Experimental Brain Research最新文献

Employing a single trial motor equivalent analysis for the assessment of motor learning. 采用单试验运动等效分析评估运动学习。

IF 1.7 4区医学

Experimental Brain Research Pub Date : 2025-06-20 DOI: 10.1007/s00221-025-07123-7

Matthew Beerse, Kimberly E Bigelow, Joaquin A Barrios

{"title":"Employing a single trial motor equivalent analysis for the assessment of motor learning.","authors":"Matthew Beerse, Kimberly E Bigelow, Joaquin A Barrios","doi":"10.1007/s00221-025-07123-7","DOIUrl":"10.1007/s00221-025-07123-7","url":null,"abstract":"The uncontrolled manifold analysis (UCM) is a useful technique for motor learning research enabling the classification of movement variability into solutions and errors. Less explored methodological considerations within the UCM framework are the selection of mean configurations outside of the current performance, as found in the Motor Equivalence Analysis, and a single trial approach. In this study, we demonstrated how calculating deviations away from varying mean configurations within the UCM influences the results and interpretations within motor learning experiments. Twelve young adult subjects (9F/3 M, 20.53 ± 1.25 years old) practiced the kettlebell swing over a one-week time period. We compared deviations from the mean configuration across all repetitions, to the mean of the first ten repetitions before practice and to the mean of their last ten repetitions after practice. Results suggested that subjects abandoned their initial mean performance within the first sets of kettlebell swings and reduced their errors and solutions towards what would become their mean performance after practice. They continued to refine their performance 1 week later. Subjects then completed a transfer task, testing their ability to adapt to a water-filled kettlebell. We evaluated deviations from their mean performance with the metal kettlebell and their mean performance with the water-filled kettlebell. Subjects did not reduce errors towards their mean metal kettlebell performance, but instead towards a new performance that matched the dynamics of the water-filled kettlebell. When performance is expected to change, i.e., motor learning, assessing how the variance structure changes with respect to different mean configurations can provide further insight when using a UCM approach.","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"243 7","pages":"179"},"PeriodicalIF":1.7,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12181205/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144332677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brain activation during vocal motor imagery: a pilot functional near-infrared spectroscopy (fNIRS) study. 在声音运动想象过程中的大脑激活：一个试点功能近红外光谱（fNIRS）研究。

IF 1.7 4区医学

Experimental Brain Research Pub Date : 2025-06-20 DOI: 10.1007/s00221-025-07125-5

Narihiro Kodama, Ryo Hatazoe, Kohei Kotegawa

{"title":"Brain activation during vocal motor imagery: a pilot functional near-infrared spectroscopy (fNIRS) study.","authors":"Narihiro Kodama, Ryo Hatazoe, Kohei Kotegawa","doi":"10.1007/s00221-025-07125-5","DOIUrl":"https://doi.org/10.1007/s00221-025-07125-5","url":null,"abstract":"Objective: The purpose of this study was to clarify the differences in brain activation during actual vocalization and imagery, thereby deepening our understanding of the neural mechanisms underlying motor imagery.Study design: Prospective study.Methods: A cross-sectional study was conducted on 23 healthy young adults (aged 21-22 years) who met strict voice and hearing criteria. Participants performed sustained phonation and vocal imagery tasks while listening to pre-recorded audio of the vowel /a:/ and humming /m:/. Brain activity in the right prefrontal cortex (rPFC), frontal pole (FP), and left prefrontal cortex (IPFC) was measured using a 16-channel functional near-infrared spectroscopy (fNIRS) system. A block design with baseline correction was applied to calculate changes in oxyhemoglobin concentration. Motor imagery ability was assessed using imagined Timed Up and Go Test (iTUG), and delta times between normal and maximum walking speeds were calculated.Results: No significant differences in activation values of the rPFC, FP, and IPFC were observed between the vocalization and imagery conditions. In addition, both conditions exhibited large variability across all regions, indicating substantial individual differences. Furthermore, while a significant correlation was found between the delta times of normal and maximum walking speeds, no significant correlations were observed between brain activation in the rPFC, FP, or IPFC and the delta times under the imagery condition.Conclusions: No significant differences were found in neural activation between vocalization and imagery, but high variability in both conditions suggests individual differences. This study highlights both the potential and limitations of using fNIRS to assess brain activity in these tasks.Level of evidence: 4: ","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"243 7","pages":"177"},"PeriodicalIF":1.7,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144332729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of L-carnitine on aging-related learning changes and glutamate-mediated molecular mechanisms. 左旋肉碱对衰老相关学习变化的影响及谷氨酸介导的分子机制。

