Folia morphologica最新文献

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Comparison of the efficacy of medial tarsal venous flaps and traditional venous/arterial free flaps in the reconstruction of hand soft tissue defects: A new type of physiological flap. 跗骨内侧静脉皮瓣与传统静脉/动脉游离皮瓣在重建手部软组织缺损中的疗效比较:一种新型的生理性皮瓣。
IF 1.2 4区 医学
Folia morphologica Pub Date : 2024-11-04 DOI: 10.5603/fm.101621
Xiangchang Cao, Fuzhou Yang, Rong Fang, Yaping Zhu, Luo Huang, Fusan Hua, Changqing Bai, Qiming Chen
{"title":"Comparison of the efficacy of medial tarsal venous flaps and traditional venous/arterial free flaps in the reconstruction of hand soft tissue defects: A new type of physiological flap.","authors":"Xiangchang Cao, Fuzhou Yang, Rong Fang, Yaping Zhu, Luo Huang, Fusan Hua, Changqing Bai, Qiming Chen","doi":"10.5603/fm.101621","DOIUrl":"https://doi.org/10.5603/fm.101621","url":null,"abstract":"<p><strong>Background: </strong>The treatment of hand soft tissue defects primarily relies on flap reconstruction. However, traditional venous/arterial free flaps have several disadvantages, including damage to the donor site, bruising, discoloration, blister formation, and even necrosis. These issues can significantly impact patient recovery and outcomes. Therefore, there is a need for alternative approaches that minimize these complications and improve overall patient care.</p><p><strong>Objective: </strong>To compare the efficacy of medial tarsal venous flaps and traditional venous/arterial free flaps in the reconstruction of hand soft tissue defects, evaluating various clinical outcomes and patient recovery metrics.</p><p><strong>Materials and methods: </strong>We screened 30 suitable patients with hand soft tissue defects and randomly assigned them to three groups. Patients in each group were transplanted with either medial tarsal free venous flaps or traditional arterial/venous free flaps to achieve coverage and reconstruction of the soft tissue defects. The results were compared and analyzed using the following metrics: operation time, survival rate, complication rate, pain index, postoperative infection rate, and functional evaluations of both the donor and recipient areas.</p><p><strong>Results: </strong>There was no significant difference in operation time between the medial tarsal free venous flaps and the traditional forearm free venous flaps. The operative time for both types of flaps was shorter than that of the traditional free fibular flap from the hallux. The survival rate of the medial tarsal free venous flaps was comparable to that of the fibular free arterial flaps from the great toes and significantly higher than that of the traditional forearm free venous flaps. The complication rate showed an inverse trend to the survival rate of the flaps. In terms of pain, the pain index for the medial tarsal free venous flaps was significantly lower than that of the fibular free arterial flaps from the hallux and comparable to that of the forearm free venous flaps. Regarding postoperative infection rates, the forearm free venous flap had the highest rate, while there was no significant difference between the medial tarsal free venous flaps and the fibular free arterial flaps from the great toes. The functional recovery of the medial tarsal free venous flaps was good in both the donor and recipient areas. There was no poor functional performance in the donor areas of the fibular free arterial flaps from the hallux or the recipient areas of the forearm free venous flaps.</p><p><strong>Conclusions: </strong>The medial tarsal free venous flaps effectively avoid the disadvantages of traditional venous and arterial free flaps, combining their advantages. These flaps offer shorter operative times, higher survival rates, and lower pain indices. They also provide excellent functional recovery in both donor and recipient areas. Thus, medial tarsal","PeriodicalId":12251,"journal":{"name":"Folia morphologica","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142566901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quantitative anatomy of the infraspinatus muscle in the human fetus. 人类胎儿冈下肌的定量解剖。
