Experimental Brain Research最新文献

{"title":"The link between eye movements and cognitive function in mild to moderate Alzheimer's disease.","authors":"Xiao-Ting Ma, Lin-Lin Yao, Shan-Wen Liu, Xiao-Fen Weng, Run-Ying Bao, Yi-Fan Yang, Yi-Feng Li, Yan-Yun Sun, Dan Xu, Zhen-Yu Jia, Hua Hu","doi":"10.1007/s00221-024-06957-x","DOIUrl":"https://doi.org/10.1007/s00221-024-06957-x","url":null,"abstract":"<p><p>This study investigated the relationship between eye movement parameters and cognitive function in patients with mild to moderate Alzheimer's disease (AD). A total of 80 patients with AD (mild and moderate) and 34 normal controls (NC) participated. Neuropsychological assessments were conducted using the Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA), while eye movements were recorded using eye-tracking technology. Comparisons of neuropsychological scores and eye movement parameters were made across the groups, and partial correlation analysis was performed to examine associations between eye movement metrics and specific cognitive domains. No significant differences were found among the groups in pursuit and fixation tasks. However, in pro-saccade tasks, patients in the moderate AD group exhibited significantly lower accuracy and longer latency compared to those in the mild AD and NC groups. Similarly, in anti-saccade tasks, the moderate AD group showed significantly lower accuracy and error correction rates compared to the other groups. Partial correlation analysis revealed that overall cognitive function was positively associated with the accuracy of pro-saccade and anti-saccade tasks, as well as the error correction rate of anti-saccade tasks, but negatively associated with pro-saccade latency. Further, orientation was negatively correlated with saccade latency and positively correlated with saccade accuracy, while visuospatial skills were positively associated with the accuracy of both saccade and anti-saccade tasks. A positive correlation was also observed between word fluency and both saccade accuracy and error correction rate. These findings indicate that eye movement parameters, particularly those related to saccade and anti-saccade tasks, are associated with various cognitive domains in mild to moderate AD patients. Eye-tracking technology may provide a convenient and non-invasive tool for assessing cognitive function and aiding in the diagnosis and evaluation of AD.</p>","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"243 1","pages":"39"},"PeriodicalIF":1.7,"publicationDate":"2025-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142926972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing auditory and visual aspects of multisensory working memory using bimodally matched feature patterns.","authors":"Işıl Uluç, Tori Turpin, Parker Kotlarz, Kaisu Lankinen, Fahimeh Mamashli, Jyrki Ahveninen","doi":"10.1007/s00221-024-06991-9","DOIUrl":"https://doi.org/10.1007/s00221-024-06991-9","url":null,"abstract":"<p><p>Working memory (WM) reflects the transient maintenance of information in the absence of external input, which can be attained via multiple senses separately or simultaneously. Pertaining to WM, the prevailing literature suggests the dominance of vision over other sensory systems. However, this imbalance may be stemming from challenges in finding comparable stimuli across modalities. Here, we addressed this problem by using a balanced multisensory retro-cue WM design, which employed combinations of auditory (ripple sounds) and visuospatial (Gabor patches) patterns, adjusted relative to each participant's discrimination ability. In three separate experiments, the participant was asked to determine whether the (retro-cued) auditory and/or visual items maintained in WM matched or mismatched the subsequent probe stimulus. In Experiment 1, all stimuli were audiovisual, and the probes were either fully mismatching, only partially mismatching, or fully matching the memorized item. Experiment 2 was otherwise the same as Experiment 1, but the probes were unimodal. In Experiment 3, the participant was cued to maintain only the auditory or visual aspect of an audiovisual item pair. In Experiments 1 and 3, the participant's matching performance was significantly more accurate for the auditory than visual attributes of probes. When the perceptual and task demands are bimodally equated, auditory attributes can be matched to multisensory items in WM at least as accurately as, if not more precisely than, their visual counterparts.</p>","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"243 1","pages":"38"},"PeriodicalIF":1.7,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deciphering brain activation during wrist movements: comparative fMRI and fNIRS analysis of active, passive, and imagery states.","authors":"Maziar Jalalvandi, Hamid Sharini, Lida Shafaghi, Nader Riyahi Alam","doi":"10.1007/s00221-024-06977-7","DOIUrl":"https://doi.org/10.1007/s00221-024-06977-7","url":null,"abstract":"<p><p>Understanding the complex activation patterns of brain regions during motor tasks is crucial. Integrated functional magnetic resonance imaging (fMRI) and functional near-infrared spectroscopy (fNIRS) offers advanced insights into how brain activity fluctuates with motor activities. This study explores neuronal activation patterns in the cerebral cortex during active, passive, and imagined wrist movements using these functional imaging techniques. Data were collected from 10 right-handed volunteers performing a