IF 1.7 4区医学

Experimental Brain Research Pub Date : 2025-06-20 DOI: 10.1007/s00221-025-07089-6

Betül Danışman, Güven Akçay, Çiğdem Gökçek-Saraç, Ayşe Özkan, Mutay Aslan, Dijle Kipmen-Korgun, Narin Derin

{"title":"Effects of L-carnitine on aging-related learning changes and glutamate-mediated molecular mechanisms.","authors":"Betül Danışman, Güven Akçay, Çiğdem Gökçek-Saraç, Ayşe Özkan, Mutay Aslan, Dijle Kipmen-Korgun, Narin Derin","doi":"10.1007/s00221-025-07089-6","DOIUrl":"https://doi.org/10.1007/s00221-025-07089-6","url":null,"abstract":"Age-related cognitive loss has been linked to a possible imbalance in the brain's oxidant/antioxidant system. Additionally, neurotransmitter concentrations, the activity and levels of receptors change in different brain regions depending on aging. The aim of this study was to investigate the effect of chronic L-carnitine administration on learning and memory in naturally aging rat, focusing on its impact on glutamate cycle and receptors. Sixty male 10-month old male Wistar rats were randomly divided into two groups as control and L-carnitine groups. For a period of 7 months, L-carnitine was given at 50 mg/kg/day via oral gavage. The cognitive performance was assessed by novel object recognition and active avoidance tests. Total oxidant capacity and antioxidant capacity levels as well as glutamate and glutamine concentrations were analyzed in the hippocampi. NMDA and AMPA receptors, VGLUT-1, VGLUT-2, EAAT-1, EAAT-2, EAAT-3 levels in hippocampi were evaluated. L-carnitine administration increased learning performance. Total oxidant capacity levels decreased and total antioxidant capacity levels increased in the hippocampus of aged rats treated with L-carnitine. Furthermore, a small shift in the glutamate and glutamine concentrations between control and L-carnitine treated groups were observed. During the aging process, L-carnitine administration caused an increase in VGLUT-1, VGLUT-2, EAAT-1, EAAT-2, EAAT-3 levels in hippocampus tissues. In addition, NMDAR1 and slightly NMDAR2 mRNA levels increased, while AMPAR1 level decreased in the L-carnitine-treated group. Our data suggest that the molecular and functional changes controlling glutamate homeostasis in the hippocampus with aging may be attenuated by long-term L-carnitine usage.","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"243 7","pages":"178"},"PeriodicalIF":1.7,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144332730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Direction-dependent effects of gravity on speed-accuracy trade-off during vertical pointing movements. 在垂直指向运动中，重力对速度-精度权衡的方向依赖效应。

IF 1.7 4区医学

Experimental Brain Research Pub Date : 2025-06-16 DOI: 10.1007/s00221-025-07120-w

Soma Okuuchi, Shinji Yamamoto, Keisuke Tani, Keisuke Kushiro

{"title":"Direction-dependent effects of gravity on speed-accuracy trade-off during vertical pointing movements.","authors":"Soma Okuuchi, Shinji Yamamoto, Keisuke Tani, Keisuke Kushiro","doi":"10.1007/s00221-025-07120-w","DOIUrl":"https://doi.org/10.1007/s00221-025-07120-w","url":null,"abstract":"This study aimed to clarify the effects of gravity on the speed-accuracy trade-off (SAT) for vertical pointing movements. For downward movements, gravity assists the initial acceleration phase and opposes the later deceleration phase; for upward movements, it opposes the initial acceleration and assists the later deceleration. We hypothesized that gravity influences the SAT asymmetry in vertical pointing movements depending on movement direction, which would be observable as temporal kinematic differences during the acceleration and deceleration phases. Twelve participants engaged in vertical pointing movements toward targets of different directions, sizes, and distances. The movement time (MT) obtained was fitted using Fitts's equations: MT = a + b × ID and ID = log2(2A/W), where ID, A, W, a, and b represent the index of difficulty, distance, target size, intercept, and slope factor, respectively. The results showed that the MTs were longer for downward movements than for upward movements. In addition, the slope factor b, which indicates the changing ratio of the MT relative to the term ID, was larger for downward movements than that for upward movements, indicating that the MTs for downward movements changed largely as the target size and distance changed. Furthermore, the temporal properties of pointing movements changed asymmetrically, depending on the movement direction. These results suggest that gravity asymmetrically affects the initial and later phases of vertical pointing movements depending on the movement direction.","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"243 7","pages":"175"},"PeriodicalIF":1.7,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Postural sway variability in young adults presents higher complexity during morning compared to evening hours while in older adults remains the same. 年轻人的体位摇摆变异性在早晨比晚上表现出更高的复杂性，而在老年人中则保持不变。