IF 1.2 4区 医学
Folia morphologica Pub Date : 2024-10-29 DOI: 10.5603/fm.102413
Maciej Biernacki, Michał Szpinda, Magdalena Grzonkowska, Mateusz Badura, Katarzyna Bogacz, Mariusz Baumgart
{"title":"Quantitative anatomy of the infraspinatus muscle in the human fetus.","authors":"Maciej Biernacki, Michał Szpinda, Magdalena Grzonkowska, Mateusz Badura, Katarzyna Bogacz, Mariusz Baumgart","doi":"10.5603/fm.102413","DOIUrl":"https://doi.org/10.5603/fm.102413","url":null,"abstract":"<p><strong>Background: </strong>The study presents one of the six scapulohumeral muscles, which occupies most of the osteofibrous infraspinatus compartment. Along with the supraspinatus, teres minor and subscapularis muscles, the infraspinatus muscle contributes to the rotator cuff. It protects the posterior aspect of the articular capsule of the shoulder joint, adducts and externally rotates the arm. The aim of the study was to perform the quantitative analysis of the infraspinatus muscle in human fetuses and to elaborate growth dynamics for its morphometric parameters.</p><p><strong>Materials and methods: </strong>Using anatomical dissection, digital image analysis (NIS Elements AR3.0) and statistics (Student's t-test, regression analysis), the vertical, transverse and oblique diameters, muscle circumference and projection surface area of the infraspinatus muscle were measured in 36human fetuses of both sexes (17♂, 19♀) aged 18-30weeks. The infraspinatus muscle revealed neither sex nor laterality differences.</p><p><strong>Results: </strong>All examined morphometric parameters of the infraspinatus muscle increased commensurately in accordance with the following linear functions: y=-4.024 + 0.903×Age ± 0.621 (R²=0.96) for transverse diameter, y=-3.089 + 1.321×Age ± 0.897 (R²=0.97) for vertical diameter, y=-1.161 + 0.632×Age ± 0.444 (R²=0.97) for oblique diameter, y=-13.575 + 3.851×Age ± 1.938 (R²=0.98) for muscle circumference and y=-293.512 + 23.228×Age ±19.650 (R²=0.95) for projection surface area.</p>","PeriodicalId":12251,"journal":{"name":"Folia morphologica","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142521490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Digital image analysis of vertebral body L4 and its ossification center in the human fetus. 人类胎儿 L4 椎体及其骨化中心的数字图像分析。
IF 1.2 4区 医学
Folia morphologica Pub Date : 2024-10-29 DOI: 10.5603/fm.101420
Mariusz Baumgart, Magdalena Grzonkowska, Michał Kułakowski
{"title":"Digital image analysis of vertebral body L4 and its ossification center in the human fetus.","authors":"Mariusz Baumgart, Magdalena Grzonkowska, Michał Kułakowski","doi":"10.5603/fm.101420","DOIUrl":"https://doi.org/10.5603/fm.101420","url":null,"abstract":"<p><p>Using a Siemens-Biograph 128 mCT camera the morphometric analysis of the L4 vertebral body and its ossification center were done in 55human fetuses aged 17 to 30weeks. No sex differences were found. The mean height, transverse and sagittal diameters of L4 vertebral body followed the logarithmic functions: y = -11.797+ 5.208 × ln(age) ± 0.372, y = -23.462 + 9.428 × ln(age) ± 0.702, y = 2.770 + 13.521 × ln(age) ± 1.722, respectively. The mean cross-sectional area of L4 vertebral body followed the linear function: y = -30.683 + 1.976 × age ± 2.701. The mean volume of L4 vertebral body followed the second-degree polynomial function: y = -93.983+ 0.385 × (age)² ± 23.707. The mean transverse and sagittal diameters of the ossification center of L4 vertebral body followed the natural logarithmic function: y = -27.106 + 10.178 × ln(age) ± 0.769 and y = -13.345 + 5.458 × ln(age) ± 0.424, respectively. The mean cross-sectional area and the volume of the ossification center of L4 vertebral body followed the linear function: y = -30.683 + 1.976 × age ± 2.701 and y = -43.214 + 2.760 × age ± 4.085, respectively.</p>","PeriodicalId":12251,"journal":{"name":"Folia morphologica","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142521488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Morphological observation of occipital condyle position in Chinese skulls and potential clinical significance. 中国人头骨枕骨髁位置的形态学观察及其潜在的临床意义。
