC: >0.9) were rated excellent while SICI was rated good (ICC: 0.7-0.9). At baseline, between sessions, in the vastus lateralis, Mmax (ICC: >0.9) and MEP·Mmax-1 (ICC: 0.7) demonstrated good reliability; LICI was moderate (ICC: 0.5), and SICI was poor (ICC: 0.3). Across the fatiguing task, Mmax demonstrated excellent reliability (ICC > 0.8), MEP·Mmax-1 ranged good to excellent (ICC: 0.7-0.9), LICI was moderate to excellent (ICC: 0.5-0.9), and SICI remained poorly reliable (ICC: 0.3-0.6). These results corroborate the cruciality of retaining mode-specific testing measurements and suggest that during cycling, Mmax, MEP·Mmax-1, and LICI measures are reliable whereas SICI, although less reliable across days, can be reliable within the same session.","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141160290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Traumatic brain injury heterogeneity affects cell death and autophagy. 创伤性脑损伤的异质性会影响细胞死亡和自噬。

IF 1.7 4区医学

Experimental Brain Research Pub Date : 2024-07-01 Epub Date: 2024-05-24 DOI: 10.1007/s00221-024-06856-1

Brandon Z McDonald, Aria W Tarudji, Haipeng Zhang, Sangjin Ryu, Kent M Eskridge, Forrest M Kievit

{"title":"Traumatic brain injury heterogeneity affects cell death and autophagy.","authors":"Brandon Z McDonald, Aria W Tarudji, Haipeng Zhang, Sangjin Ryu, Kent M Eskridge, Forrest M Kievit","doi":"10.1007/s00221-024-06856-1","DOIUrl":"10.1007/s00221-024-06856-1","url":null,"abstract":"Traumatic brain injury (TBI) mechanism and severity are heterogenous clinically, resulting in a multitude of physical, cognitive, and behavioral deficits. Impact variability influences the origin, spread, and classification of molecular dysfunction which limits strategies for comprehensive clinical intervention. Indeed, there are currently no clinically approved therapeutics for treating the secondary consequences associated with TBI. Thus, examining pathophysiological changes from heterogeneous impacts is imperative for improving clinical translation and evaluating the efficacy of potential therapeutic strategies. Here we utilized TBI models that varied in both injury mechanism and severity including severe traditional controlled cortical impact (CCI), modified mild CCI (MTBI), and multiple severities of closed-head diffuse TBI (DTBI), and assessed pathophysiological changes. Severe CCI induced cortical lesions and necrosis, while both MTBI and DTBI lacked lesions or significant necrotic damage. Autophagy was activated in the ipsilateral cortex following CCI, but acutely impaired in the ipsilateral hippocampus. Additionally, autophagy was activated in the cortex following DTBI, and autophagic impairment was observed in either the cortex or hippocampus following impact from each DTBI severity. Thus, we provide evidence that autophagy is a therapeutic target for both mild and severe TBI. However, dramatic increases in necrosis following CCI may negatively impact the clinical translatability of therapeutics designed to treat acute dysfunction in TBI. Overall, these results provide evidence that injury sequalae affiliated with TBI heterogeneity is linked through autophagy activation and/or impaired autophagic flux. Thus, therapeutic strategies designed to intervene in autophagy may alleviate pathophysiological consequences, in addition to the cognitive and behavioral deficits observed in TBI.","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141093243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dissociated cerebellar contributions to feedforward gait adaptation. 小脑对前馈步态适应的不同贡献

IF 1.7 4区医学

Experimental Brain Research Pub Date : 2024-07-01 Epub Date: 2024-05-17 DOI: 10.1007/s00221-024-06840-9

Karen L Bunday, Toby J Ellmers, M Rashmi Wimalaratna, Luxme Nadarajah, Adolfo M Bronstein