motor task using fMRI and fNIRS. fMRI utilized a 3T scanner and a 20-channel head coil, while fNIRS recorded data with a 48-channel device at 765 nm and 855 nm. Analysis focused on key motor and sensory cortices using NIRS-SPM and SPM12, applying a significance threshold of p < 0.05 and a minimum cluster size of 10 voxels for group analysis. Super-threshold voxels were identified with FWE thresholding in SPM12. For activation map extraction we focused on the primary motor cortex, primary somatosensory cortex, somatosensory association cortex, premotor cortex, and supplementary motor cortex. Both fMRI and fNIRS detected activation in the primary motor cortex (M1). The primary somatosensory cortex was found to influence movement direction coding, with smaller activation sizes for upward movements. Combining fNIRS with fMRI provided clearer differentiation of brain activation patterns for wrist movements in various directions and conditions (p < 0.05). This study highlights variations in left motor cortex activity across different movement states. fNIRS proved effective in detecting brain function and showed strong correlation with fMRI results, suggesting it as a viable alternative for those unable to undergo fMRI.</p>","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"243 1","pages":"36"},"PeriodicalIF":1.7,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Force drifts and matching errors in the lower extremities: implications for the control and perception of foot force.","authors":"Indrek Rannama, Anna Zusa, Mark L Latash","doi":"10.1007/s00221-024-06990-w","DOIUrl":"https://doi.org/10.1007/s00221-024-06990-w","url":null,"abstract":"<p><p>Accurate control of force on the environment is mechanically necessary for many tasks involving the lower extremities. We investigated drifts in the horizontal (shear) active force produced by right-footed seated subjects and the effects of force matching by the other foot. Subjects generated constant shear force at 15% and 30% of maximal voluntary contraction (MVC) using one foot. Visual feedback of shear force magnitude was provided for the first 5s, then turned off for 30s. During the 30% MVC task, we observed parallel drops in active shear and vertical force magnitudes leading to consistent drifts in the resultant force magnitude, not in its direction. Force matching by the other foot resulted in significantly lower forces when feedback was available throughout the trial. No feedback was provided for the matching foot. When the matching foot began exerting force, the task foot experienced a notable drop in all force components, with a change in force direction only for the task foot. After this initial drop, the downward drift in the task foot stopped or reversed. Subjects were unaware of these drifts and errors. Our findings suggest that shear force production involves setting a referent coordinate vector, which shows drifts and matching errors, while its direction remains stable. Involvement of the matching foot appears to perturb the neural commands to the task foot, with minor differences observed between feet. The discrepancy between the consistent force drifts and lack of awareness of the drifts indicates a difference between force perception-to-act and perception-to-report.</p>","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"243 1","pages":"37"},"PeriodicalIF":1.7,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term forced-use therapy after sensorimotor cortex lesions restores contralesional hand function and promotes its preference in Macaca mulatta.","authors":"Warren G Darling, Marc A Pizzimenti, Diane L Rotella, Jizhi Ge, Kimberly S Stilwell-Morecraft, Robert J Morecraft","doi":"10.1007/s00221-024-06949-x","DOIUrl":"https://doi.org/10.1007/s00221-024-06949-x","url":null,"abstract":"<p><p>Injury to one cerebral hemisphere can result in paresis of the contralesional hand and subsequent preference of the ipsilesional hand in daily activities. However, forced use therapy in humans can improve function of the contralesional paretic hand and increase its use in daily activities, although the ipsilesional hand may remain preferred for fine motor activities. Studies in monkeys have shown that minimal forced use of the contralesional hand, which was the preferred hand prior to brain injury, can produce remarkable recovery of function. Here we tested the hypothesis that long-term forced use of the contralesional hand during the post-lesion period can return it to preferred status. Four rhesus monkeys received tests of hand preference prior to surgical lesions of primary motor cortex, lateral premotor cortex and anterior parietal cortex (F2P2 lesion) contralateral to the preferred hand. Beginning two weeks after the lesion, forced use therapy involving contralateral hand reaches to acquire food targets occurred 3X weekly with at least 300 reaches/session until 24 weeks post-lesion. Despite initial paresis of the contralesional hand, its manipulation skill returned to near pre-lesion levels or higher and all four monkeys returned to a contralesional hand preference late in the post-lesion period. Favorable reorganization of spared cortical and subcortical neural networks may promote recovery of hand function and preference. These results have relevance for the use of extensive forced-use therapy in humans who experience unilateral periRolandic injury to potentially support better recovery of contralesional hand function.