Experimental Brain Research最新文献_第9页

Cue modality modulates interaction between exogenous spatial attention and audiovisual integration. 提示模态调节外源性空间注意与视听整合之间的相互作用。

IF 1.7 4区医学

Experimental Brain Research Pub Date : 2024-12-19 DOI: 10.1007/s00221-024-06970-0

Aijun Wang, Hong Zhang, Meihua Lu, Jinjin Wang, Xiaoyu Tang, Ming Zhang

{"title":"Cue modality modulates interaction between exogenous spatial attention and audiovisual integration.","authors":"Aijun Wang, Hong Zhang, Meihua Lu, Jinjin Wang, Xiaoyu Tang, Ming Zhang","doi":"10.1007/s00221-024-06970-0","DOIUrl":"10.1007/s00221-024-06970-0","url":null,"abstract":"Exogenous spatial attention attenuates audiovisual integration (AVI). Previous studies on the effects of exogenous spatial attention on AVI have focused on the inhibition of return (IOR) effect induced by visual cues and the facilitation effect induced by auditory cues, but the differences between the effects of exogenous spatial attention (induced by visual and auditory cues) on AVI remain unclear. The present study used the exogenous spatial cue-target paradigm and manipulated cue stimulus modality (visual cue, auditory cue) in two experiments (Experiment 1: facilitation effect; Experiment 2: IOR effect) to examine the effects of exogenous spatial attention (evoked by cues in different modalities) on AVI. The results of Experiment 1 showed that the AVI effect at valid cue locations was significantly lower than that at invalid cue locations in both visual and auditory cue conditions, suggesting that the exogenous spatial facilitation effect evoked by both visual and auditory cues attenuated AVI. Further analysis showed that the facilitation effect induced by visual cues attenuated AVI to a greater extent than that induced by auditory cues. In Experiment 2, the AVI effect was significantly lower at valid cue locations than at invalid cue locations in the visual cue condition, whereas there was no significant difference in AVI effect between valid and invalid cue locations in the auditory cue condition, suggesting that the exogenous spatial IOR effect evoked by visual cues attenuated AVI, while the IOR effect evoked by auditory cues had no significant effect on AVI. Taken together, these results may suggest that exogenous spatial attention induced by visual cues has a greater effect on AVI than that induced by auditory cues.","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"243 1","pages":"26"},"PeriodicalIF":1.7,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of attentional focus on spatial localization of distal body parts and touch in two-arm position matching. 双臂位置匹配中注意焦点对远端肢体空间定位和触觉的影响。

IF 1.7 4区医学

Experimental Brain Research Pub Date : 2024-12-19 DOI: 10.1007/s00221-024-06976-8

Wojciech Jelonek, Jakub Malik, Dawid Łochyński

{"title":"Effects of attentional focus on spatial localization of distal body parts and touch in two-arm position matching.","authors":"Wojciech Jelonek, Jakub Malik, Dawid Łochyński","doi":"10.1007/s00221-024-06976-8","DOIUrl":"10.1007/s00221-024-06976-8","url":null,"abstract":"This study investigated how the judgment of proximal joint position can be affected by touch alone, focused attention on the distal body part, or touch spatial localization. Participants completed a two-arm elbow joint position-matching task, in which they indicated the location of one forearm by the placement of the other. In four test conditions, matching was performed during (1) detection of touch (tactile stimulation of index finger pads), (2) spatial localization of fingers (attention focused on the position of index finger pads), (3) spatial localization of touch on fingers (attention focused on tactile stimulation of index finger pads), and (4) detection of touch but localization of fingers (tactile stimulation of index finger pads, but attention focusing on the spatial position of the pads). In the first experiment (n = 23), the sensitivity of muscle spindle receptors in both reference and indicator arms was reduced and equalized by both-slack conditioning. In the second experiment (n = 20), the illusion of excessive elbow flexion in the reference arm and excessive extension in the indicator arm was generated through extension-flexion conditioning. In the first experiment, the accuracy and precision of matching were unaffected in any test condition. In the second experiment, participants made amplified undershooting errors under attention-focused conditions. In conclusion, focused attention on the location of a distal body part and touch affects both the spatial localization of the limb and tactile remapping only when the perceived forearm position is misinterpreted due to imbalanced proprioceptive input from antagonistic arm muscles.","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"243 1","pages":"27"},"PeriodicalIF":1.7,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Motor information contributes to visuotactile interaction in trunk-centered peripersonal space during a pedaling situation. 运动信息有助于在以躯干为中心的周围个人空间在踩踏板的情况下的视觉互动。

