Systematic review and meta-analyses of adipokine levels in hypothyroidism: a role for retinol-binding protein 4.

IF 2.7 Q3 ENDOCRINOLOGY & METABOLISM
Emiliana Maria Torres, Mariana Lorena Tellechea
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引用次数: 0

Abstract

Background: Hypothyroidism (HT) is associated with numerous well-characterized comorbidities and established biomarkers for subclinical atherosclerosis which may lead to an elevated risk of cardiovascular disease; however, the precise molecular mechanism underlying these pathological features remains elusive. Increased levels of adipokines may have adverse effects on multiple atherosclerotic risk factors in HT. Different studies have evaluated the association between HT and adipokines with conflicting results.

Methods: A systematic review and meta-analyses were conducted to provide an overview of adipokine levels in HT. The last literature search was done in February 2024 for studies analyzing traditional and novel circulating adipokines levels (excluding resistin and irisin) in patients with HT. The standard mean differences and 95% confidence intervals (CI) were calculated using random-effect models except if no heterogeneity was found.

Results: HT was not associated with leptin, adiponectin, omentin-1, visfatin, or apelin levels; however, increased retinol-binding protein 4 (RPB4) levels were found in both overall and subclinical HT (p-values = 0.0002 and 0.004 respectively).

Conclusion: While pooled analysis suggested a role for RBP4 in hypothyroid patients, associations do not imply cause-effect relationships, and therefore the potential clinical implications of these findings should await further mechanistic studies.

Registration: The protocol has been registered in the Prospective Register of Systematic Reviews (PROSPERO) under the identification number CRD42024537717.

脂肪因子水平在甲状腺功能减退中的系统回顾和荟萃分析:视黄醇结合蛋白4的作用。
背景:甲状腺功能减退症(HT)与许多特征明确的合并症和亚临床动脉粥样硬化的生物标志物相关,这可能导致心血管疾病的风险升高;然而,这些病理特征背后的精确分子机制仍然难以捉摸。脂肪因子水平升高可能对HT患者的多种动脉粥样硬化危险因素有不利影响。不同的研究评估了HT和脂肪因子之间的关系,结果相互矛盾。方法:进行系统回顾和荟萃分析,以提供脂肪因子水平在HT的概述。最后一次文献检索是在2024年2月完成的,用于分析HT患者中传统和新型循环脂肪因子水平(不包括抵抗素和鸢尾素)的研究。除未发现异质性外,使用随机效应模型计算标准均值差和95%置信区间(CI)。结果:HT与瘦素、脂联素、网膜蛋白-1、visfatin或apelin水平无关;然而,视黄醇结合蛋白4 (RPB4)水平在整体和亚临床HT中均升高(p值分别为0.0002和0.004)。结论:虽然综合分析表明RBP4在甲状腺功能减退患者中起作用,但相关性并不意味着因果关系,因此这些发现的潜在临床意义有待进一步的机制研究。注册:该方案已在系统评价前瞻性注册(PROSPERO)中注册,识别号为CRD42024537717。
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来源期刊
Expert Review of Endocrinology & Metabolism
Expert Review of Endocrinology & Metabolism ENDOCRINOLOGY & METABOLISM-
CiteScore
4.80
自引率
0.00%
发文量
44
期刊介绍: Implicated in a plethora of regulatory dysfunctions involving growth and development, metabolism, electrolyte balances and reproduction, endocrine disruption is one of the highest priority research topics in the world. As a result, we are now in a position to better detect, characterize and overcome the damage mediated by adverse interaction with the endocrine system. Expert Review of Endocrinology and Metabolism (ISSN 1744-6651), provides extensive coverage of state-of-the-art research and clinical advancements in the field of endocrine control and metabolism, with a focus on screening, prevention, diagnostics, existing and novel therapeutics, as well as related molecular genetics, pathophysiology and epidemiology.
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