Folia morphologica最新文献

筛选
英文 中文
Inferior mesenteric artery detailed anatomy and morphometry. 肠系膜下动脉详细解剖及形态测定。
IF 1.2 4区 医学
Folia morphologica Pub Date : 2025-06-12 DOI: 10.5603/fm.105299
Radosław Chmiel, Jakub Batko, Aleksiej Juszczak, Jerzy A Walocha, Rafał Jakiel, Michał Piotrowski, Julia Karpierz, Artur Moskała, Krzysztof Woźniak, Dariusz Chmiel, Artur Pasternak
{"title":"Inferior mesenteric artery detailed anatomy and morphometry.","authors":"Radosław Chmiel, Jakub Batko, Aleksiej Juszczak, Jerzy A Walocha, Rafał Jakiel, Michał Piotrowski, Julia Karpierz, Artur Moskała, Krzysztof Woźniak, Dariusz Chmiel, Artur Pasternak","doi":"10.5603/fm.105299","DOIUrl":"https://doi.org/10.5603/fm.105299","url":null,"abstract":"<p><strong>Background: </strong>The inferior mesenteric artery (IMA) supplies blood to the distal transverse colon, descending colon, sigmoid colon, and rectum. A thorough understanding of IMA anatomy is crucial in colon cancer surgeries and emerging percutaneous interventions. However, there is limited research on its precise morphometry, including vessel length, diameters, and branching angles. This study aims to provide a detailed analysis of the IMA focusing on parameters essential for optimizing percutaneous vascular treatments and colon surgeries.</p><p><strong>Materials and methods: </strong>Multiplanar reconstructions and maximum intensity projections were generated from contrast-enhanced computed tomography angiography scans of 105 human bodies obtained during forensic examinations. The inferior mesenteric artery and its branches were assessed, with each scan analyzed and measured using specialized software. Left colic artery (LCA) has been divided into two groups based on its trunk length, and superior rectal artery (SRA) has been divided into three subgroups.</p><p><strong>Results: </strong>A short trunk of the LCA was observed in 38.1% of cases, with an average length of 2.4 mm. A long trunk was observed in 61.9% of scans, with an average length of 42.6 mm. SRA type 1 was found in 53.3% of cases, type 2 in 38.1% of cases, and type 3 in 8.6% of cases. A larger number of sigmoid arteries was observed in women (p = 0.001).</p><p><strong>Conclusions: </strong>In patients with a short left colic artery trunk, procedures in its branches may be easier due to wider angles and larger diameters, improving catheter access. Additionally, extra superior rectal arteries may form before the sigmoid arteries, which could impact colon surgery.</p>","PeriodicalId":12251,"journal":{"name":"Folia morphologica","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Real color sectioned images and correspondence with ultrasound images of the dorsal wrist. 真实彩色切片图像和对应的超声图像的手腕背。
IF 1.2 4区 医学
Folia morphologica Pub Date : 2025-06-12 DOI: 10.5603/fm.106442
Seul Ki Kim, Jin Seo Park, Mi-Sun Hur
{"title":"Real color sectioned images and correspondence with ultrasound images of the dorsal wrist.","authors":"Seul Ki Kim, Jin Seo Park, Mi-Sun Hur","doi":"10.5603/fm.106442","DOIUrl":"https://doi.org/10.5603/fm.106442","url":null,"abstract":"<p><strong>Background: </strong>This study integrated high-resolution sectioned images with ultrasound imaging to investigate the sequential anatomical transitions of the dorsal wrist, focusing on both bony morphology and the positioning of extensor tendons.</p><p><strong>Materials and methods: </strong>As the shapes and articulations of carpal bones changed distally, corresponding shifts in tendon trajectories - such as the radial migration of the extensor pollicis longus tendon and the convergence of the extensor carpi ulnaris and extensor digiti minimi tendons - were consistently observed.</p><p><strong>Results: </strong>These dynamic spatial relationships provide important clinical insights for differentiating normal anatomical variation from tendon displacement or injury.</p><p><strong>Conclusions: </strong>By integrating detailed anatomical visualization with ultrasound assessment, this approach enhances diagnostic accuracy, supports safer minimally invasive procedures, and informs surgical planning for dorsal wrist pathologies.</p>","PeriodicalId":12251,"journal":{"name":"Folia morphologica","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The median sacral artery and its surgical anatomy in pelvic and spinal surgery: a systematic review and meta-analysis. 骨盆和脊柱手术中骶正中动脉及其外科解剖:系统回顾和荟萃分析。
