Folia morphologica最新文献

{"title":"Synergistic effect of curcumin and adriamycin on apoptosis in retinal tumor cells: a molecular and cellular analysis.","authors":"Semih Doğan, Mehmet Cudi Tuncer, İlhan Özdemir","doi":"10.5603/fm.104970","DOIUrl":"https://doi.org/10.5603/fm.104970","url":null,"abstract":"<p><strong>Introduction: </strong>Retinoblastoma (RB) is a highly aggressive eye tumor and directly affects many children due to socioeconomic and medical constraints. Although there are various approaches to the treatment of RB, satisfactory results cannot be obtained. Natural products of plant origin have shown definite therapeutic effects in the treatment of various tumors and are widely used in the study of RB. Curcumin (Cur) is closely related to the expression and activity of various regulatory proteins. In this study, the anticancer roles of the combination of curcumin with a strong chemotherapy agent such as adryamycin (Adr) were demonstrated.</p><p><strong>Materials and methods: </strong>The human retinoblastoma cell line WERI-Rb-1 (HTB-169) was used in the study. It was determined that cytotoxicity increased in cancer cells treated with IC50 doses of Cur and Adr for 48 hours in combined applications. Differences in mRNA levels of Caspase-3, P53 and Survivin genes, which are important triggers and regulators of apoptosis in treated cells, were determined by quantitative simultaneous PCR (qRT-PCR).</p><p><strong>Results: </strong>While it was determined that Cur and Adr application caused a significant increase in both Caspase-3 and P53 mRNA levels, a significant decrease was detected in the mRNA level of Survivin (p < 0.05). In this study, it was shown for the first time that Cur and Adr can exhibit anti-cancer properties by triggering the apoptosis death pathway in retinoblastoma cell lines.</p>","PeriodicalId":12251,"journal":{"name":"Folia morphologica","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subcortical gray matter changes in juvenile myoclonic epilepsy: a volBrain study.","authors":"Gülay Güngör, Olcay Güngör, Yunus Emre Kaban, Onur Orhan, Danış Aygün, Beste Kipçak Yüzbaşı, Vefa Çakmak","doi":"10.5603/fm.103357","DOIUrl":"https://doi.org/10.5603/fm.103357","url":null,"abstract":"<p><strong>Background: </strong>Routine magnetic resonance imaging (MRI) in juvenile myoclonic epilepsy (JME) often shows no obvious abnormalities. However, recent neuroimaging investigations have highlighted potential structural and functional abnormalities in the thalamus of JME patients. This study aimed to investigate brain anatomical differences in JME patients using volBrain, a quantitative assessment method that, to our knowledge, represents one of the first such analyses in the literatüre.</p><p><strong>Materials and methods: </strong>Seventeen patients diagnosed with JME, 18 patients with generalized tonic-clonic seizures alone (GTCA), and 15 healthy controls (HCs) were included in the study. Before starting antiepileptic treatment, we analyzed subcortical gray matter volumes in patients with JME, those with alone GTCA, and HCs using the volBrain method.</p><p><strong>Results: </strong>Seventeen patients with JME (11 females, mean age = 16.1 ± 3.2), 18 patients with GTCS (10 females, mean age = 15.5 ± 2.9), and HCs (10 females, mean age = 15.9 ± 2.8) were included in the analysis. No significant difference was found for relative globus pallidus, caudate, and putamen volumes among the groups with JME, GTCA, and the HC group. In pairwise comparisons, both right and left thalamic volumes were lower in patients with JME than in HCs and in patients with JME than in patients with GTCA.</p><p><strong>Conclusions: </strong>This study underscores the role of volume analysis and the volBrain method in detecting thalamic microstructural changes in JME patients, even when conventional MRI results are normal.</p>","PeriodicalId":12251,"journal":{"name":"Folia morphologica","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardioprotective effect of phytosterol stigmasterol supplementation against doxorubicin-induced cardiotoxicity.","authors":"Ying Wang","doi":"10.5603/fm.103866","DOIUrl":"https://doi.org/10.5603/fm.103866","url":null,"abstract":"<p><strong>Background and objectives: </strong>Stigmasterol, a phytosterol abundantly found in various plant sources, including soybeans and other legumes, plays a significant pharmaceutical role due to its pharmacological properties. Research suggests that stigmasterol exhibits anti-inflammatory, antioxidant, and cholesterol-lowering effects, making it a promising candidate for managing cardiovascular disorders. In this work, we elucidated the cardioprotective potency of stigmasterol against doxorubicin-induced cardiotoxicity in rats.</p><p><strong>Materials and methods: </strong>Hence we have evaluated the potency of stigmasterol supplementation in preventing doxorubicin-induced cardiotoxicity. Male Wistar rats were treated with doxorubicin (2.5 mg/kg) and supplemented with 25 and 50 mg/kg doses of stigmasterol for 14 days. On 14th day of treatment tail-cuff plethysmography was conducted to assess the hemodynamic parameters. The concentrations of oxidative stress markers, cardiac function markers, myocardial damage markers, and inflammatory biomarkers were assessed in the experimental rats using the commercial kits. The heart tissues were subjected to the histopathological analysis. Docking study was also conducted with NF-κB.