IF 1.2 4区 医学
Folia morphologica Pub Date : 2024-10-29 DOI: 10.5603/fm.101276
Feng Yuan, Zilan Zhong, Rui Qin, Chuhua Lin, Yikai Li
{"title":"Morphological observation of occipital condyle position in Chinese skulls and potential clinical significance.","authors":"Feng Yuan, Zilan Zhong, Rui Qin, Chuhua Lin, Yikai Li","doi":"10.5603/fm.101276","DOIUrl":"10.5603/fm.101276","url":null,"abstract":"<p><strong>Background: </strong>To study the anatomy of the Chinese occipital condyle and its position relative to the occipital foramen and skull.</p><p><strong>Materials and methods: </strong>Measurements were taken from 106 adult Chinese skulls using a Cartesian coordinate system centered on the foramen magnum. Measurements included the longitudinal diameter of the foramen magnum, distances from various points on the occipital condyles to the foramen magnum and skull landmarks, and the occipital condyle classification index (OCI) and skull-occipital condyle classification index (SOCI).</p><p><strong>Results: </strong>OCI categorized the position of the foramen magnum and occipital condyles into three groups: OCI ≤ 0.40 (3 cases, 2.83%), 0.40 < OCI ≤ 0.50 (75 cases, 70.75%), and OCI > 0.50 (28 cases, 26.42%). SOCI categorized the relationship between the skull and occipital condyles into two groups: 0.5 < SOCI ≤ 0.6 (49 cases, 46.23%) and 0.6 < SOCI ≤ 0.7 (57 cases, 53.77%). Four relationship types were identified based on specific measurements: Type I (23 cases, 21.70%), Type II (42 cases, 39.62%), Type III (4 cases, 3.77%), and Type IV (37 cases, 34.91%).</p><p><strong>Conclusions: </strong>Sagittal movement of the occipital condyle affects the cervical spine's curvature. Asymmetry between the occipital condyles and the foramen magnum may misalign the skull with the body's coronal plane.</p>","PeriodicalId":12251,"journal":{"name":"Folia morphologica","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142521489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Poliumoside inhibits apoptosis, oxidative stress and neuro-inflammation to prevent intracerebroventricular Streptozotocin-induced cognitive dysfunction in Sprague-Dawley Rats: in in-vivo, in-vitro and in-silico study. 波立莫苷抑制细胞凋亡、氧化应激和神经炎症,防止脑室内注射链脲佐菌素诱导的斯普拉格-道利大鼠认知功能障碍:体内、体外和微观研究。
IF 1.2 4区 医学
Folia morphologica Pub Date : 2024-10-24 DOI: 10.5603/fm.101463
Yanan Zuo, Bineng Chen, Xiaokun Li, Guocheng Liu
{"title":"Poliumoside inhibits apoptosis, oxidative stress and neuro-inflammation to prevent intracerebroventricular Streptozotocin-induced cognitive dysfunction in Sprague-Dawley Rats: in in-vivo, in-vitro and in-silico study.","authors":"Yanan Zuo, Bineng Chen, Xiaokun Li, Guocheng Liu","doi":"10.5603/fm.101463","DOIUrl":"https://doi.org/10.5603/fm.101463","url":null,"abstract":"<p><strong>Background: </strong>Alzheimer's disease (AD) is a severe neurological illness causes cognitive decline and mortality if not treated early. However, the current therapeutic modalities are inefficient to manage the cognitive dysfunction of AD. Therefore, in the present manuscript, we have enumerated the pharmacological benefit of Poliumoside in the Streptozotocin-induced cognitive dysfunction in Sprague-Dawley (SD) rats.</p><p><strong>Materials and methods: </strong>Initially, the cognitive dysfunction in rats was induced by the intracerebroventricular administration of Streptozotocin, then rats received PMD (5 mg and 10 mg/kg body weight) was given. Various behavioural analysis, such as Morris water maze (MWM), and object recognition tests (ORT), and locomotor analysis was conducted in PMD treated group. Various biochemical analysis was conducted to analyze the effect of PMD on hippocampus oxidative-nitrosative stress and pro-inflammatory cytokines. MTT assay and annexin V/PI staining was performed to analyse the effect of PMD on the cell viability and neuronal toxicity of PC12 cells, respectively. Molecular docking analysis was also conducted with crystal structure of human AChE.