IF 1.7 4区医学

Experimental Brain Research Pub Date : 2024-12-16 DOI: 10.1007/s00221-024-06975-9

Naoki Kuroda, Wataru Teramoto

{"title":"Motor information contributes to visuotactile interaction in trunk-centered peripersonal space during a pedaling situation.","authors":"Naoki Kuroda, Wataru Teramoto","doi":"10.1007/s00221-024-06975-9","DOIUrl":"10.1007/s00221-024-06975-9","url":null,"abstract":"Peripersonal space (PPS), the space immediately surrounding one's body, contributes to interactions with the external environment. Previous studies have demonstrated that PPS expands during whole-body self-motion. Furthermore, motor and proprioceptive information contributes to this phenomenon. However, no study has disentangled the role of motor commands. Therefore, this study investigated the role of motor commands via a bike pedaling situation in a virtual reality environment. We compared three self-motion conditions: active condition where participants actively pedaled at a constant speed, passive condition where they were forced to pedal by the pedaling (exercise) device, and no-pedaling condition where they did not pedal at all. Participants observed large-field optic flow that simulated forward self-motion in all the conditions. For PPS measurements, we asked participants to quickly respond to the tactile stimulus on their chests when they observed an approaching visual probe. The PPS range was defined as the maximum distance at which the visual probe facilitated tactile detection (visual-facilitation effect). Results showed that the visual-facilitation effects were larger in the active pedaling condition than in the no-pedaling condition. Furthermore, the effects were attenuated as the probe distances from the body increased. These results suggest that motor command information can strongly contribute to PPS expansion.","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"243 1","pages":"25"},"PeriodicalIF":1.7,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brain microRNA profiles after exposure to heroin in rats. 大鼠暴露于海洛因后的脑微rna谱。

IF 1.7 4区医学

Experimental Brain Research Pub Date : 2024-12-13 DOI: 10.1007/s00221-024-06972-y

Halime Hanim Pence, Ertugrul Kilic, Birsen Elibol, Sibel Kuras, Mustafa Guzel, Yalcin Buyuk, Sadrettin Pence

{"title":"Brain microRNA profiles after exposure to heroin in rats.","authors":"Halime Hanim Pence, Ertugrul Kilic, Birsen Elibol, Sibel Kuras, Mustafa Guzel, Yalcin Buyuk, Sadrettin Pence","doi":"10.1007/s00221-024-06972-y","DOIUrl":"10.1007/s00221-024-06972-y","url":null,"abstract":"Heroin addiction is one of the neuropsychiatric burdens that affects many genetic and epigenetic systems. While it is known that heroin may change the expressions of some genes in the brain during dependence, there is no detailed study related to which gene are mostly affected. Therefore, in the current study, we aimed to determine alterations in the miRNA profiles of rats' brains for providing a detailed analysis of molecular mechanisms in heroin addiction-related toxicology. Next generation global miRNA sequencing was used to predict potential miRNAs in prefrontal cortex (PC), hippocampus, ventral tegmental area (VTA), striatum, and Nucleus accumbens (NA) of rats that exposed to heroin by intravenous injections. The total daily dose was started with 2 mg/kg and ended with 10 mg/kg on the 10th day. In the striatum, miR-18a, miR-17-5p, miR-20a-5p, miR-106a, miR-301a-3p, miR872-5p, miR-15a-5p, miR-500-3p, and miR-339-5p expressions were upregulated by nearly 2-to-4 times with heroin. The expressions of hippocampal miR-153-3p, miR-130a-3p, miR-204-5p, miR-15b-5p, and miR-137-3p and the expressions of miR-872, miR-183-5p, miR-20a-5p, miR-325-5p, miR-379-5p, and miR-340-5p in the VTA were 2-times higher in the heroin-addicted rats. While there was nearly 2-times increase in the miR-129-1-3p and miR-3068-3p expressions in the NA, no change was noted in the PC due to heroin. The only heroin-dependent downregulation was observed in the expressions of striatal miR-450b-3p and miR-103-1-5p of VTA. These results suggested that heroin addiction might give harm to brain by altering cytokine balance and increasing neuroinflammation and apoptosis. In addition, neurons also try to compensate these abnormalities by enhancing neurogenesis and angiogenesis through several miRNAs in the different brain regions. In conclusion, the present study may provide a more integrated view of the molecular mechanism and a potential biomarker that will aid in clinical diagnosis and treatment of heroin-dependence.","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"243 1","pages":"24"},"PeriodicalIF":1.7,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Overexpression of miR-133a-3p reduces microglia activation by binding to GCH1, alleviating neuroinflammation and neuropathic pain. 过表达miR-133a-3p通过与GCH1结合减少小胶质细胞的激活，减轻神经炎症和神经性疼痛。