</p><p><strong>Results: </strong>The stigmasterol treatment effectively increased the body weight and heart weight and elevated the hemodynamic parameters in doxorubinin-induced rats. The stigmasterol treatment also decreased the oxidative stress via increasing antioxidants, reduced the cardiac function markers, and decreased the myocardial damage markers in the doxorubicin-induced rats. Furthermore, the stigmasterol treatment also reduced the inflammatory markers in the doxorubicin-induced rats. The cardioprotective properties of the stigmasterol was further supported by the results of histopathological analysis and docking analysis where it showed excellent binding affinity for NF-κB.</p><p><strong>Conclusions: </strong>The results of tail-cuff plethysmography and cardiac tissue histopathological analysis authentically proved the inhibitory effect of stigmasterol against doxorubicin induced cardiotoxicity. To conclude supplementation with phytochemical stigmasterol persuasively ameliorated doxorubicin induced cardiotoxicity.</p>","PeriodicalId":12251,"journal":{"name":"Folia morphologica","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The rodent amygdala under acute psychological stress: a review.","authors":"Beata Ludkiewicz, Adriana Pszczolinska, Janusz Moryś, Przemysław Kowiański","doi":"10.5603/fm.104021","DOIUrl":"https://doi.org/10.5603/fm.104021","url":null,"abstract":"<p><p>Stress is a common experience in everyday life. Exposure of organisms to threat stimuli requires adaptive mechanisms to maintain homeostasis. Thus, animals possess integrated circuits to generate defensive responses appropriate to the threat and to approach responses proportional to potential gains. The amygdala is a brain structure critical for the stress response. It is subdivided into nuclei that, due to their connections and cytoarchitecture, specifically modulate stress-related behavior. This review focuses on the role of the major amygdala nuclei in response to acute stressors that elicit emotional responses in rodents. Of the two nuclei, central and medial (Me), which constitute the main amygdala output to hypothalamic and brainstem stress-related regions, it is Me appears to be most important in generating anxiety-related responses to an acute psychological stressor. The Me neurons can influence the functioning of the hormonal and the autonomic systems, thereby regulating the defensive and reproductive behavior under stress conditions. The Me not only plays a role in integrating and relaying sensory cues to downstream targets, but also controls behavioral output itself and represents the earliest stage at which specific behavioral responses are determined. The basolateral complex (BLC) appears to play less direct, more 'analytical' functions such as evaluating the valence of stimuli or regulating behavior in situations involving an uncertainty or unpredictability. Moreover, under stress, the BLC may influence regional stress-induced immune and metabolic changes in other limbic structures. The role of the remaining amygdala nuclei involved in stress response is less examined and awaits further research.</p>","PeriodicalId":12251,"journal":{"name":"Folia morphologica","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zygomaticofacial foramen and its surgical anatomy in plastic and maxillofacial surgery - a systematic review with a meta-analysis.","authors":"Grzegorz Fibiger, Katarzyna Majka, Jakub Obrzut, Maksymilian Osiowski, Aleksander Osiowski, Radosław Chudy, Tetiana Tkachuk, Julia Wędrychowicz, Anna Fibiger, Tomasz S Kozioł, Jerzy A Walocha, Przemysław Pękala, Jonasz Tempski","doi":"10.5603/fm.104757","DOIUrl":"https://doi.org/10.5603/fm.104757","url":null,"abstract":"<p><p>A comprehensive understanding of the ZFF is essential in clinical and surgical settings, particularly in procedures involving facial trauma repair, reconstructive and plastic surgery. The aim of this meta-analysis was to obtain anatomical data on ZFF and its variations, in order to emphasize its physiological, as well as clinical implications. A large-scale search was conducted in all major databases (PubMed, Embase, Science Direct, Scopus and Web of Science) in order to determine and pool all available and relevant ZFF data. A total of 22 studies (5438 skull sides) was included. The analysis revealed that in the majority of skull sides, the number of ZFF is one (45.34%, 95% CI: 41.56-49.12), followed by two (25.83%, 95% CI: 18.27-33.39), and then zero (14.11%, 95% CI: 10.15-18.07). The mean diameter of ZFF was 1.23 mm (95% CI: 0.33-2.13). The mean distance from the ZFF to the zygomatic angle was 12.02 mm (95% CI: 10.06-13.98), to the closest point of the orbital rim - 6.71 mm (95% CI: 5.98-7.43), to the midpoint of frontozygomatic suture - 25.50 mm (95% CI: 24.91-26.10), and to the lowest point of the zygomaticomaxillary suture - 19.00 mm (95% CI: 18.39-19.61). Understanding the precise anatomy and variability of the ZFF's prevalence, number and spatial relationships is critical in surgical and clinical practices involving the midfacial region.