</p><p><strong>Results: </strong>PMD treatment improved cognitive capacity in rats in MWM and ORT. Compared to STZ rats, PMD-treated rats had significantly higher locomotor activity and lower AChE activity. PMD also restores dopamine, 5-HT, and NE levels and reduces metabolic their deactivation as evidenced by increased levels of DOPAC, HVA, 5-HIAA. Nitrite, MDA, SOD, CAT, and GSH levels were restored near normal in PMD-treated rats, reducing hippocampus oxidative-nitrosative stress. Pro-inflammatory cytokines were similarly lowered in PMD-treated rats. In in-vitro studies, PMD did not affect PC12 cell survival at the maximal dose of 10 µM. In addition, PMD concentration-dependently prevents H₂O₂-induced neuronal death in PC12 cells. The in-silico docking analysis showed that the PMD fit snugly into the active site of human AChE by engaging with the anionic domain and the catalytic triad of Trp86, Tyr337, Phe338, and Gly121 residues.</p><p><strong>Conclusions: </strong>In conclusion, our study demonstrated that PMD have significant impact on AD by inhibiting ACheE and restoring neurotransmitter levels, which enhances Ach levels in rats and improves cognitive impairment in STZ rats.</p>","PeriodicalId":12251,"journal":{"name":"Folia morphologica","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142497767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A case report of an Adachi-Williams type CG plus H aortic arch anomaly and implications for the development of the cervicothoracic circulation. 阿达奇-威廉姆斯 CG+H 型主动脉弓畸形病例报告及对颈胸循环发育的影响。
IF 1.2 4区 医学
Folia morphologica Pub Date : 2024-10-10 DOI: 10.5603/fm.102366
Masaharu Yoshihara, Yoshitoku Watabe, Momo Morikawa, Suguru Iwata, Michito Hamada, Tetsuya Sasaki, Noriko Homma, Yosuke Takei
{"title":"A case report of an Adachi-Williams type CG plus H aortic arch anomaly and implications for the development of the cervicothoracic circulation.","authors":"Masaharu Yoshihara, Yoshitoku Watabe, Momo Morikawa, Suguru Iwata, Michito Hamada, Tetsuya Sasaki, Noriko Homma, Yosuke Takei","doi":"10.5603/fm.102366","DOIUrl":"https://doi.org/10.5603/fm.102366","url":null,"abstract":"<p><strong>Background: </strong>It is unclear whether the development of the branches of the subclavian artery is dependent on the proximal part of this artery since great vessel formation is partially regulated by haemodynamic stress. For example, the vertebral artery that usually arises from the subclavian artery might be affected by anomalies in the aortic arch branches. This uncertainty is partly due to the limited reports of highly anomalous cases of proximal and distal branching morphologies. Here, we report an Adachi-Williams type CG plus H aortic arch case found during student dissection and discuss the development of the cervicothoracic circulation.</p><p><strong>Case report: </strong>Here, we report an aberrant right subclavian artery that arose from the aorta distal to the left subclavian artery, via a retroesophageal course, whereas the right and left common carotid arteries arose from a short common trunk from the aorta (the carotid trunk) (Adachi-Williams type H). In addition, the left vertebral artery arose directly from the aortic arch between the carotid trunk and the left subclavian artery (Adachi-Williams type CG). Anomalies in the branching arteries from this aberrant right subclavian artery (the right vertebral artery, internal thoracic artery, thyrocervical trunk, costocervical trunk and thoracoacromial artery) were unidentifiable. The right vagus nerve directly innervates the laryngeal muscles without forming the recurrent nerve.</p><p><strong>Conclusions: </strong>The development of an aberrant right subclavian artery might affect haemodynamic stress in both the proximal and distal regions of the anterior limb region. The distal branching morphology, however, was normal, suggesting an independence of proximal and distal vasculature development. Since the concomitance of Adachi-Williams-type CG and H is rare, rather than sequentially develop, the distal arteries develop in a fine-tuned manner to adapt to anomalies in the proximal arteries.</p>","PeriodicalId":12251,"journal":{"name":"Folia morphologica","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142461531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Incidence and effect of an extra root on the crown morphometry of the maxillary second molars among Malaysian Mongoloids. 马来西亚蒙古人上颌第二臼齿多根的发生率及其对牙冠形态的影响。