IF 1.7 4区医学

Experimental Brain Research Pub Date : 2024-12-12 DOI: 10.1007/s00221-024-06956-y

Chengcan Gao, Tao Yang, Jia Shu, Xu Gao, Chunyang Meng

{"title":"Overexpression of miR-133a-3p reduces microglia activation by binding to GCH1, alleviating neuroinflammation and neuropathic pain.","authors":"Chengcan Gao, Tao Yang, Jia Shu, Xu Gao, Chunyang Meng","doi":"10.1007/s00221-024-06956-y","DOIUrl":"10.1007/s00221-024-06956-y","url":null,"abstract":"Neuropathic pain is a chronic pain condition that is primarily caused by underlying neurological damage and dysfunction. Recent studies have identified microRNAs (miRNAs) as a key factor in the treatment of neuropathic pain. To explore the effects of miR-133a-3p on neuroinflammation and neuropathic pain via GTP cyclohydrolase (GCH1), and its underlying mechanisms. In vitro models were constructed using BV-2 cells that had been treated with lipopolysaccharide, followed by treatment with either miR-133a-3p mimic or GCH1 viral knockdown/overexpression. The expression of miR-133a-3p and GCH1 in BV-2 cells was quantified by RT-qPCR. The degree of neuroinflammation was quantified using an enzyme-linked immunosorbent assay (ELISA). The targeting relationship between miR-133a-3p and GCH1 was confirmed by western blot and dual luciferase reporter assay. A chronic constriction injury model was employed to induce neuropathic pain in rats, and the mechanical withdrawal threshold (MWT) was quantified. Immunofluorescence was used to demonstrate alterations in microglial cells. The expression of miR-133a-3p was found to be decreased in lipopolysaccharide-induced BV-2 cells. The overexpression of miR-133a-3p was observed to inhibit the expression of IL-1β, IL-6, TNF-α and iNOS, which was attributed to a reduction in GCH1.Nevertheless, OE-GCH1 could partially reverse the downregulation by miR-133a-3p of the expression of inflammatory factors. In animal experiments, intrathecal injection of AVV-miR-133a-3p was observed to alleviate mechanical nociceptive abnormalities induced by activated microglia. Furthermore, miR-133a-3p ameliorated neuroinflammation in the spinal cord of chronic constriction injury rats. In summary, miR-133a-3p improves neuroinflammation and neuropathic pain by binding to GCH1. The binding of miR-133a-3p to GCH1 has been demonstrated to improve neuroinflammation and neuropathic pain.This insight will facilitate the development of new methods to effectively treat neuropathic pain.","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"243 1","pages":"23"},"PeriodicalIF":1.7,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Repeated epidural stimulation modulates cervical spinal cord excitability in healthy adult rats. 反复硬膜外刺激调节健康成年大鼠颈脊髓兴奋性。

IF 1.7 4区医学

Experimental Brain Research Pub Date : 2024-12-12 DOI: 10.1007/s00221-024-06965-x

Pawan Sharma, Hema Rampersaud, Prithvi K Shah

{"title":"Repeated epidural stimulation modulates cervical spinal cord excitability in healthy adult rats.","authors":"Pawan Sharma, Hema Rampersaud, Prithvi K Shah","doi":"10.1007/s00221-024-06965-x","DOIUrl":"10.1007/s00221-024-06965-x","url":null,"abstract":"Spinal evoked motor responses (SEMR) are utilized in longitudinal pre-clinical and human studies to reflect the in-vivo physiological changes in neural networks secondary to a spinal cord injury (SCI) or neuro-rehabilitative treatments utilizing epidural stimulation (ES). However, it remains unknown whether the repeated ES exposure during SEMR testing itself modulates spinal cord physiology and accompanying SEMR characteristics. To answer this, ES was delivered to the cervical spinal cord using standard stimulation paradigms during multiple SEMR data acquisition sessions (~ 17 h spanning across 100 days) in ten healthy adult rats. Cervical SEMR at rest and forelimb muscle activity during reaching and grasping task were collected before and after 100 days. We noted a persistent increase in SEMR activity relative to baseline, with prominent changes in the mono and poly-synaptic components of SEMR. The findings indicate increased spinal cord excitability. Increased spinal cord excitability translated into increased forelimb muscle activation during the reaching and grasping task. For the majority of SEMR and muscle activity increase, effect size was large or very large. Cervical SEMR are amenable to modulation by routine ES testing protocols, with prominent changes in the mono and poly-synaptic components of SEMR. Since repeated stimulation during multiple testing alone increases cord excitability, we recommend (1) SEMR may be used with caution to infer the physiological status of the spinal circuitry (2) utilizing appropriate control groups and motor behavioral correlates for meaningful functional interpretation in longitudinal neuromodulation studies involving multiple SEMR testing sessions following a SCI.","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"243 1","pages":"22"},"PeriodicalIF":1.7,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intermittent adaptation to pelvis perturbation during walking enhances retention and generalization of motor learning in people with incomplete spinal cord injury. 不完全性脊髓损伤患者步行时骨盆扰动的间歇性适应增强了运动学习的保留和泛化。