{"title":"Dissociated cerebellar contributions to feedforward gait adaptation.","authors":"Karen L Bunday, Toby J Ellmers, M Rashmi Wimalaratna, Luxme Nadarajah, Adolfo M Bronstein","doi":"10.1007/s00221-024-06840-9","DOIUrl":"10.1007/s00221-024-06840-9","url":null,"abstract":"The cerebellum is important for motor adaptation. Lesions to the vestibulo-cerebellum selectively cause gait ataxia. Here we investigate how such damage affects locomotor adaptation when performing the 'broken escalator' paradigm. Following an auditory cue, participants were required to step from the fixed surface onto a moving platform (akin to an airport travellator). The experiment included three conditions: 10 stationary (BEFORE), 15 moving (MOVING) and 10 stationary (AFTER) trials. We assessed both behavioural (gait approach velocity and trunk sway after stepping onto the moving platform) and neuromuscular outcomes (lower leg muscle activity, EMG). Unlike controls, cerebellar patients showed reduced after-effects (AFTER trials) with respect to gait approach velocity and leg EMG activity. However, patients with cerebellar damage maintain the ability to learn the trunk movement required to maximise stability after stepping onto the moving platform (i.e., reactive postural behaviours). Importantly, our findings reveal that these patients could even initiate these behaviours in a feedforward manner, leading to an after-effect. These findings reveal that the cerebellum is crucial for feedforward locomotor control, but that adaptive locomotor behaviours learned via feedback (i.e., reactive) mechanisms may be preserved following cerebellum damage.","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11208272/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140957076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Haptic and visuo-haptic impairments for object recognition in children with autism spectrum disorder: focus on the sensory and multisensory processing dysfunctions. 自闭症谱系障碍儿童在物体识别方面的触觉和视觉触觉障碍：关注感官和多感官处理功能障碍。

IF 1.7 4区医学

Experimental Brain Research Pub Date : 2024-07-01 Epub Date: 2024-05-31 DOI: 10.1007/s00221-024-06855-2

G Purpura, S Petri, R Tancredi, F Tinelli, S Calderoni

{"title":"Haptic and visuo-haptic impairments for object recognition in children with autism spectrum disorder: focus on the sensory and multisensory processing dysfunctions.","authors":"G Purpura, S Petri, R Tancredi, F Tinelli, S Calderoni","doi":"10.1007/s00221-024-06855-2","DOIUrl":"10.1007/s00221-024-06855-2","url":null,"abstract":"Dysfunctions in sensory processing are widely described in individuals with autism spectrum disorder (ASD), although little is known about the developmental course and the impact of these difficulties on the learning processes during the preschool and school ages of ASD children. Specifically, as regards the interplay between visual and haptic information in ASD during developmental age, knowledge is very scarce and controversial. In this study, we investigated unimodal (visual and haptic) and cross-modal (visuo-haptic) processing skills aimed at object recognition through a behavioural paradigm already used in children with typical development (TD), with cerebral palsy and with peripheral visual impairments. Thirty-five children with ASD (age range: 5-11 years) and thirty-five age-matched and gender-matched typically developing peers were recruited. The procedure required participants to perform an object-recognition task relying on only the visual modality (black-and-white photographs), only the haptic modality (manipulation of real objects) and visuo-haptic transfer of these two types of information. Results are consistent with the idea that visuo-haptic transfer may be significantly worse in ASD children than in TD peers, leading to significant impairment in multisensory interactions for object recognition facilitation. Furthermore, ASD children tended to show a specific deficit in haptic information processing, while a similar trend of maturation of visual modality between the two groups is reported. This study adds to the current literature by suggesting that ASD differences in multisensory processes also regard visuo-haptic abilities necessary to identify and recognise objects of daily life.","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11208199/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141179288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of distinct cognitive domains on gait variability in individuals with mild cognitive impairment and dementia. 不同认知领域对轻度认知障碍和痴呆症患者步态变异性的影响。

IF 1.7 4区医学

Experimental Brain Research Pub Date : 2024-07-01 Epub Date: 2024-05-16 DOI: 10.1007/s00221-024-06832-9

