Experimental Brain Research最新文献

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Body weight and attentional capture in children. 儿童的体重和注意力捕获。
IF 1.7 4区 医学
Experimental Brain Research Pub Date : 2025-04-25 DOI: 10.1007/s00221-025-07086-9
Shuma Tsurumi, So Kanazawa, Masami K Yamaguchi
{"title":"Body weight and attentional capture in children.","authors":"Shuma Tsurumi, So Kanazawa, Masami K Yamaguchi","doi":"10.1007/s00221-025-07086-9","DOIUrl":"10.1007/s00221-025-07086-9","url":null,"abstract":"<p><p>The present study examined whether numerical representations of body weight capture visual attention in young children. Developmental studies showed that even newborn infants could distinguish between typical and atypical human bodies, and infants aged around six months detect multisensory events occurring on their bodies. These findings suggest that the body image develops earlier and continues to establish. However, the development of recognition of numerical own body information such as body weight is less understood. Therefore, we employed an attentional capture task where children identified a target embedded in a visual stream, preceded by their body weight number presented before the target. A total of 44 Japanese children (ages 8-9 years; equal number of boys and girls) participated. Results indicated that girls exhibited attentional bias toward their weight, whereas boys did not. Compared to boys, girls showed the attentional capture of body weight.</p>","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"243 5","pages":"129"},"PeriodicalIF":1.7,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modulation of individual and synchronized activities of ankle plantarflexors during quiet standing in aroused emotions. 情绪唤醒时静立时踝关节跖屈肌个体和同步活动的调节。
IF 1.7 4区 医学
Experimental Brain Research Pub Date : 2025-04-22 DOI: 10.1007/s00221-025-07046-3
Ryogo Takahashi, Naotsugu Kaneko, Atsushi Oshima, Naoki Tsukamoto, Bowen Liu, Inhyeok Jeong, Mayu Dohata, Kimitaka Nakazawa
{"title":"Modulation of individual and synchronized activities of ankle plantarflexors during quiet standing in aroused emotions.","authors":"Ryogo Takahashi, Naotsugu Kaneko, Atsushi Oshima, Naoki Tsukamoto, Bowen Liu, Inhyeok Jeong, Mayu Dohata, Kimitaka Nakazawa","doi":"10.1007/s00221-025-07046-3","DOIUrl":"10.1007/s00221-025-07046-3","url":null,"abstract":"<p><p>Emotions influence postural control, but previous studies have mainly examined postural dynamics during quiet standing using the center of pressure as a measure. During quiet standing, neuromuscular activities of ankle plantarflexors are crucial for maintaining postural balance, both in terms of individual and synchronized activities. This study aimed to clarify the emotional effects on the individual and synchronized neuromuscular activities of ankle plantarflexors during quiet standing. Twenty-four healthy male participants were instructed to stand and view emotional pictures for 72 s following a fixation cross. The task was repeated four times with four picture conditions, which was composed of two arousals (High and Low) and two valences (Pleasant and Unpleasant). During the task, electromyograms (EMG) of the tibialis anterior (TA), soleus (SOL), and medial (MG) and lateral gastrocnemius muscles (LG) were recorded. The EMG signals were rectified, and mean amplitude was calculated to assess individual neuromuscular activity. Inter-muscular coherence (IMC) between ankle plantarflexors was calculated to assess synchronized neuromuscular activity, with mean IMC calculated at 0-4 Hz, 8-12 Hz, 15-30 Hz, and 30-40 Hz. Results showed that aroused emotions induced a reduction in SOL activity. Aroused emotions also increased IMC at 8-12 Hz, indicating enhanced physiological tremor and reduced capacity for postural adjustment. In addition, IMC at 15-30 Hz was increased while 30-40 Hz was decreased in aroused emotions, implying modulation of cortical common drive to ankle plantarflexors.These findings deepen our understanding of the emotional impacts on standing postural control.</p>","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"243 5","pages":"126"},"PeriodicalIF":1.7,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12014843/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143971615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of transcranial direct current stimulation over the posterior parietal cortex on tactile spatial discrimination. 经颅直流电刺激后顶叶皮层对触觉空间辨别的影响。
IF 1.7 4区 医学
Experimental Brain Research Pub Date : 2025-04-22 DOI: 10.1007/s00221-025-07081-0
Taiga Hiraga, Kei Saito, Sho Kojima, Hideaki Onishi