IF 1.2 4区 医学
Folia morphologica Pub Date : 2025-06-12 DOI: 10.5603/fm.105386
Grzegorz Fibiger, Jonasz Tempski, Jakub Wilczek, Katarzyna Majka, Maksymilian Osiowski, Aleksander Osiowski, Szymon Matejuk, Tomasz Stanisław Kozioł, Aleksandra Malik, Wojciech Fibiger, Jerzy A Walocha, Przemysław Pękala
{"title":"The median sacral artery and its surgical anatomy in pelvic and spinal surgery: a systematic review and meta-analysis.","authors":"Grzegorz Fibiger, Jonasz Tempski, Jakub Wilczek, Katarzyna Majka, Maksymilian Osiowski, Aleksander Osiowski, Szymon Matejuk, Tomasz Stanisław Kozioł, Aleksandra Malik, Wojciech Fibiger, Jerzy A Walocha, Przemysław Pękala","doi":"10.5603/fm.105386","DOIUrl":"https://doi.org/10.5603/fm.105386","url":null,"abstract":"<p><strong>Background: </strong>The median sacral artery (MSA) is a small but clinically significant artery arising from the aortic bifurcation and traveling along the anterior sacrum. It supplies the lumbar and sacral vertebrae and, in some cases, parts of the rectum. Despite its size, the MSA is crucial in regional circulation and is particularly relevant in spinal, pelvic, and vascular surgeries. This meta-analysis aims to provide a comprehensive synthesis of anatomical evidence regarding the MSA's origin, variations, and surgical relevance.</p><p><strong>Materials and methods: </strong>A systematic search was conducted in major databases (PubMed, Embase, ScienceDirect, Scopus, Web of Science, and SciELO) until January 2025. Studies reporting anatomical data on the MSA, including its origin, variations, and clinical significance, were included. A total of 13 studies (n = 1,007 arteries) met the criteria.</p><p><strong>Results: </strong>The MSA originated directly from the aorta in 89.98% (95% CI: 84.05%-95.92%) of cases. In 8.27% (95% CI: 3.29%-13.25%), it shared a common origin with a lumbar artery, typically the 4th lumbar artery (97.86%). The 5th lumbar artery variation was rare (0.66%). Regarding its position relative to the sacral midline, the MSA was found on the left (48.80%), right (31.32%), or directly along the midline (13.35%). The mean distance from the midline was 3.54 mm.</p><p><strong>Conclusions: </strong>Recognizing MSA variations is essential for surgical planning to prevent vascular injury during spinal and gynecological procedures. Further cadaveric and imaging studies are needed to enhance procedural safety.</p>","PeriodicalId":12251,"journal":{"name":"Folia morphologica","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characteristics of Vietnamese supraclavicular artery island flap in reconstruction. 越南锁骨上动脉岛状皮瓣重建的特点。
IF 1.2 4区 医学
Folia morphologica Pub Date : 2025-06-12 DOI: 10.5603/fm.106377
Khoa Xuan Ngo, Huu Van Pham, Trung Quang Nguyen, Thinh Duy Ngo, Khang Minh Do
{"title":"Characteristics of Vietnamese supraclavicular artery island flap in reconstruction.","authors":"Khoa Xuan Ngo, Huu Van Pham, Trung Quang Nguyen, Thinh Duy Ngo, Khang Minh Do","doi":"10.5603/fm.106377","DOIUrl":"https://doi.org/10.5603/fm.106377","url":null,"abstract":"<p><strong>Background: </strong>The supraclavicular artery island flap (SCAIF) is increasingly used in head and neck reconstruction due to its consistent anatomy and ease of harvest. However, anatomical studies specific to the Vietnamese population are limited.</p><p><strong>Materials and methods: </strong>A total of 30 flaps were dissected from 15 Vietnamese adult cadavers. Origin, diameter, length, branching patterns, and vascular territory were evaluated.</p><p><strong>Results: </strong>The artery originated from the transverse cervical artery in all cases. Mean diameter was 1.16 ± 0.12 mm; length was 29.40 ± 1.72 mm. Bifurcation was the most common pattern (76.67%), followed by single and trifurcation patterns. Vascular territory averaged 169.11 × 92.33 mm.</p><p><strong>Conclusions: </strong>The supraclavicular artery shows reliable anatomy in Vietnamese cadavers, supporting the clinical applicability of SCAIF. Further clinical studies are needed to confirm the flap's viability and effectiveness in live patients.</p>","PeriodicalId":12251,"journal":{"name":"Folia morphologica","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical approach to anatomical variations of the maxillary sinus - a surgical perspective. 上颌窦解剖变异的临床方法-外科视角。