Edward Ofori, Ferdinand Delgado, Dara L James, Jeffrey Wilken, Laura M Hancock, Glen M Doniger, Mark Gudesblatt

{"title":"Impact of distinct cognitive domains on gait variability in individuals with mild cognitive impairment and dementia.","authors":"Edward Ofori, Ferdinand Delgado, Dara L James, Jeffrey Wilken, Laura M Hancock, Glen M Doniger, Mark Gudesblatt","doi":"10.1007/s00221-024-06832-9","DOIUrl":"10.1007/s00221-024-06832-9","url":null,"abstract":"Background: Gait variability is a common feature in neurodegenerative diseases and has been linked to cognitive impairment. Despite this link, the influence of specific cognitive domains, such as memory, visual spatial skills, executive function, and verbal function on gait variability is not well-understood.Objective: To investigate the predictive value of these specific cognitive domains on gait variability in people with mild cognitive impairment (MCI) and dementia during preferred and dual task walking.Method: One hundred and two participants with either MCI or dementia underwent a comprehensive cognitive assessment and completed preferred and dual-task walking trials on a pressure-sensing walkway. Gait variability was assessed using the PKMAS software. Lower extremity function was evaluated with a self-reported validated scale.Results: Our findings indicate that only visual spatial abilities had a moderate predictive value on gait variability [F (1, 78) = 17.30, p < 0.01, r = 0.43], both in preferred pace walking (70% direct effect) and dual-task walking (90% direct effect) (p's < 0.05). Additionally, lower extremity functional skills had a significant indirect effect (30%) on gait variability in preferred walking contexts.Conclusion: For individuals diagnosed with MCI or dementia, increased gait variability may be driven by deficits in visual spatial processing. An increased understanding of the role of visual spatial processing in gait variability can aid in the assessment and management of individuals with MCI or dementia, potentially leading to targeted interventions to improve mobility and safety.","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140944625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

C8-ceramide modulates microglia BDNF expression to alleviate postoperative cognition dysfunction via PKCδ/NF-κB signaling pathway. C8-神经酰胺通过PKCδ/NF-κB信号通路调节小胶质细胞BDNF的表达，从而缓解术后认知功能障碍。

IF 1.7 4区医学

Experimental Brain Research Pub Date : 2024-07-01 Epub Date: 2024-05-15 DOI: 10.1007/s00221-024-06847-2

Guangqian Li, Yuhao Wang, Lei Qian, Danni Li, Yuchen Yao, Jian Pan, Dan Fan

{"title":"C8-ceramide modulates microglia BDNF expression to alleviate postoperative cognition dysfunction via PKCδ/NF-κB signaling pathway.","authors":"Guangqian Li, Yuhao Wang, Lei Qian, Danni Li, Yuchen Yao, Jian Pan, Dan Fan","doi":"10.1007/s00221-024-06847-2","DOIUrl":"10.1007/s00221-024-06847-2","url":null,"abstract":"Postoperative cognitive dysfunction (POCD) is a kind of serious postoperative complication in surgery with general anesthesia and it may affect patients' normal lives. Activated microglia are thought to be one of the key factors in the regulation of POCD process. Once activated, resident microglia change their phenotype and secrete kinds of cytokines to regulate inflammatory response in tissues. Among these secretory factors, brain-derived neurotrophic factor (BDNF) is considered to be able to inhibit inflammation response and protect nervous system. Therefore, the enhancement of BDNF expression derived from resident microglia is suggested to be potential treatment for POCD. In our study, we focused on the role of C8-ceramide (a kind of interventional drug) and assessed its regulatory effect on improving the expression of BDNF secreted from microglia to treat POCD. According to the results of our study, we observed that C8-ceramide stimulated primary microglia to up-regulate the expression of BDNF mRNA after being treated with lipopolysaccharide (LPS) in vitro. We proved that C8-ceramide had ability to effectively improve POCD of mice after being accepted carotid artery exposure and their abnormal behavior recovered better than that of mice from the surgery group. Furthermore, we also demonstrated that C8-ceramide enhanced the cognitive function of mice via the PKCδ/NF-κB signaling pathway. In general, our study has confirmed a potential molecular mechanism that led to the occurrence of POCD caused by surgery and provided a new clinical strategy to treat POCD.","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11208206/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140944555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of older age on visual and self-motion sensory cue integration in navigation. 年龄增长对导航中视觉和自我运动感觉线索整合的影响。