{"title":"Effects of transcranial direct current stimulation over the posterior parietal cortex on tactile spatial discrimination.","authors":"Taiga Hiraga, Kei Saito, Sho Kojima, Hideaki Onishi","doi":"10.1007/s00221-025-07081-0","DOIUrl":"10.1007/s00221-025-07081-0","url":null,"abstract":"<p><p>The posterior parietal cortex (PPC) plays an important role in discriminating tactile spatial information. Dual-hemisphere transcranial direct current stimulation (tDCS) is a noninvasive and powerful method that can alter cortical excitability. Therefore, the effect of dual-hemisphere tDCS over the PPC on tactile spatial discrimination performance was investigated using the right index finger of 25 participants with normal neurology. The grating orientation discrimination task was performed before, during, and immediately after delivering dual-hemisphere tDCS or unilateral-hemisphere tDCS over the PPC. For dual-hemisphere tDCS, anodal tDCS was applied to the right PPC and cathodal tDCS to the left PPC. Results showed that the effect of dual-hemisphere tDCS and anodal tDCS over the PPC on tactile discrimination performance was significantly higher than sham stimulation. Furthermore, a significant negative correlation was observed between the pre-stimulation tactile discrimination performance and the change in tactile discrimination performance. In conclusion, the stimulatory effect of dual-hemisphere and anodal tDCS over the PPC on tactile discrimination of the right index finger was greater than that of sham stimulation. The effect of both stimulation regimes was associated with baseline tactile discrimination performance.</p>","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"243 5","pages":"125"},"PeriodicalIF":1.7,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143980691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Perceptions and trunk movements elicited by trunk muscle vibration in young adults in static position. 静态状态下年轻人躯干肌肉振动引起的知觉和躯干运动。
IF 1.7 4区 医学
Experimental Brain Research Pub Date : 2025-04-21 DOI: 10.1007/s00221-025-07069-w
Robert Maurice Etoumbe, Carole Fortin, Éloi Dieterlen, Étienne Marteau, Cyril Duclos
{"title":"Perceptions and trunk movements elicited by trunk muscle vibration in young adults in static position.","authors":"Robert Maurice Etoumbe, Carole Fortin, Éloi Dieterlen, Étienne Marteau, Cyril Duclos","doi":"10.1007/s00221-025-07069-w","DOIUrl":"10.1007/s00221-025-07069-w","url":null,"abstract":"<p><p>The present study aimed to investigate whether proprioceptive stimulation by means of multiple muscle vibration (MV) can induce perceptual and actual trunk responses that may differ according to the stability of the body position during stimulation. Fifteen healthy young adults (25.2 ± 4.3 years old) were recruited. Muscle vibration at 80 Hz was applied to multiple abdominal and spinal muscles in sitting and standing positions with the eyes closed in order to see whether position could affect trunk responses. Perceptions and actual trunk movements were assessed using a numeric rating scale (0: no movement perception - 10: vivid movement perception) and a 3D movement analysis system (VICON), respectively. Statistical tests were used to compare different MV conditions in sitting and standing positions and correlations between outcomes. MV induced perceptions of trunk movements, with same median scores (inter-quartile range) of 5.5(3.5)/10 in both sitting and standing positions. Perception of movement in most MV conditions was mostly (37.5-75%) directed toward the direction of concentric contraction of the stimulated muscles, contrary to what is usually expected. The actual movement direction of the trunk aligned with the perceived movement, with average amplitudes in sitting and standing positions between 1.0 and 5.0° depending on the planes of movement and conditions. Amplitude of actual movement and perception scores were moderately correlated, in sitting and standing positions (ρ = 0.38, p < 0.001, both). Findings confirm that MV can temporarily modify the perception and the actual trunk posture in healthy individuals and warrant further investigation in individuals with altered trunk postures.</p>","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"243 5","pages":"124"},"PeriodicalIF":1.7,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anodal transcranial direct current stimulation combined with physical exercise increases postural sway in Parkinson's disease: a double-blind and cross-over study. 经颅阳极直流电刺激联合体育锻炼增加帕金森病的体位摇摆:一项双盲交叉研究
IF 1.7 4区 医学
Experimental Brain Research Pub Date : 2025-04-19 DOI: 10.1007/s00221-025-07004-z
