Folia morphologica最新文献_第2页

Development and validation of modified prechiasmatic rat model of subarachnoid hemorrhage. 改良大鼠蛛网膜下腔出血交叉前模型的建立与验证。

IF 1.2 4区医学

Folia morphologica Pub Date : 2025-06-12 DOI: 10.5603/fm.105668

Yizhen Ou, Chao Qin

{"title":"Development and validation of modified prechiasmatic rat model of subarachnoid hemorrhage.","authors":"Yizhen Ou, Chao Qin","doi":"10.5603/fm.105668","DOIUrl":"https://doi.org/10.5603/fm.105668","url":null,"abstract":"Background: Subarachnoid hemorrhage (SAH) is a severe type of stroke characterized with high morbidity and mortality. Early brain injury (EBI) plays an important role in influencing the prognosis of SAH. Currently few animal models could fully simulate the disease process, and the modeling procedures are complicated and error-prone. We aimed to develop a modified prechiasmatic injection rat model which is reproducible and easy to perform.Materials and methods: The male Sprague-Dawley rats were randomly allocated to the sham group (n = 15) and the model group (n = 15). A burr hole was drilled on the skull,1mm beside the intersection point of the midline and transverse line, and 30μl of autologous blood was slowly injected into the prechiasmatic pool. Neurologic functions, brain water content, and Nisslstaining were conducted to examine early brain injury. GPX4, MDA, GSHand iron concentrations were tested to investigate ferroptosis in SAH rats.Results: The mortality rate of the model group within 24 hours post-modeling was 13.33% (2/15). Blood clots were observed distributed around the prechiasmatic pool and the periphery, indicating successful replication of SAH. Neurologic functions, brain water content, and Nisslstaining confirmed the pathology of early brain injury. GPX4, GSH, MDA and iron levels indicated the presence of ferroptosis.Conclusions: The proposed modified prechiasmatic injection rat model is feasible and reproducible. The model has the potential to be used for investigating mechanisms of subarachnoid hemorrhage and early brain injury.","PeriodicalId":12251,"journal":{"name":"Folia morphologica","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantitative anatomy of the growing iliacus muscle in the human fetus - an anatomical, digital and statistical study. 人类胎儿生长中的髂肌的定量解剖-一项解剖、数字和统计研究。

IF 1.2 4区医学

Folia morphologica Pub Date : 2025-05-22 DOI: 10.5603/fm.104994

Magdalena Grzonkowska, Michał Szpinda, Michał Kułakowski, Agnieszka Rogalska, Bartłomiej Hankiewicz, Karol Elster, Mariusz Baumgart

引用次数: 0

Anomalous celiac trunk associated with accessory spleens and variant renal and inferior phrenic vessels: case report and brief review. 腹腔干异常伴副脾及肾、膈下血管变异一例报告及简要回顾。

IF 1.2 4区医学

Folia morphologica Pub Date : 2025-05-22 DOI: 10.5603/fm.105213

Gehan El-Akbawy, Emad Nafie, Yuko Ito, Nabil Eid

{"title":"Anomalous celiac trunk associated with accessory spleens and variant renal and inferior phrenic vessels: case report and brief review.","authors":"Gehan El-Akbawy, Emad Nafie, Yuko Ito, Nabil Eid","doi":"10.5603/fm.105213","DOIUrl":"https://doi.org/10.5603/fm.105213","url":null,"abstract":"Background: Identification of anatomical variations in the celiac trunk is crucial for the success of various diagnostic and surgical procedures, including liver transplantation, splenectomy, and hepatobiliary and pancreatic operations. A lack of studies exists reporting the coexistence of celiac trunk variants and visceral variations, such as an accessory spleen.Case report: During a routine dissection of 26 formalin-fixed cadavers for undergraduate students, the authors observed an anomalous celiac trunk in a 78-year-old woman. The typical trifurcation of the celiac trunk into the left gastric, splenic, and common hepatic arteries was absent. It was replaced by two trunks arising from the abdominal aorta: a gastrosplenic trunk branching into the left gastric and splenic arteries and a hepatomesenteric trunk giving rise to the superior mesenteric and common hepatic arteries. These two arterial trunks were consistent with the type V branching pattern of the celiac trunk based on the Adachi classification. Notably, two accessory spleens were also seen near the splenic hilum. Further dissection revealed an accessory left renal vein, a high origin of the right renal artery, and a common inferior phrenic artery trunk.Conclusions: This is the first report of a combination of accessory spleens and variations in the celiac trunk and phrenic and renal vessels. The presented findings have implications for splenic, renal, and gastrointestinal surgery.","PeriodicalId":12251,"journal":{"name":"Folia morphologica","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Variations in the anatomy of the basal vein of Rosenthal: a systematic review. 罗森塔尔基底静脉解剖学的变异：系统回顾。