</p>","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"243 1","pages":"35"},"PeriodicalIF":1.7,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142893092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Noisy galvanic vestibular stimulation induces stochastic resonance in vestibular perceptual thresholds assessed efficiently using confidence reports.","authors":"Talie Stone, Torin K Clark, David R Temple","doi":"10.1007/s00221-024-06984-8","DOIUrl":"https://doi.org/10.1007/s00221-024-06984-8","url":null,"abstract":"<p><p>In sensory perception, stochastic resonance (SR) refers to the application of noise to enhance information transfer, allowing for the sensing of lower-level stimuli. Previously, subjective-assessments identified SR in vestibular perceptual thresholds, assessed using a standard two alternative (i.e., binary), forced-choice task, when applying noisy Galvanic Vestibular Stimulation (nGVS). However, this required extensive testing of at least 100 binary trials to yield sufficiently precise thresholds at each of several nGVS amplitudes, leading to confounds of fatigue, sleepiness, learning, etc. stalling the study of vestibular SR. To mitigate this, we explore confidence reporting, which via a confidence signal detection (CSD) model may much more efficiently identify SR (i.e., with fewer trials), if SR exists in CSD thresholds. To test this, Y-translation thresholds were tested with 100 trials at each nGVS amplitude (0 or sham, 0.1, 0.2, 0.3 and 0.4 mA peak-to-peak). To objectively identify SR, we applied a machine learning classification algorithm trained on simulated datasets. We found significant evidence of SR exhibition using CSD thresholds (p = 0.0025), with six of 10 subjects classified as exhibiting SR. Next, we considered fewer trials, finding the false positive rate of SR identification to be better using CSD thresholds with as few as 50 trials, when compared to 100 binary trials. Applying the CSD model to our subject's data with a subset of their trials found similar classifications of SR exhibition as with 100 binary trials. We demonstrate CSD thresholds exhibit SR, proving a means of better and much more efficiently identifying SR.</p>","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"243 1","pages":"34"},"PeriodicalIF":1.7,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142880656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A detailed inquiry of the differences between headphones and loudspeakers influences on dynamic postural task performance.","authors":"Anat V Lubetzky, Yi Wu, Delong Lin, Alvaro F Olsen, Anjali Yagnik, Daphna Harel, Agnieszka Roginska","doi":"10.1007/s00221-024-06983-9","DOIUrl":"https://doi.org/10.1007/s00221-024-06983-9","url":null,"abstract":"<p><p>We examined the impact of auditory stimuli and their methods on a dynamic balance task performance. Twenty-four young adults wore an HTC Vive headset and dodged a virtual ball to the right or left based on its color (blue to the left, red to the right, and vice versa). We manipulated the environment by introducing congruent (auditory stimuli from the correct direction) or incongruent (auditory stimuli played randomly from either side) and comparing a multimodal (visual and congruent auditory stimuli) to unimodal (visual or auditory stimuli) presentation. We tested four apparatuses: loudspeakers, headphones, passthrough, (wearing headphones while auditory stimuli come from loudspeakers) and room simulation (externalization via headphones). We quantified reaction time (RT) and accuracy (choosing the correct direction to dodge) from the head movement. We hypothesized that the weight of the headset will slow RT, and that externalization of the auditory stimuli will make it more usable when no visual cues are provided. Interestingly, both hypotheses were refuted. In silent conditions, RT was faster with headphones compared to loudspeakers, but this difference disappeared when auditory stimuli were introduced. Participants used congruent auditory stimuli to improve accuracy but disregarded incongruent auditory stimuli across all apparatuses except for room simulation. In conclusion, this study confirmed that healthy young adults can use congruent auditory stimuli to enhance accuracy and disregard incongruent auditory stimuli such that accuracy is not harmed. RT was either faster or the same with headphones compared to loudspeakers. Notably, this specific room simulation did not enhance performance.</p>","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"243 1","pages":"32"},"PeriodicalIF":1.7,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of individually calibrated white and pink noise vestibular stimulation on standing balance of young healthy adults.","authors":"Alkistis Gavriilidou, Vasileios Mylonas, Ioannis Tsalavoutas, Vasileios Konstantakos, George Psillas, Max Wuehr, Vassilia Hatzitaki","doi":"10.1007/s00221-024-06979-5","DOIUrl":"10.1007/s00221-024-06979-5","url":null,"abstract":"<p><p>Imperceptible noisy galvanic vestibular stimulation (nGVS) improves standing balance due to the presence of stochastic resonance (SR). There is, however, a lack of consensus regarding the optimal levels and type of noise used to elicit SR like dynamics. We aimed to confirm the presence of SR behavior in the vestibular system of young healthy adults by examining postural responses to increasing amplitudes of white and pink noise stimulation scaled to individual cutaneous perceptual threshold. Forty (40) healthy young participants (19 males, 25.1 ± 5.6 