IF 1.2 4区 医学
Folia morphologica Pub Date : 2025-06-12 DOI: 10.5603/fm.105540
Jakub Jobda, Robert Franczyk, Zygmunt Stopa
{"title":"Clinical approach to anatomical variations of the maxillary sinus - a surgical perspective.","authors":"Jakub Jobda, Robert Franczyk, Zygmunt Stopa","doi":"10.5603/fm.105540","DOIUrl":"https://doi.org/10.5603/fm.105540","url":null,"abstract":"<p><strong>Background: </strong>The maxillary sinus, the largest of paranasal sinuses, according to the unique anatomy, is a structure of great clinical importance for numerous specialists. While the typical sinus anatomy is widely known, the awareness of anatomical variations remains underestimated. The aim of this study is to highlight the clinical significance of co-existing anatomical variations of the maxillary sinus.</p><p><strong>Case report: </strong>The study presents radiological findings noticed in a computed tomography (CT) scans of three patients referred to the Department of Cranio-Maxillo-Facial Surgery with symptoms of the maxillary sinus diseases. In addition to the cause of symptoms, the presence of the ethmomaxillary sinus (case report 1), maxillary sinus (Underwood's) septa, pneumatization and accessory maxillary ostia (case report 2) were noticed. Moreover, the silent sinus syndrome is presented (case report 3).</p><p><strong>Conclusions: </strong>surgeons operating on the maxillary sinus should be aware of anatomical variations, which may affect the procedure outcomes and safety. The presence of coexisting anatomical variations can be challenging to the operator.</p>","PeriodicalId":12251,"journal":{"name":"Folia morphologica","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development and validation of modified prechiasmatic rat model of subarachnoid hemorrhage. 改良大鼠蛛网膜下腔出血交叉前模型的建立与验证。
IF 1.2 4区 医学
Folia morphologica Pub Date : 2025-06-12 DOI: 10.5603/fm.105668
Yizhen Ou, Chao Qin
{"title":"Development and validation of modified prechiasmatic rat model of subarachnoid hemorrhage.","authors":"Yizhen Ou, Chao Qin","doi":"10.5603/fm.105668","DOIUrl":"https://doi.org/10.5603/fm.105668","url":null,"abstract":"<p><strong>Background: </strong>Subarachnoid hemorrhage (SAH) is a severe type of stroke characterized with high morbidity and mortality. Early brain injury (EBI) plays an important role in influencing the prognosis of SAH. Currently few animal models could fully simulate the disease process, and the modeling procedures are complicated and error-prone. We aimed to develop a modified prechiasmatic injection rat model which is reproducible and easy to perform.</p><p><strong>Materials and methods: </strong>The male Sprague-Dawley rats were randomly allocated to the sham group (n = 15) and the model group (n = 15). A burr hole was drilled on the skull,1mm beside the intersection point of the midline and transverse line, and 30μl of autologous blood was slowly injected into the prechiasmatic pool. Neurologic functions, brain water content, and Nisslstaining were conducted to examine early brain injury. GPX4, MDA, GSHand iron concentrations were tested to investigate ferroptosis in SAH rats.</p><p><strong>Results: </strong>The mortality rate of the model group within 24 hours post-modeling was 13.33% (2/15). Blood clots were observed distributed around the prechiasmatic pool and the periphery, indicating successful replication of SAH. Neurologic functions, brain water content, and Nisslstaining confirmed the pathology of early brain injury. GPX4, GSH, MDA and iron levels indicated the presence of ferroptosis.</p><p><strong>Conclusions: </strong>The proposed modified prechiasmatic injection rat model is feasible and reproducible. The model has the potential to be used for investigating mechanisms of subarachnoid hemorrhage and early brain injury.</p>","PeriodicalId":12251,"journal":{"name":"Folia morphologica","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quantitative anatomy of the growing iliacus muscle in the human fetus - an anatomical, digital and statistical study. 人类胎儿生长中的髂肌的定量解剖-一项解剖、数字和统计研究。