IF 1.2 4区医学

Folia morphologica Pub Date : 2025-05-22 DOI: 10.5603/fm.105260

Luigi Cofone, Flavio Forte, Mauro Palmieri, Alessandra Serraino, Benedetta Giordano, Samanta Taurone, Ivano Pindinello, Antonio Santoro, Marco Artico, Francesco Maria Galassi

{"title":"Variations in the anatomy of the basal vein of Rosenthal: a systematic review.","authors":"Luigi Cofone, Flavio Forte, Mauro Palmieri, Alessandra Serraino, Benedetta Giordano, Samanta Taurone, Ivano Pindinello, Antonio Santoro, Marco Artico, Francesco Maria Galassi","doi":"10.5603/fm.105260","DOIUrl":"https://doi.org/10.5603/fm.105260","url":null,"abstract":"Background: The basal vein of Rosenthal (BVR) is a venous structure in the deep cerebral venous system. It plays an important role in cerebral hemorrhages, particularly subarachnoid hemorrhages and perimesencephalic hemorrhages. The aim of this paper was to evaluate the BVR's anatomical and functional classification and its role in various clinical situations.Aim of the study: The review was conducted from inception to September 27, 2024. It was made according to the PRISMA Statement 2020 and using the following databases: Scopus, Pubmed and Web of Science. Studies were considered eligible if they provided precise data and information on the anatomical variation of the basal vein of Rosenthal. The quality assessment was assessed using the Newcastle-Ottawa Quality Assessment Scale.Materials and methods: A total of 12 articles, whose studies were conducted in different countries were included. Data on the classification of the basal vein of Rosenthal, surgical or radiological, and the outcome, mainly haemorrhagic, were reported. BVR type b or c correlates with increased venous fragility and an outcome of idiopathic haemorrhage.Conclusions: The anatomical classification of the BVR highlights the importance of careful surgical planning and prophylactic measures while providing valuable insights into idiopathic cerebral hemorrhages.","PeriodicalId":12251,"journal":{"name":"Folia morphologica","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inflammatory Signaling Pathways and Non-Coding RNAs in Myocardial Infarction: Insights into Pathogenesis and Therapeutic Opportunities. 心肌梗死中的炎症信号通路和非编码rna：发病机制和治疗机会的见解。

IF 1.2 4区医学

Folia morphologica Pub Date : 2025-05-22 DOI: 10.5603/fm.105003

Sining Bi, Lei Yu, Yongwen Gu

{"title":"Inflammatory Signaling Pathways and Non-Coding RNAs in Myocardial Infarction: Insights into Pathogenesis and Therapeutic Opportunities.","authors":"Sining Bi, Lei Yu, Yongwen Gu","doi":"10.5603/fm.105003","DOIUrl":"https://doi.org/10.5603/fm.105003","url":null,"abstract":"Acute myocardial infarction (AMI) is a major contributor to both morbidity and mortality, resulting from the abrupt blockage of a coronary artery. Myocardial reperfusion refers to the re-establishment of coronary blood flow following a period of coronary occlusion, which may provoke an intensified and rapid injury to the myocardium, known as ischemia-reperfusion (I/R) injury. Inflammation is a key feature of myocardial infarction (MI) and ischemia/reperfusion (MI/R) injury, playing a central role among the pathological mechanisms involved in AMI and MI/R injury. Non-coding RNAs (ncRNAs), such as miRNAs, lncRNAs, and circRNAs, constitute a significant portion of the transcribed genome, with their essential roles and potential in regulating and resolving inflammation now well established. Abnormal ncRNA expression has been linked to the worsening of inflammatory processes and plays a role in the pathogenesis of MI and MI/R injury. This study emphasizes the essential roles played by miRNAs and competitive endogenous RNAs (ceRNAs) in the progression of MI and MI/R. In addition, our final section provides an in-depth analysis of the therapeutic targeting of ncRNAs through a variety of methods, including pharmacological interventions, herbal medicine, and exosome-derived stem cell applications, aimed at alleviating inflammation and possibly advancing MI treatment.","PeriodicalId":12251,"journal":{"name":"Folia morphologica","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combination of Quercetin and Curcumin modulates NF-κB inflammatory signaling pathway in murine model of esophageal erosive reflux disease erosive reflux disease. 槲皮素与姜黄素联合对食管糜烂性反流病小鼠模型NF-κB炎症信号通路的调节作用