IF 1.7 4区医学

Experimental Brain Research Pub Date : 2024-06-01 Epub Date: 2024-03-28 DOI: 10.1007/s00221-024-06818-7

Corey S Shayman, Maggie K McCracken, Hunter C Finney, Andoni M Katsanevas, Peter C Fino, Jeanine K Stefanucci, Sarah H Creem-Regehr

{"title":"Effects of older age on visual and self-motion sensory cue integration in navigation.","authors":"Corey S Shayman, Maggie K McCracken, Hunter C Finney, Andoni M Katsanevas, Peter C Fino, Jeanine K Stefanucci, Sarah H Creem-Regehr","doi":"10.1007/s00221-024-06818-7","DOIUrl":"10.1007/s00221-024-06818-7","url":null,"abstract":"Older adults demonstrate impairments in navigation that cannot be explained by general cognitive and motor declines. Previous work has shown that older adults may combine sensory cues during navigation differently than younger adults, though this work has largely been done in dark environments where sensory integration may differ from full-cue environments. Here, we test whether aging adults optimally combine cues from two sensory systems critical for navigation: vision (landmarks) and body-based self-motion cues. Participants completed a homing (triangle completion) task using immersive virtual reality to offer the ability to navigate in a well-lit environment including visibility of the ground plane. An optimal model, based on principles of maximum-likelihood estimation, predicts that precision in homing should increase with multisensory information in a manner consistent with each individual sensory cue's perceived reliability (measured by variability). We found that well-aging adults (with normal or corrected-to-normal sensory acuity and active lifestyles) were more variable and less accurate than younger adults during navigation. Both older and younger adults relied more on their visual systems than a maximum likelihood estimation model would suggest. Overall, younger adults' visual weighting matched the model's predictions whereas older adults showed sub-optimal sensory weighting. In addition, high inter-individual differences were seen in both younger and older adults. These results suggest that older adults do not optimally weight each sensory system when combined during navigation, and that older adults may benefit from interventions that help them recalibrate the combination of visual and self-motion cues for navigation.","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11111325/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140318127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The center of a face catches the eye in face perception. 在人脸感知中，人脸的中心会吸引人的目光。

IF 1.7 4区医学

Experimental Brain Research Pub Date : 2024-06-01 Epub Date: 2024-04-02 DOI: 10.1007/s00221-024-06822-x

Toshikazu Kawagoe, Wataru Teramoto

引用次数: 0

Mutual oligosynaptic inhibition of group Ia afferents between the anterior and posterior parts of the deltoid in humans. 人类三角肌前部和后部之间 Ia 群传入的相互寡突触抑制。

IF 1.7 4区医学

Experimental Brain Research Pub Date : 2024-06-01 Epub Date: 2024-05-03 DOI: 10.1007/s00221-024-06834-7

Takuya Yoshimoto, Mitsuhiro Nito, Wataru Hashizume, Kazuto Shimada, Tomomi Sato, Masaomi Shindo, Akira Naito