Pedro Paulo Gutierrez, Diego Orcioli-Silva, Gabriel Antonio Gazziero Moraca, Beatriz Regina Legutke, Thiago Martins Sirico, Victor Spiandor Beretta, José Angelo Barela
{"title":"Anodal transcranial direct current stimulation combined with physical exercise increases postural sway in Parkinson's disease: a double-blind and cross-over study.","authors":"Pedro Paulo Gutierrez, Diego Orcioli-Silva, Gabriel Antonio Gazziero Moraca, Beatriz Regina Legutke, Thiago Martins Sirico, Victor Spiandor Beretta, José Angelo Barela","doi":"10.1007/s00221-025-07004-z","DOIUrl":"10.1007/s00221-025-07004-z","url":null,"abstract":"<p><p>Transcranial direct current stimulation (tDCS) has shown promising effects on postural control in people with Parkinson's disease (PwPD). However, the characteristics of the stimulation, such as the specific cortical area targeted and combination with exercise, seem to influence the tDCS effects. Therefore, analyzing these factors is essential for identifying key characteristics and optimizing rehabilitation protocols for postural control in PD.We aimed to analyze the efficacy of tDCS over the primary motor (M1) and pre-frontal cortices (PFC) combined with aerobic exercise on postural control in PwPD. Twenty-one PwPD participated in this crossover, randomized, and double-blind study. The intervention consisted of exercising on a treadmill at moderate intensity for 30 min while receiving the stimulation. tDCS was applied during the central 20 min of exercise over M1, PFC, or sham on 3 different days. Three one-minute trials were conducted with participants standing still on a force platform to assess the center of pressure parameters in anteroposterior (AP) and mediolateral (ML) directions in pre- and post-intervention. Time*stimulation interaction was observed for sway area (p = 0.038) and sway mean amplitude in both the AP (p = 0.009) and ML directions (p = 0.059, marginal effect). Post-hoc analysis indicated a larger sway area and mean amplitude in both directions post-intervention compared to pre-intervention after tDCS application to the M1 and PFC. No significant differences were observed for the sham condition. Our findings suggest that the combination of exercise and tDCS, regardless of the area stimulated, modifies postural control in PwPD, leading to a larger sway.</p>","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"243 5","pages":"123"},"PeriodicalIF":1.7,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143975753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A meta-analysis of functional neuroimaging tasks associated with pseudoneglect. 假性忽视相关功能性神经成像任务的荟萃分析。
IF 1.7 4区 医学
Experimental Brain Research Pub Date : 2025-04-18 DOI: 10.1007/s00221-025-07077-w
Mura Abdul-Nabi, Matthias Niemeier
{"title":"A meta-analysis of functional neuroimaging tasks associated with pseudoneglect.","authors":"Mura Abdul-Nabi, Matthias Niemeier","doi":"10.1007/s00221-025-07077-w","DOIUrl":"10.1007/s00221-025-07077-w","url":null,"abstract":"<p><p>Major evidence for a right-hemisphere dominance of the brain in spatial and/or attentional tasks comes from lesion studies in patients with spatial neglect. However, the neuroanatomy of the different forms of neglect remains a matter of debate, and it remains unclear how dysfunctions in neglect relate to intact processes. In the healthy brain, perceptual pseudoneglect has been considered to be a phenomenon complementary to specific subtypes of neglect as observed in paradigms such as the line bisection task. Therefore, the current study investigated the intact functional anatomy of perceptual pseudoneglect using a meta-analysis to compensate for some of the limitations of individual imaging studies. We collated the data from 24 articles that tested 952 participants with a range of paradigms (landmark task, line bisection, grating-scales task, and number line task) obtaining 337 foci. Using Activation Likelihood Estimation (ALE) we identified a right-hemisphere biased network of cortical areas, including superior and intraparietal regions, the intraoccipital sulcus together with other occipital regions, as well as inferior frontal areas that were associated with perceptual pseudoneglect in partial agreement with lesion studies in patients with neglect. Our study is the first meta-analysis on the mechanisms underlying perceptual judgments which have been shown to give rise to perceptual pseudoneglect.</p>","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"243 5","pages":"122"},"PeriodicalIF":1.7,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Video head impulse test and seasickness susceptibility. 视频头部脉冲测试和晕船易感性。
IF 1.7 4区 医学