IF 1.2 4区医学

Folia morphologica Pub Date : 2025-05-22 DOI: 10.5603/fm.105075

Xiangyun Kong, Jin Xu, Shaik Althaf Hussain, Turki Mayudh Alrubie, Narendra Maddu, Hui Wei

{"title":"Combination of Quercetin and Curcumin modulates NF-κB inflammatory signaling pathway in murine model of esophageal erosive reflux disease erosive reflux disease.","authors":"Xiangyun Kong, Jin Xu, Shaik Althaf Hussain, Turki Mayudh Alrubie, Narendra Maddu, Hui Wei","doi":"10.5603/fm.105075","DOIUrl":"https://doi.org/10.5603/fm.105075","url":null,"abstract":"Background: This study aimed to investigate whether quercetin, in combination with curcumin, modulates the nuclear factor-kappa B (NF-κB) inflammatory signaling pathway in a murine model of esophageal erosive reflux disease.Materials and methods: The expression levels of NF-κB and inflammatory factors such as interleukin-1beta (IL-1β), IL-8, and tumor necrosis factor-alpha (TNF-α) were analyzed using Real-Time PCR. Additionally, enzyme-linked immunosorbent assay (ELISA) was employed to validate the Real-Time PCR findings. The western blot study was also conducted to determine the effects on NF-kB p-p65, TNF-α, IL-1β, IL-8.Results: The results demonstrated that the combination of quercetin and curcumin significantly suppressed the NF-κB inflammatory pathway by reducing the expression of various examined pro-inflammatory cytokines in the murine model of esophageal erosive reflux disease, achieving greater efficacy than when either compound was used individually.Conclusions: The findings suggest that the synergistic effect of quercetin and curcumin offers a promising approach to mitigating inflammation via modulation of the NF-κB pathway in esophageal erosive reflux disease.","PeriodicalId":12251,"journal":{"name":"Folia morphologica","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypoplasia-like lung deformity in a porcine foetus. 猪胎儿肺发育不全样畸形。

IF 1.2 4区医学

Folia morphologica Pub Date : 2025-05-22 DOI: 10.5603/fm.105471

Hidaka Anetai, Saori Anetai, Takashi Amari, Masahiro To, Nae Hinata

引用次数: 0

Root and canal morphology of mandibular first premolars in a Polish population: A cone-beam computed tomography study. 波兰人群下颌第一前磨牙的根管形态：锥束计算机断层扫描研究。

IF 1.2 4区医学

Folia morphologica Pub Date : 2025-05-22 DOI: 10.5603/fm.105466

Mateusz Mrozek, Ewa Marek, Hannah Blum, Deborah Pauly, Till Dammaschke, Liliana Szyszka-Sommerfeld, Agnieszka Droździk, Ryta Łagocka, Krzysztof Safranow, Mariusz Lipski

{"title":"Root and canal morphology of mandibular first premolars in a Polish population: A cone-beam computed tomography study.","authors":"Mateusz Mrozek, Ewa Marek, Hannah Blum, Deborah Pauly, Till Dammaschke, Liliana Szyszka-Sommerfeld, Agnieszka Droździk, Ryta Łagocka, Krzysztof Safranow, Mariusz Lipski","doi":"10.5603/fm.105466","DOIUrl":"https://doi.org/10.5603/fm.105466","url":null,"abstract":"Background: This study aimed to assess the root and canal morphology of mandibular first premolars in a Polish population using cone-beam computed tomography (CBCT) and to correlate the findings with tooth position and patient gender. Additionally, the symmetry of root and canal anatomy between the right and left sides in the same patient was evaluated.Materials and methods: The root and root canal morphology of 479 mandibular first premolars of 277 Polish patients with a mean age of 43.2 years, varying from 18 to 76 years were analyzed using CBCT. In 202 patients, the available documentation allowed a bilateral symmetry assessment.Results: Among the 479 examined premolars, 467 teeth (97.5%) had a single root, 11 (2.3%) had two roots, and one (0.2%) had three roots. Regarding canal configuration, 387 teeth (80.8%) had a single canal, 88 (18.4%) had two canals; and four (0.8%) had three canals. The most common canal configuration were type I (80.8%) and type V (14.6%). No statistically significant differences were observed in root or root canal morphology concerning tooth side and gender. A high degree of perfect symmetry (94.6%) was noted.Conclusions: Single-root with one root canal was the most prevalent of first mandibular premolar in the Polish population. However, incidence of another root and canal configurations were detected. These findings may help Polish dentists in diagnosis, decision-making and root canal treatment of premolar teeth.","PeriodicalId":12251,"journal":{"name":"Folia morphologica","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morphometric analysis and typing of talus and calcaneus bones from the Eastern Anatolian population. 东安纳托利亚人群距骨和跟骨形态计量学分析及分型。