</p>","PeriodicalId":12251,"journal":{"name":"Folia morphologica","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Opinions of doctors and students regarding teaching aids used during human anatomy course in medical faculties assessed with a questionnaire.","authors":"Jarosław Fugiel, Anna Rohan-Fugiel, Bartosz Poniewierka, Adam Wiatkowski, Marek Syrycki, Dominika Domagała","doi":"10.5603/fm.101743","DOIUrl":"https://doi.org/10.5603/fm.101743","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;The human anatomy course is a fundamental subject in medical education. Understanding the structure and topography of the human body is essential for the years to come and is vital in a doctor's career. Quality education for future doctors is key to teaching process which requires adequate equipment to ensure proper level of training. This concerns the need to create several dissecting rooms to accommodate preserved specimens and whole corpses. It is also necessary to employ teaching, laboratory and technical staff with appropriate competences and experience. Various educational resources have been introduced recently to support anatomy education and enhance teaching, such as virtual anatomical tables and digital anatomical applications, which are already being used by some universities. However, the question remains: can these new methods replace traditional teaching ones? Should the virtual experience prevail over cadaver dissection, during anatomy course? The objective of the study was to gather opinions from doctors and medical students on the effectiveness of teaching human anatomy using anatomical preparations, cadaver dissection, digital applications and other resources to support the educational process.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Materials and methods: &lt;/strong&gt;A total of 962 participants joined the study, including 127 doctors (20 residents and interns) and 835 students (154 first year students and 681 second- to sixth-year students). The study employed a diagnostic survey method, using a questionnaire as the primary tool. In the section of the questionnaire where respondents were asked to evaluate educational resources for teaching human anatomy, they were asked to assess the effectiveness of learning through anatomical preparations, cadaver dissection and digital anatomical applications. The frequency of responses (in percentages) was calculated and differences between doctors and students were analysed using chi-square test.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Majority of respondents agreed that anatomical knowledge is important for other subjects in later years of medical studies and for future professional work. This opinion was shared by both doctors and medical students. Similar amount of respondents also considered anatomical preparations and human cadavers to be the most effective way to teach anatomy. Virtual programs are seen as an interesting and useful additional teaching tool, but they cannot replace hands-on experience in the form of dissection. This was expressed by both doctors and medical students.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;Knowledge of human anatomy is a basic requirement for doctors and the skills acquired through practical classes using anatomical preparations and autopsies are extremely important. Digital anatomical programs are useful as an additional resource in the educational process but cannot replace dissection room classes where students gain hands-on experience in actual cadaver pre","PeriodicalId":12251,"journal":{"name":"Folia morphologica","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meyer's loop and its anatomical importance in surgical planning - a systematic review.","authors":"Agata Mazurek, Urszula Durlak, Viktoriia Popadynets, Julia Dyrcz, Jerzy A Walocha, Tomasz Iskra","doi":"10.5603/fm.104490","DOIUrl":"https://doi.org/10.5603/fm.104490","url":null,"abstract":"<p><strong>Background: </strong>Meyer's loop (ML), the anterior extension of the optic radiation, is critical in neurosurgical planning for temporal lobe procedures. Establishment of accurate localization of ML relative to key anatomical landmarks is crucial to minimize post-surgical visual field deficits.</p><p><strong>Materials and methods: </strong>A systematic review was conducted using PubMed, Scopus, and Embase databases from September to December 2024, following PRISMA 2020 guidelines. Anatomical and radiological studies focused on distances from Meyer's loop to surgical landmarks were included.</p><p><strong>Results: </strong>Out of 1,466 identified studies, 27 met the inclusion criteria (21 radiological and 6 anatomical). 26 of included articles presented measurements of ML-TP distance which ranged from 14.0 to 54.4 mm. Asymmetry of the ML was observed in approximately half of the cases.</p><p><strong>Conclusions: </strong>This review highlights the variability in ML positioning. Thorough individualized surgical planning with properly selected imaging protocol might reduce the risk of postoperative visual field deficits.