Food & Nutrition Research最新文献

{"title":"Erratum: Nobiletin inhibits breast cancer via p38 mitogen-activated protein kinase, nuclear transcription factor-κB, and nuclear factor erythroid 2-related factor 2 pathways in MCF-7 cells.","authors":"Jianli Liu, Shuai Wang, Siqi Tian, Yin He, Hong Lou, Zhijun Yang, Yuchi Kong, Xiangyu Cao","doi":"10.29219/fnr.v69.12680","DOIUrl":"https://doi.org/10.29219/fnr.v69.12680","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.29219/fnr.v62.1323.].</p>","PeriodicalId":12119,"journal":{"name":"Food & Nutrition Research","volume":"69 ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12664300/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145647907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inclusion of macroalgae in the diet - a comparative survey from Norway, Chile and China.","authors":"Franz Goecke, Inger Aakre, Lisse Angarita, Na Li, Xiaodong Li, María Cristina Escobar, Silvana Cisternas, Lianzhu Wang, Shaojun Pang, Åshild Ergon","doi":"10.29219/fnr.v69.10856","DOIUrl":"10.29219/fnr.v69.10856","url":null,"abstract":"<p><strong>Background: </strong>Macroalgae have been an important dietary component in many parts of the world for centuries, especially in Eastern Asia. In recent years, a combination of factors has contributed to enhance the use of macroalgae as food in the global market. Since macroalgae as a commercially available food are new in many countries, only a handful of studies have investigated their use and consumption.</p><p><strong>Objective: </strong>In this tri-continental survey, we included three distant countries, each known for macroalgae producers with a long coast: Chile, China, and Norway. Our objective was to compare current uses of macroalgae as food, in a convenient sample dominated by male and female adult students.</p><p><strong>Design: </strong>A macroalgae-specific food frequency questionnaire with a 4-week recall period was used to assess intake frequencies, species, and product types among a convenient sample of Norwegian, Chinese, and Chilean students.</p><p><strong>Results: </strong>A total of 585 respondents who answered the survey considered macroalgae as appealing foods due to their flavor (23-67%) and nutritional benefits (49-90%). This study reported lack of awareness about potential food safety issues in this group. In the samples from Chile and China, tradition was important in terms of consumption of macroalgae, while food novelty seemed to be a major factor in the Norwegian group. However, all three countries consumed a similar number of species (17-19) and products containing macroalgae (17-18). Chinese respondents especially stood out for their frequency of consuming different products containing algae.</p><p><strong>Discussion and conclusion: </strong>A variety of species were found the diet in all the population groups, either in pure form or as an ingredient in a variety of products. Further research on macroalgae intake in Norway, including amounts consumed, would be useful to develop food regulations and, furthermore, recommendations that are commonly known to consumers.</p>","PeriodicalId":12119,"journal":{"name":"Food & Nutrition Research","volume":"69 ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12255160/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A thermogenic botanical composition containing <i>Citrus aurantifolia</i> fruit rind and <i>Theobroma cacao</i> seed extracts improves body composition in overweight adults: a clinical investigation.","authors":"Amulya Chadalavada, Yean Kyoung Koo, SukJin Kim, Sudipta Veeramachaneni, Guru Ramanathan, Amulya Yalamanchi","doi":"10.29219/fnr.v69.12159","DOIUrl":"10.29219/fnr.v69.12159","url":null,"abstract":"<p><strong>Background and objective: </strong>CL19183, or Theolim™, is a novel, proprietary combination of standardized extracts of <i>Citrus aurantifolia</i> fruit rind and <i>Theobroma cacao</i> seeds. Earlier, CL19183 supplementation demonstrated thermogenic activity and weight loss in high-fat diet-induced obese rats. This randomized, double-blind, placebo-controlled, multicenter clinical study (RCT) assessed whether CL19183 supplementation reduced body weight (BW) and improved body composition (BC) in overweight adults.