Expert Review of Endocrinology & Metabolism最新文献_第6页

Molecular imaging of thyroid and parathyroid diseases. 甲状腺和甲状旁腺疾病的分子成像。

IF 2.7

Expert Review of Endocrinology & Metabolism Pub Date : 2024-07-01 Epub Date: 2024-06-18 DOI: 10.1080/17446651.2024.2365776

Petra Petranović Ovčariček, Letizia Calderoni, Alfredo Campenni, Stefano Fanti, Luca Giovanella

{"title":"Molecular imaging of thyroid and parathyroid diseases.","authors":"Petra Petranović Ovčariček, Letizia Calderoni, Alfredo Campenni, Stefano Fanti, Luca Giovanella","doi":"10.1080/17446651.2024.2365776","DOIUrl":"10.1080/17446651.2024.2365776","url":null,"abstract":"Introduction: Molecular imaging of thyroid and parathyroid diseases has changed in recent years due to the introduction of new radiopharmaceuticals and new imaging techniques. Accordingly, we provided an clinicians-oriented overview of such techniques and their indications.Areas covered: A review of the literature was performed in the PubMed, Web of Science, and Scopus without time or language restrictions through the use of one or more fitting search criteria and terms as well as through screening of references in relevant selected papers. Literature up to and including December 2023 was included. Screening of titles/abstracts and removal of duplicates was performed and the full texts of the remaining potentially relevant articles were retrieved and reviewed.Expert opinion: Thyroid and parathyroid scintigraphy remains integral in patients with thyrotoxicosis, thyroid nodules, differentiated thyroid cancer and, respectively, hyperparathyroidism. In the last years positron-emission tomography with different tracers emerged as a more accurate alternative in evaluating indeterminate thyroid nodules [18F-fluorodeoxyglucose (FDG)], differentiated thyroid cancer [124I-iodide, 18F-tetrafluoroborate, 18F-FDG] and hyperparathyroidism [18F-fluorocholine]. Other PET tracers are useful in evaluating relapsing/advanced forms of medullary thyroid cancer (18F-FDOPA) and selecting patients with advanced follicular and medullary thyroid cancers for theranostic treatments (68Ga/177Ga-somatostatin analogues).","PeriodicalId":12107,"journal":{"name":"Expert Review of Endocrinology & Metabolism","volume":"19 4","pages":"317-333"},"PeriodicalIF":2.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141426666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Obesity in type 1 diabetes: an overlooked immune-metabolic issue. 1 型糖尿病患者的肥胖问题：一个被忽视的免疫代谢问题。

IF 3.2

Expert Review of Endocrinology & Metabolism Pub Date : 2024-07-01 Epub Date: 2024-05-06 DOI: 10.1080/17446651.2024.2351868

Ernesto Maddaloni, Dario Tuccinardi

引用次数: 0

Unmasking the escalation: a comparative analysis of diabetic ketoacidosis severity before and during the COVID-19 pandemic in a Tunisian pioneer study. 揭开升级的面纱：突尼斯先驱研究对 COVID-19 大流行之前和期间糖尿病酮症酸中毒严重程度的比较分析。

IF 3.2

Expert Review of Endocrinology & Metabolism Pub Date : 2024-07-01 Epub Date: 2024-05-16 DOI: 10.1080/17446651.2024.2353723

Asma Gorchane, Taieb Ach, Jihene Sahli, Nassim Bel Hadj Salah, Nadia Ben Lasfar, Asma Ben Abdelkrim, Manel Mallouli, Foued Bellazreg, Wissem Hachfi, Molka Chadli Chaieb, Amel Letaief, Koussay Ach