IF 1.7 4区医学

Experimental Brain Research Pub Date : 2025-06-16 DOI: 10.1007/s00221-025-07121-9

Vasileios Mylonas, Stylianos Grioriadis, Christos Chalitsios, Nick Stergiou, Thomas Nikodelis

{"title":"Postural sway variability in young adults presents higher complexity during morning compared to evening hours while in older adults remains the same.","authors":"Vasileios Mylonas, Stylianos Grioriadis, Christos Chalitsios, Nick Stergiou, Thomas Nikodelis","doi":"10.1007/s00221-025-07121-9","DOIUrl":"10.1007/s00221-025-07121-9","url":null,"abstract":"Human movement variability reflects the adaptive capacity of the nervous system, yet how it is influenced by aging and circadian rhythms remain unclear. Therefore, the purpose of this study was to investigate postural sway variability as a function of aging and time of day. Nineteen young and nineteen older adults completed one 60-s quite stance trial with eyes open while standing on a force platform, at 12 p.m. and 12 a.m. Postural sway variability was evaluated regarding both its magnitude (total travel distance and interquartile range) and the complexity (a exponent using Detrended Fluctuation Analysis) of its temporal structure using the center of pressure time series. A two-way ANOVA (2 age groups × 2 times of day) was used. Correlation analysis was also performed to further investigate the relationship between circadian regulation and postural sway complexity. Complexity was higher for the young compared to the older group independently of the time of day. Furthermore, young adults presented higher values during the morning as compared to evening, while older adults did not reveal significant differences within the day. Finally, a strong correlation was found but only for young adults. In general, our results suggested that complexity of postural sway variability is affected both by age and time of day. Aging impacts postural control by reducing the complexity of sway variability and diminishing its sensitivity to circadian influences. Future work will address the effect of chronotype, sleep, and arousal levels on these novel findings and assess their impact on overall health.","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"243 7","pages":"176"},"PeriodicalIF":1.7,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170733/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neural oscillations in the nucleus accumbens-dorsal hippocampal circuits and behavioral effects of acute fluoxetine administration during the Tail suspension test in mice. 小鼠悬尾试验中伏隔核-海马背侧回路的神经振荡和氟西汀急性给药对行为的影响。

IF 1.7 4区医学

Experimental Brain Research Pub Date : 2025-06-11 DOI: 10.1007/s00221-025-07115-7

Ibrahim Abbas Atiyah, Seree Niyomdecha, Dania Cheaha

{"title":"Neural oscillations in the nucleus accumbens-dorsal hippocampal circuits and behavioral effects of acute fluoxetine administration during the Tail suspension test in mice.","authors":"Ibrahim Abbas Atiyah, Seree Niyomdecha, Dania Cheaha","doi":"10.1007/s00221-025-07115-7","DOIUrl":"https://doi.org/10.1007/s00221-025-07115-7","url":null,"abstract":"Major depressive disorder (MDD) involves dysregulation of limbic circuits mediating stress and reward processing. While selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine typically require chronic administration for clinical efficacy, preclinical studies suggest that a single dose can rapidly modulate neural activity and produce antidepressant-like effects. The present study examined the effects of a single oral dose of fluoxetine (20 mg/kg) on behavioral and neural dynamics in mice undergoing the tail suspension test (TST), a validated paradigm of despair-like behavior. Electrodes were implanted in the nucleus accumbens (NAc) and dorsal hippocampus (dHP), and LFPs were recorded during resting and TST conditions. Behavioral assessments demonstrated that fluoxetine increased locomotor activity during resting and significantly reduced immobility during TST. Spectral analysis revealed that fluoxetine enhanced high-frequency gamma oscillations in the NAc and dHP during both mobility and immobility states, while attenuating stress-induced reductions in gamma power observed in the control group. Coherence analysis indicated that fluoxetine enhanced NAc-dHP functional connectivity, particularly in theta and low gamma bands, during both rest and TST. These effects were state- and region-specific, suggesting selective modulation of mesolimbic-hippocampal circuits. Collectively, these findings demonstrate that acute fluoxetine administration alters neural dynamics associated with behavioral despair and supports the hypothesis that early network-level changes contribute to the antidepressant-like effects observed in preclinical models. This work highlights oscillatory biomarkers and circuit-level targets relevant to fast-acting antidepressant responses.","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"243 7","pages":"174"},"PeriodicalIF":1.7,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144265812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Postural stability during illusory self-motion-interactions of vision and touch. 幻觉自我运动-视觉和触觉相互作用时的姿势稳定性。