IF 1.2 4区 医学
Folia morphologica Pub Date : 2025-05-22 DOI: 10.5603/fm.104994
Magdalena Grzonkowska, Michał Szpinda, Michał Kułakowski, Agnieszka Rogalska, Bartłomiej Hankiewicz, Karol Elster, Mariusz Baumgart
{"title":"Quantitative anatomy of the growing iliacus muscle in the human fetus - an anatomical, digital and statistical study.","authors":"Magdalena Grzonkowska, Michał Szpinda, Michał Kułakowski, Agnieszka Rogalska, Bartłomiej Hankiewicz, Karol Elster, Mariusz Baumgart","doi":"10.5603/fm.104994","DOIUrl":"https://doi.org/10.5603/fm.104994","url":null,"abstract":"<p><p>In the present study, we aimed to quantitatively evaluate the growth of the iliacus muscle in human fetuses. Using anatomical dissection, digital-image analysis (NIS Elements AR 3.0), the volumetric hydrostatic method, and statistical analysis (Student's t-test, regression analysis), we assessed five direct morphometric parameters of the iliacus in 67 human fetuses of both sexes (31 male, 36 female) aged 16-28 weeks of gestation. No significant differences were found between males and females, or between right and left sides, in the measured parameters of the growing iliacus. All linear dimensions (i.e., length and widths) increased according to a logarithmic model, whereas the projected surface area and volume followed a linear growth pattern. The numerical data regarding the iliacus obtained in the present study may be useful in assessing both the skeletal system and fetal development, with potential relevance in surgery.</p>","PeriodicalId":12251,"journal":{"name":"Folia morphologica","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Variations in the anatomy of the basal vein of Rosenthal: a systematic review. 罗森塔尔基底静脉解剖学的变异:系统回顾。
IF 1.2 4区 医学
Folia morphologica Pub Date : 2025-05-22 DOI: 10.5603/fm.105260
Luigi Cofone, Flavio Forte, Mauro Palmieri, Alessandra Serraino, Benedetta Giordano, Samanta Taurone, Ivano Pindinello, Antonio Santoro, Marco Artico, Francesco Maria Galassi
{"title":"Variations in the anatomy of the basal vein of Rosenthal: a systematic review.","authors":"Luigi Cofone, Flavio Forte, Mauro Palmieri, Alessandra Serraino, Benedetta Giordano, Samanta Taurone, Ivano Pindinello, Antonio Santoro, Marco Artico, Francesco Maria Galassi","doi":"10.5603/fm.105260","DOIUrl":"https://doi.org/10.5603/fm.105260","url":null,"abstract":"<p><strong>Background: </strong>The basal vein of Rosenthal (BVR) is a venous structure in the deep cerebral venous system. It plays an important role in cerebral hemorrhages, particularly subarachnoid hemorrhages and perimesencephalic hemorrhages. The aim of this paper was to evaluate the BVR's anatomical and functional classification and its role in various clinical situations.</p><p><strong>Aim of the study: </strong>The review was conducted from inception to September 27, 2024. It was made according to the PRISMA Statement 2020 and using the following databases: Scopus, Pubmed and Web of Science. Studies were considered eligible if they provided precise data and information on the anatomical variation of the basal vein of Rosenthal. The quality assessment was assessed using the Newcastle-Ottawa Quality Assessment Scale.</p><p><strong>Materials and methods: </strong>A total of 12 articles, whose studies were conducted in different countries were included. Data on the classification of the basal vein of Rosenthal, surgical or radiological, and the outcome, mainly haemorrhagic, were reported. BVR type b or c correlates with increased venous fragility and an outcome of idiopathic haemorrhage.</p><p><strong>Conclusions: </strong>The anatomical classification of the BVR highlights the importance of careful surgical planning and prophylactic measures while providing valuable insights into idiopathic cerebral hemorrhages.</p>","PeriodicalId":12251,"journal":{"name":"Folia morphologica","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inflammatory Signaling Pathways and Non-Coding RNAs in Myocardial Infarction: Insights into Pathogenesis and Therapeutic Opportunities. 心肌梗死中的炎症信号通路和非编码rna:发病机制和治疗机会的见解。