{"title":"Unmasking the escalation: a comparative analysis of diabetic ketoacidosis severity before and during the COVID-19 pandemic in a Tunisian pioneer study.","authors":"Asma Gorchane, Taieb Ach, Jihene Sahli, Nassim Bel Hadj Salah, Nadia Ben Lasfar, Asma Ben Abdelkrim, Manel Mallouli, Foued Bellazreg, Wissem Hachfi, Molka Chadli Chaieb, Amel Letaief, Koussay Ach","doi":"10.1080/17446651.2024.2353723","DOIUrl":"10.1080/17446651.2024.2353723","url":null,"abstract":"Background: The severity of diabetic ketoacidosis (DKA) at diagnosis increased during the global COVID-19 pandemic. This study aimed to analyze the impact of the pandemic on the clinical and biological severity of DKA in patients with new-onset diabetes mellitus (DM) in Tunisia.Research design and methods: The study included patients hospitalized for new-onset DKA 2 years prior and 2 years during the COVID-19 pandemic. Data was collected retrospectively, and DKA severity was classified based on biological parameters like potential of hydrogen (pH) and HCO3-.Results: The results showed that DKA was more severe during COVID-19, as evidenced by lower potential of hydrogen (pH) (p = 0.006), and serum bicarbonate (HCO3-) levels (p = 0,005). Despite the higher severity of DKA was higher during COVID-19, intensive care unit hospitalizations remained equivalent (p = 0.359). The prevalence of hyponatremia was also higher during COVID-19 (p = 0.024).Conclusion: The findings suggest that delayed diagnosis and COVID-19 May contribute to the increased severity of DKA and electrolyte imbalance during the pandemic. Further research is needed to better understand the underlying mechanisms and develop appropriate strategies to address this issue.","PeriodicalId":12107,"journal":{"name":"Expert Review of Endocrinology & Metabolism","volume":" ","pages":"393-398"},"PeriodicalIF":3.2,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140944326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the therapeutic potential of pomegranate juice for uterine relaxation. 探索石榴汁对子宫松弛的治疗潜力。

IF 3.2

Expert Review of Endocrinology & Metabolism Pub Date : 2024-07-01 Epub Date: 2024-03-25 DOI: 10.1080/17446651.2024.2334218

Omar A M Al-Habib, Lina N Adam

{"title":"Exploring the therapeutic potential of pomegranate juice for uterine relaxation.","authors":"Omar A M Al-Habib, Lina N Adam","doi":"10.1080/17446651.2024.2334218","DOIUrl":"10.1080/17446651.2024.2334218","url":null,"abstract":"Background: The effects of pomegranate juice (PJ) and its components on uterine smooth muscle are unknown. Hence, this study unequivocally demonstrates that pomegranate juice (PJ) significantly impacts myometrial function, providing crucial insights into its relaxant properties and their potential therapeutic applications for uterine-related disorders.Research design and methods: Rat uterine smooth muscle horn strips were suspended in Krebs solution organ baths. Contractions were measured isometrically using a transducer (AD instrument Australia). The effects of PJ were evaluated on contractile activity elicited by potassium chloride (KCl 60 Mm) depolarization. Inhibitors of nitric oxide (L-NAME 3 X 10-4), guanylate cyclase (methylene blue 1 X 10-5), and Prostaglandin I2 (indomethacin 3 X 10-5), as well as Potassium Channels blockers, were determined.Results: The juice at concentrations from 1.5-5 mg/ml significantly decreased the rat uterine horn contraction induced by KCl. The NO, cGMP, and PGI2 inhibitors did not block the relaxation response. Furthermore, the PGI2 inhibitor significantly enhanced the relaxation effects; K+ channel blockers had no inhibitory effects on the relaxation responses. Contrarily, GLIB improved considerably relaxation.Conclusion: Research suggests pomegranate juice's active ingredient may reduce uterine contractions and treat uterotonic disorders, potentially preventing preterm birth and dysmenorrhea. Further research is needed to determine its mechanism of action.Trial registration: Code: AEC-013.","PeriodicalId":12107,"journal":{"name":"Expert Review of Endocrinology & Metabolism","volume":" ","pages":"377-384"},"PeriodicalIF":3.2,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140206550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improvements and future perspective in diagnostic tools for neuroendocrine neoplasms. 神经内分泌肿瘤诊断工具的改进和未来展望。

IF 2.7

Expert Review of Endocrinology & Metabolism Pub Date : 2024-07-01 Epub Date: 2024-06-05 DOI: 10.1080/17446651.2024.2363537

Sara Massironi, Marianna Franchina, Davide Ippolito, Federica Elisei, Olga Falco, Cesare Maino, Fabio Pagni, Alessandra Elvevi, Luca Guerra, Pietro Invernizzi