</p><p><strong>Methods: </strong>The present study recruited 120 overweight male and female subjects (25-55 years) [body mass index (BMI) of 25-29.9 kg/m²] and randomly assigned to receive daily either CL19183 (450 mg; <i>n</i> = 60) or a matched placebo (<i>n</i> = 60) over 16 weeks. The primary efficacy outcome measure was BW reduction in the intention-to-treat (ITT) population. Other efficacy measures included BC using Dual-energy X-ray absorptiometry (DEXA), waist and hip circumferences, resting metabolic rate (RMR) using indirect calorimetry, serum lipid profile, and serum biomarkers utilizing enzyme-linked immunosorbent assay (ELISA). The safety parameters were performed, including complete serum biochemistry, hematology, and urine analysis.</p><p><strong>Results: </strong>Post-trial, CL19183 supplementation resulted in significant reductions in BW (4.25 ± 1.35 vs. 0.96 ± 1.18 kg; <i>p</i> = 0.0001; CI [confidence interval]: 1.47, 8.59) and BMI (1.57 ± 0.53 vs 0.36 ± 0.46 kg/m², <i>p</i> < 0.0001; CI: 0.87, 2.11), from baseline as compared to placebo. Similarly, total body fat (4.28 ± 1.56 vs. 0.85 ± 1.06 kg; <i>p</i> < 0.0001; CI: 2.35, 7.79) and fat percentage (<i>p</i> < 0.0001) were also reduced from baseline in the CL19183 group vs. placebo. At baseline, after a single dose of CL19183 administration and after 16 weeks, RMR was significantly increased (<i>p</i> < 0.0001 vs. placebo). After 8 and 16 weeks of supplementation, CL19183 significantly increased serum adiponectin and glucagon-like peptide-1 and decreased ghrelin levels vs. baseline and placebo. No major adverse events were reported.</p><p><strong>Conclusion: </strong>CL19183 supplementation was well-tolerated and led to significant BW reduction and improvements in BC over 16 weeks.</p>","PeriodicalId":12119,"journal":{"name":"Food & Nutrition Research","volume":"69 ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12255159/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Definitions of ultra-processed foods beyond NOVA: a systematic review and evaluation.","authors":"Anine Christine Medin, Stine Rambekk Gulowsen, Synne Groufh-Jacobsen, Ingunn Berget, Ida Synnøve Grini, Paula Varela","doi":"10.29219/fnr.v69.12217","DOIUrl":"10.29219/fnr.v69.12217","url":null,"abstract":"<p><strong>Background: </strong>Ultra-processed foods (UPFs) are associated with negative health outcomes, but current classification systems, including the dominant NOVA system, are typically not suitable for identifying which factors of these foods may be harmful. New ways of defining UPFs are needed to better understand how food processing affects health.</p><p><strong>Objective: </strong>To identify classification systems that include a category for ultra-processed or highly processed foods with a focus on comparing their definitions and provide a current evaluation of available alternatives to NOVA.</p><p><strong>Design: </strong>A systematic literature review was conducted following the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines, with the search strategy developed in collaboration with a university librarian. The literature search was completed on 18 December 2023, using databases Medline, Embase (via Ovid), and Web of Science. No human participants were included.</p><p><strong>Results: </strong>We identified six systems - NOVA, European Prospective Investigation into Cancer and Nutrition (EPIC), International Food Policy Research Institute (IFPRI), University of North Carolina (UNC), UnProcessed Pantry Project (UP3), and Siga - that categorize highly processed food or UPFs. These systems differ in structure and detail, with NOVA, EPIC, and Siga providing specific examples of processing techniques. Regarding additives, NOVA, Siga, and UP3 include them explicitly, with Siga offering the most detailed categorization based on additives and ingredients. Siga also includes quantitative measures for nutritional quality, including cut-offs for sugar, fat, and salt, while IFPRI and UP3 address nutritional quality non-quantitatively.</p><p><strong>Discussion: </strong>When comparing NOVA's UPF category with the highly processed food or UPF categories used in the other five identified systems, we found that none specifies processing techniques clearly. Both NOVA and Siga define additives unique to their UPF categories. Siga stands out by addressing the diverse risks associated with additives and offering quantitative nutritional quality criteria, thus addressing some of the criticisms of how UPFs are commonly defined.