IF 1.2 4区 医学
Folia morphologica Pub Date : 2025-05-22 DOI: 10.5603/fm.105003
Sining Bi, Lei Yu, Yongwen Gu
{"title":"Inflammatory Signaling Pathways and Non-Coding RNAs in Myocardial Infarction: Insights into Pathogenesis and Therapeutic Opportunities.","authors":"Sining Bi, Lei Yu, Yongwen Gu","doi":"10.5603/fm.105003","DOIUrl":"https://doi.org/10.5603/fm.105003","url":null,"abstract":"<p><p>Acute myocardial infarction (AMI) is a major contributor to both morbidity and mortality, resulting from the abrupt blockage of a coronary artery. Myocardial reperfusion refers to the re-establishment of coronary blood flow following a period of coronary occlusion, which may provoke an intensified and rapid injury to the myocardium, known as ischemia-reperfusion (I/R) injury. Inflammation is a key feature of myocardial infarction (MI) and ischemia/reperfusion (MI/R) injury, playing a central role among the pathological mechanisms involved in AMI and MI/R injury. Non-coding RNAs (ncRNAs), such as miRNAs, lncRNAs, and circRNAs, constitute a significant portion of the transcribed genome, with their essential roles and potential in regulating and resolving inflammation now well established. Abnormal ncRNA expression has been linked to the worsening of inflammatory processes and plays a role in the pathogenesis of MI and MI/R injury. This study emphasizes the essential roles played by miRNAs and competitive endogenous RNAs (ceRNAs) in the progression of MI and MI/R. In addition, our final section provides an in-depth analysis of the therapeutic targeting of ncRNAs through a variety of methods, including pharmacological interventions, herbal medicine, and exosome-derived stem cell applications, aimed at alleviating inflammation and possibly advancing MI treatment.</p>","PeriodicalId":12251,"journal":{"name":"Folia morphologica","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combination of Quercetin and Curcumin modulates NF-κB inflammatory signaling pathway in murine model of esophageal erosive reflux disease erosive reflux disease. 槲皮素与姜黄素联合对食管糜烂性反流病小鼠模型NF-κB炎症信号通路的调节作用
IF 1.2 4区 医学
Folia morphologica Pub Date : 2025-05-22 DOI: 10.5603/fm.105075
Xiangyun Kong, Jin Xu, Shaik Althaf Hussain, Turki Mayudh Alrubie, Narendra Maddu, Hui Wei
{"title":"Combination of Quercetin and Curcumin modulates NF-κB inflammatory signaling pathway in murine model of esophageal erosive reflux disease erosive reflux disease.","authors":"Xiangyun Kong, Jin Xu, Shaik Althaf Hussain, Turki Mayudh Alrubie, Narendra Maddu, Hui Wei","doi":"10.5603/fm.105075","DOIUrl":"https://doi.org/10.5603/fm.105075","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to investigate whether quercetin, in combination with curcumin, modulates the nuclear factor-kappa B (NF-κB) inflammatory signaling pathway in a murine model of esophageal erosive reflux disease.</p><p><strong>Materials and methods: </strong>The expression levels of NF-κB and inflammatory factors such as interleukin-1beta (IL-1β), IL-8, and tumor necrosis factor-alpha (TNF-α) were analyzed using Real-Time PCR. Additionally, enzyme-linked immunosorbent assay (ELISA) was employed to validate the Real-Time PCR findings. The western blot study was also conducted to determine the effects on NF-kB p-p65, TNF-α, IL-1β, IL-8.</p><p><strong>Results: </strong>The results demonstrated that the combination of quercetin and curcumin significantly suppressed the NF-κB inflammatory pathway by reducing the expression of various examined pro-inflammatory cytokines in the murine model of esophageal erosive reflux disease, achieving greater efficacy than when either compound was used individually.</p><p><strong>Conclusions: </strong>The findings suggest that the synergistic effect of quercetin and curcumin offers a promising approach to mitigating inflammation via modulation of the NF-κB pathway in esophageal erosive reflux disease.</p>","PeriodicalId":12251,"journal":{"name":"Folia morphologica","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信