</p>","PeriodicalId":12251,"journal":{"name":"Folia morphologica","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical treatment for acute pancreatitis and pancreatic necrosis.","authors":"Julia Walkowska, Nicol Zielinska, Piotr Łabętowicz, Bartłomiej Szewczyk, Mariola Głowacka, Janusz Moryś, Ilona Klejbor, Łukasz Olewnik","doi":"10.5603/fm.102684","DOIUrl":"https://doi.org/10.5603/fm.102684","url":null,"abstract":"<p><p>Pancreatitis, considered by clinicians as one of the most demanding abdominal disorders, is a life-threatening disease resulting in numerous complications if treated without early diagnosis or specialized medical care. Management is based on supportive care, including rehydration, pain control, continuous monitoring of vital signs and assessment of organ function, and on early oral feeding. However, there are cases such as acute gallstone pancreatitis, necrotising pancreatitis or acute fulminant (hemorrhagic) pancreatitis that require operative or surgical intervention. As the recent years have brought more experience in the treatment of different types and subtypes of pancreatitis, the guidelines concerning the most effective therapeutic methods, including invasive treatment, are now changing. The aim of the research is to present surgical treatment of acute pancreatitis (AP) in the light of changing patterns of management.</p>","PeriodicalId":12251,"journal":{"name":"Folia morphologica","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphological characteristics of developmental anomalies of the thyroid gland: a prospective single-center cohort study.","authors":"Iryna Samec, Marek Samec, Gabriela Hešková, Ľubomír Straka, Martin Janík, Desanka Výbohová","doi":"10.5603/fm.102943","DOIUrl":"https://doi.org/10.5603/fm.102943","url":null,"abstract":"<p><strong>Background: </strong>Thyroid diverticulum originates between the first and second pharyngeal pouches, and descends via the thyroglossal duct to the level of CV to TI vertebra. By the 6th week of gestation the thyroglossal duct starts to obliterate. Failure in its obliteration causes differentiation of the distal part into the pyramidal lobe (PL), while the cranial portion may alter into a fibromuscular remnant - levator glandulae thyreoideae (LGT).</p><p><strong>Materials and methods: </strong>Morphological characteristics of PL and LGT were prospectively observed in 86 cadavers (66 male and 20 female).</p><p><strong>Results: </strong>PL was observed in 59.3%, occurring more frequently in male cadavers (60.61%) compared to female cadavers (55%). PL was more frequent on the left side (50.98%) than on the right side (39.22%). Junctional PL was determined in 58.82%, isthmic PL in 27.45%, and lobar PL in 13.73%. The average height, width, and area of PL reached 23.81 mm, 13.13 mm, and 320.16 mm², respectively. The most frequent height-to-width ratio of PL was 1.3 : 1. LGT was observed in 47.67% of cadavers. LGT prevailed in male cadavers (48.48%) over female cadavers (45%). LGT occurred commonly on the left side (53.66%) than on the right side (31.71 %). Macroscopic evaluation demonstrated prevalence of fibrous LGTs (65.85%). Hyopyramidal type of LGT was observed in 70.73% of cadavers.</p><p><strong>Conclusions: </strong>Knowledge gained from this study is applicable in the surgical field to reduce the risk of intraoperative and postoperative complications in thyroid surgery.</p>","PeriodicalId":12251,"journal":{"name":"Folia morphologica","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143500048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unique combination of two arterial variations in the neck. A case report with a proposal for enhancement of the existing classifications.","authors":"Lyubomir Gaydarski, Kristina Petrova, Iva N Dimitrova, Łukasz Olewnik, Georgi P Georgiev, Boycho Landzhov","doi":"10.5603/fm.103521","DOIUrl":"https://doi.org/10.5603/fm.103521","url":null,"abstract":"<p><p>Variations in the origin and branching pattern of the superior laryngeal artery are critically crucial for both anatomical understanding and clinical practice, especially for procedures involving the larynx. The superior laryngeal artery typically originates from the superior thyroid artery, a branch of the external carotid artery. However, alternative origins of this artery-such as from the external carotid artery, the common carotid artery, or other branches-have been documented in rare cases. Herein, we present a rare configuration of the external carotid artery branches identified on the left side of the neck of a 76-year-old male cadaver. A shared linguofacial trunk originated from the external carotid artery and then divided into the facial and lingual arteries. Afterward, the lingual artery gave rise to the superior laryngeal artery, which initially coursed horizontally before curving downward toward the larynx. Understanding such anatomical variations is essential for safe and effective surgical intervention and accurate diagnostic imaging, as these patterns can significantly impact surgical approaches in laryngeal procedures, neck reconstructive surgeries, and targeted intra-arterial chemotherapy for cancers affecting the larynx and hypopharynx.</p>","PeriodicalId":12251,"journal":{"name":"Folia morphologica","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143499013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}