IF 1.2 4区 医学
Folia morphologica Pub Date : 2024-10-10 DOI: 10.5603/fm.101502
Rasha Ibrahim Alghali, Phrabhakaran Nambiar, Wei Cheong Ngeow, Norliza Ibrahim, Muhammad Khan Asif, Abeer Saad Al-Mouallad
{"title":"Incidence and effect of an extra root on the crown morphometry of the maxillary second molars among Malaysian Mongoloids.","authors":"Rasha Ibrahim Alghali, Phrabhakaran Nambiar, Wei Cheong Ngeow, Norliza Ibrahim, Muhammad Khan Asif, Abeer Saad Al-Mouallad","doi":"10.5603/fm.101502","DOIUrl":"https://doi.org/10.5603/fm.101502","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to investigate whether the presence of two palatal roots on permanent maxillary second molars (MSMs) can affect the crown size and crown's buccolingual and mesiodistal diameters.</p><p><strong>Materials and methods: </strong>A retrospective study was conducted using 592 CBCT scans to investigate 1120 MSMs of Mongoloid Malaysians. 3D models were created to assess the four-rooted MSMs and other related teeth carefully. Crown size and crown's buccolingual and mesiodistal diameters were measured for the four-rooted MSM, the adjacent maxillary first molar (MFM), and their antimeres to investigate the effect of the presence of an extra root on the size and morphological features of the crown of these associated teeth.</p><p><strong>Results: </strong>Only six out of the 1120 MSMs displayed four roots (0.53%). The incidence was 0.67% (2/298) for the Malay males and 0.4% (1/247) for the Malay females, with the Malay male having a bilateral occurrence of four-rooted MSM. The incidence was 0.34% (1/294) for the Chinese males, while 0.71% (2/281) was detected in Chinese females. Interestingly, the four-rooted MSMs showed a wider mesiodistal distance than their three-rooted antimeres in three out of four cases. The presence of two palatal roots may also increase the crown's buccolingual diameter.</p><p><strong>Conclusions: </strong>The presence of anatomical variations and the dramatic change in crown measurements can be good indicators of the presence of extra roots, including in some of their related neighbours. This might help dentists to take precautionary measures when performing tooth extractions and endodontic therapy.</p>","PeriodicalId":12251,"journal":{"name":"Folia morphologica","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142461478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anti-oxidant, anti-apoptotic and anti-inflammatory effects of geraniin in spinal cord injury in rat: role of COX-2. 刺五加苷对大鼠脊髓损伤的抗氧化、抗凋亡和抗炎作用:COX-2 的作用。
IF 1.2 4区 医学
Folia morphologica Pub Date : 2024-10-10 DOI: 10.5603/fm.101292
Yaping Wang, XinXu Chu, Guangcui Hu, Jianbo Chang
{"title":"Anti-oxidant, anti-apoptotic and anti-inflammatory effects of geraniin in spinal cord injury in rat: role of COX-2.","authors":"Yaping Wang, XinXu Chu, Guangcui Hu, Jianbo Chang","doi":"10.5603/fm.101292","DOIUrl":"https://doi.org/10.5603/fm.101292","url":null,"abstract":"<p><strong>Background: </strong>Spinal cord injury (SCI) is devastating diseases affecting the degeneration of the spinal column, and vascular problems. However, the currently available therapeutic interventions are insufficient to address the effect of SCI which leads to significant impact on the morbidity and mortality of patients. In the present manuscript, we intend to investigate the pharmacological effect of geraniin on the SCI in Sprague-Dawley (SD) rats.