IF 1.7 4区医学

Experimental Brain Research Pub Date : 2024-12-11 DOI: 10.1007/s00221-024-06971-z

Seoung Hoon Park, Shijun Yan, Weena Dee, Renee Keefer, William Z Rymer, Ming Wu

{"title":"Intermittent adaptation to pelvis perturbation during walking enhances retention and generalization of motor learning in people with incomplete spinal cord injury.","authors":"Seoung Hoon Park, Shijun Yan, Weena Dee, Renee Keefer, William Z Rymer, Ming Wu","doi":"10.1007/s00221-024-06971-z","DOIUrl":"10.1007/s00221-024-06971-z","url":null,"abstract":"The purpose of this study was to determine whether the intermittent adaptation to pelvis perturbation load enhances retention of improved weight transfer and generalization of motor skills from treadmill to overground walking, compared with effects of the continuous adaptation. Fifteen individuals with incomplete SCI participated in two experimental sessions. Each session consisted of (1) perturbed treadmill walking with either intermittent (i.e., interspersed 3 intervals of no perturbation) or continuous (no interval) adaptation to novel walking patterns induced by external pelvis perturbation and (2) instrumented treadmill walking and overground walking before, immediately, and 10-min post perturbed treadmill walking. The external pulling force was applied to the pelvis towards the lateral side while the leg touched the treadmill belt. Participants showed a retention of improved mediolateral weight transfer (P = 0.002) and of enhanced activation of hip abductor (P = 0.016) and calf muscles (P < 0.05) in the intermittent condition, whereas the continuous condition did not (P ≥ 0.05). After the perturbed treadmill walking practice, participants exhibited increased mediolateral weight transfer during overground walking (P = 0.04) and enhanced propulsion (P = 0.047) during the instrumented treadmill walking for the intermittent condition, whereas the continuous condition did not show significant changes (P ≥ 0.13). Further, the intermittent condition induced a greater increase in overground walking speed than the continuous condition did (P = 0.002). In conclusion, intermittent adaptation to the pelvis perturbation load during treadmill walking can promote retention and generalization of motor learning for improving walking and balance in people with incomplete SCI.","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"243 1","pages":"21"},"PeriodicalIF":1.7,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Passive and active exercise do not mitigate mental fatigue during a sustained vigilance task. 被动和主动运动都不能减轻持续警戒任务中的精神疲劳。

IF 1.7 4区医学

Experimental Brain Research Pub Date : 2024-12-10 DOI: 10.1007/s00221-024-06950-4

Gianna Jeyarajan, Lian Buwadi, Azar Ayaz, Lindsay S Nagamatsu, Denait Haile, Liye Zou, Matthew Heath

{"title":"Passive and active exercise do not mitigate mental fatigue during a sustained vigilance task.","authors":"Gianna Jeyarajan, Lian Buwadi, Azar Ayaz, Lindsay S Nagamatsu, Denait Haile, Liye Zou, Matthew Heath","doi":"10.1007/s00221-024-06950-4","DOIUrl":"10.1007/s00221-024-06950-4","url":null,"abstract":"Executive function (EF) is improved following a single bout of exercise and impaired when an individual experiences mental fatigue (MF). These performance outcomes have been linked to a bi-directional change in cerebral blood flow (CBF). Here, we sought to determine whether MF-induced by a sustained vigilance task (i.e., psychomotor vigilance task: PVT) is mitigated when preceded by a single bout of exercise. Participants completed 20-min single bouts of active exercise (cycle ergometry involving volitional muscle activation), passive exercise (cycle ergometry involving a mechanical flywheel) and a non-exercise control intervention. EF was assessed pre- and post-intervention via the antisaccade task. Following each intervention, a 20-min PVT was completed to induce and assess MF, and transcranial Doppler ultrasound of middle cerebral artery velocity (MCAv) was used to estimate intervention- and PVT-based changes in CBF. Active and passive exercise provided a post-intervention reduction in antisaccade reaction times; that is, exercise benefitted EF. Notably, however, frequentist and Bayesian statistics indicated the EF benefit did not mitigate MF during the PVT. As well, although exercise (active and passive) and the PVT respectively increased and decreased CBF, these changes were not correlated with behavioral measures of EF or MF. Accordingly, a postexercise EF benefit does not mitigate MF during a sustained vigilance task and a bi-directional change in CBF does not serve as a primary mechanism associated with EF and MF changes. Such results provide a framework for future work to explore how different exercise types, intensities and durations may impact MF.","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"243 1","pages":"19"},"PeriodicalIF":1.7,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142799972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of repeated intranasal gentamicin irrigation on auditory brainstem evoked potentials in rats. 反复鼻灌庆大霉素对大鼠听脑干诱发电位的影响。