Experimental Brain Research Pub Date : 2025-04-16 DOI: 10.1007/s00221-025-07078-9
Yoni Evgeni Gutkovich, Anna Jamison, Daniel Lagami, Yuri Fonar, Kfir Siag, Dror Tal
{"title":"Video head impulse test and seasickness susceptibility.","authors":"Yoni Evgeni Gutkovich, Anna Jamison, Daniel Lagami, Yuri Fonar, Kfir Siag, Dror Tal","doi":"10.1007/s00221-025-07078-9","DOIUrl":"10.1007/s00221-025-07078-9","url":null,"abstract":"<p><p>Seasickness can have a devastating effect on a crewmember's well-being. In the literature, there is a controversy about whether car sickness could be diagnosed by vestibular evaluation tests, specifically by Video Head impulse test (vHIT) a semi-circular canal (SCC) function test. These consequences might be relevant to seasickness susceptibility. Angular acceleration at the pitch and roll planes lead to the development of seasickness. Normative data from vHIT indicates that the vestibulo-ocular reflex (VOR) gain for the anterior and posterior semicircular canals is lower and more variable compared to the lateral SCC VOR gain. It is expected that these differences will be evident in vHIT testing between individuals who are susceptible to seasickness and those who are not. Eighty-six maritime military personnel were assigned to the study. Participants were classified as non-susceptible based on Golding (1-3) and Motion sickness score ≥ 8. Seasickness-susceptible subjects were classified as Golding 6 and Motion sickness score ≤ 7. There was no significant difference in vertical VOR gains, asymmetry ratios, or the proportion of individuals with corrective saccades between the study groups. The results could not differentiate between study groups by the standard vHIT parameters. Further analysis of the left ipsilateral anterior to lateral vHIT mean VOR gain ratio has revealed a significantly lower ratio for the seasickness susceptible group (0.896 ± 0.126 and 0.963 ± 0.128 in seasickness susceptible and non-susceptible groups, respectively, Student's unpaired t-test, P = 0.0187; Cohen's d effect size 0.527543). This observation should be considered as an additional vHIT parameter when evaluating susceptibility to seasickness. This study was retrospectively registered on December 11th, 2022 and assigned the identifier number NCT05657340.</p>","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"243 5","pages":"119"},"PeriodicalIF":1.7,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Do people only adjust ongoing movements vigorously when it is advantageous to do so? 人们是否只在有利的时候才大力调整正在进行的运动?
IF 1.7 4区 医学
Experimental Brain Research Pub Date : 2025-04-16 DOI: 10.1007/s00221-025-07082-z
Eli Brenner, Melissa L Vlasblom, Ivo Rap, Jeroen B J Smeets
{"title":"Do people only adjust ongoing movements vigorously when it is advantageous to do so?","authors":"Eli Brenner, Melissa L Vlasblom, Ivo Rap, Jeroen B J Smeets","doi":"10.1007/s00221-025-07082-z","DOIUrl":"10.1007/s00221-025-07082-z","url":null,"abstract":"<p><p>We previously found that arm movements towards a jittering target are constantly guided by the latest target position: the responses to target displacements became more vigorous as the movement proceeded, as required for the movement to reach the latest position smoothly within the remaining time. Here we examine whether this behaviour was a consequence of how that experiment was designed. We compared the vigour of adjustments in blocks of trials in which targets followed a random walk, as in our previous studies, with the vigour of adjustments in blocks of trials in which the target position varied at random with respect to a fixed position. For the random walk, the latest position is the best estimate of the final position, so neglecting earlier information can be useful. For random variability around a fixed position, the target's position at any instant is equally informative about the final position, so making vigorous adjustments in response to the latest information is pointless. In that case, the best estimate of the final position is the average of all the encountered positions. Some participants responded less vigorously in the latter case, but most did not. We discuss why tuning the adjustments to be complete within the remaining time may be a good strategy, even when the target does not follow a random walk.</p>","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"243 5","pages":"121"},"PeriodicalIF":1.7,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12003514/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Parkinson's disease impairs the controllability of imagined action sequences. 帕金森氏症会损害想象动作序列的可控性。
IF 1.7 4区 医学