</p><p><strong>Materials and methods: </strong>The SCI in rats were induced by the conventional weight-drop method and treated with GER (2.5, 5, and 10 mg/kg). Subsequently, the locomotor activity of rats with SCI was assessed using Basso, Beattie, and Bresnahan (BBB) scores, while oxidative stress indicators and inflammatory variables were analyzed using commercially available kits. Additionally, neuronal death was quantified using TUNEL labeling. The enzymatic activity of caspase 3, 8, and 9 was also assessed. Furthermore, the expression levels of Bcl2, Bax, and COX-2 in rat spinal cords after SCI were analyzed by RT-PCR analysis.</p><p><strong>Results: </strong>Our research indicated that therapy with GER in a manner that depends on the dosage could enhance the functional recovery, as well as reduce the occurrence of apoptosis, mitigate the inflammatory and oxidative response in rats with SCI. Furthermore, it was observed that GER increased the expression of Bcl2 and decreased the expression of Bax and COX-2. The concentration of caspase-3, -8, and -9 was observed to be decreased in SCI rats treated with GER.</p><p><strong>Conclusions: </strong>GER might protect the spinal cord from SCI by reducing apoptosis, oxidative stress, and inflammatory response through the inhibition of COX-2.</p>","PeriodicalId":12251,"journal":{"name":"Folia morphologica","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142461476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardioprotective effect of Perakine against myocardial ischemia-reperfusion injury of type-2 diabetic rat in Langendorff-Perfused Rat Hearts: Role of TLR4/NF-kB signalling pathway. Perakine对2型糖尿病大鼠心肌缺血再灌注损伤的保护作用:TLR4/NF-kB信号通路的作用
IF 1.2 4区 医学
Folia morphologica Pub Date : 2024-10-10 DOI: 10.5603/fm.101274
Jinli Wang, Li Fan
{"title":"Cardioprotective effect of Perakine against myocardial ischemia-reperfusion injury of type-2 diabetic rat in Langendorff-Perfused Rat Hearts: Role of TLR4/NF-kB signalling pathway.","authors":"Jinli Wang, Li Fan","doi":"10.5603/fm.101274","DOIUrl":"https://doi.org/10.5603/fm.101274","url":null,"abstract":"<p><p>Myocardial ischemia-reperfusion (I/R) injury is a grave life-threatening situation, if not treated well in time. The development of natural remedies for myocardial I/R injury has witnessed dramatic growth in the last decade. Prompted by the above, in the present study, we have elucidated the pharmacological effect of Perakine (PER), an indole alkaloid in myocardial ischemia-reperfusion injury in type 2 diabetic rats. The model was established by inducing diabetes in experimental rats followed by the development of myocardial I/R injury model of isolated rat heart by the use of improved Langendorff retrograde perfusion technology. Results of the study suggest that PER significantly lowered the infarct size and infarct volume, and improvement in cardiac ability (LVSP, ±dP/dtmax, and heart rate). It also showed a significant lowering of cardiac biomarkers (CK, CK(MB), ALT, AST, and LDH) in a dose-dependent manner as compared to unprotected IR rats. The level of oxidative stress (MDA, SOD, and GSH) was also found lowered in IR rats together with a reduction in the production of pro-inflammatory cytokines (IL-1β, IL-6, IL-17, and TNF-α). The anti-inflammatory acting of PER on IR rats is believed to be linked with the reduction of TNF-α, NF-κB, and TLR4 in both RT-qPCR and western blot analysis. Our research showed that Perakine could potentially alleviate cardiac ischemia-reperfusion injury in rats by blocking the TLR4/NF-κB signaling cascade.</p>","PeriodicalId":12251,"journal":{"name":"Folia morphologica","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142461477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anatomical theater or full digitization? Students' assessment and preferences in the field of anatomy teaching. 解剖剧场还是完全数字化?解剖学教学领域的学生评估和偏好。
IF 1.2 4区 医学
Folia morphologica Pub Date : 2024-10-10 DOI: 10.5603/fm.101602
Krzysztof Starszak, Radosław Karaś, Andrzej Skalski, Karolina Czarnecka-Chrebelska, Tomasz Lepich, Grzegorz Bajor
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