years) were randomly divided into a group that received nGVS with white (WHITE group) or pink noise (PINK group). Participants performed a cutaneous perceptual threshold detection task followed by 8 trials of quiet standing and eyes closure (60s) with nGVS applied during the last 30s. Balance stabilization was quantified in the ratio of the stimulus versus pre-stimulus Centre of Pressure (CoP) 90% ellipse area, Root Mean Square (RMS) and mean velocity. Cutaneous perceptual threshold was similar across groups. Group analysis confirmed that the mean CoP velocity increased across nGVS intensities, particularly for the PINK group while the other two variables remained unchanged. Single subject analysis indicated that 55% of WHITE and 30% of PINK group participants showed an SR-like response judged by three experts. Results are puzzling with respect to the presence of SR-like response dynamics in young healthy adults and highlight the need for further research using individual calibrated stimulus intensities. White noise seems more effective than pink noise in revealing an SR-like response to nGVS.</p>","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"243 1","pages":"33"},"PeriodicalIF":1.7,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alterations of upper-extremity functional muscle networks in chronic stroke survivors.","authors":"David O'Reilly, Ioannis Delis","doi":"10.1007/s00221-024-06973-x","DOIUrl":"10.1007/s00221-024-06973-x","url":null,"abstract":"<p><p>Current clinical assessment tools don't fully capture the genuine neural deficits experienced by chronic stroke survivors and, consequently, they don't fully explain motor function throughout everyday life. Towards addressing this problem, here we aimed to characterise post-stroke alterations in upper-limb control from a novel perspective to the muscle synergy by applying, for the first time, a computational approach that quantifies diverse types of functional muscle interactions (i.e. functionally-similar (redundant), -complementary (synergistic) and -independent (unique)). From single-trials of a simple forward pointing movement, we extracted networks of functionally diverse muscle interactions from chronic stroke survivors and unimpaired controls, identifying shared and group-specific modules across each interaction type (i.e. redundant, synergistic and unique). Reconciling previous studies, we found evidence for both the concurrent preservation of healthy functional modules post-stroke and muscle network structure alterations underpinned by systemic muscle interaction re-weighting and functional reorganisation across all interaction types. Cluster analysis of stroke survivors revealed two distinct patient subgroups from each interaction type that all distinguished less impaired individuals who were able to adopt novel motor patterns different to unimpaired controls from more severely impaired individuals who did not. Our work here provides a nuanced account of post-stroke functional impairment and, in doing so, paves new avenues towards progressing the clinical use case of muscle synergy analysis.</p>","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"243 1","pages":"31"},"PeriodicalIF":1.7,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11663821/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of workload on mind-wandering of drilling operators measured by electroencephalography (EEG).","authors":"Su Hao, Xie Ruiying, Xu Lifei, Wang Jian, Jiang Jiaxin, Fan Siping, Wang Xiaoqin, Qing Xin, Liu Lu, Zhang Yufeng","doi":"10.1007/s00221-024-06974-w","DOIUrl":"https://doi.org/10.1007/s00221-024-06974-w","url":null,"abstract":"<p><p>Mind wandering can cause workers to overlook safety hazards and delay making accurate operational decisions, ultimately raising the potential for accidents. However, there is relatively little research on the physiological characteristics of drilling workers during mind wandering. The aim of this investigation was to tackle the constraints of previous studies and to establish a more comprehensive theoretical framework and practical guidance for safety management. To this end, the phenomenon of workload on mind wandering among drillers during the drilling process was investigated in depth. It focused on drilling site workers, using SART paradigm tasks and EEG devices to track cognitive states under various loads, exploring how they affect mind wandering and EEG mechanisms. Fifty workers participated, observing drilling images to judge accidents. Results showed workload influenced cognitive processes such as mind wandering occurrence, reaction time, accuracy, and brain connectivity. High workload increased reaction time, decreased accuracy, raised mind wandering frequency, altered theta, beta, and gamma waves, and reduced cerebral synchronisation and engagement. Workload affected employees' mind wandering, sensations, focus, and work status, with a positive correlation between workload and mind wandering, potentially harming work performance and safety. Analyzing EEG data helps identify mind wandering and develop intervention measures. In depth research on these features not only helps identify employee mind wandering, but also promotes the development of more precise and personalized intervention measures.</p>","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"243 1","pages":"29"},"PeriodicalIF":1.7,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142863773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}