IF 1.7 4区医学

Experimental Brain Research Pub Date : 2024-12-10 DOI: 10.1007/s00221-024-06967-9

Yusra Mansour, LeAnn Haddad, Zachary Breeden, Randy J Kulesza

{"title":"Impact of repeated intranasal gentamicin irrigation on auditory brainstem evoked potentials in rats.","authors":"Yusra Mansour, LeAnn Haddad, Zachary Breeden, Randy J Kulesza","doi":"10.1007/s00221-024-06967-9","DOIUrl":"10.1007/s00221-024-06967-9","url":null,"abstract":"Gentamicin is a bactericidal aminoglycoside antibiotic that broadly targets Gram-negative microbes. Both human and animal studies have shown that administration of gentamicin is ototoxic by several routes of administration and results in sensorineural hearing loss due to damaged hair cell at the base of the cochlea. However, gentamicin is also administered intranasally to treat sinusitis in humans, but no animal studies have examined ototoxicity of gentamicin administered via this route. We hypothesized that intranasal irrigation of gentamicin will result in ototoxicity and impaired auditory function similar to systemic delivery. We investigated this hypothesis in Sprague-Dawley rats that received intranasal irrigations of gentamicin or saline from postnatal day (P) 21-31. We examined auditory function by assessing brainstem auditory evoked potentials in response to both broadband clicks and pure tone-pips (4, 8, 16, 24 and 32 kHz) on P41. We found significant changes in auditory function in gentamicin-exposed animals. Specifically, gentamicin-exposed animals had significantly higher thresholds in response to both clicks and tone-pips. In response to broadband clicks, there were no changes in latency for waves I through IV. However, we found significantly longer wave and interwave latencies for all waves in response to the 24 kHz tone-pip. Together, these findings suggest that intranasal administration of gentamicin results in impaired auditory function consistent with other routes of delivery.","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"243 1","pages":"20"},"PeriodicalIF":1.7,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142799901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Implicit contributions to dual visuomotor adaptation. 双重视觉运动适应的内隐贡献。

IF 1.7 4区医学

Experimental Brain Research Pub Date : 2024-12-10 DOI: 10.1007/s00221-024-06963-z

Mary-Anne Vinh, Erin K Cressman

{"title":"Implicit contributions to dual visuomotor adaptation.","authors":"Mary-Anne Vinh, Erin K Cressman","doi":"10.1007/s00221-024-06963-z","DOIUrl":"10.1007/s00221-024-06963-z","url":null,"abstract":"The ability to seamlessly switch between different visuomotor mappings is critical for effective interactions in a dynamic environment. This experiment aimed to establish the contributions of implicit (unconscious) processes to the concurrent adaptation of one's reaches to two opposing, randomly switching, novel visuomotor mappings (i.e., dual visuomotor adaptation). 59 right-handed participants were divided into two groups, a Dual adaptation group and a Single adaptation group, and trained to reach when small visuomotor distortions were introduced. The Dual group trained to reach when cursor feedback was rotated (i) 20° clockwise (CW) relative to hand motion when a target was displayed in the left visual workspace and (ii) 20° counterclockwise (CCW) relative to hand motion when a target was displayed in the right visual workspace. The Single group trained to reach with just one 20° cursor rotation (CW or CCW) in both visual workspaces. Results revealed that all participants adapted their reaches to the distorted cursor feedback. For all groups, visuomotor adaptation arose implicitly, in the absence of explicit (conscious strategy) contributions. However, the Dual group demonstrated significantly less implicit adaptation than participants who trained with a Single CW distortion, even after additional reach training trials. Together, these results indicate a role for implicit processes in simultaneously updating one's reaches to two small visuomotor mappings.","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"243 1","pages":"18"},"PeriodicalIF":1.7,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142799969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0