Experimental Brain Research Pub Date : 2025-04-16 DOI: 10.1007/s00221-025-07071-2
Kathryn J M Lambert, Anthony Singhal, Ada W S Leung
{"title":"Parkinson's disease impairs the controllability of imagined action sequences.","authors":"Kathryn J M Lambert, Anthony Singhal, Ada W S Leung","doi":"10.1007/s00221-025-07071-2","DOIUrl":"10.1007/s00221-025-07071-2","url":null,"abstract":"<p><p>Parkinson's Disease (PD) leads to deficits in motor control that may stem in part from impaired processing of action representations, which can be investigated using motor imagery. The controllability component of motor imagery in particular refers to the ability to precisely manipulate a motor image. Research measuring this component in PD via the Hand Laterality Judgment Task has generated inconsistent results. We sought to examine whether PD affects the controllability of motor imagery using a test that explicitly directs the use of motor imagery and involves complex action sequences. Thirty-nine people with PD on their regular medication regimen and thirty-eight controls completed the Test of Ability in Movement Imagery (TAMI). The PD group scored significantly worse than controls on the TAMI. Poorer cognitive function predicted lower TAMI scores for the PD group only. These results indicate that people with PD imagine action sequences less accurately than healthy older adults. It is possible that the disease impairs the ability to transfer sensorimotor information across sequential actions, an ability that is key to efficient motor behaviour. An alternative explanation is that motor dysfunction leads to less well-developed action representations for the actions featured in the TAMI, resulting in motor images that were of low fidelity to the target actions in the PD group. Given the documented effects of dopaminergic medication on the cognitive control process that support action sequencing, it would be of interest to determine if a similar pattern of results emerged in people with PD who are off medication.</p>","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"243 5","pages":"120"},"PeriodicalIF":1.7,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143975011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Supraspinal kappa-opioid receptors: new therapeutic strategies for pain, pruritus, and negative emotions. 椎管上kappa-阿片受体:治疗疼痛、瘙痒和负面情绪的新策略。
IF 1.7 4区 医学
Experimental Brain Research Pub Date : 2025-04-15 DOI: 10.1007/s00221-025-07066-z
Li Zhang, Shuai Zhou, Lujin Yan, Xinyu Li, Yunqi Ju, Bo Wu, Hongjie Wang, Jian Wang, Yi Sun
{"title":"Supraspinal kappa-opioid receptors: new therapeutic strategies for pain, pruritus, and negative emotions.","authors":"Li Zhang, Shuai Zhou, Lujin Yan, Xinyu Li, Yunqi Ju, Bo Wu, Hongjie Wang, Jian Wang, Yi Sun","doi":"10.1007/s00221-025-07066-z","DOIUrl":"10.1007/s00221-025-07066-z","url":null,"abstract":"<p><p>Research on kappa-opioid receptor (KOR) regulation of pain and itching has focused primarily on spinal and peripheral levels. However, the role of central KOR in this process, as well as the mechanisms exacerbating negative emotional responses to pain and itching, remains unknown. Therefore, this study aimed to utilize the advantages of intracerebroventricular (i.c.v.) administration of U50488H to explore supraspinal KOR activation on pain, itching, and negative emotions. U50488H, a prototypical KOR agonist, was administered i.c.v., with physiological saline as the control. The Hargreaves test and intradermal injection of histamine and chloroquine were conducted to assess thermal pain and itch behavior, respectively. The elevated plus maze (EPM), open field test (OFT), and tail suspension test (TST) were performed to evaluate negative emotions. i.c.v. administration of U50488H increased thermal pain latencies, reduced scratching behavior, and decreased locomotor activity in the central zone of the OFT and in the open arms of the EPM, while increasing immobility in the TST. i.c.v. pretreatment with the KOR antagonist nor-Binaltorphimine dihydrochloride reversed all of the above behaviors. In conclusion, central administration of U50488H can exhibit analgesic and antipruritic effects while also inducing negative emotional responses. Our results highlight the potential of supraspinal KOR as a promising therapeutic target in the combined treatment of pain, pruritus, and negative emotions.</p>","PeriodicalId":12268,"journal":{"name":"Experimental Brain Research","volume":"243 5","pages":"116"},"PeriodicalIF":1.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12062100/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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