{"title":"Improvements and future perspective in diagnostic tools for neuroendocrine neoplasms.","authors":"Sara Massironi, Marianna Franchina, Davide Ippolito, Federica Elisei, Olga Falco, Cesare Maino, Fabio Pagni, Alessandra Elvevi, Luca Guerra, Pietro Invernizzi","doi":"10.1080/17446651.2024.2363537","DOIUrl":"10.1080/17446651.2024.2363537","url":null,"abstract":"Introduction: Neuroendocrine neoplasms (NENs) represent a complex group of tumors arising from neuroendocrine cells, characterized by heterogeneous behavior and challenging diagnostics. Despite advancements in medical technology, NENs present a major challenge in early detection, often leading to delayed diagnosis and variable outcomes. This review aims to provide an in-depth analysis of current diagnostic methods as well as the evolving and future directions of diagnostic strategies for NENs.Area covered: The review extensively covers the evolution of diagnostic tools for NENs, from traditional imaging and biochemical tests to advanced genomic profiling and next-generation sequencing. The emerging role of technologies such as artificial intelligence, machine learning, and liquid biopsies could improve diagnostic precision, as could the integration of imaging modalities such as positron emission tomography (PET)/magnetic resonance imaging (MRI) hybrids and innovative radiotracers.Expert opinion: Despite progress, there is still a significant gap in the early diagnosis of NENs. Bridging this diagnostic gap and integrating advanced technologies and precision medicine are crucial to improving patient outcomes. However, challenges such as low clinical awareness, limited possibility of noninvasive diagnostic tools and funding limitations for rare diseases like NENs are acknowledged.","PeriodicalId":12107,"journal":{"name":"Expert Review of Endocrinology & Metabolism","volume":" ","pages":"349-366"},"PeriodicalIF":2.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141247645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glycaemic control and its associated factors among adult Omanis with type 1 diabetes mellitus: a cross-sectional survey. 患有 1 型糖尿病的阿曼成年人的血糖控制及其相关因素：一项横断面调查。

IF 2.7

Expert Review of Endocrinology & Metabolism Pub Date : 2024-05-01 Epub Date: 2023-12-15 DOI: 10.1080/17446651.2023.2295483

Rajaa Al-Hadhrami, Omar M Al-Rawajfah, Joshua K Muliira, Atika Khalaf

{"title":"Glycaemic control and its associated factors among adult Omanis with type 1 diabetes mellitus: a cross-sectional survey.","authors":"Rajaa Al-Hadhrami, Omar M Al-Rawajfah, Joshua K Muliira, Atika Khalaf","doi":"10.1080/17446651.2023.2295483","DOIUrl":"10.1080/17446651.2023.2295483","url":null,"abstract":"Objectives: This study aimed to investigate the relationship between glycemic control and diabetes self-management (DSM) and other associated factors among adult Omanis with Type-1 Diabetes Mellitus (T1DM).Methods: A cross-sectional, descriptive design was used to collect data among 210 adult Omanis with T1DM who were conveniently recruited. All tools were self-reported, whereas the HbA1c was collected from the patient's electronic medical records.Results: The HbA1c mean value was 8.6 (SD = 2.5), 30.5% had optimal glycemic control (<7.0). A significant negative relationship between HbA1c and DSM (r = - 0.191, p = 0.006) and diabetes knowledge (r = - 0.153, p = 0.026) was found. Furthermore, the mean HbA1c was significantly lower for persons with a single marital status, have higher education level, have children, are unemployed, were not admitted to the hospital in the last year, and have a health care professional as a family member. Additionally, marital status, level of education, DSM, and social support were significant predictors of glycemic control.Conclusions: The results suggested that better glycemic control could be achieved by optimizing DSM, social support, and diabetes knowledge. Sociodemographic factors should be considered when treating individuals with T1DM to reach good glycemic control.","PeriodicalId":12107,"journal":{"name":"Expert Review of Endocrinology & Metabolism","volume":" ","pages":"279-285"},"PeriodicalIF":2.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138801055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Knowledge and attitude on the role of lifestyle modifications in the management of diabetes in Jeddah, Saudi Arabia. 沙特阿拉伯吉达对改变生活方式在糖尿病治疗中的作用的认识和态度。

IF 3.2

Expert Review of Endocrinology & Metabolism Pub Date : 2024-05-01 Epub Date: 2023-12-20 DOI: 10.1080/17446651.2023.2296618

Abdullah A Awadh, Rashed I Ibrahim, Jehad H Habeeballah, Abdulrahman F Gassim, Sultan M Alzahrani, Hassan O Bogari, Anas S AlGhamdi, Mohammed A Khan