{"title":"Mutual oligosynaptic inhibition of group Ia afferents between the anterior and posterior parts of the deltoid in humans.","authors":"Takuya Yoshimoto, Mitsuhiro Nito, Wataru Hashizume, Kazuto Shimada, Tomomi Sato, Masaomi Shindo, Akira Naito","doi":"10.1007/s00221-024-06834-7","DOIUrl":"10.1007/s00221-024-06834-7","url":null,"abstract":"The anterior (DA) and posterior parts of the deltoid (DP) show alternating contraction during shoulder flexion and extension movements. It is expected that an inhibitory spinal reflex between the DA and DP exists. In this study, spinal reflexes between the DA and DP were examined in healthy human subjects using post-stimulus time histogram (PSTH) and electromyogram averaging (EMG-A). Electrical conditioning stimulation was delivered to the axillary nerve branch that innervates the DA (DA nerve) and DP (DP nerve) with the intensity below the motor threshold. In the PSTH study, the stimulation to the DA and DP nerves inhibited (decrease in the firing probability) 31 of 54 DA motor units and 31 of 51 DP motor units. The inhibition was not provoked by cutaneous stimulation. The central synaptic delay of the inhibition between the DA and DP nerves was 1.5 ± 0.5 ms and 1.4 ± 0.4 ms (mean ± SD) longer than those of the homonymous facilitation of the DA and DP, respectively. In the EMG-A study, conditioning stimulation to the DA and DP nerves inhibited the rectified and averaged EMG of the DP and DA, respectively. The inhibition diminished with tonic vibration stimulation to the DA and DP and recovered 20-30 min after vibration removal. These findings suggest that oligo(di or tri)-synaptic inhibition mediated by group Ia afferents between the DA and DP exists in humans.","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140848568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bimanual coordinated motor skill learning in patients with a chronic cerebellar stroke. 慢性小脑中风患者的双臂协调运动技能学习

IF 1.7 4区医学

Experimental Brain Research Pub Date : 2024-06-01 Epub Date: 2024-05-09 DOI: 10.1007/s00221-024-06830-x

Estelle Gathy, Ninon Cadiat, Eloïse Gerardin, Julien Lambert, Benoît Herman, Mie Leeuwerck, Benoît Bihin, Yves Vandermeeren

{"title":"Bimanual coordinated motor skill learning in patients with a chronic cerebellar stroke.","authors":"Estelle Gathy, Ninon Cadiat, Eloïse Gerardin, Julien Lambert, Benoît Herman, Mie Leeuwerck, Benoît Bihin, Yves Vandermeeren","doi":"10.1007/s00221-024-06830-x","DOIUrl":"10.1007/s00221-024-06830-x","url":null,"abstract":"Cerebellar strokes induce coordination disorders that can affect activities of daily living. Evidence-based neurorehabilitation programs are founded on motor learning principles. The cerebellum is a key neural structure in motor learning. It is unknown whether and how well chronic cerebellar stroke individuals (CCSIs) can learn to coordinate their upper limbs through bimanual motor skill learning. The aim was to determine whether CCSIs could achieve bimanual skill learning through a serious game with the REAplan® robot and to compare CCSIs with healthy individuals (HIs). Over three consecutive days, sixteen CCSIs and eighteen HIs were trained on an asymmetric bimanual coordination task (\"CIRCUIT\" game) with the REAplan® robot, allowing quantification of speed, accuracy and coordination. The primary outcomes were the bimanual speed/accuracy trade-off (BiSAT) and bimanual coordination factor (BiCo). They were also evaluated on a bimanual REACHING task on Days 1 and 3. Correlation analyses between the robotic outcomes and clinical scale scores were computed. Throughout the sessions, BiSAT and BiCo improved during the CIRCUIT task in both HIs and CCSIs. On Day 3, HIs and CCSIs showed generalization of BiSAT, BiCo and transferred to the REACHING task. There was no significant between-group difference in progression. Four CCSIs and two HIs were categorized as \"poor learners\" according to BiSAT and/or BiCo. Increasing age correlated with reduced BiSAT but not BiCo progression. Over three days of training, HIs and CCSIs improved, retained, generalized and transferred a coordinated bimanual skill. There was no between-group difference, suggesting plastic compensation in CCSIs. Clinical trial NCT04642599 approved the 24th of November 2020.","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140897926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0