</p><p><strong>Conclusions: </strong>Siga represents a valuable, but not final, step forward in classifying UPFs and could serve as a reference in developing a new operational definition for UPFs.</p>","PeriodicalId":12119,"journal":{"name":"Food & Nutrition Research","volume":"69 ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12255158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Allium hookeri</i> extracts inhibit cisplatin-induced apoptosis and inflammation in human kidney HEK-293 cells.","authors":"Ha-Rin Moon, Wooje Lee, Jung-Mi Yun","doi":"10.29219/fnr.v69.10764","DOIUrl":"10.29219/fnr.v69.10764","url":null,"abstract":"<p><strong>Background: </strong>Cisplatin is widely utilized in the treatment of solid malignant tumors due to its potent anticancer effects through the inhibition of cell division. However, its clinical use is often limited by significant adverse effects, particularly nephrotoxicity. Recent research has focused on natural products as potential mitigators of cisplatin-induced kidney toxicity. <i>Allium hookeri</i> (<i>A. hookeri</i>), a traditional food and herbal medicine in Southeast Asia, is known for its antioxidant and anti-inflammatory properties. However, its protective effects against nephrotoxicity remain unclear.</p><p><strong>Objective: </strong>This study aimed to investigate the protective effects of <i>A. hookeri</i> against cisplatin-induced nephrotoxicity in human embryonic kidney (HEK)-293 cells.</p><p><strong>Methods: </strong>HEK-293 cells were treated with cisplatin (50 μM) with or without <i>A. hookeri</i> water extract (AHWE) and ethanol extract (AHEE) for 24 h. Cell viability was assessed using MTT assays, and nuclear morphology was examined through Hoechst 33342 staining. Intracellular reactive oxygen species (ROS) production was quantified using ROS detection assays, and nitric oxide (NO) production was measured through Griess reaction assays. Protein and mRNA expression levels were analyzed using western blotting and quantitative polymerase chain reaction (qPCR) techniques.</p><p><strong>Results: </strong>Cisplatin treatment (50 μM) significantly increased ROS production compared to untreated cells within 24 h. Both AHWE and AHEE treatments markedly attenuated ROS generation. Additionally, AHWE and AHEE significantly inhibited NO production and downregulated the expression of inflammation-related genes. The treatments also suppressed mitogen-activated protein kinase (MAPK) protein expression. Pretreatment with AHWE and AHEE decreased the Bax/Bcl-2 expression ratio, demonstrating a dose-dependent inhibition of apoptotic features.</p><p><strong>Conclusion: </strong>The findings suggest that <i>A. hookeri</i> exerts protective effects against cisplatin-induced kidney damage by modulating MAPK signaling, thereby reducing inflammation and apoptosis in HEK-293 cells. <i>A. hookeri</i> represents a promising therapeutic candidate for the prevention and treatment of nephrotoxicity.</p>","PeriodicalId":12119,"journal":{"name":"Food & Nutrition Research","volume":"69 ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12255161/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the gut microbiota's role: Monascus fermented ginseng's impact on hyperlipidemia in vitro","authors":"Qing Zhou, Yingying Zhang, Mingyue Jia, Qingsong Qu, Xinhui Peng, Wei Ren, Guoqing Li, Yuhao Xie, Bingxuan Li, Xinyuan Shi","doi":"10.1016/j.fnutr.2025.100018","DOIUrl":"https://doi.org/10.1016/j.fnutr.2025.100018","url":null,"abstract":"Hyperlipidemia (HLP) is a lipid metabolic disorder with substantial health hazards. Monascus fermented ginseng (MFG) is considered to play a role in regulating lipid metabolism and the gut microbiota imbalance induced by HLP, but its mechanism is still unclear. This study aimed to elucidate the role and mechanism of gut microbiota in the treatment of HLP by MFG in vitro . We evaluated the performance of the media and explored the optimal incubation time based on gut microbiota activity and composition. Then, MFG and the gut microbiota of HLP mice were co-incubated in an anaerobic environment in vitro . The results showed that the YCFA medium performs well in the in vitro culture of HLP mice gut microbiota. MFG intervention increased the microbial biomass and Short-chain fatty acids content, decreased the pH in vitro culture media. In addition, MFG could enhance the