{"title":"Knowledge and attitude on the role of lifestyle modifications in the management of diabetes in Jeddah, Saudi Arabia.","authors":"Abdullah A Awadh, Rashed I Ibrahim, Jehad H Habeeballah, Abdulrahman F Gassim, Sultan M Alzahrani, Hassan O Bogari, Anas S AlGhamdi, Mohammed A Khan","doi":"10.1080/17446651.2023.2296618","DOIUrl":"10.1080/17446651.2023.2296618","url":null,"abstract":"Background: Public knowledge about the role of lifestyle in managing type two diabetes (T2D) is an essential preventive strategy. Despite efforts in public awareness, the prevalence continues to rise, with the majority relying on the availability of effective therapeutics, underestimating the role of healthy lifestyle changes. This study aims to assess public awareness of the impact of lifestyle modification in managing T2D in a major metropolitan city in Saudi Arabia, which will help inform the health management authority in the country on the level of public awareness and advise on the development of educational programs.Methods: An observational cross-sectional survey study comprising 16 knowledge and 6 attitude questions was conducted among the population over 18 years old using online survey. After validation, the online self-developed questionnaire was distributed through social media.Results: The knowledge and attitude scores were similar between males and females. Participants with a family member or friend with T2D demonstrated higher knowledge scores. However, the attitude scores did not differ significantly based on family or friend relationships.Conclusion: The knowledge and attitude on the role of lifestyle modifications in preventing and managing T2D is moderate, implying an opportunity for innovative strategies to raise public knowledge and attitude.","PeriodicalId":12107,"journal":{"name":"Expert Review of Endocrinology & Metabolism","volume":" ","pages":"287-294"},"PeriodicalIF":3.2,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138801061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drug-induced hypothyroidism in tuberculosis. 结核病中药物诱发的甲状腺功能减退症。

IF 3.2

Expert Review of Endocrinology & Metabolism Pub Date : 2024-05-01 Epub Date: 2024-01-23 DOI: 10.1080/17446651.2024.2307525

Juan Eduardo Quiroz-Aldave, María Del Carmen Durand-Vásquez, Elman Rolando Gamarra-Osorio, Luis Alberto Concepción-Urteaga, Samuel Pecho-Silva, Luis Alejandro Rodríguez-Hidalgo, Marcio José Concepción-Zavaleta

{"title":"Drug-induced hypothyroidism in tuberculosis.","authors":"Juan Eduardo Quiroz-Aldave, María Del Carmen Durand-Vásquez, Elman Rolando Gamarra-Osorio, Luis Alberto Concepción-Urteaga, Samuel Pecho-Silva, Luis Alejandro Rodríguez-Hidalgo, Marcio José Concepción-Zavaleta","doi":"10.1080/17446651.2024.2307525","DOIUrl":"10.1080/17446651.2024.2307525","url":null,"abstract":"Introduction: Adverse reactions to tuberculosis treatment can impact patient adherence and prognosis. Hypothyroidism is a frequent adverse reaction caused using ethionamide, prothionamide, and para-aminosalicylic acid and is often underdiagnosed.Areas covered: We searched Scielo, Scopus, and EMBASE databases, including 67 articles. Antitubercular drug-induced hypothyroidism has a prevalence of 17%. It occurs after 2 to 3 months of treatment and resolves within 4 to 6 weeks after discontinuation. It is postulated to result from the inhibition of thyroperoxidase function, blocking thyroid hormone synthesis. Symptoms are nonspecific, necessitating individualized thyroid-stimulating hormone measurement for detection. Specific guidelines for management are lacking, but initiation of treatment with levothyroxine, as is customary for primary hypothyroidism, is recommended. Discontinuation of antitubercular drugs is discouraged, as it may lead to unfavorable consequences.Expert opinion: Antitubercular drug-induced hypothyroidism is more common than previously thought, affecting one in six MDR-TB patients. Despite diagnostic and treatment recommendations, implementation is hindered in low-income countries due to the lack of certified laboratories. New drugs for tuberculosis treatment may affect thyroid function, requiring vigilant monitoring for complications, including hypothyroidism.","PeriodicalId":12107,"journal":{"name":"Expert Review of Endocrinology & Metabolism","volume":" ","pages":"199-206"},"PeriodicalIF":3.2,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139519558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hormonal influences on cerebral aneurysms: unraveling the complex connections. 荷尔蒙对脑动脉瘤的影响：解开复杂的联系。

IF 3.2

Expert Review of Endocrinology & Metabolism Pub Date : 2024-05-01 Epub Date: 2024-05-07 DOI: 10.1080/17446651.2024.2347275