IF 1.7 4区医学

Experimental Brain Research Pub Date : 2025-06-10 DOI: 10.1007/s00221-025-07100-0

Yingjia Yu, Avijit Bakshi, Alexander S Panic, Paul DiZio, James R Lackner

{"title":"Postural stability during illusory self-motion-interactions of vision and touch.","authors":"Yingjia Yu, Avijit Bakshi, Alexander S Panic, Paul DiZio, James R Lackner","doi":"10.1007/s00221-025-07100-0","DOIUrl":"10.1007/s00221-025-07100-0","url":null,"abstract":"The role of vision in stabilizing balance has long been recognized, and previous studies have shown that non-supportive fingertip touch can enhance postural stability. However, the interaction between haptic feedback and the illusion of self-motion remains underexplored. We investigated how different phases of visual motion (no motion, visual motion, self-rotation and displacement illusion), motion order (stationary first vs. motion first), and fingertip cutaneous feedback jointly influence balance and the dynamics of haptic contact. Using a head-mounted display, we presented a virtual room that rotated around the standing participants' vertical axis. Participants viewing the rotating scene soon experience illusory self-motion and displacement. We examined how the moving visual scene destabilized posture and how it interacted with tactile cues that typically stabilize balance. Our findings revealed differential effects in classical and stochasticity-sensitive analyses. Postural regulation was distinctly influenced by motion phase, order, and tactile feedback. Changes in motion perception-no motion, visual motion, and apparent self-rotation-were linked to both classical and stochastic aspects of postural sway. In contrast, motion order specifically influenced balance metrics encoding stochasticity, with no effect on those filtering out stochastic variability. Notably, the influence of past visual motion perception persisted, affecting postural sway even after motion ceased. The stabilizing effects of touch were reaffirmed, and motion perception significantly influenced the applied touch forces. Both stochastic and non-stochastic attributes of balance and touch force are responsive to visual motion perturbations and illusions, though motion order exclusively affects stochastic dynamics. These findings provide insights into multisensory interactions.","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"243 7","pages":"173"},"PeriodicalIF":1.7,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12152044/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144265813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How a target's speed influences the extent to which the time or place at which it is intercepted is adjusted. 目标的速度如何影响其被拦截的时间或地点的调整程度。

IF 1.7 4区医学

Experimental Brain Research Pub Date : 2025-06-09 DOI: 10.1007/s00221-025-07108-6

Giorgia Bertonati, Monica Gori, Jeroen B J Smeets, Eli Brenner

{"title":"How a target's speed influences the extent to which the time or place at which it is intercepted is adjusted.","authors":"Giorgia Bertonati, Monica Gori, Jeroen B J Smeets, Eli Brenner","doi":"10.1007/s00221-025-07108-6","DOIUrl":"10.1007/s00221-025-07108-6","url":null,"abstract":"Goal-directed movements are constantly guided by the latest information about the target's position. Nevertheless, movements seldom end perfectly on target, so subsequent movements are adjusted to avoid repeating errors. One could intercept moving targets at different positions at different times, so one could adjust both the position and the timing of the endpoint of both the current and the next movement. It could be advantageous to rely more on adjusting the timing for faster targets, because for faster targets a change in timing corresponds with a larger change in position. We therefore examined how participants responded to 'errors' that were introduced by having slow and fast targets jump slightly backwards or forwards along their path. If there was enough time to adjust the ongoing movement after the jump, timing was indeed responsible for a larger fraction of the adjustment for fast targets. But the actual change in timing did not depend on the target's speed. The same change in timing compensated for a larger part of the error for fast targets, so the position could change less. If there was not enough time to adjust the ongoing movement, neither the timing nor the position on the next trial changed differently for the different target speeds. Consequently, a larger fraction of the error was compensated for if the target moved faster. Thus, how people adjust their timing does not depend on the target's speed, but the same change to the timing has more impact if the target is moving faster.","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"243 7","pages":"171"},"PeriodicalIF":1.7,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12149251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Supervised and unsupervised rehabilitation of visual field defect: cohort investigation of eye movement training at a clinical setting and at home. 视野缺损的监督和无监督康复：临床和家庭眼动训练的队列调查。