diversity and relative abundance of gut microbiota, reduce the Firmicutes/Bacteroidetes ratio. Collectively, the results described herein will contribute to the elucidation of the therapeutic mechanisms of MFG in HLP, offering new perspectives for the treatment of HLP.","PeriodicalId":12119,"journal":{"name":"Food & Nutrition Research","volume":"1 1","pages":"100018-100018"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147333740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effect of <i>Allium hookeri</i> water extract and its main compound, Cycloalliin, on foam cell formation in THP-1-derived macrophages.","authors":"Ha-Rin Moon, Jung-Mi Yun","doi":"10.29219/fnr.v69.10763","DOIUrl":"10.29219/fnr.v69.10763","url":null,"abstract":"<p><strong>Background: </strong>Low-density lipoproteins are oxidized and modified by macrophages. This process leads to the formation of macrophage-derived cholesterol-rich foam cells, which are a hallmark of early atherosclerosis. The accumulation of these form cells plays a crucial role in atherosclerosis progression. <i>Allium hookeri</i> (<i>A. hookeri</i>), a medicinal herb commonly used in Southeast Asia, is known for its various bioactive effects, including antioxidant, antibacterial, and antidiabetic properties. However, the repressive effect of <i>A. hookeri</i> extract on foam cell formation in THP-1 macrophages remains unclear.</p><p><strong>Objective: </strong>This study aims to explore the effect of <i>A. hookeri</i> hot water extract (AHWE) and its primary compound, cycloalliin, on foam cell formation. This investigation involves a combined treatment of oxidized low-density lipoprotein and lipopolysaccharide to stimulate the development of atherosclerosis <i>in vitro.</i> Additionally, the regulatory mechanisms underlying this process were elucidated.</p><p><strong>Design: </strong>THP-1 cells were differentiated by phorbol 12-myristate 13-acetate (PMA) (1 μM) for 48 h. Subsequently, they were treated with either AHWE or cycloalliin for 48 h. THP-1 macrophages were treated with combined ox-LDL (20 μg/mL) and LPS (500 ng/mL) for 24 h. Cell viability was assessed using MTT assays, while lipid accumulation was visualized through Oil Red O staining. The levels of corresponding proteins and mRNA were quantified using western blotting and quantitative polymerase chain reactions.</p><p><strong>Results: </strong>THP-1 cells were differentiated with PMA (1 μM) for 48 h and then treated with or without AHWE and cycloalliin for 48 h. Subsequently, THP-1 macrophages were treated with combined ox-LDL (20 μg/mL) and LPS (500 ng/mL) for 24 h before harvesting. Ox-LDL and LPS treatment for 24 h enhanced the lipid accumulation in foam cells compared to those in untreated cells using Oil red O staining. Conversely, AHWE and cycloalliin treatment inhibited lipid accumulation in foam cells. These treatments significantly upregulated cholesterol efflux-related genes, including ATP binding cassette subfamily A member 1 (ABCA1), liver-X-receptor ɑ (LXRɑ), and peroxisome proliferator-activated receptor gamma (PPARγ) expression. Additionally, AHWE and cycloalliin decreased lipid accumulation-related genes, including lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), cluster of differentiation 36 (CD36), and scavenger receptor A1 (SR-A1) expression. Furthermore, the combined treatment of ox-LDL and LPS increased the activation and expression of nuclear factor-κB (NF-κB), cyclooxygenase-2 (COX-2), and pro-inflammatory cytokines (tumor necrosis factor-α [TNF-α] and IL-6) compared with those in untreated cells. However, AHWE and cycloalliin suppressed the expression of NF-κB, COX-2, TNF-α, and IL-6.</p><p><strong>Conclusions: </strong>AHWE and cy","PeriodicalId":12119,"journal":{"name":"Food & Nutrition Research","volume":"69 ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12138981/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: Attenuation of postprandial blood glucose in humans consuming isomaltodextrin: carbohydrate loading studies.","authors":"Tsuyoshi Sadakiyo, Yuki Ishida, Shin-Ichiro Inoue, Yoshifumi Taniguchi, Takeo Sakurai, Ryodai Takagaki, Mayumi Kurose, Tetsuya Mori, Akiko Yamashita-Yasuda, Hitoshi Mitsuzumi, Michio Kubota, Hikaru Watanabe, Shigeharu Fukuda","doi":"10.29219/fnr.v69.12729","DOIUrl":"https://doi.org/10.29219/fnr.v69.12729","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1080/16546628.2017.1325306.].