IF 1.2 4区医学

Folia morphologica Pub Date : 2025-05-22 DOI: 10.5603/fm.104428

Asli Beril Karakas, Yalcin Akbulut, Burhan Yarar, Mukadder Sunar

{"title":"Morphometric analysis and typing of talus and calcaneus bones from the Eastern Anatolian population.","authors":"Asli Beril Karakas, Yalcin Akbulut, Burhan Yarar, Mukadder Sunar","doi":"10.5603/fm.104428","DOIUrl":"https://doi.org/10.5603/fm.104428","url":null,"abstract":"Background: The talus and calcaneus are critical components of foot biomechanics, contributing to stability and movement. Despite their importance, data on their morphometric and articular characteristics in the Eastern Anatolian population are scarce. This study aims to bridge this gap by analyzing the morphometry and facet configurations of talus and calcaneus from this region, highlighting their clinical and biomechanical significance.Materials and methods: A total of 32 tali and 29 calcanei were analyzed using high-resolution computed tomography (CT) and 3D reconstruction. Morphometric measurements, including lengths, widths, and facet areas, were performed, and articular facet types were classified based on established criteria. Comparative analyses were conducted with data from other populations.Results: Significant side-specific variations were observed in lengths and sulcus dimensions. Type B was the most prevalent facet configuration in both talus and calcaneus, with unique patterns such as Type B3 emphasizing the anatomical distinctiveness of the Eastern Anatolian population. Comparisons with other populations revealed larger morphometric dimensions and distinct facet distributions, underscoring population-specific differences.Conclusions: This study provides valuable morphometric and facet classification data for talus and calcaneus in the Eastern Anatolian population. These findings contribute to a deeper understanding of regional anatomical variations and have significant implications for clinical applications, forensic investigations, and prosthetic design.","PeriodicalId":12251,"journal":{"name":"Folia morphologica","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinically relevant anatomical variations in the posterior intercostal neurovascular bundle. 后肋间神经血管束的临床相关解剖变异。

IF 1.2 4区医学

Folia morphologica Pub Date : 2025-05-06 DOI: 10.5603/fm.104771

Bijo Elsy

{"title":"Clinically relevant anatomical variations in the posterior intercostal neurovascular bundle.","authors":"Bijo Elsy","doi":"10.5603/fm.104771","DOIUrl":"https://doi.org/10.5603/fm.104771","url":null,"abstract":"Background: This study focused on the variations of the structures in the posterior intercostal neurovascular bundle.Materials and methods: Dissected the posterior intercostal spaces (1st-11th) of 12 cadavers from the vertebral body to the anterior to the mid-axillary line. Variations in the arrangement, course, relations, patterns, and rare features of the structures were observed.Results: In the neurovascular bundle, four types of arrangement of the structures from superior to inferior were observed. Presence of a foetal connecting branch between the left 9th and 10th posterior intercostal veins and the left 7th and 8th intercostal nerves. The posterior intercostal artery passes lateral to the white ramus communicans of the corresponding intercostal nerve. The 1st thoracic ventral ramus and 2nd intercostal nerve are connected to the stellate and 2nd thoracic ganglia by different white rami communicantes. In the 1st intercostal space, type A and D intrathoracic nerves of Kuntz were observed. Collateral intercostal nerves have different points of origin, reach the superior border of the inferior rib, and have communications and terminations. A left 7th collateral intercostal nerve originated from the connecting branch between the 7th and 8th intercostal nerves. A left 9th lateral cutaneous nerve originated from the collateral intercostal nerve.Conclusions: Intercostal nerve block and thoracic clinical procedures require an understanding of the variations in the neurovascular bundle. Awareness of the different types of intrathoracic nerves of Kuntz and white rami communicantes and foetal connecting branches between adjacent intercostal nerves and posterior intercostal vessels in adults are useful in surgical approaches.","PeriodicalId":12251,"journal":{"name":"Folia morphologica","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0