Zahra Hasanpour Segherlou, Mahdieh Shakeri-Darzekonani, Armin Khavandegar, Sara Stephenson, Kimberly Ciccone, Forough Masheghati, Mohammad Reza Hosseini Siyanaki, Mac Lyerly, Brandon Lucke-Wold

{"title":"Hormonal influences on cerebral aneurysms: unraveling the complex connections.","authors":"Zahra Hasanpour Segherlou, Mahdieh Shakeri-Darzekonani, Armin Khavandegar, Sara Stephenson, Kimberly Ciccone, Forough Masheghati, Mohammad Reza Hosseini Siyanaki, Mac Lyerly, Brandon Lucke-Wold","doi":"10.1080/17446651.2024.2347275","DOIUrl":"10.1080/17446651.2024.2347275","url":null,"abstract":"Introduction: Intracranial aneurysms (IAs) occur in 3-5% of the general population and are characterized by localized structural deterioration of the arterial wall with loss of internal elastic lamina and disruption of the media. The risk of incidence and rupture of aneurysms depends on age, sex, ethnicity, and other different factors, indicating the influence of genetic and environmental factors. When an aneurysm ruptures, there is an estimated 20% mortality rate, along with an added 30-40% morbidity in survivors. The alterations in hormonal levels can influence IAs, while the rupture of an aneurysm can have various impacts on endocrine pathways and affect their outcome.Area covered: This review explores the reciprocal relationship between endocrinological changes (estrogen, growth hormone, and thyroid hormones) and IAs, as well as the effects of aneurysm ruptures on endocrine fluctuations.Expert opinion: Based on the data presented in this paper, we recommend further exploration into the influence of hormones on aneurysm formation and rupture. Additionally, we propose conducting endocrine assessments for patients who have experienced a rupture of IAs. Monitoring hormonal changes in patients with IAs could serve as a potential risk factor for rupture, leading to interventions in the approach to managing IAs.","PeriodicalId":12107,"journal":{"name":"Expert Review of Endocrinology & Metabolism","volume":" ","pages":"207-215"},"PeriodicalIF":3.2,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140861763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From islet transplantation to beta-cell regeneration: an update on beta-cell-based therapeutic approaches in type 1 diabetes. 从胰岛移植到β细胞再生：基于β细胞的 1 型糖尿病治疗方法的最新进展。

IF 3.2

Expert Review of Endocrinology & Metabolism Pub Date : 2024-05-01 DOI: 10.1080/17446651.2024.2347263

Asef Azad, Hasan Ali Altunbas, Ayse Esra Manguoglu

{"title":"From islet transplantation to beta-cell regeneration: an update on beta-cell-based therapeutic approaches in type 1 diabetes.","authors":"Asef Azad, Hasan Ali Altunbas, Ayse Esra Manguoglu","doi":"10.1080/17446651.2024.2347263","DOIUrl":"10.1080/17446651.2024.2347263","url":null,"abstract":"Introduction: Type 1 diabetes (T1D) mellitus is an autoimmune disease in which immune cells, predominantly effector T cells, destroy insulin-secreting beta-cells. Beta-cell destruction led to various consequences ranging from retinopathy and nephropathy to neuropathy. Different strategies have been developed to achieve normoglycemia, including exogenous glucose compensation, whole pancreas transplantation, islet transplantation, and beta-cell replacement.Areas covered: The last two decades of experience have shown that indigenous glucose compensation through beta-cell regeneration and protection is a peerless method for T1D therapy. Tremendous studies have tried to find an unlimited source for beta-cell regeneration, on the one hand, and beta-cell protection against immune attack, on the other hand. Recent advances in stem cell technology, gene editing methods, and immune modulation approaches provide a unique opportunity for both beta-cell regeneration and protection.Expert opinion: Pluripotent stem cell differentiation into the beta-cell is considered an unlimited source for beta-cell regeneration. Devising engineered pancreas-specific regulatory T cells using Chimeric Antigen Receptor (CAR) technology potentiates an effective immune tolerance induction for beta-cell protection. Beta-cell regeneration using pluripotent stem cells and beta-cell protection using pancreas-specific engineered regulatory T cells promises to develop a curative protocol in T1D.","PeriodicalId":12107,"journal":{"name":"Expert Review of Endocrinology & Metabolism","volume":" ","pages":"217-227"},"PeriodicalIF":3.2,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140853341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0