</p>","PeriodicalId":12119,"journal":{"name":"Food & Nutrition Research","volume":"69 ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12138979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-harvest quality management of sweet corn: Disorders, losses and preservation strategies","authors":"Aarizoo Mushtaq, Aabida Jabeen, Monisa Yousouf, Mudasir Ahmad Malik, Taha Mukhtar, Tawheed Amin, Shabnum Showkat, Asima Rafiq","doi":"10.1016/j.fnutr.2025.100007","DOIUrl":"https://doi.org/10.1016/j.fnutr.2025.100007","url":null,"abstract":"Sweet corn ( Zea mays L .) a staple food crop, serves as a significant nutritional source for humans. Belonging to the Poaceae family, sweet corn comes in diverse varieties worldwide, with regional preferences influencing the choice of specific type. Unlike field corn, sweet corn is harvested at the milk stage, characterized by high sugar and moisture content, which enhances its sensory appeal but also renders it highly perishable. Key consumer-valued traits such as sweetness, aroma, and vibrant color are particularly vulnerable to rapid deterioration after harvest. Major post-harvest disorders—including loss of sweetness due to sugar-to-starch conversion, kernel dehydration, fungal contamination, and post-cooking browning—contribute significantly to quality loss and market value reduction. Effective post-harvest management strategies, particularly low-temperature storage and controlled handling, are critical in mitigating these issues by slowing respiration rates and microbial activity. This comprehensive review examines the physiological and biochemical changes affecting sweet corn quality post-harvest, identifies the primary causes of deterioration, and evaluates current and emerging preservation techniques aimed at reducing losses and extending shelf life. The review also highlights existing research gaps and proposes integrative strategies to ensure the delivery of high-quality sweet corn from farm to consumer. • Sweet corn is perishable due to its higher respiration rate • Loss of sweetness, dehydration, fungal growth are major post-harvest issues • Use of appropriate techniques can prevent post-harvest losses","PeriodicalId":12119,"journal":{"name":"Food & Nutrition Research","volume":"1 1","pages":"100007-100007"},"PeriodicalIF":0.0,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147899485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fermented ginseng powder enriched with rare ginsenosides ameliorates high-fat diet-induced obesity by modulating adipogenesis and inflammation.","authors":"Xueyue Tai, Jiating Li, Jianwei Song, Bao Zhong, Fenglin Li","doi":"10.29219/fnr.v69.12230","DOIUrl":"10.29219/fnr.v69.12230","url":null,"abstract":"<p><p>Administration of high-dose fermented ginseng powder (2.385 mg/g) resulted in a reduction in body weight and an improvement in blood biochemical parameters in high-fat diet (HFD)-fed mice. Significant reductions in lipid droplet size were observed in both liver and epididymal adipose tissues. Western blot analysis showed increased protein levels of PPAR-α, PPAR-γ, and PGC-1 in the HFD + low-dose lyophilized fermented ginseng powder (HDL), HFD + medium-dose lyophilized fermented ginseng powder (HDM), and HFD + high-dose lyophilized fermented ginseng powder (HDH) groups compared to the HD group. Furthermore, the phosphorylation of AMPK (P-AMPK) and ACC (P-ACC) was significantly elevated. Conversely, western blot analysis demonstrated a decrease in the expression of inflammatory cytokines IL-1, IL-6, and TNF-α in the CG, HDL, HDM, and HDH groups compared to the HD group. Gene expression analysis revealed a downregulation of lipid anabolism-related genes, including <i>SREBP-1c</i> and <i>FAS</i>, along with an upregulation of <i>PPAR-γ</i> and <i>ACOX-1</i> mRNA levels. Additionally, the expression of inflammation-related genes such as <i>IL-1</i>, <i>IL-6</i>, and <i>TNF-α</i> was reduced. High-dose freeze-dried fermented ginseng powder (2.385 mg/g) significantly influenced lipid metabolism and inflammatory responses, highlighting its potential as a therapeutic agent for the management of dyslipidemia.</p>","PeriodicalId":12119,"journal":{"name":"Food & Nutrition Research","volume":"69 ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12138988/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}