IF 1.7 4区医学

Experimental Brain Research Pub Date : 2025-06-09 DOI: 10.1007/s00221-025-07105-9

Valentina Varalta, Sigrid Kenkel, Samuel Johnson, Cristina Fonte, Nicola Smania, Arash Sahraie

{"title":"Supervised and unsupervised rehabilitation of visual field defect: cohort investigation of eye movement training at a clinical setting and at home.","authors":"Valentina Varalta, Sigrid Kenkel, Samuel Johnson, Cristina Fonte, Nicola Smania, Arash Sahraie","doi":"10.1007/s00221-025-07105-9","DOIUrl":"10.1007/s00221-025-07105-9","url":null,"abstract":"Lesions along the visual pathways can lead to areas of blindness, which can extend to an entire hemifield (hemianopia). Hemianopic patients often have abnormal eye-movements which hampers their interaction with their immediate surrounds, adversely affecting their quality of life. Compensatory rehabilitation techniques are aimed at improving eye-movement efficacy enabling patients to make better use of their sighted field to compensate for the sight loss. NeuroEyeCoach (NEC) is a compensatory vision therapy that can be accessed at home and is effective in improving visual search performance and reducing perceived disability. We have compared objective and subjective assessments of visual function before and after vision rehabilitation in a cohort of patients that accessed NEC at home (N = 95) and a group of patients that completed the training under clinical supervision in a rehabilitation clinic (N = 31). Use of NEC led to improvements in both objective measures of visual function such as reduced visual search times, lower search errors, and faster completion of a cancellation task as well as reduced subjective reports of disability. The objective measures showed a larger improvement in those undergoing rehabilitation in the clinic settings compared to the home cohort, nevertheless, there was no cohort x training interaction for perceived improvements in subjective reports of disability. This indicates no significant differences on the effect of training on activities of daily living between the groups. The findings demonstrate that compensatory eye movement training is an effective tool for rehabilitation of vision loss when used in clinical settings or accessed remotely from home.","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"243 7","pages":"172"},"PeriodicalIF":1.7,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12149257/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of repeated intranasal gentamicin irrigation on structure and function of the vestibular brainstem. 反复鼻灌庆大霉素对前庭脑干结构和功能的影响。

IF 1.7 4区医学

Experimental Brain Research Pub Date : 2025-06-09 DOI: 10.1007/s00221-025-07119-3

Zachary Breeden, LeAnn Haddad, Zachary Mendola, Nickolas Vasil, Yusra Mansour, Randy J Kulesza

{"title":"Impact of repeated intranasal gentamicin irrigation on structure and function of the vestibular brainstem.","authors":"Zachary Breeden, LeAnn Haddad, Zachary Mendola, Nickolas Vasil, Yusra Mansour, Randy J Kulesza","doi":"10.1007/s00221-025-07119-3","DOIUrl":"https://doi.org/10.1007/s00221-025-07119-3","url":null,"abstract":"Gentamicin is an aminoglycoside antibiotic that broadly targets Gram-negative bacteria. While gentamicin is a clinically effective antibiotic, it has significant oto- and nephrotoxicity. In human subjects, repeated exposure to gentamicin results in dizziness, tinnitus, and high frequency hearing loss. Gentamicin has similar effects across animal species and through several different routes of delivery, including injection and direct deposits in the tympanic cavity. Gentamicin can also be administered intranasally to treat sinusitis in humans and this route of delivery is believed to minimize toxic effects. Nonetheless, we hypothesized that intranasal irrigation of gentamicin will result in ototoxicity and impaired auditory and vestibular function similar to systemic delivery. We investigated this hypothesis in Sprague-Dawley rats that received bilateral, intranasal irrigations of a therapeutic dose of gentamicin or saline from postnatal day (P) 21-31. We examined vestibular structure and function in control and gentamicin-exposed rats by assessing performance on a series of sensorimotor tasks, recording vestibular evoked myogenic potentials (VEMPs), and examining number and morphology of neurons in the brainstem vestibular nuclei. Gentamicin-exposed animals had significantly worse performance on sensorimotor tasks, significantly slower VEMPs, and significantly fewer neurons in the vestibular nuclei. Together, our findings indicate that intranasal administration of gentamicin results in impaired auditory and vestibular function consistent with other routes of delivery.","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"243 7","pages":"170"},"PeriodicalIF":1.7,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0